多功能核蛋白P54~(nrb)/NonO在肿瘤中的作用
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摘要
P54~(nrb)/NonO是一种能够行使多种生物学功能的核蛋白,在人体多种组织和细胞系中广泛表达并具有高度的种间保守性,与多种疾病的发生、发展密切相关。近年来,P54~(nrb)/NonO在多种肿瘤中的作用报道逐渐增多,然而其具体的肿瘤生物学作用和分子机制尚不明确。P54~(nrb)/NonO在乳腺癌、前列腺癌、结直肠癌、黑色素瘤、鼻咽癌、肺癌、血液系统肿瘤等多种肿瘤中发挥重要作用。
引文
[1]DONG B,HOROWITZ D S,KOBAYASHI R,et al.Purification and c DNA cloning of He La cell p54nrb,a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and drosophila NONA/BJ6[J].Nucleic Acids Res,1993,21(17):4085-4092.
[2]KNOTT G J,BOND C S,FOX A H.The DBHS proteins SFPQ,NO-NO and PSPC1:a multipurpose molecular scaffold[J].Nucleic Acids Res,2016,44(9):3989-4004.DOI:10.1093/nar/gkw271.
[3]YANG Y S,HANKE J H,CARAYANNOPOULOS L,et al.Non O,a non-POU-domain-containing,octamer-binding protein,is the mammalian homolog of drosophila nonadiss[J].Mol Cell Biol,1993,13(9):5593-5603.
[4]YANG Y S,YANG M C,TUCKER P W,et al.Non O enhances the association of many DNA-binding proteins to their targets[J].Nucleic Acids Res,1997,25(12):2284-2292.
[5]PARK Y,LEE J M,HWANG MY,et al.Non O binds to the Cp G island of oct4 promoter and functions as a transcriptional activator of oct4 gene expression[J].Mol Cells,2013,35(1):61-69.DOI:10.1007/s10059-013-2273-1.
[6]MATHUR M,TUCKER P W,SAMUELS H H.PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors[J].Mol Cell Biol,2001,21(7):2298-2311.DOI:10.1128/MCB.21.7.2298-2311.2001.
[7]BASU A,DONG B,KRAINER A R,et al.The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA-and DNA-binding protein p54nrb/Non O[J].Mol Cell Biol,1997,17(2):677-686.
[8]ZHANG Z,CARMICHAEL G G.The fate of ds RNA in the nucleus:a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs[J].Cell,2001,106(4):465-475.
[9]KAMEOKA S,DUQUE P,KONARSKA M M.p54(nrb)associates with the 5'splice site within large transcription/splicing complexes[J].EMBO J,2004,23(8):1782-1791.DOI:10.1038/sj.emboj.7600187.
[10]SHAV-TAL Y,ZIPORI D.PSF and p54(nrb)/Non O-multi-functional nuclear proteins[J].FEBS Lett,2002,531(2):109-114.
[11]UDAYAKUMAR D,DYNAN W S.Characterization of DNA binding and pairing activities associated with the native SFPQ.NONODNA repair protein complex[J].Biochem Biophys Res Commun,2015,463(4):473-478.DOI:10.1016/j.bbrc.2015.05.024.
[12]AAFAR L,LI Z,LI S,et al.SFPQ-NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining[J].Nucleic Acids Res,2017,45(4):1848-1859.DOI:10.1093/nar/gkw1209.
[13]TRAISH A M,HUANG Y H,ASHBA J,et al.Loss of expression of a 55 k Da nuclear protein(nmt55)in estrogen receptor-negative human breast cancer[J].Diagn Mol Pathol,1997,6(4):209-221.
[14]LIU L,ZHAO X,ZHAO L,et al.Arginine methylation of srebp1a via prmt5 promotes de novo lipogenesis and tumor growth[J].Cancer Res,2016,76(5):1260-1272.DOI:10.1158/0008-5472.CAN-15-1766.
[15]ZHU Z,ZHAO X,ZHAO L,et al.p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A[J].Oncogene,2016,35(11):1399-1410.DOI:10.1038/onc.2015.197.
[16]PAVAO M,HUANG Y H,HAFER L J,et al.Immunodetection of nmt55/p54nrb isoforms in human breast cancer[J/OL].BMC Cancer,2001,1:15[2017-10-29].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59838/.DOI:10.1186/1471-2407-1-15.
[17]熊薇,闫吕彬,吴嫦丽,等.NONO基因沉默对乳腺癌细胞生物学特性影响研究[J].中华肿瘤防治杂志,2016,23(13):844-848.
[18]BI Y,TIAN M,LE J,et al.Study on the expression of PAK4 and P54 protein in breast cancer[J].World J Surg Oncol,2016,14(1):160.DOI:10.1186/s12957-016-0913-6.
[19]ISHIGURO H,UEMURA H,FUJINAMI K,et al.55 k Da nuclear matrix protein(nmt55)m RNA is expressed in human prostate cancer tissue and is associated with the androgen receptor[J].Int J Cancer,2003,105(1):26-32.DOI:10.1002/ijc.11021.
[20]ISHITANI K,YOSHIDA T,KITAGAWA H,et al.p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor[J].Biochem Biophys Res Commun,2003,306(3):660-665.
[21]HO T T,HUANG J,ZHOU N,et al.Regulation of PCGEM1 by p54/nrb in prostate cancer[J].Sci Rep,2016,6:34529.DOI:10.1038/srep34529.
[22]TSOFACK S P,GARAND C,SEREDUK C,et al.NONO and RA-LY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines[J/OL].Mol Cancer,2011,10:145[2017-10-29].https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-10-145.DOI:10.1186/1476-4598-10-145.
[23]YANG P,CHEN T,XU Z,et al.Long noncoding RNA GAPLINCpromotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO[J].Oncotarget,2016,7(27):42183-42194.DOI:10.18632/oncotarget.9741.
[24]SCHIFFNER S,ZIMARA N,SCHMID R,et al.p54nrb is a new regulator of progression of malignant melanoma[J].Carcinogenesis,2011,32(8):1176-1182.DOI:10.1093/carcin/bgr103.
[25]ARGANI P,ZHONG M,REUTER V E,et al.TFE3-fusion variant analysis defines specific clinicopathologic associations among Xp11translocation cancers[J].Am J Surg Pathol,2016,40(6):723-737.DOI:10.1097/PAS.0000000000000631.
[26]CLARK J,LU Y J,SIDHAR S K,et al.Fusion of splicing factor genes PSF and Non O(p54nrb)to the TFE3 gene in papillary renal cell carcinoma[J].Oncogene,1997,15(18):2233-2239.DOI:10.1038/sj.onc.1201394.
[27]XIA Q Y,WANG Z,CHEN N,et al.Xp11.2 translocation renal cell carcinoma with NONO-TFE3 gene fusion:morphology,prognosis,and potential pitfall in detecting TFE3 gene rearrangement[J].Mod Pathol,2017,30(3):416-426.DOI:10.1038/modpathol.2016.204.
[28]MCGREGOR S M,ALIKHAN M B,JOHN R A,et al.Melanotic PEComa of the sinonasal mucosa with NONO-TFE3 fusion:an elusive mimic of sinonasal melanoma[J].Am J Surg Pathol,2017,41(5):717-722.DOI:10.1097/PAS.0000000000000778.
[29]BARBORO P,RUBAGOTTI A,ORECCHIA P,et al.Differential proteomic analysis of nuclear matrix in muscle-invasive bladder cancer:potential to improve diagnosis and prognosis[J].Cell Oncol,2008,30(1):13-26.
[30]张秀娟,熊薇,吴嫦丽,等.NONO基因沉默抑制鼻咽癌细胞的体外增殖、迁移和侵袭能力[J].肿瘤,2016,36(5):504-511.
[31]LIN S Y,LAI Y H,CHEN H Y,et al.Abstract 749:Characterization of p54nrb/Non O promoter in NSCLC[J].Cancer Res,2013,73(8Supplement):749-749.
[32]HALLIER M,TAVITIAN A,MOREAU-GACHELIN F.The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb[J].J Biol Chem,1996,271(19):11177-11181.
[33]桑婷婷,胡江江,薛建有,等.Non O蛋白在丁酸钠诱导小鼠红白血病细胞分化过程中的表达[J].解剖学报,2014,45(4):516-520.
[34]胡江江.PBDC1和Non O蛋白在红系分化过程中的功能研究及UPF0538蛋白的抗体制备[D].杭州:浙江理工大学,2015.
[35]KOWALSKA E,RIPPERGER J A,HOEGGER D C,et al.NONOcouples the circadian clock to the cell cycle[J].Proc Natl Acad Sci U S A,2013,110(5):1592-1599.DOI:10.1073/pnas.1213317110.
[36]HUANG C J,DAS U,XIE W,et al.Altered stoichiometry and nuclear delocalization of Non O and PSF promote cellular senescence[J].Aging(Albany NY),2016,8(12):3356-3374.DOI:10.18632/aging.101125.
[37]MA C,KARWACKI-NEISIUS V,TANG H,et al.Nono,a bivalent domain factor,regulates erk signaling and mouse embryonic stem cell pluripotency[J].Cell Rep,2016,17(4):997-1007.DOI:10.1016/j.celrep.2016.09.078.
[38]SCOTT D A,HERNANDEZ-GARCIA A,AZAMIAN M S,et al.Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO[J].J Med Genet,2017,54(1):47-53.DOI:10.1136/jmedgenet-2016-104039.
[39]REINSTEIN E,TZUR S,COHEN R,et al.Intellectual disability and non-compaction cardiomyopathy with a de novo NONO mutation identified by exome sequencing[J].Eur J Hum Genet,2016,24(11):1635-1638.DOI:10.1038/ejhg.2016.72.
[40]ANGOUET M,MIRCSOF D,RIO M,et al.[Mutations in NONOlead to syndromic intellectual disability and inhibitory synaptic defects][J].Med Sci(Paris),2016,32(6/7):571-573.DOI:10.1051/medsci/20163206015.
[41]GELAIS C,ROGER J,WU L.Non-POU domain-containing octamer-binding protein negatively regulates HIV-1 infection in CD4(+)T cells[J].AIDS Res Hum Retroviruses,2015,31(8):806-816.DOI:10.1089/AID.2014.0313.
[2]KNOTT G J,BOND C S,FOX A H.The DBHS proteins SFPQ,NO-NO and PSPC1:a multipurpose molecular scaffold[J].Nucleic Acids Res,2016,44(9):3989-4004.DOI:10.1093/nar/gkw271.
[3]YANG Y S,HANKE J H,CARAYANNOPOULOS L,et al.Non O,a non-POU-domain-containing,octamer-binding protein,is the mammalian homolog of drosophila nonadiss[J].Mol Cell Biol,1993,13(9):5593-5603.
[4]YANG Y S,YANG M C,TUCKER P W,et al.Non O enhances the association of many DNA-binding proteins to their targets[J].Nucleic Acids Res,1997,25(12):2284-2292.
[5]PARK Y,LEE J M,HWANG MY,et al.Non O binds to the Cp G island of oct4 promoter and functions as a transcriptional activator of oct4 gene expression[J].Mol Cells,2013,35(1):61-69.DOI:10.1007/s10059-013-2273-1.
[6]MATHUR M,TUCKER P W,SAMUELS H H.PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors[J].Mol Cell Biol,2001,21(7):2298-2311.DOI:10.1128/MCB.21.7.2298-2311.2001.
[7]BASU A,DONG B,KRAINER A R,et al.The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA-and DNA-binding protein p54nrb/Non O[J].Mol Cell Biol,1997,17(2):677-686.
[8]ZHANG Z,CARMICHAEL G G.The fate of ds RNA in the nucleus:a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs[J].Cell,2001,106(4):465-475.
[9]KAMEOKA S,DUQUE P,KONARSKA M M.p54(nrb)associates with the 5'splice site within large transcription/splicing complexes[J].EMBO J,2004,23(8):1782-1791.DOI:10.1038/sj.emboj.7600187.
[10]SHAV-TAL Y,ZIPORI D.PSF and p54(nrb)/Non O-multi-functional nuclear proteins[J].FEBS Lett,2002,531(2):109-114.
[11]UDAYAKUMAR D,DYNAN W S.Characterization of DNA binding and pairing activities associated with the native SFPQ.NONODNA repair protein complex[J].Biochem Biophys Res Commun,2015,463(4):473-478.DOI:10.1016/j.bbrc.2015.05.024.
[12]AAFAR L,LI Z,LI S,et al.SFPQ-NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining[J].Nucleic Acids Res,2017,45(4):1848-1859.DOI:10.1093/nar/gkw1209.
[13]TRAISH A M,HUANG Y H,ASHBA J,et al.Loss of expression of a 55 k Da nuclear protein(nmt55)in estrogen receptor-negative human breast cancer[J].Diagn Mol Pathol,1997,6(4):209-221.
[14]LIU L,ZHAO X,ZHAO L,et al.Arginine methylation of srebp1a via prmt5 promotes de novo lipogenesis and tumor growth[J].Cancer Res,2016,76(5):1260-1272.DOI:10.1158/0008-5472.CAN-15-1766.
[15]ZHU Z,ZHAO X,ZHAO L,et al.p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A[J].Oncogene,2016,35(11):1399-1410.DOI:10.1038/onc.2015.197.
[16]PAVAO M,HUANG Y H,HAFER L J,et al.Immunodetection of nmt55/p54nrb isoforms in human breast cancer[J/OL].BMC Cancer,2001,1:15[2017-10-29].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59838/.DOI:10.1186/1471-2407-1-15.
[17]熊薇,闫吕彬,吴嫦丽,等.NONO基因沉默对乳腺癌细胞生物学特性影响研究[J].中华肿瘤防治杂志,2016,23(13):844-848.
[18]BI Y,TIAN M,LE J,et al.Study on the expression of PAK4 and P54 protein in breast cancer[J].World J Surg Oncol,2016,14(1):160.DOI:10.1186/s12957-016-0913-6.
[19]ISHIGURO H,UEMURA H,FUJINAMI K,et al.55 k Da nuclear matrix protein(nmt55)m RNA is expressed in human prostate cancer tissue and is associated with the androgen receptor[J].Int J Cancer,2003,105(1):26-32.DOI:10.1002/ijc.11021.
[20]ISHITANI K,YOSHIDA T,KITAGAWA H,et al.p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor[J].Biochem Biophys Res Commun,2003,306(3):660-665.
[21]HO T T,HUANG J,ZHOU N,et al.Regulation of PCGEM1 by p54/nrb in prostate cancer[J].Sci Rep,2016,6:34529.DOI:10.1038/srep34529.
[22]TSOFACK S P,GARAND C,SEREDUK C,et al.NONO and RA-LY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines[J/OL].Mol Cancer,2011,10:145[2017-10-29].https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-10-145.DOI:10.1186/1476-4598-10-145.
[23]YANG P,CHEN T,XU Z,et al.Long noncoding RNA GAPLINCpromotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO[J].Oncotarget,2016,7(27):42183-42194.DOI:10.18632/oncotarget.9741.
[24]SCHIFFNER S,ZIMARA N,SCHMID R,et al.p54nrb is a new regulator of progression of malignant melanoma[J].Carcinogenesis,2011,32(8):1176-1182.DOI:10.1093/carcin/bgr103.
[25]ARGANI P,ZHONG M,REUTER V E,et al.TFE3-fusion variant analysis defines specific clinicopathologic associations among Xp11translocation cancers[J].Am J Surg Pathol,2016,40(6):723-737.DOI:10.1097/PAS.0000000000000631.
[26]CLARK J,LU Y J,SIDHAR S K,et al.Fusion of splicing factor genes PSF and Non O(p54nrb)to the TFE3 gene in papillary renal cell carcinoma[J].Oncogene,1997,15(18):2233-2239.DOI:10.1038/sj.onc.1201394.
[27]XIA Q Y,WANG Z,CHEN N,et al.Xp11.2 translocation renal cell carcinoma with NONO-TFE3 gene fusion:morphology,prognosis,and potential pitfall in detecting TFE3 gene rearrangement[J].Mod Pathol,2017,30(3):416-426.DOI:10.1038/modpathol.2016.204.
[28]MCGREGOR S M,ALIKHAN M B,JOHN R A,et al.Melanotic PEComa of the sinonasal mucosa with NONO-TFE3 fusion:an elusive mimic of sinonasal melanoma[J].Am J Surg Pathol,2017,41(5):717-722.DOI:10.1097/PAS.0000000000000778.
[29]BARBORO P,RUBAGOTTI A,ORECCHIA P,et al.Differential proteomic analysis of nuclear matrix in muscle-invasive bladder cancer:potential to improve diagnosis and prognosis[J].Cell Oncol,2008,30(1):13-26.
[30]张秀娟,熊薇,吴嫦丽,等.NONO基因沉默抑制鼻咽癌细胞的体外增殖、迁移和侵袭能力[J].肿瘤,2016,36(5):504-511.
[31]LIN S Y,LAI Y H,CHEN H Y,et al.Abstract 749:Characterization of p54nrb/Non O promoter in NSCLC[J].Cancer Res,2013,73(8Supplement):749-749.
[32]HALLIER M,TAVITIAN A,MOREAU-GACHELIN F.The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb[J].J Biol Chem,1996,271(19):11177-11181.
[33]桑婷婷,胡江江,薛建有,等.Non O蛋白在丁酸钠诱导小鼠红白血病细胞分化过程中的表达[J].解剖学报,2014,45(4):516-520.
[34]胡江江.PBDC1和Non O蛋白在红系分化过程中的功能研究及UPF0538蛋白的抗体制备[D].杭州:浙江理工大学,2015.
[35]KOWALSKA E,RIPPERGER J A,HOEGGER D C,et al.NONOcouples the circadian clock to the cell cycle[J].Proc Natl Acad Sci U S A,2013,110(5):1592-1599.DOI:10.1073/pnas.1213317110.
[36]HUANG C J,DAS U,XIE W,et al.Altered stoichiometry and nuclear delocalization of Non O and PSF promote cellular senescence[J].Aging(Albany NY),2016,8(12):3356-3374.DOI:10.18632/aging.101125.
[37]MA C,KARWACKI-NEISIUS V,TANG H,et al.Nono,a bivalent domain factor,regulates erk signaling and mouse embryonic stem cell pluripotency[J].Cell Rep,2016,17(4):997-1007.DOI:10.1016/j.celrep.2016.09.078.
[38]SCOTT D A,HERNANDEZ-GARCIA A,AZAMIAN M S,et al.Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO[J].J Med Genet,2017,54(1):47-53.DOI:10.1136/jmedgenet-2016-104039.
[39]REINSTEIN E,TZUR S,COHEN R,et al.Intellectual disability and non-compaction cardiomyopathy with a de novo NONO mutation identified by exome sequencing[J].Eur J Hum Genet,2016,24(11):1635-1638.DOI:10.1038/ejhg.2016.72.
[40]ANGOUET M,MIRCSOF D,RIO M,et al.[Mutations in NONOlead to syndromic intellectual disability and inhibitory synaptic defects][J].Med Sci(Paris),2016,32(6/7):571-573.DOI:10.1051/medsci/20163206015.
[41]GELAIS C,ROGER J,WU L.Non-POU domain-containing octamer-binding protein negatively regulates HIV-1 infection in CD4(+)T cells[J].AIDS Res Hum Retroviruses,2015,31(8):806-816.DOI:10.1089/AID.2014.0313.