表面增强拉曼光谱技术检测食品及农产品中的非法添加剂
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摘要
如今,食品安全问题引起越来越多的关注。其中,食品中非法添加剂问题尤为突出,相应的检测变得愈加迫切。传统的检测方法操作复杂、检测时间长并对样品具有破坏性,而表面增强拉曼光谱检测技术相对来说操作简单、无损、所需样品量少,能够达到快速检测的目的,在食品添加剂的检测上具有广阔发展前景。故此以表面增强拉曼光谱技术对β-受体激动剂(盐酸克仑特罗、苯乙醇胺A、莱克多巴胺)、硝基呋喃类药物、孔雀石绿、镇定剂及三聚氰胺等检测项目进行概述,简述其研究进展,同时对其中存在的一些问题进行分析,并对其在食品添加剂检测领域的应用做出展望。
Nowadays,food safety is a serious issue that attracts people's attention,with abusing illegal additives in particular. Therefore,it is urgent to find methods to detect such additives. In comparison to traditional methods that are difficult to operate,time-consuming and can damage samples easily,surface-enhanced raman spectroscopy( SERS) is easy to operate,fast,non-destructive,and needs small amounts of samples. This review summarized the research progress on SERS detecting illegal additives,such as β-receptor stimulants,nitrofurans,and malachite green etc. in foods and agricultural products. Additionally,the existing problems were analyzed,and further applications of SERS in the field of detecting food additives were discussed.
Nowadays,food safety is a serious issue that attracts people's attention,with abusing illegal additives in particular. Therefore,it is urgent to find methods to detect such additives. In comparison to traditional methods that are difficult to operate,time-consuming and can damage samples easily,surface-enhanced raman spectroscopy( SERS) is easy to operate,fast,non-destructive,and needs small amounts of samples. This review summarized the research progress on SERS detecting illegal additives,such as β-receptor stimulants,nitrofurans,and malachite green etc. in foods and agricultural products. Additionally,the existing problems were analyzed,and further applications of SERS in the field of detecting food additives were discussed.
引文
[1] GB 2760—2014,食品安全国家标准食品添加剂使用标准[S].北京:中国标准出版社,2015.
[2]范燕斐,何兰君,李俊毅,等.高效液相色谱法同时测定食品中安赛蜜、苯甲酸、山梨酸、糖精钠[J].科技信息,2006(9):5.
[3]米建萍,徐远金,朱平川,等.液质联用技术在滥用食品添加剂及食品中违法添加物测定中的应用及研究进展[J].基因组学与应用生物学,2015,34(7):1 579-1 586.
[4]周建峰,张碧宇. GC法同时检测食品中七种添加剂[J].食品安全导刊,2017,4(12):84.
[5]高晓娟,史斌斌,张艳红.利用气质联用仪分析检测白酒中的甜蜜素[J].酿酒,2014,41(3):73-75.
[6] FLEISCHMANN M,HENDRA P J,MCQUILLAN A J.Raman spectra of pyridine adsorbed at a silver electrode[J]. Chemical Physics Letters,1974,26(2):163-166.
[7]李明心,常化仿,谢云,等.基于贵金属纳米颗粒的表面增强拉曼光谱免疫层析分析法(SERS-ICA)检测β-激动剂(瘦肉精)[C]//中国化学会第十八届全国有机分析及生物分析学术研讨会论文集.北京:中国化学会,2015:77-79.
[8]甘盛,赖青鸟,李志成,等.表面增强拉曼光谱法研究β受体激动剂在生猪体内代谢与残留[J].中国兽医学报,2016,36(9):1 550-1 557.
[9] XIE Yun,CHANG Huafang,ZHAO Kang,et al. A novel immunochromatographic assay(ICA)based on surface-enhanced Raman scattering for the sensitive and quantitative determination of clenbuterol[J]. Analytical Methods,2015,7:513-520.
[10] LI Mingxin,YANG Hong,LI Shuqun,et al. Ultrasensitive and quantitative detection of a newβ-agonist phenylethanolamine a by a novel immunochromatog-raphic assay based on surface-enhanced Raman scattering(SERS)[J].Journal of Agricultural&Food Chemistry,2014,62(45):10 896-10 902.
[11]窦斌.基于微流控芯片和SERS的瘦肉精类物质检测[D].大连:大连理工大学,2014.
[12]翟福丽,黄轶群,王锡昌,等.应用表面增强拉曼光谱技术快速检测尿样中的β-兴奋剂[J].分析化学,2012,40(5):718-723.
[13] YU Meng,HU Yongjun,LIU Jianzhi. Simultaneous detection of clenbuterol and ractopamine based on multiplexed competitive surface enhanced Raman scattering(SERS)immunoassay[J]. New Journal of Chemistry,2017,41(18):10 407-10 414.
[14] XIE Yunfei,ZHU Xinyu,SUN Yingying,et al. Rapid detection method for nitrofuran antibiotic residues by surface-enhanced Raman spectroscopy[J]. European Food Research&Technology,2012,235(3):555-561.
[15]竺芯宇,谢云飞,汪和雅,等.表面增强拉曼光谱法快速检测硝基呋喃类抗生素呋喃妥因及呋喃它酮[C]//第十七届全国分子光谱学学术会议论文集.北京:光谱学与光谱分析,2012,32(10):207-208.
[16] LI Mingxin,YANG Hong,LI Shuqun,et al. An ultrasensitive competitive immunochromatographic assay(ICA)based on surface-enhanced Raman scattering(SERS)for direct detection of 3-amino-5-methylmorpholino-2-oxazolidinone(AMOZ)in tissue and urine samples[J]. Analytical Methods,2015,7(2):513-520.
[17]刘名扬,肖珊珊,于兵,等.水产品中孔雀石绿和结晶紫残留检测技术的研究进展[J].食品安全质量检测学报,2015,6(1):35-40.
[18]翟毓秀,郭莹莹,耿霞,等.孔雀石绿的代谢机理及生物毒性研究进展[J].中国海洋大学学报(自然科学版),2007(1):27-32.
[19]余婉松.基于金属溶胶表面增强拉曼光谱技术检测饲料及水产品中呋喃唑酮和孔雀石绿的研究[D].上海:上海海洋大学,2015.
[20]顾振华,赵宇翔,吴卫平,等.表面增强拉曼光谱法快速检测水产品中的孔雀石绿[J].化学世界,2011,52(1):14-16.
[21] SUN Hongbao,LIU Hai,WU Yiyong. A flexible and highly sensitive surface-enhanced Raman scattering film in-situ detection of malachite green on fish skin[J].Materials Letters,2017,207:125-128.
[22]魏晋梅,周围,解迎双,等.快速高分辨率液相色谱-串联质谱法测定牛肉中24种镇静剂类兽药残留量[J].食品与发酵工业,2016,42(2):191-196.
[23]孙雷,张骊,徐倩,等.超高效液相色谱-串联质谱法检测猪肉和猪肾中残留的10种镇静剂类药物[J].色谱,2010,28(1):38-42.
[24]齐士林,吴敏,严丽娟,等.超高效液相色谱-质谱对动物源食品中氯丙嗪、异丙嗪及其代谢物的测定[J].分析测试学报,2009,28(6):677-681.
[25]吴宁鹏,班付国,彭丽,等.超高效液相色谱-串联四极杆飞行时间质谱法筛查饲料中11种镇静剂类药物[J].质谱学报,2012,33(2):94-98.
[26]靳明,杨波,赵敏.食品安全事件对我国乳制品产业的冲击影响与恢复研究———以“三聚氰胺”等事件为例[J].商业经济与管理,2015(12):81-91.
[27]佘永新,柳江英,吕晓玲,等.三聚氰胺的毒性及其危害[J].食品与药品,2009,11(3):71-74.
[28]孙贵朋,谢云飞,陏丽敏,等.三聚氰胺的危害及其检测[J].上海食品药品监管情报研究,2008(5):42-47.
[29]杨欣,王军,苗虹,等.牛奶中三聚氰胺的表面增强拉曼光谱检测法与国标检测法的比较[J].食品安全质量检测学报,2014,5(10):3 219-3 222.
[30]杨青青.表面增强拉曼光谱法在硫氰酸盐、三聚氰胺和亚硝酸盐测定中的应用[D].长春:吉林大学,2016.
[31] GIOVANNOZZI A M,ROLLE F,SEGA M,et al. Rapid and sensitive detection of melamine in milk with gold nanoparticles by surface enhanced Raman scattering[J].Food Chemistry,2014,159(6):250-256.
[32]陈建,张卫红,谢方艳,等.高稳定性和重复性表面增强拉曼(SERS)活性基底Pd Ni合金[C]//第十五届全国光散射学术会议论文摘要集.郑州:中国物理学会光散射专业委员会,2009:1.
[33]邓悦,吴世法,李睿,等.三种不同银纳米粒子SERS基底比较研究[J].光散射学报,2015,27(3):231-238.
[34]高书燕,张树霞,杨恕霞,等.表面增强拉曼散射活性基底[J].化学通报,2007(12):908-914.
[35]杨盼.表面增强拉曼基底的研制及应用[D].重庆:重庆师范大学,2014.
[2]范燕斐,何兰君,李俊毅,等.高效液相色谱法同时测定食品中安赛蜜、苯甲酸、山梨酸、糖精钠[J].科技信息,2006(9):5.
[3]米建萍,徐远金,朱平川,等.液质联用技术在滥用食品添加剂及食品中违法添加物测定中的应用及研究进展[J].基因组学与应用生物学,2015,34(7):1 579-1 586.
[4]周建峰,张碧宇. GC法同时检测食品中七种添加剂[J].食品安全导刊,2017,4(12):84.
[5]高晓娟,史斌斌,张艳红.利用气质联用仪分析检测白酒中的甜蜜素[J].酿酒,2014,41(3):73-75.
[6] FLEISCHMANN M,HENDRA P J,MCQUILLAN A J.Raman spectra of pyridine adsorbed at a silver electrode[J]. Chemical Physics Letters,1974,26(2):163-166.
[7]李明心,常化仿,谢云,等.基于贵金属纳米颗粒的表面增强拉曼光谱免疫层析分析法(SERS-ICA)检测β-激动剂(瘦肉精)[C]//中国化学会第十八届全国有机分析及生物分析学术研讨会论文集.北京:中国化学会,2015:77-79.
[8]甘盛,赖青鸟,李志成,等.表面增强拉曼光谱法研究β受体激动剂在生猪体内代谢与残留[J].中国兽医学报,2016,36(9):1 550-1 557.
[9] XIE Yun,CHANG Huafang,ZHAO Kang,et al. A novel immunochromatographic assay(ICA)based on surface-enhanced Raman scattering for the sensitive and quantitative determination of clenbuterol[J]. Analytical Methods,2015,7:513-520.
[10] LI Mingxin,YANG Hong,LI Shuqun,et al. Ultrasensitive and quantitative detection of a newβ-agonist phenylethanolamine a by a novel immunochromatog-raphic assay based on surface-enhanced Raman scattering(SERS)[J].Journal of Agricultural&Food Chemistry,2014,62(45):10 896-10 902.
[11]窦斌.基于微流控芯片和SERS的瘦肉精类物质检测[D].大连:大连理工大学,2014.
[12]翟福丽,黄轶群,王锡昌,等.应用表面增强拉曼光谱技术快速检测尿样中的β-兴奋剂[J].分析化学,2012,40(5):718-723.
[13] YU Meng,HU Yongjun,LIU Jianzhi. Simultaneous detection of clenbuterol and ractopamine based on multiplexed competitive surface enhanced Raman scattering(SERS)immunoassay[J]. New Journal of Chemistry,2017,41(18):10 407-10 414.
[14] XIE Yunfei,ZHU Xinyu,SUN Yingying,et al. Rapid detection method for nitrofuran antibiotic residues by surface-enhanced Raman spectroscopy[J]. European Food Research&Technology,2012,235(3):555-561.
[15]竺芯宇,谢云飞,汪和雅,等.表面增强拉曼光谱法快速检测硝基呋喃类抗生素呋喃妥因及呋喃它酮[C]//第十七届全国分子光谱学学术会议论文集.北京:光谱学与光谱分析,2012,32(10):207-208.
[16] LI Mingxin,YANG Hong,LI Shuqun,et al. An ultrasensitive competitive immunochromatographic assay(ICA)based on surface-enhanced Raman scattering(SERS)for direct detection of 3-amino-5-methylmorpholino-2-oxazolidinone(AMOZ)in tissue and urine samples[J]. Analytical Methods,2015,7(2):513-520.
[17]刘名扬,肖珊珊,于兵,等.水产品中孔雀石绿和结晶紫残留检测技术的研究进展[J].食品安全质量检测学报,2015,6(1):35-40.
[18]翟毓秀,郭莹莹,耿霞,等.孔雀石绿的代谢机理及生物毒性研究进展[J].中国海洋大学学报(自然科学版),2007(1):27-32.
[19]余婉松.基于金属溶胶表面增强拉曼光谱技术检测饲料及水产品中呋喃唑酮和孔雀石绿的研究[D].上海:上海海洋大学,2015.
[20]顾振华,赵宇翔,吴卫平,等.表面增强拉曼光谱法快速检测水产品中的孔雀石绿[J].化学世界,2011,52(1):14-16.
[21] SUN Hongbao,LIU Hai,WU Yiyong. A flexible and highly sensitive surface-enhanced Raman scattering film in-situ detection of malachite green on fish skin[J].Materials Letters,2017,207:125-128.
[22]魏晋梅,周围,解迎双,等.快速高分辨率液相色谱-串联质谱法测定牛肉中24种镇静剂类兽药残留量[J].食品与发酵工业,2016,42(2):191-196.
[23]孙雷,张骊,徐倩,等.超高效液相色谱-串联质谱法检测猪肉和猪肾中残留的10种镇静剂类药物[J].色谱,2010,28(1):38-42.
[24]齐士林,吴敏,严丽娟,等.超高效液相色谱-质谱对动物源食品中氯丙嗪、异丙嗪及其代谢物的测定[J].分析测试学报,2009,28(6):677-681.
[25]吴宁鹏,班付国,彭丽,等.超高效液相色谱-串联四极杆飞行时间质谱法筛查饲料中11种镇静剂类药物[J].质谱学报,2012,33(2):94-98.
[26]靳明,杨波,赵敏.食品安全事件对我国乳制品产业的冲击影响与恢复研究———以“三聚氰胺”等事件为例[J].商业经济与管理,2015(12):81-91.
[27]佘永新,柳江英,吕晓玲,等.三聚氰胺的毒性及其危害[J].食品与药品,2009,11(3):71-74.
[28]孙贵朋,谢云飞,陏丽敏,等.三聚氰胺的危害及其检测[J].上海食品药品监管情报研究,2008(5):42-47.
[29]杨欣,王军,苗虹,等.牛奶中三聚氰胺的表面增强拉曼光谱检测法与国标检测法的比较[J].食品安全质量检测学报,2014,5(10):3 219-3 222.
[30]杨青青.表面增强拉曼光谱法在硫氰酸盐、三聚氰胺和亚硝酸盐测定中的应用[D].长春:吉林大学,2016.
[31] GIOVANNOZZI A M,ROLLE F,SEGA M,et al. Rapid and sensitive detection of melamine in milk with gold nanoparticles by surface enhanced Raman scattering[J].Food Chemistry,2014,159(6):250-256.
[32]陈建,张卫红,谢方艳,等.高稳定性和重复性表面增强拉曼(SERS)活性基底Pd Ni合金[C]//第十五届全国光散射学术会议论文摘要集.郑州:中国物理学会光散射专业委员会,2009:1.
[33]邓悦,吴世法,李睿,等.三种不同银纳米粒子SERS基底比较研究[J].光散射学报,2015,27(3):231-238.
[34]高书燕,张树霞,杨恕霞,等.表面增强拉曼散射活性基底[J].化学通报,2007(12):908-914.
[35]杨盼.表面增强拉曼基底的研制及应用[D].重庆:重庆师范大学,2014.