何首乌化学成分与药理作用研究进展
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摘要
何首乌为常见的补益类中药,在临床中具有广泛的应用。近年来有较多与何首乌相关的文献报道,通过对国内外相关文献进行整理和分析,概述何首乌的化学成分及其药理作用的研究进展。目前,已从何首乌中分离出二苯乙烯苷类、蒽醌类、黄酮类、磷脂类、苯丙素类以及其他化合物共133种,其中二苯乙烯苷二聚体以及二蒽酮苷是近期从何首乌中分离得到的两类新化合物。何首乌的药理活性研究主要有抗氧化、抗肿瘤、抗动脉粥样硬化以及神经保护等作用,在治疗神经退行性疾病、防治动脉粥样硬化、降血糖等方面具有潜力,其药效成分主要包括二苯乙烯苷类、蒽醌类以及黄酮类,其中二苯乙烯苷类中2,3,5,4'-四羟基二苯乙烯-2-O-葡萄糖苷即THSG显示出多种生物活性,但对何首乌中其他化合物药理活性的研究较少。因此,为保证何首乌的进一步开发利用,建议对其药效的物质基础进行更加深入、全面的研究。
As a common tonic traditional Chinese medical herb,Polygoni Multiflori Radix has been extensively applied in clinic. In recent years, there have been many literatures related to Polygoni Multiflori Radix. By reviewing the literatures in domestic and foreign, the latest progress on chemical components and pharmacology of Polygoni Multiflori Radix have been summarized and analyzed. At present,more than 133 kinds of compounds have been isolated from Polygoni Multiflori Radix,such as stilbene glycosides,terpenoids,flavonoids,phospholipids and phenylpropanoids. Among them,stilbene dimer and dianthrone glycosides are two kind of new compounds recently isolated from it. The current researches about the pharmacological effect of Polygoni Multiflori Radix focus on anti-oxidative, anti-tumor, anti-atherosclerosis and neuro-protective effects, with potentials in treating neurodegenerative diseases,preventing and treating arterial and reducing blood sugar. Its medicinal ingredients mainly include stilbene glycosides, terpenoids and flavonoids, in which 2, 3, 5, 4'-tetrahydroxysilbene 2-O-glucopyranoside shows a variety of biological activities. However,there are a few studies on the pharmacological activities of other compounds. Therefore,to ensure the further development and utilization of Polygoni Multiflori Radix,it is suggested to conduct a more in-depth and comprehensive research on the material basis of its efficacy.
As a common tonic traditional Chinese medical herb,Polygoni Multiflori Radix has been extensively applied in clinic. In recent years, there have been many literatures related to Polygoni Multiflori Radix. By reviewing the literatures in domestic and foreign, the latest progress on chemical components and pharmacology of Polygoni Multiflori Radix have been summarized and analyzed. At present,more than 133 kinds of compounds have been isolated from Polygoni Multiflori Radix,such as stilbene glycosides,terpenoids,flavonoids,phospholipids and phenylpropanoids. Among them,stilbene dimer and dianthrone glycosides are two kind of new compounds recently isolated from it. The current researches about the pharmacological effect of Polygoni Multiflori Radix focus on anti-oxidative, anti-tumor, anti-atherosclerosis and neuro-protective effects, with potentials in treating neurodegenerative diseases,preventing and treating arterial and reducing blood sugar. Its medicinal ingredients mainly include stilbene glycosides, terpenoids and flavonoids, in which 2, 3, 5, 4'-tetrahydroxysilbene 2-O-glucopyranoside shows a variety of biological activities. However,there are a few studies on the pharmacological activities of other compounds. Therefore,to ensure the further development and utilization of Polygoni Multiflori Radix,it is suggested to conduct a more in-depth and comprehensive research on the material basis of its efficacy.
引文
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[13]刘振丽,李林福,巢志茂,等.何首乌炮制后化学成分的研究[J].天然产物研究与开发,2009,21(2):239-241,248.
[14]余意,李佳兴,金艳,等. UPLC-MS/MS法测定制何首乌中9种二苯乙烯苷类成分含量[J].中药材,2018,41(6):1395-1398.
[15] SUN Y N,CUI L,LI W,et al. Promotion effect of constituents from the root of Polygonum multiflorum on hair growth[J]. Bioorg Med Chem Lett,2013,23(17):4801-4805.
[16] LI S G,CHEN L L,HUANG X J,et al. Five new stilbene glycosides from the roots of Polygonum multiflorum[J].J Asian Nat Prod Res,2013,15(11):1145-1151.
[17]陈万生,杨根金,张卫东,等.制首乌中两个新化合物[J].药学学报,2000,35(4):273-276.
[18]颜世伦.制何首乌的化学成分研究[D].天津:天津大学,2014.
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[21] Büchter C,ZHAO L,Havermann S,et al. TSG(2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside)from the Chinese herb Polygonum multiflorum increases life span and stress resistance of caenorhabditis elegans[J]. Oxid Med Cell Longev,2015,2015(3):124357.
[22] ZHANG R, SUN F, ZHANG L, et al.Tetrahydroxystilbene glucoside inhibitsα-synuclein aggregation and apoptosis in A53tα-synucleintransfected cells exposed to Mpp[J]. Can J Physiol Pharmacol,2017,95(6):750-758.
[23] YAO W J, GU C J, SHAO H R, et al.Tetrahydroxystilbene glucoside improves TNF-α-induced endothelial dysfunction:involvement of Tgfβ/Smad pathway and inhibition of vimentin expression[J]. Am J Chin Med,2015,43(1):183-198.
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