小剂量泼尼松治疗亚急性甲状腺炎临床效果与安全性
|
摘要
目的探讨小剂量泼尼松治疗亚急性甲状腺炎临床效果与安全性。方法将2017年7月至2018年7月在我院内分泌科治疗的92例亚急性甲状腺炎患者随机分为两组,均使用泼尼松治疗,对照组采用常规30 mg/d的剂量,观察组使用15 mg/d的小剂量,比较两组患者的症状消失时间、临床疗效、不良反应。结果观察组发热、疼痛、触痛、肿胀等症状消失时间与对照组相比无明显差异(P>0.05);观察组治疗有效率为97.83%,与对照组的95.65%相比,无明显差异(P>0.05);观察组体质量增加、胃痛、反酸、嗳气、面部痤疮等不良反应发生率明显低于对照组(P<0.05)。结论小剂量泼尼松治疗亚急性甲状腺炎临床效果显著,能促进症状的快速消退,减少不良反应发生率,提升生活质量,具有积极的临床意义。
Objective To explore the clinical effects and safety of low-dose prednisone in the treatment of subacute thyroiditis. Methods 92 cases of subacute thyroiditis who were treated in Department of Endocrinology in Jining No.1 People's Hospital from July 2017 to July 2018 were selected for study. They were randomly divided into a control group and an observation group. Both of the groups were treated with prednisone, and the doses were conventional dose of 30 mg/d and a lower dose of 15 mg/d respectively. Then the two groups were compared in the aspects of disappearance time of symptoms, clinical effects, and adverse reactions. Results There was no significant difference in the disappearance time of fever, pain and tenderness and swelling between the two groups(P>0.05).The effective rates of the observation group and the control group were 97.83% respectively, and thus there is no significantly difference from between the two groups(P> 0.05); The incidence of adverse reactions such as increase in body weight, stomach pain, acid regurgitation, belching, facial acne was significantly lower than that of the control group(P<0.05). Conclusion Low-dose prednisone has significant clinical effects in the treatment of subacute thyroiditis, which can shorten the disappearance time of symptoms, reduce the incidence of adverse reactions, and improve the quality of life of patients. Therefore, low-dose prednisone has positive effects on clinic practice.
Objective To explore the clinical effects and safety of low-dose prednisone in the treatment of subacute thyroiditis. Methods 92 cases of subacute thyroiditis who were treated in Department of Endocrinology in Jining No.1 People's Hospital from July 2017 to July 2018 were selected for study. They were randomly divided into a control group and an observation group. Both of the groups were treated with prednisone, and the doses were conventional dose of 30 mg/d and a lower dose of 15 mg/d respectively. Then the two groups were compared in the aspects of disappearance time of symptoms, clinical effects, and adverse reactions. Results There was no significant difference in the disappearance time of fever, pain and tenderness and swelling between the two groups(P>0.05).The effective rates of the observation group and the control group were 97.83% respectively, and thus there is no significantly difference from between the two groups(P> 0.05); The incidence of adverse reactions such as increase in body weight, stomach pain, acid regurgitation, belching, facial acne was significantly lower than that of the control group(P<0.05). Conclusion Low-dose prednisone has significant clinical effects in the treatment of subacute thyroiditis, which can shorten the disappearance time of symptoms, reduce the incidence of adverse reactions, and improve the quality of life of patients. Therefore, low-dose prednisone has positive effects on clinic practice.
引文
[1]邙建波,周冬仙,廖兵飞.小剂量泼尼松治疗亚急性甲状腺炎的临床观察[J].山西医科大学学报,2015,46(5):472-474.
[2]邙建波,刘新杰,李敏.不同剂量泼尼松治疗亚急性甲状腺炎的临床对照观察[J].海南医学,2015,26(16):2438-2440.
[3]周琼,余书勇,陈森良.亚急性甲状腺炎患者采用不同剂量泼尼松治疗的效果对比分析[J].中国煤炭工业医学杂志,2016,19(4):522-525.
[4]陈海燕.小剂量泼尼松治疗亚急性甲状腺炎临床效果与安全性探讨[J].中国疗养医学,2018,27(5):529-531.
[5]黄伟,方轶群.应用小剂量泼尼松治疗亚急性甲状腺炎患者的临床效果[J].中国现代医生,2016,54(24):31-33.
[6]黎克江,雷永红,刘新华.小剂量糖皮质激素联合消炎痛用于亚急性甲状腺炎治疗效果的分析[J].河北医药,2014,36(1):65-67.
[2]邙建波,刘新杰,李敏.不同剂量泼尼松治疗亚急性甲状腺炎的临床对照观察[J].海南医学,2015,26(16):2438-2440.
[3]周琼,余书勇,陈森良.亚急性甲状腺炎患者采用不同剂量泼尼松治疗的效果对比分析[J].中国煤炭工业医学杂志,2016,19(4):522-525.
[4]陈海燕.小剂量泼尼松治疗亚急性甲状腺炎临床效果与安全性探讨[J].中国疗养医学,2018,27(5):529-531.
[5]黄伟,方轶群.应用小剂量泼尼松治疗亚急性甲状腺炎患者的临床效果[J].中国现代医生,2016,54(24):31-33.
[6]黎克江,雷永红,刘新华.小剂量糖皮质激素联合消炎痛用于亚急性甲状腺炎治疗效果的分析[J].河北医药,2014,36(1):65-67.