NMDA受体在阿片类精神依赖中的研究进展
摘要
<正>药物依赖是一种以强迫性觅药为特征的慢性、复发性脑疾病~[1,2]。世界卫生组织将药物依赖分为精神依赖和身体依赖。精神依赖又称为心理依赖,是指药物使人产生一种心理满足、愉快的感觉,因而需要定期地或连续地使用它以保持那种舒适感或者为了避免不舒服。凡能引起令人愉快意识状态的药物即可引起精神依赖。引起精神依赖的药物种类很多,其中阿片类药物(如吗啡)是典型的一类。有研究表
引文
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[24]罗素元,郭萍,钱刚,等.延胡索水提物与左旋延胡索乙素抗吗啡条件性位置偏爱效应机制研究和效果比较[J].中国中药杂志,2012,37:3457-3461.
[25]Portugal GS,Ream AH,Fakiraet AK,et al.Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference[J].J Neurosci,2014,34:527-538.
[26]邵晓霞,李洁,何繁漪,等.吗啡诱导条件性位置偏爱大鼠海马CA1区NR2A、NR2B的表达变化[J].昆明医科大学学报,2013:17-20.
[27]Nestler EJ,Aghajanian GK.Molecular and cellular basis of addiction[J].Science,1997,278:58-63.
[28]王宇晶,牛晨,陈元寿,等.海洛因依赖大鼠VTA区NMDA受体介导的多巴胺神经元膜电流的变化[J].神经解剖学杂志,2012,28:385-391.
[29]Zhong HJ,Huo ZH,Dang J,et al.Functional polymorphisms of the glutamate receptor N-methy-D-aspartate 2A gene are associated with herion addiction[J].Genet Mol Res,2014,13:8714-8721.
[30]Shen H,Moussawi K,Zhou W,et al.Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-contaning receptors[J].Proc Natl Acad Sci USA,2011,108:19407-19412.
[31]肖邦,潘贵书.海洛因成瘾对大鼠海马CA3区NR1、NR2A亚基表达的影响[J].国际检验医学杂志,2014,17:2275-2276.
[2]Koob GF,Ahmed SH,Boutrel B,et al.Neurobiological mechanisms in the transition from drug use to drug dependence[J].Neurosci Biobehav Rev,2004,27:739-749.
[3]Drummond DC.Theories of drug craving ancient and modem[J].Addiction,2001,96:33-36.
[4]Kaniakova M,Krausova B,Vyklicky V,et al.Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of NMDA receptors[J].J Biol Chem,2012,287:26423-26434.
[5]Dingledine R,Borges K,Bowie D,et al.The glutamate receptor ion channels[J].Pharmacol Rev,1999,51:7-61.
[6]Anderson EM,Del Valle-Pinero AY,Suckow SK,et al.Morphine and MK-801 adiministration leads to alternative NMDAR1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay[J].Neuroscience,2012,214:14-27.
[7]Flores-soto ME,Chaparro-Huerta V,Escoto-Delgadillo M,et al.Structure and function of NMDA type glutamate receptor subunits[J].Neurologia,2012,27:301-310.
[8]Tsien JZ,Huerta PT,Tonegawa S.The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory[J].Cell,1996,87:1327-1338.
[9]Cui Z,Wang H,Tan Y,et al.Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain[J].Neuron,2004,41:781-793.
[10]王玉兰,许铁军,樊红彬,等.出生后早起大鼠海马NR亚单位NR1、NR2A和NR2B的表达变化[J]神经解剖学杂志,2003,19:413-418.
[11]Kadotani H,Hirano T,Masugi M,et al.Motor dis-coordination results from combined gene disruption of the NMDA receptor NR2Aand NR2C subunits,but not from single disruption of the NR2A or NR2C subunit[J].J Neurosci,1996,16,7859-7867.
[12]Wee KS,Zhang Y,Khanna S,et al.Immunolocalization of NMDAreceptor subunit NR3B in selected structures in the rat forebrain,cerebellum,and lumbar spinal cord[J].J Comp Neurol,2008,509:118-135.
[13]Tong G,Takahashi H,Tu S,et al.Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons[J].J Neurophysiol,2008,99:122-132.
[14]Larsen RS,Corlew RJ,Henson MA,et al.NR3A containing NMDARs promote neurotransmitter release and spike timing dependent plasticity[J].Nat Neurosci,2011,14:338-344.
[15]Niemann S,Kanki H,Fukui Y,et al.Genetic ablation of NMDAreceptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes[J].Eur J Neurosci,2007,26:1407-1420.
[16]Sedaghati M,Vousooghi N,Goodarzi A,et al.Expression of NR3Bbut not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies[J].Eur J Pharmacol,2010,633:50-54
[17]Bisaga A,Popik P.In search of a new pharmacological treatment for drug and alcohol addiction:N-methyl-D-aspartate(NMDA)antagonists[J].Drug Alcohol depend,2000,59:1-15.
[18]Tzschentke TM.Measuring reward with the conditioned place preference paradigm:a comprehensive review of drug effects,recent progress and new issues[J].Prog Neurobiol,1998,56:613-672.
[19]Makarska-Biaek K,Kamiński RM,Czuczwar SJ.Influence of the antagonist of the glycine site of NMDA receptors,MRZ 2/576,on the anticonvulsant activity of conventional antiepileptic drugs in mice[J].Pharmacol Rep,2005,57:458-566.
[20]Rasmussen K,Brodsky M,Inturrisi CE.NMDA antagonists and clonidine block c-fos expression during morphine withdrawal[J].Synapse,1995,20:68-74.
[21]Jiang SX,Zheng RY,Zeng JQ,et al.Reversible inhibition of intracellular calcium influx through NMDA receptors by imidazoline I-2 receptor antagonists[J].Eur J Pharmacol,2009,629:12-19.
[22]Han Z,Yang JL,Jiang SX,et al.Fast,non-competitive and reversible inhibition of NMDA-activated currents by 2-BFI confers neuroprotection.[J]PLoS One,2013,8:e64894.
[23]Fukumori R,Takarada T,Nakazato R,et al.Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons[J].PLoS One,2013,8:e69718.
[24]罗素元,郭萍,钱刚,等.延胡索水提物与左旋延胡索乙素抗吗啡条件性位置偏爱效应机制研究和效果比较[J].中国中药杂志,2012,37:3457-3461.
[25]Portugal GS,Ream AH,Fakiraet AK,et al.Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference[J].J Neurosci,2014,34:527-538.
[26]邵晓霞,李洁,何繁漪,等.吗啡诱导条件性位置偏爱大鼠海马CA1区NR2A、NR2B的表达变化[J].昆明医科大学学报,2013:17-20.
[27]Nestler EJ,Aghajanian GK.Molecular and cellular basis of addiction[J].Science,1997,278:58-63.
[28]王宇晶,牛晨,陈元寿,等.海洛因依赖大鼠VTA区NMDA受体介导的多巴胺神经元膜电流的变化[J].神经解剖学杂志,2012,28:385-391.
[29]Zhong HJ,Huo ZH,Dang J,et al.Functional polymorphisms of the glutamate receptor N-methy-D-aspartate 2A gene are associated with herion addiction[J].Genet Mol Res,2014,13:8714-8721.
[30]Shen H,Moussawi K,Zhou W,et al.Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-contaning receptors[J].Proc Natl Acad Sci USA,2011,108:19407-19412.
[31]肖邦,潘贵书.海洛因成瘾对大鼠海马CA3区NR1、NR2A亚基表达的影响[J].国际检验医学杂志,2014,17:2275-2276.