禽流感病毒H5N1亚型NS1蛋白的研究进展
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摘要
NS1蛋白(non-structural protein 1)是A型流感病毒重要的非结构蛋白,作为流感病毒的致病因子,NS1通过多种方式增强病毒的致病性和毒力。就H5N1禽流感病毒NS1蛋白的结构与功能进行了综述。
NS1 is an important nonstructural protein of influenza A virus. It enhances the pathogenicity and virulence of the virus through several mechanisms. This review summarized the structure and function of NS1.
NS1 is an important nonstructural protein of influenza A virus. It enhances the pathogenicity and virulence of the virus through several mechanisms. This review summarized the structure and function of NS1.
引文
[1]Takeyama N.,Minari K.,Kajihara M.,et al.Detection of highly pathogenic avian influenza virus infection in vaccinated chicken flocks by monitoring antibodies against non-structural protein 1(NS1)[J].Veterinary Microbiology,2011,147(3-4):283-291.
[2]John S.,Lowen A.,Pena L.,et al.Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 Highly pathogenic avian influenza[J].Journal of Virology,2009,83(4):1742-1753.
[3]Cumulative number?of confirmed cases?of avian?influenza A/(H5N1)?reported to the?WHO(http://www.who.int/influenza/human_animal_interface/H5N1_cumulative_table_archives/en/index.html).
[4]Area E.,Martin B.,Gastaminza P.,et al.3D structure of the influenza virus polymerase complex:localization of subunit domains[J].PNAS,2004,101(1):308-313.
[5]Zachary A.,Bornholdt B..Prasad V.X-ray structure of NS1from a highly pathogenic H5N1 influenza virus[J].Nature,2008,456(7224):985-988.
[6]Long JX.,Peng DX.,Liu YL.,et al.Virulence of H5N1 avian in fluenza virus enhanced by a 1 5 nucleotide deletion in the viral nonstructural gene[J].Virus Genes,2008,36(3):471-478.
[7]蒋培余,黄惠莲,周洪昌,等.人高致病性H5N1亚型禽流感病毒NSl蛋白多克隆抗体的制备及鉴定[J].中华实验和临床病毒学杂志,2013,27(2):138-140.
[8]Enami M.,Enami K.Characterization of influenza virus NS1protein by using a novel helper-virus-free reverse genetic system[J].Journal of virology,2000,74(12):5556-5561.
[9]Chien C.,Xu Y.,Xiao R.,et al.Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus:evidence for a novel RNA-binding mode[J].Biochemistry,2004,43(7):1950-1962.
[10]Cheng A.,Wong S.,Yuan Y.,et al.Structural basis for dsRNA recognition by NS1 protein of influenza A virus[J].Cell Research,2009,19(2):187-195.
[11]郭莹莹,王靖飞.A型流感病毒NS1蛋白结构研究进展[J].生命科学,2010,22(2):115-118.
[12]Das K.,Ma L.,Xiao R.,et al.Structural basis for suppression of a host antiviral response by influenza A virus[J].PNAS,2008,105(35):13093-13098.pes[J].Journal of Virology,2007,81:5995-6006.
[13]Yang L.,Anderson D.,Liu Q.,et al.Mechanism of influenza A virus NS1 protein interaction with the p85β,but not the p85α,subunit of phosphatidylinositol 3-Kinase(PI3K)and up-regulation of PI3K activity[J].Journal of Biological Chemistry,2008,283(34):23397-23409.
[14]Nemeroff M.,Barabino S.,Li Y.,et al.Influenza virus NS1protein interacts with the cellular 30 ku subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs[J].Molecular cell,1998,l(7):991-1000.
[15]Wang XD.,Shen Y.,Qiu YF.,et al.The non-structural(NS1)protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis[J].Biochemical and Biophysical Research Communications,2010,395(1):141-145.
[16]Heikkinen LS.,Kazlauskas A.,Melen K.,et al.Avian and1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling[J].J Biol Chem,2008,283(9):5719-5727.
[17]Matsuda M.,Suizu F.,Hirata N.,et al.Characterization of the interaction of influenza virus NS1 with Akt[J].Biochemical and Biophysical Research Communications,2010,395(3):312-317.
[18]Ehrhardt C.,Wolff T.,Pleschka S.,et al.Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses[J].Journal of Virology,2007,81(7):3058-3067.
[19]Samar K.D,Elena M.,Nicole E F.,et al.Influenza A/Hong Kong/156/1997(H5N1)virus NS1 gene mutations F103L and M106I both increase IFN antagonism,virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30[J].Virology Journal,2013,10:243.doi:10.1186/1743-422X-10-243.
[20]Chen Z.,Li Y.,Krug RM.Influenza A virus NSl protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery[J].EMBO Journal,1999,18(8):2273-2283.
[21]Lu Y.,Warnbach M.,Katze M.,et al.Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that PhosPhorylates the elF-2 translation initiation factor[J].Virology,1995,214(1):222-228.
[22]Zhu CY,Zheng FL,Sun TT,et al.Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1[J].Virus Genes,2012,46(2):287-292.
[23]Falcon A.,Fortes P.,Marion R.,et al.Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro[J].Nucleic Acids Research,1999,7(11):2241-2247.
[24]Thomas A.,Luna S.,Isabel N.,et al.Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein,a translational activator of influenza virus[J].Molecular and Cellular Biology,2000,20(17):6259-6268.
[25]Shufang F.,Catherine A.M.,Chengjun L.,et al.Synergistic Effect of the PDZ and p85Binding Domains of the NS1 Protein on Virulence of an Avian H5N1 Influenza A Virus[J].Journal of Virology,2013,87(9):4861-4871.
[26]张传福,周晓巍,黄培堂.A型流感病毒非结构蛋白NS1与宿主相互作用的研究进展[J].生物技术通讯,2007,18(4):697-699.
[27]Zhao L.,Xu L.,Zhou X.,et al.Interaction of influenza virus NS1 protein with growth arrest-specific protein 8[J].Journal of Virology,2009,6:218-227.
[2]John S.,Lowen A.,Pena L.,et al.Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 Highly pathogenic avian influenza[J].Journal of Virology,2009,83(4):1742-1753.
[3]Cumulative number?of confirmed cases?of avian?influenza A/(H5N1)?reported to the?WHO(http://www.who.int/influenza/human_animal_interface/H5N1_cumulative_table_archives/en/index.html).
[4]Area E.,Martin B.,Gastaminza P.,et al.3D structure of the influenza virus polymerase complex:localization of subunit domains[J].PNAS,2004,101(1):308-313.
[5]Zachary A.,Bornholdt B..Prasad V.X-ray structure of NS1from a highly pathogenic H5N1 influenza virus[J].Nature,2008,456(7224):985-988.
[6]Long JX.,Peng DX.,Liu YL.,et al.Virulence of H5N1 avian in fluenza virus enhanced by a 1 5 nucleotide deletion in the viral nonstructural gene[J].Virus Genes,2008,36(3):471-478.
[7]蒋培余,黄惠莲,周洪昌,等.人高致病性H5N1亚型禽流感病毒NSl蛋白多克隆抗体的制备及鉴定[J].中华实验和临床病毒学杂志,2013,27(2):138-140.
[8]Enami M.,Enami K.Characterization of influenza virus NS1protein by using a novel helper-virus-free reverse genetic system[J].Journal of virology,2000,74(12):5556-5561.
[9]Chien C.,Xu Y.,Xiao R.,et al.Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus:evidence for a novel RNA-binding mode[J].Biochemistry,2004,43(7):1950-1962.
[10]Cheng A.,Wong S.,Yuan Y.,et al.Structural basis for dsRNA recognition by NS1 protein of influenza A virus[J].Cell Research,2009,19(2):187-195.
[11]郭莹莹,王靖飞.A型流感病毒NS1蛋白结构研究进展[J].生命科学,2010,22(2):115-118.
[12]Das K.,Ma L.,Xiao R.,et al.Structural basis for suppression of a host antiviral response by influenza A virus[J].PNAS,2008,105(35):13093-13098.pes[J].Journal of Virology,2007,81:5995-6006.
[13]Yang L.,Anderson D.,Liu Q.,et al.Mechanism of influenza A virus NS1 protein interaction with the p85β,but not the p85α,subunit of phosphatidylinositol 3-Kinase(PI3K)and up-regulation of PI3K activity[J].Journal of Biological Chemistry,2008,283(34):23397-23409.
[14]Nemeroff M.,Barabino S.,Li Y.,et al.Influenza virus NS1protein interacts with the cellular 30 ku subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs[J].Molecular cell,1998,l(7):991-1000.
[15]Wang XD.,Shen Y.,Qiu YF.,et al.The non-structural(NS1)protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis[J].Biochemical and Biophysical Research Communications,2010,395(1):141-145.
[16]Heikkinen LS.,Kazlauskas A.,Melen K.,et al.Avian and1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling[J].J Biol Chem,2008,283(9):5719-5727.
[17]Matsuda M.,Suizu F.,Hirata N.,et al.Characterization of the interaction of influenza virus NS1 with Akt[J].Biochemical and Biophysical Research Communications,2010,395(3):312-317.
[18]Ehrhardt C.,Wolff T.,Pleschka S.,et al.Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses[J].Journal of Virology,2007,81(7):3058-3067.
[19]Samar K.D,Elena M.,Nicole E F.,et al.Influenza A/Hong Kong/156/1997(H5N1)virus NS1 gene mutations F103L and M106I both increase IFN antagonism,virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30[J].Virology Journal,2013,10:243.doi:10.1186/1743-422X-10-243.
[20]Chen Z.,Li Y.,Krug RM.Influenza A virus NSl protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery[J].EMBO Journal,1999,18(8):2273-2283.
[21]Lu Y.,Warnbach M.,Katze M.,et al.Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that PhosPhorylates the elF-2 translation initiation factor[J].Virology,1995,214(1):222-228.
[22]Zhu CY,Zheng FL,Sun TT,et al.Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1[J].Virus Genes,2012,46(2):287-292.
[23]Falcon A.,Fortes P.,Marion R.,et al.Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro[J].Nucleic Acids Research,1999,7(11):2241-2247.
[24]Thomas A.,Luna S.,Isabel N.,et al.Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein,a translational activator of influenza virus[J].Molecular and Cellular Biology,2000,20(17):6259-6268.
[25]Shufang F.,Catherine A.M.,Chengjun L.,et al.Synergistic Effect of the PDZ and p85Binding Domains of the NS1 Protein on Virulence of an Avian H5N1 Influenza A Virus[J].Journal of Virology,2013,87(9):4861-4871.
[26]张传福,周晓巍,黄培堂.A型流感病毒非结构蛋白NS1与宿主相互作用的研究进展[J].生物技术通讯,2007,18(4):697-699.
[27]Zhao L.,Xu L.,Zhou X.,et al.Interaction of influenza virus NS1 protein with growth arrest-specific protein 8[J].Journal of Virology,2009,6:218-227.