针刺联合脐疗治疗中度卵巢过度刺激综合征(脾肾阳虚证)的临床研究
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摘要
目的观察针刺联合脐疗治疗中度卵巢过度刺激综合征的临床疗效并探讨其作用机制。方法 54例患者随机分为对照组和观察组各27例。对照组给予静脉滴注万汶,肌注黄体酮注射液,口服来曲唑和阿司匹林肠溶片,肛塞溴隐亭等常规治疗。观察组在此基础上加用脐疗联合针刺治疗。两组连续治疗7 d。观察两组的临床疗效。结果治疗后两组症状积分均低于治疗前(均P <0.05);且治疗后观察组症状积分低于对照组(P <0.05)。两组治疗前肌酐、红细胞比积、D-二聚体、ALT指标比较,差别均不大(均P> 0.05)。两组治疗后各指标与治疗前比较均明显改善(均P <0.05);两组治疗后红细胞比积和D-二聚体两项指标比较,差别均不大(P> 0.05),而观察组肌酐和ALT两项指标均较对照组改善明显(均P <0.05)。结论针刺联合脐疗可提高卵巢过度刺激综合征(脾肾阳虚证)的临床疗效。
Objective: To observe the clinical effect of acupuncture combined with umbilical cord therapy on ovarian hyperstimulation syndrome(OHSS). Methods: 54 patients were randomly divided into the control group and the observation group,27 cases in each. The observation group was treated with umbilical cord therapy combined with acupuncture on the basis of routine treatment of the control group,and the clinical efficacy of the two groups was observed. Results: There was no significant difference in symptom scores between the two groups before treatment(P > 0.05). After treatment,the scores of symptoms in both groups were lower than those before treatment(all P < 0.05),and the scores of symptoms in the observation group were lower than those in the control group(P < 0.05). There were no significant differences in creatinine,hematocrit,D-dimer and ALT between the two groups before treatment(all P > 0.05). After treatment,the indexes of the two groups were significantly improved compared with those before treatment(all P < 0.05). After treatment,there was no significant difference in hematocrit and D-dimer between the two groups(P > 0.05),while creatinine and ALT in the observation group were significantly better than those in the control group(P < 0.05). Conclusion: Acupuncture combined with umbilical cord therapy can improve the clinical efficacy of ovarian hyperstimulation syndrome of spleen and kidney Yang deficiency,worthy of further promotion and application.
Objective: To observe the clinical effect of acupuncture combined with umbilical cord therapy on ovarian hyperstimulation syndrome(OHSS). Methods: 54 patients were randomly divided into the control group and the observation group,27 cases in each. The observation group was treated with umbilical cord therapy combined with acupuncture on the basis of routine treatment of the control group,and the clinical efficacy of the two groups was observed. Results: There was no significant difference in symptom scores between the two groups before treatment(P > 0.05). After treatment,the scores of symptoms in both groups were lower than those before treatment(all P < 0.05),and the scores of symptoms in the observation group were lower than those in the control group(P < 0.05). There were no significant differences in creatinine,hematocrit,D-dimer and ALT between the two groups before treatment(all P > 0.05). After treatment,the indexes of the two groups were significantly improved compared with those before treatment(all P < 0.05). After treatment,there was no significant difference in hematocrit and D-dimer between the two groups(P > 0.05),while creatinine and ALT in the observation group were significantly better than those in the control group(P < 0.05). Conclusion: Acupuncture combined with umbilical cord therapy can improve the clinical efficacy of ovarian hyperstimulation syndrome of spleen and kidney Yang deficiency,worthy of further promotion and application.
引文
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[10]戴杰,周永,李新玲,等.影响后循环脑梗死急性期阿司匹林和氯吡格雷联合抗血小板治疗预后的相关因素[J].临床神经病学杂志,2014,27(1):22-25.
[11]王林林,陈雪莲,马具淼,等.多巴胺受体激动剂在预防OHSS中应用研究进展[J].世界最新医学信息文摘,2018,18(76):128-129.
[12]陈燕,骆喜宝,潘云.羟乙基淀粉的药理作用和临床应用研究进展[J].医学综述,2012,18(4):593-595.
[14]林丽波,姚美玉,吴效科,等.卵巢过度刺激综合征的中医治疗概述[J].世界中西医结合杂志,2009,4(3):225-226.
[13]代淑华,王玉贤,魏秀英,等.胸腹腔置管定期引流治疗重度卵巢过度刺激综合征22例临床分析[J].实用妇产科杂志,2016,32(4):305-308.
[15]李小华,李欢欢.中西医结合治疗卵巢过度刺激综合征临床观察[J].中国中医急症,2015,24(6):1088-1090.
[16]杜娟,李莉,杜珍珍,等.健脾利水法治疗卵巢过度刺激综合征临床研究[J].亚太传统医药,2016,12(12):108-109.
[17]霍君怡,刘小红,吴克明.针刺预防卵巢过度刺激综合征临床研究进展[J].亚太传统医药,2016,12(11):44-45.
[2]张玉珍.中医妇科学[M].7版.北京:中国医药科技出版社,2005:320.
[3]中华人民共和国卫生部.中药新药临床研究指导原则[M]北京:中国医药科技出版社,2002:385-390.
[4]刘风华,杨业洲,张松英,等.辅助生殖技术并发症诊断及处理共识[J].生殖与避孕,2015,35(7):431-439.
[5]曹泽毅.中华妇产科学[M].3版.北京:人民卫生出版社,2014:2874-2877.
[6]Soares SR,Gomez R,Simon C,et al.Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome[J].Hum Reprod Update,2008(14):321-333.
[7]Kwik M,Maxwell E.Pathophysiology,treatment and prevention of ovarian hyperstimulation syndrome[J].Current Opinion in Obstetrics&Gynecology,2016,28(4):236-241.
[8]Polymorphisms of VEGF and VEGF receptors are associated with the occurrence of ovarian hyperstimulation syndrome(OHSS)-a retrospective case-control study[J].Journal of O-varian Research,2014,7(1):1-7.
[9]李艳花.阿司匹林抗血小板治疗的药学服务[J].临床合理用药杂志,2017,10(11):92-93.
[10]戴杰,周永,李新玲,等.影响后循环脑梗死急性期阿司匹林和氯吡格雷联合抗血小板治疗预后的相关因素[J].临床神经病学杂志,2014,27(1):22-25.
[11]王林林,陈雪莲,马具淼,等.多巴胺受体激动剂在预防OHSS中应用研究进展[J].世界最新医学信息文摘,2018,18(76):128-129.
[12]陈燕,骆喜宝,潘云.羟乙基淀粉的药理作用和临床应用研究进展[J].医学综述,2012,18(4):593-595.
[14]林丽波,姚美玉,吴效科,等.卵巢过度刺激综合征的中医治疗概述[J].世界中西医结合杂志,2009,4(3):225-226.
[13]代淑华,王玉贤,魏秀英,等.胸腹腔置管定期引流治疗重度卵巢过度刺激综合征22例临床分析[J].实用妇产科杂志,2016,32(4):305-308.
[15]李小华,李欢欢.中西医结合治疗卵巢过度刺激综合征临床观察[J].中国中医急症,2015,24(6):1088-1090.
[16]杜娟,李莉,杜珍珍,等.健脾利水法治疗卵巢过度刺激综合征临床研究[J].亚太传统医药,2016,12(12):108-109.
[17]霍君怡,刘小红,吴克明.针刺预防卵巢过度刺激综合征临床研究进展[J].亚太传统医药,2016,12(11):44-45.