核酸适配体在环境雌激素检测领域的研究进展
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摘要
环境雌激素指具有雌激素效应,能够模拟天然雌激素,干扰内分泌功能的一类化合物。它可通过干扰或阻断雌激素受体与内源性雌激素的相互作用,影响天然激素的合成、分泌、运输、反应和代谢等,从而导致生殖、神经和免疫系统等的异常。因此急需建立环境雌激素的快速检测方法。核酸适配体是在体外筛选得到的一小段寡核苷酸,能够与靶标高亲和力、高特异性的结合,具有靶标范围广、灵敏度高、易于修饰等优点,被广泛应用于环境雌激素快速检测。该文主要综述环境雌激素的分类、筛选以及适配体技术在环境雌激素快速检测中的应用。
Environment estrogens have estrogen effect which can simulate natural hormones and influence vital endocrine functions. Environment estrogens interfere the hormones synthesis,secretion,transport,reaction and metabolism by mimicing or blocking the interaction of the endogenous hormones and the hormone's receptor,therefore it can lead to abnormal phenomena of genital,nervous,and immunologic system. Hence,it is necessary to establish rapid methods for environment estrogens detection. Aptamers are DNA or RNA sequences were selected in vitro for their ability to bind targets with high affinity and specificity. Aptamers have been widely used in analysis field because of its target diversity,high sensitivity,and easy to modified for applications. The classification and selection of environment estrogens, and aptasensor application in environment estrogens rapid detection methods were summarized.
Environment estrogens have estrogen effect which can simulate natural hormones and influence vital endocrine functions. Environment estrogens interfere the hormones synthesis,secretion,transport,reaction and metabolism by mimicing or blocking the interaction of the endogenous hormones and the hormone's receptor,therefore it can lead to abnormal phenomena of genital,nervous,and immunologic system. Hence,it is necessary to establish rapid methods for environment estrogens detection. Aptamers are DNA or RNA sequences were selected in vitro for their ability to bind targets with high affinity and specificity. Aptamers have been widely used in analysis field because of its target diversity,high sensitivity,and easy to modified for applications. The classification and selection of environment estrogens, and aptasensor application in environment estrogens rapid detection methods were summarized.
引文
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[9]Gallistl C,Proctor K,Bader K,et al.Synthesis of the DDT metabolite 2,4-dichloro-1-[2-chloro-1-(4-chlorophenyl)ethenyl]benzene(o-Cl-DDMU)and its detection in abiotic and biotic samples[J].Environmental Science&Pollution Research International,2017,24(20):16815-16828
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[13]贾毅娜,梁刚.环境雌激素对生殖腺及卵黄蛋白原影响的研究进展[J].生物技术通报,2013,35(6):46-52
[14]Zheng Y,Zhao Y,Di Y,et al.DNA aptamers from whole-serum SE-LEX as new diagnostic agents against gastric cancer[J].RSC Advances,2019,9:950-957
[15]Ye H,Lu Q,Duan N,et al.GO-amplified fluorescence polarization assay for high-sensitivity detection of aflatoxin B1 with low dosage aptamer probe[J].Analytical and Bioanalytical Chemistry,2019,411(5):1107-1115
[16]Dong Y,Xu Y,Yong W,et al.Aptamer and its potential applications for food safety[J].Critical reviews in food science and nutrition,2014,54(12):1548-1561
[17]Liu X,Zhang X.Aptamer-Based Technology for Food Analysis[J].Applied Biochemistry&Biotechnology,2015,175(1):603-624
[18]Nguyen V T,Kwon Y S,Gu M B.Aptamer-based environmental biosensors for small molecule contaminants[J].Current opinion in biotechnology,2017,45:15-23
[19]Ma C,Liu H,Zhang L,et al.Multiplexed aptasensor for simultaneous detection of carcinoembryonic antigen and mucin-1 based on metal ion electrochemical labels and Ru(NH3)63+electronic wires[J].Biosensors&Bioelectronics,2017,99:8-13
[20]Lin B,Yu Y,Li R,et al.Turn-on sensor for quantification and imaging of acetamiprid residues based on quantum dots functionalized with aptamer[J].Sensors and Actuators B:Chemical,2016,229:100-109
[21]张桂兰,朱超,黄亚飞,等.基于适配体技术的雌性激素检测方法研究进展[J].分析测试学报,2017,36(3):422-430
[22]Jo M,Ahn J Y,Lee J,et al.Development of Single-Stranded DNAAptamers for Specific Bisphenol A Detection[J].Oligonucleotides,2011,21(2):85-91
[23]Kim Y S,Jung H S,Matsuura T,et al.Electrochemical detection of17beta-estradiol using DNA aptamer immobilized gold electrode chip[J].Biosensors&Bioelectronics,2007,22(11):2525-2531
[24]Alsager O A,Kumar S,Willmott G R,et al.Small molecule detection in solution via the size contraction response of aptamer functionalized nanoparticles[J].Biosensors and Bioelectronics,2014,57:262-268
[25]Alsager O A,Kumar S,Zhu B,et al.Ultrasensitive colorimetric detection of 17β-estradiol:The effect of shortening DNA aptamer sequences[J].Analytical Chemistry,2015,87(8):4201-4209
[26]Vanschoenbeek K,Vanbrabant J,Hosseinkhani B,et al.Aptamers targeting different functional groups of 17β-estradiol[J].The Journal of Steroid Biochemistry and Molecular Biology,2015,147:10-16
[27]Akki S U,Werth C J,Silverman S K.Selective Aptamers for Detection of Estradiol and Ethynylestradiol in Natural Waters[J].Environmental Science&Technology,2015,49(16):9905-9913
[28]Jiménez G C,Eissa S,Ng A,et al.Aptamer-Based Label-Free Impedimetric Biosensor for Detection of Progesterone[J].Analytical Chemistry,2015,87(2):1075-1082
[29]Xu J,Li Y,Bie J,et al.Colorimetric method for determination of bisphenol A based on aptamer-mediated aggregation of positively charged gold nanoparticles[J].Microchimica Acta,2015,182(13/14):2131-2138
[30]Liu J,Bai W,Niu S,et al.Highly sensitive colorimetric detection of17β-estradiol using split DNA aptamers immobilized on unmodified gold nanoparticles[J].Scientific reports,2014,4:7571
[31]Zhang D,Yang J,Ye J,et al.Colorimetric detection of bisphenol Abased on unmodified aptamer and cationic polymer aggregated gold nanoparticles[J].Analytical biochemistry,2016,499:51-56
[32]Du G,Zhang D,Xia B,et al.A label-free colorimetric progesterone aptasensor based on the aggregation of gold nanoparticles[J].Microchimica Acta,2016,183(7):2251-2258
[33]Huang H,Shi S,Xing G,et al.A universal label-free fluorescent aptasensor based on Ru complex and quantum dots for adenosine,dopamine and 17β-estradiol detection[J].Biosensors&Bioelectronics,2016,79:198-204
[34]Ni X,Xia B,Wang L,et al.Fluorescent aptasensor for 17β-estradiol determination based on gold nanoparticles quenching the fluorescence of Rhodamine B[J].Analytical Biochemistry,2017,523:17-23
[35]Yingyue Zhu,Yilin Cai.Building An Aptamer/Graphene Oxide FRET Biosensor for One-Step Detection of BisphenolA.American Chemical Society,2015,1021:7492-7496
[36]Li Y,Xu J,Wang L,et al.Aptamer-based fluorescent detection of bisphenol A using nonconjugated gold nanoparticles and CdTe quantum dots[J].Sensors&Actuators B Chemical,2016,222:815-822
[37]Huang K J,Liu Y J,Zhang J Z.Aptamer-based electrochemical assay of 17β-estradiol using a glassy carbon electrode modified with copper sulfide nanosheets and gold nanoparticles,and applying enzyme-based signal amplification[J].Microchimica Acta,2015,182(1/2):409-417
[38]Soh J H,Lin Y,Rana S,et al.Colorimetric Detection of Small Molecules in Complex Matrixes via Target-Mediated Growth of Aptamer-Functionalized Gold Nanoparticles[J].Analytical Chemistry,2015,87(15):7644-7652
[39]Povedano E,Cincotto F H,Parrado C,et al.Decoration of reduced graphene oxide with rhodium nanoparticles for the design of a sensitive electrochemical enzyme biosensor for 17β-estradiol[J].Biosensors and Bioelectronics,2017,89:343-351
[40]Liu Y,Liu Y,Liu B.A dual-signaling strategy for ultrasensitive detection of bisphenol A by aptamer-based electrochemical biosensor[J].Journal of Electroanalytical Chemistry,2016,781:265-271
[41]Zhang Y,Wang Y,Zhu W,et al.Simultaneous colorimetric determination of bisphenol A and bisphenol S via a multi-level DNA circuit mediated by aptamers and gold nanoparticles[J].Microchimica Acta,2017,184(3):951-959
[2]Adeel M,Song X,Wang Y,et al.Environmental impact of estrogens on human,animal and plant life:A critical review[J].Environment International,2016,99:107-119
[3]刘建林.雌激素化合物在土壤中的吸附行为及生物降解的研究[D].北京:华北电力大学,2012
[4]Ting Y F,Praveena S M.Sources,mechanisms,and fate of steroid estrogens in wastewater treatment plants:a mini review[J].Environmental monitoring and assessment,2017,189(4):178:1-19
[5]Feng H,Ning L,Xiao Li L.Simultaneous Determination of Hexoestrol,Diethylstilbestrol,Estrone and 17-Beta-estradiol in Feed by Gas Chromatography-mass Spectrometry[J].Journal of Northeast A-gricultural University(English Edition),2016,23(1):44-49
[6]Soni M,Kridawati A,Bandelow S,et al.Phytoestrogen consumption and risk for cognitive decline and dementia:With consideration of thyroid status and other possible mediators[J].Journal of Steroid Biochemistry&Molecular Biology,2016,160(4):67-77
[7]Schaefer W R,Fischer W R,er al.In vitro-Ishikawa cell for assessing tissue-specific chemical effects on human endometrium[J].Repro-ductive Toxicology,2010,30(1):89-93
[8]Nault R,Fader K A,Kirby M P,et al.Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin[J].Toxicological Sciences An Official Journal of the Society of Toxicology,2016,149(2):358-371
[9]Gallistl C,Proctor K,Bader K,et al.Synthesis of the DDT metabolite 2,4-dichloro-1-[2-chloro-1-(4-chlorophenyl)ethenyl]benzene(o-Cl-DDMU)and its detection in abiotic and biotic samples[J].Environmental Science&Pollution Research International,2017,24(20):16815-16828
[10]Carvalho F P.Pesticides,environment,and food safety[J].Food and Energy Security,2017,6(2):48-60
[11]Kumar R,Gaurav,Heena,et al.Efficient analysis of selected estrogens using fabric phase sorptive extraction and high performance liquid chromatography-fluorescence detection[J].Journal of Chromatography A,2014,1359(15):16-25
[12]许志刚,刘智敏,杨保民,等.酚类环境雌激素的分析检测方法研究进展[J].化学试剂,2012,34(5):424-428
[13]贾毅娜,梁刚.环境雌激素对生殖腺及卵黄蛋白原影响的研究进展[J].生物技术通报,2013,35(6):46-52
[14]Zheng Y,Zhao Y,Di Y,et al.DNA aptamers from whole-serum SE-LEX as new diagnostic agents against gastric cancer[J].RSC Advances,2019,9:950-957
[15]Ye H,Lu Q,Duan N,et al.GO-amplified fluorescence polarization assay for high-sensitivity detection of aflatoxin B1 with low dosage aptamer probe[J].Analytical and Bioanalytical Chemistry,2019,411(5):1107-1115
[16]Dong Y,Xu Y,Yong W,et al.Aptamer and its potential applications for food safety[J].Critical reviews in food science and nutrition,2014,54(12):1548-1561
[17]Liu X,Zhang X.Aptamer-Based Technology for Food Analysis[J].Applied Biochemistry&Biotechnology,2015,175(1):603-624
[18]Nguyen V T,Kwon Y S,Gu M B.Aptamer-based environmental biosensors for small molecule contaminants[J].Current opinion in biotechnology,2017,45:15-23
[19]Ma C,Liu H,Zhang L,et al.Multiplexed aptasensor for simultaneous detection of carcinoembryonic antigen and mucin-1 based on metal ion electrochemical labels and Ru(NH3)63+electronic wires[J].Biosensors&Bioelectronics,2017,99:8-13
[20]Lin B,Yu Y,Li R,et al.Turn-on sensor for quantification and imaging of acetamiprid residues based on quantum dots functionalized with aptamer[J].Sensors and Actuators B:Chemical,2016,229:100-109
[21]张桂兰,朱超,黄亚飞,等.基于适配体技术的雌性激素检测方法研究进展[J].分析测试学报,2017,36(3):422-430
[22]Jo M,Ahn J Y,Lee J,et al.Development of Single-Stranded DNAAptamers for Specific Bisphenol A Detection[J].Oligonucleotides,2011,21(2):85-91
[23]Kim Y S,Jung H S,Matsuura T,et al.Electrochemical detection of17beta-estradiol using DNA aptamer immobilized gold electrode chip[J].Biosensors&Bioelectronics,2007,22(11):2525-2531
[24]Alsager O A,Kumar S,Willmott G R,et al.Small molecule detection in solution via the size contraction response of aptamer functionalized nanoparticles[J].Biosensors and Bioelectronics,2014,57:262-268
[25]Alsager O A,Kumar S,Zhu B,et al.Ultrasensitive colorimetric detection of 17β-estradiol:The effect of shortening DNA aptamer sequences[J].Analytical Chemistry,2015,87(8):4201-4209
[26]Vanschoenbeek K,Vanbrabant J,Hosseinkhani B,et al.Aptamers targeting different functional groups of 17β-estradiol[J].The Journal of Steroid Biochemistry and Molecular Biology,2015,147:10-16
[27]Akki S U,Werth C J,Silverman S K.Selective Aptamers for Detection of Estradiol and Ethynylestradiol in Natural Waters[J].Environmental Science&Technology,2015,49(16):9905-9913
[28]Jiménez G C,Eissa S,Ng A,et al.Aptamer-Based Label-Free Impedimetric Biosensor for Detection of Progesterone[J].Analytical Chemistry,2015,87(2):1075-1082
[29]Xu J,Li Y,Bie J,et al.Colorimetric method for determination of bisphenol A based on aptamer-mediated aggregation of positively charged gold nanoparticles[J].Microchimica Acta,2015,182(13/14):2131-2138
[30]Liu J,Bai W,Niu S,et al.Highly sensitive colorimetric detection of17β-estradiol using split DNA aptamers immobilized on unmodified gold nanoparticles[J].Scientific reports,2014,4:7571
[31]Zhang D,Yang J,Ye J,et al.Colorimetric detection of bisphenol Abased on unmodified aptamer and cationic polymer aggregated gold nanoparticles[J].Analytical biochemistry,2016,499:51-56
[32]Du G,Zhang D,Xia B,et al.A label-free colorimetric progesterone aptasensor based on the aggregation of gold nanoparticles[J].Microchimica Acta,2016,183(7):2251-2258
[33]Huang H,Shi S,Xing G,et al.A universal label-free fluorescent aptasensor based on Ru complex and quantum dots for adenosine,dopamine and 17β-estradiol detection[J].Biosensors&Bioelectronics,2016,79:198-204
[34]Ni X,Xia B,Wang L,et al.Fluorescent aptasensor for 17β-estradiol determination based on gold nanoparticles quenching the fluorescence of Rhodamine B[J].Analytical Biochemistry,2017,523:17-23
[35]Yingyue Zhu,Yilin Cai.Building An Aptamer/Graphene Oxide FRET Biosensor for One-Step Detection of BisphenolA.American Chemical Society,2015,1021:7492-7496
[36]Li Y,Xu J,Wang L,et al.Aptamer-based fluorescent detection of bisphenol A using nonconjugated gold nanoparticles and CdTe quantum dots[J].Sensors&Actuators B Chemical,2016,222:815-822
[37]Huang K J,Liu Y J,Zhang J Z.Aptamer-based electrochemical assay of 17β-estradiol using a glassy carbon electrode modified with copper sulfide nanosheets and gold nanoparticles,and applying enzyme-based signal amplification[J].Microchimica Acta,2015,182(1/2):409-417
[38]Soh J H,Lin Y,Rana S,et al.Colorimetric Detection of Small Molecules in Complex Matrixes via Target-Mediated Growth of Aptamer-Functionalized Gold Nanoparticles[J].Analytical Chemistry,2015,87(15):7644-7652
[39]Povedano E,Cincotto F H,Parrado C,et al.Decoration of reduced graphene oxide with rhodium nanoparticles for the design of a sensitive electrochemical enzyme biosensor for 17β-estradiol[J].Biosensors and Bioelectronics,2017,89:343-351
[40]Liu Y,Liu Y,Liu B.A dual-signaling strategy for ultrasensitive detection of bisphenol A by aptamer-based electrochemical biosensor[J].Journal of Electroanalytical Chemistry,2016,781:265-271
[41]Zhang Y,Wang Y,Zhu W,et al.Simultaneous colorimetric determination of bisphenol A and bisphenol S via a multi-level DNA circuit mediated by aptamers and gold nanoparticles[J].Microchimica Acta,2017,184(3):951-959