深圳市光明区10717例女性人乳头状瘤病毒感染亚型分析
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摘要
目的:调查深圳市光明区育龄女性人乳头状瘤病毒(human papillomavirus,HPV)感染率、感染亚型及年龄分布情况,为预防HPV感染和宫颈癌提供依据。方法:回顾性分析2015年1月至2018年9月在深圳市光明区28家社康中心行HPV分型检测的女性患者标本10 717例。结果:感染HPV患者1 470例,感染率为13.7%,其中HPV高危型1 308例,低危型244例。HPV高危型感染率前3位的分别为52、16、58亚型,其感染率分别为22.3%、12.8%、9.8%。患者年龄分析表明,感染率最高的是≤20岁年龄组(23.2%),其次是>50岁年龄组(20.7%)。结论:深圳市光明区女性HPV感染以HPV52、16、58亚型为主。应加强对年轻女性及50岁以上女性HPV感染的监测力度。
Objective: To investigate the infection rate, subtypes and age distribution of human papillomavirus(HPV) among women of childbearing age in Guangming District of Shenzhen,and to provide evidence for preventing HPV infection and cervical cancer. Method: 10 717 female patients who underwent HPV typing tests in 28 social health centers in Guangming District of Shenzhen from January 2015 to September 2018 was retrospectively analyzed. Result: There were 1 470 cases of HPV infection, and the infection rate was 13.7%,including 1 308 cases of high-risk HPV type and 244 cases of low-risk HPV type.The top three high-risk HPV infection rates were 52, 16 and 58 subtypes, and the infection rates were 22.3%,12.8% and 9.8% respectively. Age analysis showed that the highest infection rate was in the age group of ≤ 20 years old(23.2%),followed by the age group of > 50 years old(20.7%). Conclusion:HPV 52,16 and 58 subtypes were the main types of HPV infection among women in Guangming District of Shenzhen. The surveillance of HPV infection in young women and women over 50 years old should be strengthened.
Objective: To investigate the infection rate, subtypes and age distribution of human papillomavirus(HPV) among women of childbearing age in Guangming District of Shenzhen,and to provide evidence for preventing HPV infection and cervical cancer. Method: 10 717 female patients who underwent HPV typing tests in 28 social health centers in Guangming District of Shenzhen from January 2015 to September 2018 was retrospectively analyzed. Result: There were 1 470 cases of HPV infection, and the infection rate was 13.7%,including 1 308 cases of high-risk HPV type and 244 cases of low-risk HPV type.The top three high-risk HPV infection rates were 52, 16 and 58 subtypes, and the infection rates were 22.3%,12.8% and 9.8% respectively. Age analysis showed that the highest infection rate was in the age group of ≤ 20 years old(23.2%),followed by the age group of > 50 years old(20.7%). Conclusion:HPV 52,16 and 58 subtypes were the main types of HPV infection among women in Guangming District of Shenzhen. The surveillance of HPV infection in young women and women over 50 years old should be strengthened.
引文
[1]邱惠萍,姚水洪,徐卫东.女性人乳头状瘤病毒感染与宫颈病变关系研究[J].中华医院感染学杂志,2009,19(1):65-68.
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[3]靳大川,郭宇辉.郑州市女性人乳头状瘤病毒感染的流行病学特征及分析[J].医学研究杂志,2017,46(11):88-92.
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[5]吴瑞芳,刘植华,周庆芝,等.深圳女性生殖道人乳头瘤病毒感染与子宫颈上皮内瘤样病变现患率调查及子宫颈癌筛查方法的评价[J].中国医学科学院学报,2010,32(1):90-95.
[6]郭晓霞,田玉旺,张立英,等.41751例女性宫颈细胞中HPV基因分型的回顾性分析[J].临床与病理杂志,2016,36(2):113-127.
[7]詹银珠,陈小琴,谢秀敏,等.深圳市观澜地区人乳头瘤病毒感染亚型分析[J].广东医学,2017,38(13):2057-2059.
[8]江卫红,范世珍,莫莉,等.深圳市福田区18749例妇女宫颈人乳头瘤病毒分型检测结果的分析[J].中国实验诊断学,2017,21(7):1201-1205.
[9]何成山,马晨芸,陆志成.上海部分区域人乳头瘤状病毒基因分型及感染状况[J].职业与健康,2018,34(16):2226-2229.
[10]SASAGAWA T,MAEHAMA T,IDETA K,et al.Population-based study for human papillomavirus(HPV)infection in young women in Japan:A multicenter study by the Japanese human papillomavirus disease education research survey group(J-HERS)[J].J Med Virol,2016,88(2):324-335.
[11]GALLEGOS-BOLA?OS J,RIVERA-DOMíNGUEZJ A,PRESNO-BERNAL J M,et al.High prevalence of co-infection between human papillomavirus(HPV)51 and 52 in Mexican population[J].BMC Cancer,2017,17(1):531.
[12]DICKSON E L,VOGEL R I,BLISS R L,et al.Multiple-type human papillomavirus(HPV)infections:a cross-sectional analysis of the prevalence of specific types in 309,000 women referred for HPV testing at the time of cervical cytology[J].Int J Gynecol Cancer,2013,23(7):1295-1302.
[13]刘文姬,刘志强,郭庆枝,等.HPV疫苗接种及其对宫颈癌筛查方案影响研究进展[J].现代妇产科进展,2018,27(3):228-231.
[2]苏士海,陈晓晴,余坚.人乳头状瘤病毒多重感染不同类型与宫颈病变程度的关系[J].中华医院感染学杂志,2012,22(23):5292-5294.
[3]靳大川,郭宇辉.郑州市女性人乳头状瘤病毒感染的流行病学特征及分析[J].医学研究杂志,2017,46(11):88-92.
[4]王月云,彭绩,周海滨,等.深圳市妇女子宫颈人乳头瘤病毒感染分子流行病学分析[J].中国慢性病预防与控制,2012,20(3):293-295.
[5]吴瑞芳,刘植华,周庆芝,等.深圳女性生殖道人乳头瘤病毒感染与子宫颈上皮内瘤样病变现患率调查及子宫颈癌筛查方法的评价[J].中国医学科学院学报,2010,32(1):90-95.
[6]郭晓霞,田玉旺,张立英,等.41751例女性宫颈细胞中HPV基因分型的回顾性分析[J].临床与病理杂志,2016,36(2):113-127.
[7]詹银珠,陈小琴,谢秀敏,等.深圳市观澜地区人乳头瘤病毒感染亚型分析[J].广东医学,2017,38(13):2057-2059.
[8]江卫红,范世珍,莫莉,等.深圳市福田区18749例妇女宫颈人乳头瘤病毒分型检测结果的分析[J].中国实验诊断学,2017,21(7):1201-1205.
[9]何成山,马晨芸,陆志成.上海部分区域人乳头瘤状病毒基因分型及感染状况[J].职业与健康,2018,34(16):2226-2229.
[10]SASAGAWA T,MAEHAMA T,IDETA K,et al.Population-based study for human papillomavirus(HPV)infection in young women in Japan:A multicenter study by the Japanese human papillomavirus disease education research survey group(J-HERS)[J].J Med Virol,2016,88(2):324-335.
[11]GALLEGOS-BOLA?OS J,RIVERA-DOMíNGUEZJ A,PRESNO-BERNAL J M,et al.High prevalence of co-infection between human papillomavirus(HPV)51 and 52 in Mexican population[J].BMC Cancer,2017,17(1):531.
[12]DICKSON E L,VOGEL R I,BLISS R L,et al.Multiple-type human papillomavirus(HPV)infections:a cross-sectional analysis of the prevalence of specific types in 309,000 women referred for HPV testing at the time of cervical cytology[J].Int J Gynecol Cancer,2013,23(7):1295-1302.
[13]刘文姬,刘志强,郭庆枝,等.HPV疫苗接种及其对宫颈癌筛查方案影响研究进展[J].现代妇产科进展,2018,27(3):228-231.