调节性坏死:认识和防治损伤相关性疾病的新途径
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摘要
坏死也受到信号通路严密调控,称为调节性坏死,包括程序性坏死(necroptosis)、铁坏死(ferroptosis)、parthanatos和亲环素D(Cyp D)依赖的坏死等,它们与损伤相关性疾病如缺血性心脏病、脑卒中、神经退行性疾病等的发生、发展和预后密切相关。阐明各种调节性坏死的信号传导途径和调控机制,对于寻找损伤相关性疾病的防治药物和指导临床治疗具有深远意义。
Necrosis is also tightly controlled by signaling pathways,thus it is called as regulated necrosis,which includes necroptosis,ferroptosis,parthanatos and Cyp D-mediated necrosis.It has been shown that regulated necrosis is closely related to the occurrence,development and prognosis of injury-relevant diseases such as myocardial infarction,stroke,neurodegenerative diseases. It will be significant for prevention and therapy of injuryrelevant diseases to clarify the signal transductions and regulatory mechanisms for the regulated necrosis.
Necrosis is also tightly controlled by signaling pathways,thus it is called as regulated necrosis,which includes necroptosis,ferroptosis,parthanatos and Cyp D-mediated necrosis.It has been shown that regulated necrosis is closely related to the occurrence,development and prognosis of injury-relevant diseases such as myocardial infarction,stroke,neurodegenerative diseases. It will be significant for prevention and therapy of injuryrelevant diseases to clarify the signal transductions and regulatory mechanisms for the regulated necrosis.
引文
[1]Galluzzi L,Kroemer G.Necroptosis:a specialized pathway of programmed necrosis[J].Cell,2008,135(7):1161-3.
[2]Zhou W,Yuan J.Necroptosis in health and diseases[J].Semin Cell Dev Biol,2014,35:14-23.
[3]Conrad M,Angeli J P,Vandenabeele P,Stockwell B R.Regulated necrosis:disease relevance and therapeutic opportunities[J].Nat Rev Drug Discov,2016,15(5):348-66.
[4]Liu X,Shi F,Li Y,et al.Post-translational modifications as key regulators of TNF-induced necroptosis[J].Cell Death Dis,2016,7(7):e2293.
[5]Vanden Berghe T,Linkermann A,Jouan-Lanhouet S,et al.Regulated necrosis:the expanding network of non-apoptotic cell death pathways[J].Nat Rev Mol Cell Biol,2014,15(2):135-47.
[6]Christofferson D E,Yuan J.Necroptosis as an alternative form of programmed cell death[J].Curr Opin Cell Biol,2010,22(2):263-8.
[7]Moquin D M,Mc Quade T,Chan F K.CYLD deubiquitinates RIP1in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis[J].PLo S One,2013,8(10):e76841.
[8]Wu X N,Yang Z H,Wang X K,et al.Distinct roles of RIP1-RIP3hetero-and RIP3-RIP3 homo-interaction in mediating necroptosis[J].Cell Death Differ,2014,21(11):1709-20.
[9]Murphy J M,Czabotar P E,Hildebrand J M,et al.The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism[J].Immunity,2013,39(3):443-53.
[10]Wang H,Sun L,Su L,et al.Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3[J].Mol Cell,2014,54(1):133-46.
[11]Nikoletopoulou V,Markaki M,Palikaras K,Tavernarakis N.Crosstalk between apoptosis,necrosis and autophagy[J].Biochim Biophys Acta,2013,1833(12):3448-59.
[12]Wu J,Huang Z,Ren J,et al.Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis[J].Cell Res,2013,23(8):994-1006.
[13]Fauster A,Rebsamen M,Huber K V,et al.A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis[J].Cell Death Dis,2015,6:e1767.
[14]Degterev A,Linkermann A.Generation of small molecules to interfere with regulated necrosis[J].Cell Mol Life Sci,2016,73(11-12):2251-67.
[15]Blériot C,Lecuit M.The interplay between regulated necrosis and bacterial infection[J].Cell Mol Life Sci,2016,73(11-12):2369-78.
[16]Dixon S J,Lemberg K M,Lamprecht M R,et al.Ferroptosis:an iron-dependent form of nonapoptotic cell death[J].Cell,2012,149(5):1060-72.
[17]Cao J Y,Dixon S J.Mechanisms of ferroptosis[J].Cell Mol Life Sci,2016,73(11-12):2195-209.
[18]宗绍波,魏盛,孙鹏,等.经前平颗粒对愤怒情绪模型大鼠不同脑区单胺类神经递质的影响及分析[J].中国药理学通报,2012,28(11):1615-9.[18]Zong S B,Wei S,Sun P,et al.Effect of Jingqianping granule on monoamine neurotransmitters in different brain regions of anger-out model rats[J].Chin Pharmacol Bull,2012,28(11):1615-9.
[19]Yang W S,Sriramaratnam R,Welsch M E,et al.Regulation of ferroptotic cancer cell death by GPX4[J].Cell,2014,156(1-2):317-31.
[20]Yang W S,Stockwell B R.Ferroptosis:death by lipid peroxidation[J].Trends Cell Biol,2016,26(3):165-76.
[21]郭妍,迟晓丽,马渊,等.喂养型代谢综合征小鼠及大鼠模型的建立方法探讨[J].中国药理学通报,2010,26(4):551-6.[21]Guo Y,Chi X L,Ma Y,et al.Establishment of the metabolic syndrome rodent model[J].Chin Pharmacol Bull,2010,26(4):551-6.
[22]Friedmann Angeli J P,Schneider M,Proneth B,et al.Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J].Nat Cell Biol,2014,16(12):1180-91.
[23]Dixon S J,Stockwell B R.The role of iron and reactive oxygen species in cell death[J].Nat Chem Biol,2013,10(1):9-17.
[24]魏守鹏,梁建辉.酒精依赖综合征治疗药物的研究进展[J].中国药理学通报,2014,30(10):1333-7.[24]Wei S P,Liang J H.Research progress on therapeutic agents for alcohol dependence syndrome[J].Chin Pharmacol Bull,2014,30(10):1333-7.
[25]Shore E R,Awais M,Kershaw N M,et al.Small molecule inhibitors of cyclophilin D to protect mitochondrial function as a potential treatment for acute pancreatitis[J].J Med Chem,2016,59(6):2596-611.
[26]Valasani K R,Sun Q,Fang D,et al.Identification of a small molecule cyclophilin D inhibitor for rescuing a beta-mediated mitochondrial dysfunction[J].ACS Med Chem Lett,2016,7(3):294-9.
[27]Guo X,Sesaki H,Qi X.Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo[J].Biochem J,2014,461(1):137-46.
[28]David K K,Andrabi S A,Dawson T M,Dawson V L.Parthanatos,a messenger of death[J].Front Biosci(Landmark Ed),2009,14:1116-28.
[29]Fatokun A A,Dawson V L,Dawson T M.Parthanatos:mitochondrial-linked mechanisms and therapeutic opportunities[J].Br J Pharmacol,2014,171(8):2000-16.
[30]陈长仁,何发忠,周宏灏,张伟.精准医学的基础研究与临床转化[J].中国药理学通报,2015,31(12):1629-32.[30]Chen Z R,He F Z,Zhou H H,Zhang W.Basic research and clinical translation of precision medicine[J].Chin Pharmacol Bull,2015,31(12):1629-32.
[2]Zhou W,Yuan J.Necroptosis in health and diseases[J].Semin Cell Dev Biol,2014,35:14-23.
[3]Conrad M,Angeli J P,Vandenabeele P,Stockwell B R.Regulated necrosis:disease relevance and therapeutic opportunities[J].Nat Rev Drug Discov,2016,15(5):348-66.
[4]Liu X,Shi F,Li Y,et al.Post-translational modifications as key regulators of TNF-induced necroptosis[J].Cell Death Dis,2016,7(7):e2293.
[5]Vanden Berghe T,Linkermann A,Jouan-Lanhouet S,et al.Regulated necrosis:the expanding network of non-apoptotic cell death pathways[J].Nat Rev Mol Cell Biol,2014,15(2):135-47.
[6]Christofferson D E,Yuan J.Necroptosis as an alternative form of programmed cell death[J].Curr Opin Cell Biol,2010,22(2):263-8.
[7]Moquin D M,Mc Quade T,Chan F K.CYLD deubiquitinates RIP1in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis[J].PLo S One,2013,8(10):e76841.
[8]Wu X N,Yang Z H,Wang X K,et al.Distinct roles of RIP1-RIP3hetero-and RIP3-RIP3 homo-interaction in mediating necroptosis[J].Cell Death Differ,2014,21(11):1709-20.
[9]Murphy J M,Czabotar P E,Hildebrand J M,et al.The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism[J].Immunity,2013,39(3):443-53.
[10]Wang H,Sun L,Su L,et al.Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3[J].Mol Cell,2014,54(1):133-46.
[11]Nikoletopoulou V,Markaki M,Palikaras K,Tavernarakis N.Crosstalk between apoptosis,necrosis and autophagy[J].Biochim Biophys Acta,2013,1833(12):3448-59.
[12]Wu J,Huang Z,Ren J,et al.Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis[J].Cell Res,2013,23(8):994-1006.
[13]Fauster A,Rebsamen M,Huber K V,et al.A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis[J].Cell Death Dis,2015,6:e1767.
[14]Degterev A,Linkermann A.Generation of small molecules to interfere with regulated necrosis[J].Cell Mol Life Sci,2016,73(11-12):2251-67.
[15]Blériot C,Lecuit M.The interplay between regulated necrosis and bacterial infection[J].Cell Mol Life Sci,2016,73(11-12):2369-78.
[16]Dixon S J,Lemberg K M,Lamprecht M R,et al.Ferroptosis:an iron-dependent form of nonapoptotic cell death[J].Cell,2012,149(5):1060-72.
[17]Cao J Y,Dixon S J.Mechanisms of ferroptosis[J].Cell Mol Life Sci,2016,73(11-12):2195-209.
[18]宗绍波,魏盛,孙鹏,等.经前平颗粒对愤怒情绪模型大鼠不同脑区单胺类神经递质的影响及分析[J].中国药理学通报,2012,28(11):1615-9.[18]Zong S B,Wei S,Sun P,et al.Effect of Jingqianping granule on monoamine neurotransmitters in different brain regions of anger-out model rats[J].Chin Pharmacol Bull,2012,28(11):1615-9.
[19]Yang W S,Sriramaratnam R,Welsch M E,et al.Regulation of ferroptotic cancer cell death by GPX4[J].Cell,2014,156(1-2):317-31.
[20]Yang W S,Stockwell B R.Ferroptosis:death by lipid peroxidation[J].Trends Cell Biol,2016,26(3):165-76.
[21]郭妍,迟晓丽,马渊,等.喂养型代谢综合征小鼠及大鼠模型的建立方法探讨[J].中国药理学通报,2010,26(4):551-6.[21]Guo Y,Chi X L,Ma Y,et al.Establishment of the metabolic syndrome rodent model[J].Chin Pharmacol Bull,2010,26(4):551-6.
[22]Friedmann Angeli J P,Schneider M,Proneth B,et al.Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J].Nat Cell Biol,2014,16(12):1180-91.
[23]Dixon S J,Stockwell B R.The role of iron and reactive oxygen species in cell death[J].Nat Chem Biol,2013,10(1):9-17.
[24]魏守鹏,梁建辉.酒精依赖综合征治疗药物的研究进展[J].中国药理学通报,2014,30(10):1333-7.[24]Wei S P,Liang J H.Research progress on therapeutic agents for alcohol dependence syndrome[J].Chin Pharmacol Bull,2014,30(10):1333-7.
[25]Shore E R,Awais M,Kershaw N M,et al.Small molecule inhibitors of cyclophilin D to protect mitochondrial function as a potential treatment for acute pancreatitis[J].J Med Chem,2016,59(6):2596-611.
[26]Valasani K R,Sun Q,Fang D,et al.Identification of a small molecule cyclophilin D inhibitor for rescuing a beta-mediated mitochondrial dysfunction[J].ACS Med Chem Lett,2016,7(3):294-9.
[27]Guo X,Sesaki H,Qi X.Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo[J].Biochem J,2014,461(1):137-46.
[28]David K K,Andrabi S A,Dawson T M,Dawson V L.Parthanatos,a messenger of death[J].Front Biosci(Landmark Ed),2009,14:1116-28.
[29]Fatokun A A,Dawson V L,Dawson T M.Parthanatos:mitochondrial-linked mechanisms and therapeutic opportunities[J].Br J Pharmacol,2014,171(8):2000-16.
[30]陈长仁,何发忠,周宏灏,张伟.精准医学的基础研究与临床转化[J].中国药理学通报,2015,31(12):1629-32.[30]Chen Z R,He F Z,Zhou H H,Zhang W.Basic research and clinical translation of precision medicine[J].Chin Pharmacol Bull,2015,31(12):1629-32.