预测动脉瘤性蛛网膜下腔出血预后的相关生物标志物
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摘要
动脉瘤性蛛网膜下腔出血(aSAH)是最常见的非创伤性蛛网膜下腔出血,是世界范围内死亡和残疾的主要原因。目前,世界神经外科医师联盟量表和修正的Fisher分级量表常用于评估aSAH的严重程度和预测预后。虽然aSAH后早期脑损伤的病理生理机制非常复杂,但炎症已被证实参与了aSAH后的早期脑损伤。因此,炎症生物标志物引起临床医师的广泛关注。未来,通过研究与aSAH预后相关的生物标志物,对aSAH的进展进行早期干预,可为其临床治疗提供新思路。
Aneurysm subarachnoid hemorrhage( a SAH) is the most common non-traumatic subarachnoid hemorrhage,and the main cause of death and disability worldwide. At present,World Federation of Neurosurgical Societies Scale and the modified Fisher Scale are often used to assess the severity of a SAH and predict the prognosis. Although the pathophysiological mechanism of early brain injury after a SAH is very complex,inflammation has been proved to be involved. Therefore,biomarkers of inflammation have attracted wide attention from the clinicians. In the future,early intervention on the progress of a SAH by studying biomarkers related to the prognosis of a SAH will provide new ideas for its clinical treatment.
Aneurysm subarachnoid hemorrhage( a SAH) is the most common non-traumatic subarachnoid hemorrhage,and the main cause of death and disability worldwide. At present,World Federation of Neurosurgical Societies Scale and the modified Fisher Scale are often used to assess the severity of a SAH and predict the prognosis. Although the pathophysiological mechanism of early brain injury after a SAH is very complex,inflammation has been proved to be involved. Therefore,biomarkers of inflammation have attracted wide attention from the clinicians. In the future,early intervention on the progress of a SAH by studying biomarkers related to the prognosis of a SAH will provide new ideas for its clinical treatment.
引文
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[18]Wang JX,Hou Y,Ruan SP,et al.Plasma visfatin,a possible prognostic marker in aneurysmal subarachnoid hemorrhage[J].Peptides,2013,50:8-12.
[19]Milne GL,Yin H,Morrow JD.Human biochemistry of the isoprostane pathway[J].J Biol Chem,2008,6,283(23):15533-15537.
[20]Milne GL,Yin H,Brooks JD,et al.Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress[J].Methods Enzymol,2007,433:113-126.
[21]Liu W,Morrow JD,Yin H.Quantification of F2-isoprostanes as a reliable index of oxidative stress in vivo using gas chromatography-mass spectrometry(GC-MS)method[J].Free Radic Biol Med,2009,47(8):1101-1107.
[22]Wiswedel I.F2-isoprostanes:Sensitive biomarkers of oxidative stress in vitro and in vivo:A gas chromatography-mass spectrometric approach[J].Methods Mol Biol,2009,580:3-16.
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[24]Du Q,Yu WH,Dong XQ,et al.Plasma 8-iso-Prostaglandin F2αconcentrations and outcomes after acute intracerebral hemorrhage[J].Clin Chim Acta,2014,437:141-146.
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[28]Sanchez-Garcia S,Habernau MA,Quirce S.Biomarkers in inflammometry pediatric asthma:Utility in daily clinical practice[J].Eur Clin Respir J,2017,4(1):1356160.
[29]Wu H,Chen L,Xie J,et al.Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension[J].Mol Med Rep,2016,14(1):776-782.
[30]Dong XQ,Yu WH,Du Q,et al.Serum periostin concentrations and outcomes after severe traumatic brain injury[J].Clin Chim Acta,2017,471:298-303.
[31]Liu L,Kawakita F,Fujimoto M,et al.Role of periostin in early brain injury after subarachnoid hemorrhage in mice[J].Stroke,2017,48(4):1108-1111.
[32]Luo W,Wang H,Hu J.Increased concentration of serum periostin is associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage[J].J Clin Lab Anal,2018,32(5):e22389.
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[34]Cunningham GM,Roman MG,Flores LC,et al.The paradoxical role of thioredoxin on oxidative stress and aging[J].Arch Biochem Biophys,2015,576:32-38.
[35]Wu MH,Song FY,Wei LP,et al.Serum levels of thioredoxin are associated with stroke risk,severity,and lesion volumes[J].Mol Neurobiol,2016,53(1):677-685.
[36]Qi AQ,Li Y,Liu Q,et al.Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke[J].Free Radic Biol Med,2015,80:129-135.
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