银屑病患者血清IgE水平增高的Meta分析
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摘要
目的:Meta分析银屑病患者血清IgE增高情况。方法:计算机检索1976年1月至2018年1月Pubmed、Embase、Cochrane Library、中国生物医学文献数据库、万方数据库及中国知网等数据库中关于银屑病患者血清IgE相关的研究文献,采用stata12.0软件进行数据分析。结果:纳入符合标准的文献共10篇,共涉及2545例研究对象,其中包含1223例银屑病患者及1322名对照,Meta分析结果显示银屑病患者血清总IgE升高所占比例高于对照组,(OR=2.85%,95%CI:2.23～3.65),差异有显著统计学意义(P<0.05)。结论:银屑病患者血清总IgE明显增高,可能与银屑病发病有关。
Objective: To analyze the elevated IgE level in the patients with psoriasis. Methods: The articles of the IgE level in the patients with psoriasis were searched in MEDLINE,EMBASE,Cochrane Library,SinoM ed,CNKI and Wanfang database from January 1976 to January 2018. The data was analyzed by Stata12.0. Results: Ten articles including 1223 cases met the criteria. Meta analysis showed the ratio of the patients with elevated serum IgE was higher than that of the controls( OR = 2.8595%,95%CI: 2.23-3.65),with a significant difference( P<0.05). Conclusion: The level of IgE in the patients with psoriasis is increased,which means that IgE may play an important role in the pathogenesis of psoriasis.
Objective: To analyze the elevated IgE level in the patients with psoriasis. Methods: The articles of the IgE level in the patients with psoriasis were searched in MEDLINE,EMBASE,Cochrane Library,SinoM ed,CNKI and Wanfang database from January 1976 to January 2018. The data was analyzed by Stata12.0. Results: Ten articles including 1223 cases met the criteria. Meta analysis showed the ratio of the patients with elevated serum IgE was higher than that of the controls( OR = 2.8595%,95%CI: 2.23-3.65),with a significant difference( P<0.05). Conclusion: The level of IgE in the patients with psoriasis is increased,which means that IgE may play an important role in the pathogenesis of psoriasis.
引文
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[3]Eyerich S,Eyerich K,Pennino D,et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling[J].J Clin Investig,2009,119(12):3573-3585.
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[5]范斌,李斌,陈淙洁,等.湿疹、银屑病患者血清特异性IgG、IgE检测结果及分析[J].皮肤病与性病,2008,30(2):8-10.
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[9]Ojetti V,Aguilar Sanchez JA,De Simone C,et al. The role of immune serological parameters and allergological tests in psoriasis[J]. J Eur Acad Dermatol Venereol,2008,22(5):621-622.
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[13]Lajevardi V,Ghiasi M,Goodarzi A,et al. Total serum IgE concentration in patients with psoriasis:a case-control study[J].Acta Med Iran,2014,52(7):515-518.
[14]nal ES,Gül ,Dursun AB,et al. Prediction of atopy via total immunoglobulin E levels and skin prick tests in patients with psoriasis[J].Turk J Med Sci,2017,47(2):577-582.
[15]李静,吴佳纹,肖生祥,等.银屑病患者血清球蛋白E水平检测及其临床意义[J].陕西医学杂志,2016,45(11):1466-1467.
[16]Lotfi RA,El-Sayed MH,El-Gabry SH. Assessment of serum levels of IgEin psoriasis:the relationship with clinical types of the disease[J].J Egyptian Women's Dermatol Soci,2015,12:63-67.
[17]Li LF,Sujan SA,Yang H,et al. Serum immunoglobulins in psoriatic erythroderma[J]. Clin Exp Dermatol,2005,30(2):125-127.
[18]Jain S,Kaur IR,Das S,et al. T helper 1 to T helper 2 shift in cytokine expression:an autoregulatory process in superantigen-associated psoriasis progression?[J]. J Med Microbiol,2009,58(Pt2):180-184.
[19] Kraft S,Kinet JP. New developments in FcεRIregulation,function and inhibition[J]. Nat Rev Immunol,2007,7(5):365-378.
[20]Yan KX,Huang Q,Fang X,et al. IgEand FcεRI are highly expressed on innate cells in psoriasis[J].Br J Dermatol,2016,175(1):122-133.
[21]Milovanovic M,Drozdenko G,Weise C,et al. Interleukin-17A promotes IgEproduction in human B cells[J].J Invest Dermatol,2010,130:2621-2628.
[22]Pigatto PD. Atopy and contact sensitization in psoriasis[J].Acta Derm Venereol Suppl,2000,211:19-20.
[2]Wilson NJ,Boniface K,Chan JR,et al. Development,cytokine profile and function of human interleukin 17-producing helper T cells[J].Nat Immunol,2007,8(9):950-957.
[3]Eyerich S,Eyerich K,Pennino D,et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling[J].J Clin Investig,2009,119(12):3573-3585.
[4]王德旭,张炜,苏东宝,等.银屑病患者血清食物变应原特异性IgE、IgG的检测[J].中华皮肤科杂志,2013,46(10):744-745.
[5]范斌,李斌,陈淙洁,等.湿疹、银屑病患者血清特异性IgG、IgE检测结果及分析[J].皮肤病与性病,2008,30(2):8-10.
[6]Wells GA,Shea B,O’Connell D. Newcastle-Ottawa Scale(NOS)for assessing the quality of nonrandomised studies in meta-analyses[EB/OL]. http://www. ohri. ca/programs/clinical_epidemiology/oxford.asp,2014-09-16.
[7]Guilhou JJ,Clot J,Meynadier J,et al.Immunological aspects of psoriasis. I. Immunoglobulins and anti-IgGfactors Immunological aspects of psoriasis[J]. Br J Dermatol,1976,94(5):501-507.
[8]Chen ZY,Ainsworth SK,Khan T,et al. Immunoglobulin E in psoriasis evaluated by paper radioimmunosorbent and paper enzyme-immunosorbent tests[J].Acta Derm Venereol,1985,65(1):14-18.
[9]Ojetti V,Aguilar Sanchez JA,De Simone C,et al. The role of immune serological parameters and allergological tests in psoriasis[J]. J Eur Acad Dermatol Venereol,2008,22(5):621-622.
[10]Ovcina-Kurtovic N,Kasumagic-Halilovic E. Serum levels of total immunoglobulin E in patients with psoriasis:relationship with clinical type of disease[J].Med Arh,2010,64(1):28-29.
[11]Ding Y,Yi X,Yu N. Serum IgElevels are increased in patients with generalized pustular psoriasis[J]. Clin Exp Dermatol,2013,38(5):549-552.
[12]Hajdarbegovic E,Nijsten T,Westgeest A,et al. Decreased prevalence of atopic features in patients with psoriatic arthritis,but not in psoriasis vulgaris[J]. J Am Acad Dermatol,2013,68(2):270-277.
[13]Lajevardi V,Ghiasi M,Goodarzi A,et al. Total serum IgE concentration in patients with psoriasis:a case-control study[J].Acta Med Iran,2014,52(7):515-518.
[14]nal ES,Gül ,Dursun AB,et al. Prediction of atopy via total immunoglobulin E levels and skin prick tests in patients with psoriasis[J].Turk J Med Sci,2017,47(2):577-582.
[15]李静,吴佳纹,肖生祥,等.银屑病患者血清球蛋白E水平检测及其临床意义[J].陕西医学杂志,2016,45(11):1466-1467.
[16]Lotfi RA,El-Sayed MH,El-Gabry SH. Assessment of serum levels of IgEin psoriasis:the relationship with clinical types of the disease[J].J Egyptian Women's Dermatol Soci,2015,12:63-67.
[17]Li LF,Sujan SA,Yang H,et al. Serum immunoglobulins in psoriatic erythroderma[J]. Clin Exp Dermatol,2005,30(2):125-127.
[18]Jain S,Kaur IR,Das S,et al. T helper 1 to T helper 2 shift in cytokine expression:an autoregulatory process in superantigen-associated psoriasis progression?[J]. J Med Microbiol,2009,58(Pt2):180-184.
[19] Kraft S,Kinet JP. New developments in FcεRIregulation,function and inhibition[J]. Nat Rev Immunol,2007,7(5):365-378.
[20]Yan KX,Huang Q,Fang X,et al. IgEand FcεRI are highly expressed on innate cells in psoriasis[J].Br J Dermatol,2016,175(1):122-133.
[21]Milovanovic M,Drozdenko G,Weise C,et al. Interleukin-17A promotes IgEproduction in human B cells[J].J Invest Dermatol,2010,130:2621-2628.
[22]Pigatto PD. Atopy and contact sensitization in psoriasis[J].Acta Derm Venereol Suppl,2000,211:19-20.