中医药与高血压内皮功能障碍的研究进展
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摘要
目的高血压病是我国最常见的慢性病之一,动脉压的持续升高可导致靶器官如心、脑、肾和视网膜等脏器的损害。而在高血压的发生发展过程中血管内皮功能紊乱发挥着重要的作用。现代临床中药药理研究显示,中药可以很好改善血管内皮功能,从而为防治高血压提供一条新思路,现综述近年来关于血管内皮的相关报道以及中医药与高血压内皮之间的研究。
Hypertension is one of the most common chronic diseases in our country. The rising blood pressure can damage target organs such as heart,brain,kidney and retina. Endothelial dysfunction plays an important role in the process of the occurrence of hypertension development. Modern clinical Chinese medicine pharmacological studies have shown that traditional Chinese medicine can improve endothelial function,so that provide a new kind of way to treat hypertension.
Hypertension is one of the most common chronic diseases in our country. The rising blood pressure can damage target organs such as heart,brain,kidney and retina. Endothelial dysfunction plays an important role in the process of the occurrence of hypertension development. Modern clinical Chinese medicine pharmacological studies have shown that traditional Chinese medicine can improve endothelial function,so that provide a new kind of way to treat hypertension.
引文
[1]中国老年学学会心脑血管病专业委员会,降压治疗保护血管功能共识专家组.降压治疗保护血管功能中国专家共识[J].中华高血压杂志,2013,21(3):215-218.
[2]Tang EHC,Vanhoutte PM.Endothelial dysfunction:a strategic target in the treatment of hypertension[J].Pflugers Archiv European Journal of Physiology,2010,459(6):995-1004.
[3]K J Diehl,B R Weil,J J Greiner,et al.Impaired endogenous fibrinolytic capacity in prehypertensive men[J].Journal of Human Hypertension,2015,29(8):468-472.
[4]Chantal Dessy,Olivier Feron,Jean-Luc Balligand.The regulation of endothelial nitric oxide synthase by caveolin:a paradigm validated in vivo and shared by the”endothelium-derived hyper polarizing factor”[J].Pflügers Archiv,2010,459(6):817-827.
[5]Caroline Bleakley,MD,MRCP,et al.Endothelial Function in Hypertension:Victim or Culprit?[J].The Journal of Clinical Hypertension,2015,17(8):651-654.
[6]Rekhviashvili A,Giorgobiani T,Minashvili A,et al.Influence of circadian blood pressure profile on endothelial function in patients with and without arterial[J].Georgian Medical News,2015(240):29-32.
[7]Wang Jing,Tao YM,Cheng XY,et al.Vascular?endothelial?growth factor affects dendritic cell activity in hypertensive disorders of pregnancy[J].Mol Med Rep,2015,12(3):3781-3786.
[8]De Jesus M J,Girard P,Bourgeouis M,et al.Tube spin satellites:afast track approach for process development with animal cells usingshaking technology[J].Biochem Eng J,2004,17(3):217-223.
[9]Kumar S,Sun X,Wiseman DA,et al.Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity[J].DNA Cell Biol,2009,28(3):119-129.
[10]Ma Y,Wang B,Gong B,et al.miR-24 improvesβ-like globin gene expression through targeting Sp1[J].Chin J Biotech,2013,29(7):946-954.
[11]Svenningsen Per,Andersen Kenneth,Thuesen Anne D,et al.T-type Ca(2+)channels facilitate NO-formation,vasodilatation and NO-mediated modulation of blood pressure[J].Pflugers Arch,2014,466(12):2205-2214.
[12]刘永生,韩洪波.内皮型一氧化氮合酶基因多态性与原发性高血压发病相关性的研究[D]吉林:吉林大学第二临床学院.2014.
[13]Houston Mark,Hays Laurie.Acute effects of an oral nitric oxide supplement on blood pressure,endothelial function,and vascular compliance in hypertensive patients[J].Clin Hypertens,2014,16(7):524-529.
[14]Milger Katrin,Felix Janine F,Voswinckel Robert,et al.Sildenafil versus nitric oxide for acute vasodilator testing in pulmonary arterial hypertension[J].Pulm Circ,2015,5(2):305-312.
[15]中药新药治疗高血压病的临床研究指导原则[J].中医药临床杂志,2007,19(2):118-119.
[16]王丽颖,李元,李娜,等.1508例高血压病患者中医证候分布调查研究[J].中华中医药杂志,2010,25(12):1960-1963.
[17]刘玉霞,王亚红.郭维琴教授从”心主血脉”治疗高血压病[J].吉林中医药,2013,33(2):119-121.
[18]雍苏南,张稳,谭超,等.复方七芍降压片对SHR内皮损伤的干预作用[J].中国医学创新,2015,12(31):10-13.
[19]黄丹娥,黄琳,曾巧煌,等.复方芪麻胶囊对自发性高血压大鼠血压及血清NO、ET、AngⅡ的影响[J].广东药学院学报,2015,31(6):791-794.
[20]蔡金,唐朝政,王梅,等.苗药通窍化栓方对急性脑梗死病人ET和NO的影响[J].中西医结合心脑血管病杂志,2015,13(18):2051-2054.
[21]Han Lei,Li Minggao.Protection of vascular endothelial cells injured by angiotensin II and hypoxia in vitro by Ginkgo biloba(Ginaton)[J].Vasc Endovascular Surg,2013,47(7):546-550.
[22]Wang Ming,Lei Yan.Time-effect relationship of extracts from ginseng,notoginseng and chuanxiong on vascular endothelial cells senescence[J].Chin J Integr Med,2014,20(10):758-763.
[2]Tang EHC,Vanhoutte PM.Endothelial dysfunction:a strategic target in the treatment of hypertension[J].Pflugers Archiv European Journal of Physiology,2010,459(6):995-1004.
[3]K J Diehl,B R Weil,J J Greiner,et al.Impaired endogenous fibrinolytic capacity in prehypertensive men[J].Journal of Human Hypertension,2015,29(8):468-472.
[4]Chantal Dessy,Olivier Feron,Jean-Luc Balligand.The regulation of endothelial nitric oxide synthase by caveolin:a paradigm validated in vivo and shared by the”endothelium-derived hyper polarizing factor”[J].Pflügers Archiv,2010,459(6):817-827.
[5]Caroline Bleakley,MD,MRCP,et al.Endothelial Function in Hypertension:Victim or Culprit?[J].The Journal of Clinical Hypertension,2015,17(8):651-654.
[6]Rekhviashvili A,Giorgobiani T,Minashvili A,et al.Influence of circadian blood pressure profile on endothelial function in patients with and without arterial[J].Georgian Medical News,2015(240):29-32.
[7]Wang Jing,Tao YM,Cheng XY,et al.Vascular?endothelial?growth factor affects dendritic cell activity in hypertensive disorders of pregnancy[J].Mol Med Rep,2015,12(3):3781-3786.
[8]De Jesus M J,Girard P,Bourgeouis M,et al.Tube spin satellites:afast track approach for process development with animal cells usingshaking technology[J].Biochem Eng J,2004,17(3):217-223.
[9]Kumar S,Sun X,Wiseman DA,et al.Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity[J].DNA Cell Biol,2009,28(3):119-129.
[10]Ma Y,Wang B,Gong B,et al.miR-24 improvesβ-like globin gene expression through targeting Sp1[J].Chin J Biotech,2013,29(7):946-954.
[11]Svenningsen Per,Andersen Kenneth,Thuesen Anne D,et al.T-type Ca(2+)channels facilitate NO-formation,vasodilatation and NO-mediated modulation of blood pressure[J].Pflugers Arch,2014,466(12):2205-2214.
[12]刘永生,韩洪波.内皮型一氧化氮合酶基因多态性与原发性高血压发病相关性的研究[D]吉林:吉林大学第二临床学院.2014.
[13]Houston Mark,Hays Laurie.Acute effects of an oral nitric oxide supplement on blood pressure,endothelial function,and vascular compliance in hypertensive patients[J].Clin Hypertens,2014,16(7):524-529.
[14]Milger Katrin,Felix Janine F,Voswinckel Robert,et al.Sildenafil versus nitric oxide for acute vasodilator testing in pulmonary arterial hypertension[J].Pulm Circ,2015,5(2):305-312.
[15]中药新药治疗高血压病的临床研究指导原则[J].中医药临床杂志,2007,19(2):118-119.
[16]王丽颖,李元,李娜,等.1508例高血压病患者中医证候分布调查研究[J].中华中医药杂志,2010,25(12):1960-1963.
[17]刘玉霞,王亚红.郭维琴教授从”心主血脉”治疗高血压病[J].吉林中医药,2013,33(2):119-121.
[18]雍苏南,张稳,谭超,等.复方七芍降压片对SHR内皮损伤的干预作用[J].中国医学创新,2015,12(31):10-13.
[19]黄丹娥,黄琳,曾巧煌,等.复方芪麻胶囊对自发性高血压大鼠血压及血清NO、ET、AngⅡ的影响[J].广东药学院学报,2015,31(6):791-794.
[20]蔡金,唐朝政,王梅,等.苗药通窍化栓方对急性脑梗死病人ET和NO的影响[J].中西医结合心脑血管病杂志,2015,13(18):2051-2054.
[21]Han Lei,Li Minggao.Protection of vascular endothelial cells injured by angiotensin II and hypoxia in vitro by Ginkgo biloba(Ginaton)[J].Vasc Endovascular Surg,2013,47(7):546-550.
[22]Wang Ming,Lei Yan.Time-effect relationship of extracts from ginseng,notoginseng and chuanxiong on vascular endothelial cells senescence[J].Chin J Integr Med,2014,20(10):758-763.