miRNA对自然杀伤细胞生长发育及功能的调控作用
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摘要
微小RNA(microRNAs,miRNAs)是长度为19～24 nt的内源性非编码小RNA。miRNA与自然杀伤(naturalkiller,NK)细胞的分化和功能密切相关,并参与传染病,肿瘤和其他病理过程的免疫调节。本文对近年来发现的miRNAs在NK细胞发育、分化和功能调控中的作用进行综述。
MicroRNAs(miRNAs)are endogenous non-coding small RNAs that are 19 to 24 nt in length. miRNAs are closely related to the differentiation and function of natural killer(NK)cells and are involved in the immune regulation of infectious diseases,tumors and other pathological processes. In this review, the role of miRNAs discovered in recent years in the development,differentiation and functional regulation of NK cells will be sammarizes.
MicroRNAs(miRNAs)are endogenous non-coding small RNAs that are 19 to 24 nt in length. miRNAs are closely related to the differentiation and function of natural killer(NK)cells and are involved in the immune regulation of infectious diseases,tumors and other pathological processes. In this review, the role of miRNAs discovered in recent years in the development,differentiation and functional regulation of NK cells will be sammarizes.
引文
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[15]Wang H,Zhang Y,Wu X,et al.Regulation of human natural killer cell ifn-gamma production by microrna-146a via targeting the nf-kappab signaling pathway[J].Front Immunol,2018,9:293.
[16]Gong J,Liu R,Zhuang R,et al.Mir-30c-1*promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor hmbox1[J].Cancer Sci,2012,103(4):645-652.
[17]Zawislak CL,Beaulieu AM,Loeb GB,et al.Stagespecific regulation of natural killer cell homeostasis and response against viral infection by microrna-155[J].Proc Natl Acad Sci USA,2013,110(17):6967-6972.
[18]Cheng YQ,Ren JP,Zhao J,et al.Microrna-155 regulates interferon-gamma production in natural killer cells via tim-3 signalling in chronic hepatitis c virus infection[J].Immunology,2015,145(4):485-497.
[19]Xu D,Han Q,Hou Z,et al.Mir-146a negatively regulates nk cell functions via stat1 signaling[J].Cell Mol Immunol,2017,14(8):712-720.
[20]Ge J,Huang Z,Liu H,et al.Lower expression of microrna-155 contributes to dysfunction of natural killer cells in patients with chronic hepatitis b[J].Front Immunol,2017,8:1173.
[21]Abdelhamid AK,Yacoub RA,Fawzy IO,et al.Microrna-34a and natural killer cells:An immuno-epigenetic approach to halt hepatocellular carcinoma progression[J].J Hepatol,2017,66(1):S231-S231.
[22]Abdelrahman MM,Fawzy IO,Bassiouni AA,et al.Enhancing nk cell cytotoxicity by mir-182 in hepatocellular carcinoma[J].Hum Immunol,2016,77(8):667-673.
[23]Breunig C,Pahl J,Kublbeck M,et al.Microrna-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells[J].Cell Death Dis,2017,8(8):e2973.
[24]Wang P,Gu Y,Zhang Q,et al.Identification of resting and type i ifn-activated human nk cell mirnomes reveals microrna-378 and microrna-30e as negative regulators of nk cell cytotoxicity[J].Journal of Immunology,2012,189(1):211-221.
[25]Liu SY,Chen LM,Zeng Y,et al.Suppressed expression of mir-378 targeting gzmb in nk cells is required to control dengue virus infection[J].Cellular&Molecular Immunology,2016,13(5):700-708.
[2]Caligiuri MA.Human natural killer cells[J].Blood,2008,112(3):461-469.
[3]Lanier LL,Phillips JH,Hackett J,et al.Natural killer cells:definition of a cell type rather than a function[J].J Immunol,1986,137(9):2735-2739.
[4]Ambros V.The functions of animal micrornas[J].Nature,2004,431(7006):350-355.
[5]Bartel DP.Micrornas:Genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
[6]Wang X,Xu X,Ma Z,et al.Dynamic mechanisms for pre-mirna binding and export by exportin-5[J].RNA,2011,17(8):1511-1528.
[7]Schwarz DS,Hutvagner G,Du T,et al.Asymmetry in the assembly of the rnai enzyme complex[J].Cell,2003,115(2):199-208.
[8]Cichocki F,Felices M,McCullar V,et al.Cutting edge:microrna-181 promotes human nk cell development by regulating notch signaling[J].J Immunol,2011,187(12):6171-6175.
[9]Sullivan RP,Leong JW,Schneider SE,et al.Microrna-15/16 antagonizes myb to control nk cell maturation[J].J Immunol,2015,195(6):2806-2817.
[10]Bezman NA,Chakraborty T,Bender T,et al.Mir-150 regulates the development of nk and inkt cells[J].J ExpMed,2011,208(13):2717-2731.
[11]Trotta R,Chen L,Costinean S,et al.Overexpression of mir-155 causes expansion,arrest in terminal differentiation and functional activation of mouse natural killer cells[J].Blood,2013,121(16):3126-3134.
[12]Ni F,Guo C,Sun R,et al.Microrna transcriptomes of distinct human nk cell populations identify mir-362-5p as an essential regulator of nk cell function[J].Sci Rep,2015,5:9993.
[13]Fehniger TA,Wylie T,Germino E,et al.Next-generation sequencing identifies the natural killer cell microrna transcriptome[J].Genome Res,2010,20(11):1590-1604.
[14]Sullivan RP,Leong JW,Schneider SE,et al.Microrna-deficient nk cells exhibit decreased survival but enhanced function[J].J Immunol,2012,188(7):3019-3030.
[15]Wang H,Zhang Y,Wu X,et al.Regulation of human natural killer cell ifn-gamma production by microrna-146a via targeting the nf-kappab signaling pathway[J].Front Immunol,2018,9:293.
[16]Gong J,Liu R,Zhuang R,et al.Mir-30c-1*promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor hmbox1[J].Cancer Sci,2012,103(4):645-652.
[17]Zawislak CL,Beaulieu AM,Loeb GB,et al.Stagespecific regulation of natural killer cell homeostasis and response against viral infection by microrna-155[J].Proc Natl Acad Sci USA,2013,110(17):6967-6972.
[18]Cheng YQ,Ren JP,Zhao J,et al.Microrna-155 regulates interferon-gamma production in natural killer cells via tim-3 signalling in chronic hepatitis c virus infection[J].Immunology,2015,145(4):485-497.
[19]Xu D,Han Q,Hou Z,et al.Mir-146a negatively regulates nk cell functions via stat1 signaling[J].Cell Mol Immunol,2017,14(8):712-720.
[20]Ge J,Huang Z,Liu H,et al.Lower expression of microrna-155 contributes to dysfunction of natural killer cells in patients with chronic hepatitis b[J].Front Immunol,2017,8:1173.
[21]Abdelhamid AK,Yacoub RA,Fawzy IO,et al.Microrna-34a and natural killer cells:An immuno-epigenetic approach to halt hepatocellular carcinoma progression[J].J Hepatol,2017,66(1):S231-S231.
[22]Abdelrahman MM,Fawzy IO,Bassiouni AA,et al.Enhancing nk cell cytotoxicity by mir-182 in hepatocellular carcinoma[J].Hum Immunol,2016,77(8):667-673.
[23]Breunig C,Pahl J,Kublbeck M,et al.Microrna-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells[J].Cell Death Dis,2017,8(8):e2973.
[24]Wang P,Gu Y,Zhang Q,et al.Identification of resting and type i ifn-activated human nk cell mirnomes reveals microrna-378 and microrna-30e as negative regulators of nk cell cytotoxicity[J].Journal of Immunology,2012,189(1):211-221.
[25]Liu SY,Chen LM,Zeng Y,et al.Suppressed expression of mir-378 targeting gzmb in nk cells is required to control dengue virus infection[J].Cellular&Molecular Immunology,2016,13(5):700-708.