NONO/p54nrb在肿瘤发生发展中作用的研究进展
|
摘要
不含POU结构域的八聚体核苷酸结合蛋白(non-POU domain-containing octamer-binding protein,NONO)也称54 k D核RNA/DNA结合蛋白(54 k D Nuclear RNA-and DNA-binding protein,p54nrb),是一种能与DNA和RNA结合的多功能核蛋白,参与多种细胞生物活动,包括转录调节、DNA修复、RNA核保留复制、细胞增殖调控以及形成亚核结构paraspeckle等。当NONO蛋白表达异常时,是否会导致肿瘤的发生呢?现研究表明在多数肿瘤中NONO蛋白表达异常。与鼻咽癌、前列腺癌、膀胱癌、乳头状肾细胞癌、大肠癌、恶性黑色素瘤以及白血病等多种肿瘤发生发展密切相关。本综述就NONO蛋白结构、功能以及在肿瘤发生、发展中的作用予以综述。
Non-POU domain-containing octamer-binding protein(NONO),also known as 54 kD Nuclear RNA-and DNA-binding protein(p54 nrb),is a multifunctional nuclear protein which binds to DNA or RNA and implicated in many biological processes,including transcriptional regulation,DNA repair,nuclear RNA repair and replication,cell proliferation regulation and formation of paraspeckle,etc.When the abnormal expression of NONO,will lead to tumors? Recent research shows that NONO protein abnormally expressions in most tumors.It is closely related to the development of nasopharyngeal carcinoma,prostate cancer,bladder cancer,papillary renal cell carcinoma,colorectal cancer,malignant melanoma and leukemia.This article reviews the structure and function of NONO protein and in the genesis and development of tumors.
Non-POU domain-containing octamer-binding protein(NONO),also known as 54 kD Nuclear RNA-and DNA-binding protein(p54 nrb),is a multifunctional nuclear protein which binds to DNA or RNA and implicated in many biological processes,including transcriptional regulation,DNA repair,nuclear RNA repair and replication,cell proliferation regulation and formation of paraspeckle,etc.When the abnormal expression of NONO,will lead to tumors? Recent research shows that NONO protein abnormally expressions in most tumors.It is closely related to the development of nasopharyngeal carcinoma,prostate cancer,bladder cancer,papillary renal cell carcinoma,colorectal cancer,malignant melanoma and leukemia.This article reviews the structure and function of NONO protein and in the genesis and development of tumors.
引文
Amelio A.L.,Miraglia L.J.,Conkright J.J.,Mercer B.A.,Batalov S.,Cavett V.,Qrth A.P.,Busby J.,Hogenesch J.B.,and Conkright M.D.,2007,A coactivator trap identifies NONO(p54nrb)asa component of the c AMP-signaling pathway,PNAS,104(51):20314-20319
Bruelle C.,Bdard M.,Blier S.,Gauthier M.,Traish A.M.,and Vincent M.,2011,The mitotic phosphorylation of p54nrb modulates its RNA binding activity,Biochemistry and Cell Biology,89(4):423-433
Cheng J.H.,2011,Study on the upstream control region of gene in non-small cell lung cancer,Thesis for M.S.,Institute of Biomedical Sciences,National Chung Hsing University,Supervisor:Chen J.W.,pp.36-50(陈建宏,2011,探討p54nrb基因在非小細胞肺癌之上游調控區域,硕士学位论文,国立中兴大学生物医学研究所,导师:陈健尉,pp.36-50)
Clark J.,Lu Y.J.,Sidhar S.K.,Parker C.,Gill S.,Smedley D.,Hamoudi R.,Linehan W.M.,Shipley J.,and Cooper C.S.,1997,Fusion of splicing factor genes PSF and Non O(p54nrb)to the TFE3 gene in papillary renal cell carcinoma,Oncogene,15(18):2233-2239
Duvignaud J.,Bdard M.,Nagata T.,Nagata T.,Muto Y.,Yokoyama S.,Gagne S.M.,and Vincent M.,2016,Structure,dynamics,and interaction of p54nrb/Non O RRM1with 5'Splice site RNA sequence,Biochemistry,55(18):2553-2566
Dong X.,Yu C.,Shynlova O.,Challis J.R.G.,Rennie P.S.,and Lye S.J.,2009,p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene,Connexin 43(Gja1),Molecular Endocrinology,23(8):1147-1160
Fox A.H.,and Lamond A.I.,2010,Paraspeckles,Cold Spring Harbor Perspectives in Biology,2(7):a687
Ho T.,Huang J.,Zhou N.,Zhang Z.,Koirala P.,Zhou X.,Wu F.,Ding X.,and Mo Y.,2016,Regulation of PCGEM1 by p54/nrb in prostate cancer,Scientific Reports,6(1):34529
Hata K.,Nishimura R.,Muramatsu S.,Matsuda A.,Matsubara T.,Amano K.,Ikeda F.,Harley V.R.,and Yoneda T.,2008,Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice,Journal of Clinical Investigation,118(9):3098-3108
Huang C.J.,Das U.,Xie W.,Ducasse M.,and Tucker H.O.,2016,Altered stoichiometry and nuclear delocalization of Non Oand PSF promote cellular senescence,Aging(Albany NY),8(12):3356-3374
Izumi H.,Mccloskey A.,Shinmyozu K.,and Ohno M.,2014,p54nrb/Non O and PSF promote U sn RNA nuclear export by accelerating its export complex assembly,Nucleic Acids Research,42(6):3998-4007
Knott G.J.,Bond C.S.,and Fox A.H.,2016,The DBHS proteins SFPQ,NONO and PSPC1:a multipurpose molecular scaffold,Nucleic Acids Research,44(9):3989-4004
Kaneko S.,Rozenblatt-Rosen O.,Meyerson M.,and Manley J.L.,2007,The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-m RNA 3'processing and transcription termination,Genes&Development,21(14):1779-1789
Lee A.R.,Hung W.,Xie N.,Liu L.,He L.,and Dong X.,2016,Tyrosine residues regulate multiple nuclear functions of P54nrb,Journal of Cellular Physiology,232(4):852-861
Liu P.Y.Erriquez D.,Marshall G.M.,Tee A.E.,Polly P.,Mathew W.,Liu B.,Bell J.L.,Zhang X.D.,Milazzo G.,Cheung B.B.,Fox A.,Swarbrick A.,Huttelmaier S.,Kavallaris M.,Perini G.,Mattick J.S.,Dinger M.E.,and Liu T.,2014,Effects of a novel long noncoding RNA,lnc USMyc N,on N-Myc expression and neuroblastoma progression,JNCI Journal of the National Cancer Institute,106(7):u113
Li Q.,Guo H.,Li H.,Zhu Q.,and Liu Y.,2017,P54/nrb prompts rheumatoid arthritis progression mainly by transcription-ally activating NF-资B signaling,Pharmazie,72(5):260-264
Li S.,Li Z.,Shu F.J.,Xiong H.,Phillips A.C.,and Dynan W.S.,2014,Double-strand break repair deficiency in NONOknockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog,Nucleic Acids Research,42(15):9771-9780
Marc H.,Armand T.,and Francoise M.G.,1996,The transcription factor Spi-1 PU.1 binds RNA and interferes with the RNA-binding protein p54nrb,The Journal of Biological Chemistry,271(19):11177-11181
Maeva L.,Dennis M.,Marlene R.,Jeanne A.,Steven B.,and Laurence C.,2015,Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects,Nature Neuroscience,32(6-7):571-573
Ma C.,Karwacki-Neisius V.,Tang H.,Li W.,Shi Z.,Hu H.,Xu W.,Wang Z.,Kong L.,Lv R.,Fan Z.,Zhou W.,Yang P.,Wu F.,Diao J.,Tan L.,Shi Y.,Lan F.,and Shi Y.,2016,Nono,a bivalent domain factor,regulates erk signaling and mouse embryonic stem cell pluripotency,Cell Reports,17(4):997-1007
Nonomura N.,Takayama H.,Nakayama M.,Nakai Y.,Kawashima A.,Mukai M.,Nagahara A.,Aozasa K.,and Tsujimura A.,2010,Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer,BJU International,107(12):1918-1922
Passon D.M.,Lee M.,Rackham O.,Stanley W.A.,Sadowska A.,Filipovska A.,Fox A.H.,and Bond C.S.,2012,Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation,Proc.Natl.Acad.Sci.USA,109(13):4846-4850
Paola B.,Rubagotti A.,Orecchia P.,Spina B.,Mauro T.,Repaci E.,Carmignani G.,Romagnoli A.,Introini C.,Boccardo F.,Carnemolla B.,and Balbi C.,2008,Differential proteomic analysis of nuclear matrix in muscle-invasive bladder cancer:Potential to improve diagnosis and prognosis,Cellular Oncology,30(2008):13-26
Pavao M.,Huang Y.H.,Hafer L.J.,Moreland R.B.,and Traish A.M.,2001,Immunodetection of nmt55/p54nrb isoforms in human breast cancer,BMC Cancer,1(1):15-24
Ren Z.,Wang Z.,Hu Z.,Hu X.,Zhang H.,Wu H.,Hu R.,and Liu H.,2014,Decreased expression of P54nrb/Non O correlates with collagen deposition and fibrosis in human aortic dissection,Histopathology,65(4):570-580
Shav-Tal Y.,and Zipori D.,2002,PSF and p54nrb/Non O-multi-functional nuclear proteins,FEBS Letters,531(2):109-114
Schiffner S.,Zimara N.,Schmid R.,and Bosserhoff A.K.,2011,p54nrb is a new regulator of progression of malignant melanoma,Carcinogenesis,32(8):1176-1182
Shen W.,Liang X.,Sun H.,Hoyos C.L.D.,and Crooke S.T.,2017,Depletion of NEAT1 lnc RNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation,PLo S One,12(3):e173494
Salton M.,Lerenthal Y.,Wang S.Y.,Chen D.J.,and Shiloh Y.,2010,Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response,Cell Cycle,9(8):1568-1576
Shelkovnikova T.A.,Robinson H.K.,Troakes C.,Ninkina N.,and Buchman V.L.,2014,Compromised paraspeckle formation as a pathogenic factor in FUSopathies,Human Molecular Genetics,23(9):2298-2312
Sasakia Y.T.F.,Ideue T.,Sano M.,Mituyama T.,and Hirose T.,2009,MEN/noncoding RNAs are essential for structural integrity of nuclear paraspeckles,PNAS,106(8):b2525-2530
Tsofack S.P.,Garand C.,Sereduk C.,Chow D.,Aziz M.,Guay D.,Yin H.H.,and Lebel M.,2011,NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines,Mol.Cancer,10:145-152
Udayakumar D.,and Dynan W.S.,2015,Characterization of DNA binding and pairing activities associated with the native SFPQ NONO DNA repair protein complex,Biochemical and Biophysical Research Communications,463(4):473-478
Vavougios G.D.,Solenov E.I.,Hatzoglou C.,Baturina G.S.,Katkova L.E.,Molyvdas P.A.,Gourgoulianis K.I.,and Zaragiannis S.G.,2015,Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma,American Journal of Physiology-Lung Cellular and Molecular Physiology,309(7):L677-L686
Xiong W.,Zhang X.J.,Yan L.B.,Wu C.L.,and Chen C.L.,2016,Effects of NONO silencing on the biological characteristics of breast cancer cells,Zhonghua Zhongliu Fangzhi Zazhi(Chin.J.Cancer Prev.Treat.),23(13):844-848(熊薇,张秀娟,闫吕彬,吴嫦丽,陈春玲,2016,NONO基因沉默对乳腺癌细胞生物学特性影响研究,中华肿瘤防治杂志,23(13):844-848)
Yadav S.P.,Hao H.,Yang H.J.,Kautzmann M.A.I.,Brooks M.,Nellissery J.,Klocke B.,Seifert M.,and Swaroop A.,2014,The transcription-splicing protein Non O/p54nrb and three Non O-interacting proteins bind to distal enhancer region and augment rhodopsin expression,Human Molecular Genetics,23(8):2132-2144
Yang P.,Chen T.,Xu Z.,Zhu H.,Wang J.,and He Z.,2016,Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSFand NONO,Oncotarget,7(21):42183-42194
Zhu Z.,Zhao X.,Zhao L.,Yang L.,Liu L.,Wu J.,Yang F.,Huang G.,and Liu J.,2015,p54(nrb)NONO regulates lipid metabolism and breast cancer growth through SREBP-1A,Oncogene,35(11):1399-1410
Zhang X J.,Wu C L.,Xiong W.,Chen C.L.,Li R.,and Zhou G J.,2016,Knockdown of p54nrb inhibits migration,invasion and TNF-αrelease of human acute monocytic leukemia THP1 cells,Oncology Reports,35(6):3742-3748
Zhang X.J.,Xiong W.,Wu C.L.,Chen C.L.,and Zhou G.J.,2016,NONO gene-silencing inhibits the proliferation,migaration and incasion of nasopharyngeal carcinoma cells in vitro,Zhongliu(Tumor),36(5):504-511(张秀娟,熊薇,吴嫦丽,陈春玲,周光纪,2016,NONO基因沉默抑制鼻咽癌细胞的体外增殖、迁移和侵袭能力,肿瘤,36(5):504-511)
Zhang L.,Zhang W.,Wang Y.,Zhang W.,Zhao F.,Kulkarni A.,and Sun Z.,2015,Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma,Cell Death and Disease,6(5):e1771
Bruelle C.,Bdard M.,Blier S.,Gauthier M.,Traish A.M.,and Vincent M.,2011,The mitotic phosphorylation of p54nrb modulates its RNA binding activity,Biochemistry and Cell Biology,89(4):423-433
Cheng J.H.,2011,Study on the upstream control region of gene in non-small cell lung cancer,Thesis for M.S.,Institute of Biomedical Sciences,National Chung Hsing University,Supervisor:Chen J.W.,pp.36-50(陈建宏,2011,探討p54nrb基因在非小細胞肺癌之上游調控區域,硕士学位论文,国立中兴大学生物医学研究所,导师:陈健尉,pp.36-50)
Clark J.,Lu Y.J.,Sidhar S.K.,Parker C.,Gill S.,Smedley D.,Hamoudi R.,Linehan W.M.,Shipley J.,and Cooper C.S.,1997,Fusion of splicing factor genes PSF and Non O(p54nrb)to the TFE3 gene in papillary renal cell carcinoma,Oncogene,15(18):2233-2239
Duvignaud J.,Bdard M.,Nagata T.,Nagata T.,Muto Y.,Yokoyama S.,Gagne S.M.,and Vincent M.,2016,Structure,dynamics,and interaction of p54nrb/Non O RRM1with 5'Splice site RNA sequence,Biochemistry,55(18):2553-2566
Dong X.,Yu C.,Shynlova O.,Challis J.R.G.,Rennie P.S.,and Lye S.J.,2009,p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene,Connexin 43(Gja1),Molecular Endocrinology,23(8):1147-1160
Fox A.H.,and Lamond A.I.,2010,Paraspeckles,Cold Spring Harbor Perspectives in Biology,2(7):a687
Ho T.,Huang J.,Zhou N.,Zhang Z.,Koirala P.,Zhou X.,Wu F.,Ding X.,and Mo Y.,2016,Regulation of PCGEM1 by p54/nrb in prostate cancer,Scientific Reports,6(1):34529
Hata K.,Nishimura R.,Muramatsu S.,Matsuda A.,Matsubara T.,Amano K.,Ikeda F.,Harley V.R.,and Yoneda T.,2008,Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice,Journal of Clinical Investigation,118(9):3098-3108
Huang C.J.,Das U.,Xie W.,Ducasse M.,and Tucker H.O.,2016,Altered stoichiometry and nuclear delocalization of Non Oand PSF promote cellular senescence,Aging(Albany NY),8(12):3356-3374
Izumi H.,Mccloskey A.,Shinmyozu K.,and Ohno M.,2014,p54nrb/Non O and PSF promote U sn RNA nuclear export by accelerating its export complex assembly,Nucleic Acids Research,42(6):3998-4007
Knott G.J.,Bond C.S.,and Fox A.H.,2016,The DBHS proteins SFPQ,NONO and PSPC1:a multipurpose molecular scaffold,Nucleic Acids Research,44(9):3989-4004
Kaneko S.,Rozenblatt-Rosen O.,Meyerson M.,and Manley J.L.,2007,The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-m RNA 3'processing and transcription termination,Genes&Development,21(14):1779-1789
Lee A.R.,Hung W.,Xie N.,Liu L.,He L.,and Dong X.,2016,Tyrosine residues regulate multiple nuclear functions of P54nrb,Journal of Cellular Physiology,232(4):852-861
Liu P.Y.Erriquez D.,Marshall G.M.,Tee A.E.,Polly P.,Mathew W.,Liu B.,Bell J.L.,Zhang X.D.,Milazzo G.,Cheung B.B.,Fox A.,Swarbrick A.,Huttelmaier S.,Kavallaris M.,Perini G.,Mattick J.S.,Dinger M.E.,and Liu T.,2014,Effects of a novel long noncoding RNA,lnc USMyc N,on N-Myc expression and neuroblastoma progression,JNCI Journal of the National Cancer Institute,106(7):u113
Li Q.,Guo H.,Li H.,Zhu Q.,and Liu Y.,2017,P54/nrb prompts rheumatoid arthritis progression mainly by transcription-ally activating NF-资B signaling,Pharmazie,72(5):260-264
Li S.,Li Z.,Shu F.J.,Xiong H.,Phillips A.C.,and Dynan W.S.,2014,Double-strand break repair deficiency in NONOknockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog,Nucleic Acids Research,42(15):9771-9780
Marc H.,Armand T.,and Francoise M.G.,1996,The transcription factor Spi-1 PU.1 binds RNA and interferes with the RNA-binding protein p54nrb,The Journal of Biological Chemistry,271(19):11177-11181
Maeva L.,Dennis M.,Marlene R.,Jeanne A.,Steven B.,and Laurence C.,2015,Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects,Nature Neuroscience,32(6-7):571-573
Ma C.,Karwacki-Neisius V.,Tang H.,Li W.,Shi Z.,Hu H.,Xu W.,Wang Z.,Kong L.,Lv R.,Fan Z.,Zhou W.,Yang P.,Wu F.,Diao J.,Tan L.,Shi Y.,Lan F.,and Shi Y.,2016,Nono,a bivalent domain factor,regulates erk signaling and mouse embryonic stem cell pluripotency,Cell Reports,17(4):997-1007
Nonomura N.,Takayama H.,Nakayama M.,Nakai Y.,Kawashima A.,Mukai M.,Nagahara A.,Aozasa K.,and Tsujimura A.,2010,Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer,BJU International,107(12):1918-1922
Passon D.M.,Lee M.,Rackham O.,Stanley W.A.,Sadowska A.,Filipovska A.,Fox A.H.,and Bond C.S.,2012,Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation,Proc.Natl.Acad.Sci.USA,109(13):4846-4850
Paola B.,Rubagotti A.,Orecchia P.,Spina B.,Mauro T.,Repaci E.,Carmignani G.,Romagnoli A.,Introini C.,Boccardo F.,Carnemolla B.,and Balbi C.,2008,Differential proteomic analysis of nuclear matrix in muscle-invasive bladder cancer:Potential to improve diagnosis and prognosis,Cellular Oncology,30(2008):13-26
Pavao M.,Huang Y.H.,Hafer L.J.,Moreland R.B.,and Traish A.M.,2001,Immunodetection of nmt55/p54nrb isoforms in human breast cancer,BMC Cancer,1(1):15-24
Ren Z.,Wang Z.,Hu Z.,Hu X.,Zhang H.,Wu H.,Hu R.,and Liu H.,2014,Decreased expression of P54nrb/Non O correlates with collagen deposition and fibrosis in human aortic dissection,Histopathology,65(4):570-580
Shav-Tal Y.,and Zipori D.,2002,PSF and p54nrb/Non O-multi-functional nuclear proteins,FEBS Letters,531(2):109-114
Schiffner S.,Zimara N.,Schmid R.,and Bosserhoff A.K.,2011,p54nrb is a new regulator of progression of malignant melanoma,Carcinogenesis,32(8):1176-1182
Shen W.,Liang X.,Sun H.,Hoyos C.L.D.,and Crooke S.T.,2017,Depletion of NEAT1 lnc RNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation,PLo S One,12(3):e173494
Salton M.,Lerenthal Y.,Wang S.Y.,Chen D.J.,and Shiloh Y.,2010,Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response,Cell Cycle,9(8):1568-1576
Shelkovnikova T.A.,Robinson H.K.,Troakes C.,Ninkina N.,and Buchman V.L.,2014,Compromised paraspeckle formation as a pathogenic factor in FUSopathies,Human Molecular Genetics,23(9):2298-2312
Sasakia Y.T.F.,Ideue T.,Sano M.,Mituyama T.,and Hirose T.,2009,MEN/noncoding RNAs are essential for structural integrity of nuclear paraspeckles,PNAS,106(8):b2525-2530
Tsofack S.P.,Garand C.,Sereduk C.,Chow D.,Aziz M.,Guay D.,Yin H.H.,and Lebel M.,2011,NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines,Mol.Cancer,10:145-152
Udayakumar D.,and Dynan W.S.,2015,Characterization of DNA binding and pairing activities associated with the native SFPQ NONO DNA repair protein complex,Biochemical and Biophysical Research Communications,463(4):473-478
Vavougios G.D.,Solenov E.I.,Hatzoglou C.,Baturina G.S.,Katkova L.E.,Molyvdas P.A.,Gourgoulianis K.I.,and Zaragiannis S.G.,2015,Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma,American Journal of Physiology-Lung Cellular and Molecular Physiology,309(7):L677-L686
Xiong W.,Zhang X.J.,Yan L.B.,Wu C.L.,and Chen C.L.,2016,Effects of NONO silencing on the biological characteristics of breast cancer cells,Zhonghua Zhongliu Fangzhi Zazhi(Chin.J.Cancer Prev.Treat.),23(13):844-848(熊薇,张秀娟,闫吕彬,吴嫦丽,陈春玲,2016,NONO基因沉默对乳腺癌细胞生物学特性影响研究,中华肿瘤防治杂志,23(13):844-848)
Yadav S.P.,Hao H.,Yang H.J.,Kautzmann M.A.I.,Brooks M.,Nellissery J.,Klocke B.,Seifert M.,and Swaroop A.,2014,The transcription-splicing protein Non O/p54nrb and three Non O-interacting proteins bind to distal enhancer region and augment rhodopsin expression,Human Molecular Genetics,23(8):2132-2144
Yang P.,Chen T.,Xu Z.,Zhu H.,Wang J.,and He Z.,2016,Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSFand NONO,Oncotarget,7(21):42183-42194
Zhu Z.,Zhao X.,Zhao L.,Yang L.,Liu L.,Wu J.,Yang F.,Huang G.,and Liu J.,2015,p54(nrb)NONO regulates lipid metabolism and breast cancer growth through SREBP-1A,Oncogene,35(11):1399-1410
Zhang X J.,Wu C L.,Xiong W.,Chen C.L.,Li R.,and Zhou G J.,2016,Knockdown of p54nrb inhibits migration,invasion and TNF-αrelease of human acute monocytic leukemia THP1 cells,Oncology Reports,35(6):3742-3748
Zhang X.J.,Xiong W.,Wu C.L.,Chen C.L.,and Zhou G.J.,2016,NONO gene-silencing inhibits the proliferation,migaration and incasion of nasopharyngeal carcinoma cells in vitro,Zhongliu(Tumor),36(5):504-511(张秀娟,熊薇,吴嫦丽,陈春玲,周光纪,2016,NONO基因沉默抑制鼻咽癌细胞的体外增殖、迁移和侵袭能力,肿瘤,36(5):504-511)
Zhang L.,Zhang W.,Wang Y.,Zhang W.,Zhao F.,Kulkarni A.,and Sun Z.,2015,Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma,Cell Death and Disease,6(5):e1771