磁性纳米标记检测技术在生物医学即时检测领域的研究进展
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摘要
基于磁性纳米材料的磁标记检测技术具有灵敏度高、线性范围广、信号检测便捷等优点。由于生物样品自身磁背景信号极低,相比于光学标记检测技术,磁标记检测技术在蛋白质、核酸、细胞、病原体及生物组织检测中均表现出更高的灵敏度,在生物医学即时检测领域展现了良好的应用前景。该文围绕磁性纳米粒在即时检测领域的最新研究进展,重点介绍了其在蛋白质、核酸以及几类病原体检测方面的应用,并对基于磁性纳米粒的即时检测技术发展方向及应用前景进行了展望。
Magnetic labeling detection technology based on magnetic nanomaterials has the advantages of high sensitivity,wide linear range and easy operation,while the traditional labeling detection technology based on optical label usually could achieve qualitative detection or semi-quantitative detection only.Most biological samples have low magnetic signal,leading to low background interference.Therefore,the magnetic labeling detection technology has shown higher sensitivity than optical labeling detection technology.It could not only carry out quantitative detection,but also reduce the pretreatment time.Point of care testing(POCT) could be performed at or near the sites of patient care,which is the trend of medical diagnosis.Magnetic labeling detection technology has an application potential in POCT,especially in biomedical use,such as detecting protein,nucleic acid,cell,pathogens and biological tissue.The latest research progress of magnetic nanoparticles in POCT is focused in this paper,and their applications in detecting protein,nucleic acid and several kinds of pathogens are discussed.Finally,the development direction and application prospect of POCT technology based on magnetic nanoparticles are outlined.
Magnetic labeling detection technology based on magnetic nanomaterials has the advantages of high sensitivity,wide linear range and easy operation,while the traditional labeling detection technology based on optical label usually could achieve qualitative detection or semi-quantitative detection only.Most biological samples have low magnetic signal,leading to low background interference.Therefore,the magnetic labeling detection technology has shown higher sensitivity than optical labeling detection technology.It could not only carry out quantitative detection,but also reduce the pretreatment time.Point of care testing(POCT) could be performed at or near the sites of patient care,which is the trend of medical diagnosis.Magnetic labeling detection technology has an application potential in POCT,especially in biomedical use,such as detecting protein,nucleic acid,cell,pathogens and biological tissue.The latest research progress of magnetic nanoparticles in POCT is focused in this paper,and their applications in detecting protein,nucleic acid and several kinds of pathogens are discussed.Finally,the development direction and application prospect of POCT technology based on magnetic nanoparticles are outlined.
引文
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