Ki-67、P53在Her-2阴性乳腺癌中的表达与ER、腋窝淋巴结转移相关性
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摘要
目的观察Ki-67、P53在Her-2阴性乳腺癌组织中的表达与ER及腋窝淋巴结转移相关性,探讨其临床意义,提示乳腺癌预后。方法 202例Her-2阴性乳腺患者,根据ER表达情况,将患者分为ER阴性组和ER阳性组,其中ER阴性组99例,ER阳性组103例,研究Ki-67、P53在Her-2阴性乳腺癌组织中的表达与ER及腋窝淋巴结转移相关性。结果 Her-2阴性乳腺癌组织中Ki-67增殖指数在ER阴性组表达明显高于ER阳性组,差异有统计学意义(P<0.05),Ki-67增殖指数在腋窝淋巴结阳性组明显高于淋巴结阴性组,差异有统计学意义(P<0.05)。P53在ER阴性组表达明显高于ER阳性组,差异有统计学意义(P<0.05),P53表达在腋窝淋巴结阳性组和阴性组差异无统计学意义(P>0.05)。结论 Her-2阴性乳腺癌组织中Ki-67增殖指数与ER阴性表达正相关,且腋窝淋巴结转移可能性大,P53与ER阴性表达正相关,与腋窝淋巴结转移无明显相关。提示Ki-67、P53可能为Her-2阴性乳腺癌的不良预后因素。
Objective To study the relationship between Ki-67、P53 expression and ER、 axillary lymph node metastasis in Her-2 negative breast cancer,discuss its clinical significance and evaluate the prognosis of breast cancer.Methods 202 cases of Her-2 negative breast cancer patients were divided into two groups,ER negative group had 99 cases and ER positive group had 103 cases.The relationship between Ki-67、P53 and ER、axillary lymph node metastasis in Her-2 negative breast cancer were dicussed.Results In Her-2 negative breast cancer tissue,Ki-67 proliferation index was obviously higher in ER negative group than in ER positive group(P<0.05) and it was also obviously higher in group with axillary lymph node metastasis than in groupwithout lymph node metastasis(P<0.05).The expression of P53 was obviously higher in ER negative group than in ER positive group(P<0.05)and it was not obviously higher in group with axillary lymph node metastasis than in group without lymph node metastasis(P>0.05).Conclusion In Her-2 negative breast cancer,the expression of Ki-67 has positive correlation with ER negative expression,may indicate possibility of axillary lymph node metastasis.The expression of P53 has positive correlation with ER negative expression,but it has no significant correlation with axillary lymph node metastasis.The positive correlation between P53 and ER negative expression may indicate poor prognosis in Her-2 negative breast.
Objective To study the relationship between Ki-67、P53 expression and ER、 axillary lymph node metastasis in Her-2 negative breast cancer,discuss its clinical significance and evaluate the prognosis of breast cancer.Methods 202 cases of Her-2 negative breast cancer patients were divided into two groups,ER negative group had 99 cases and ER positive group had 103 cases.The relationship between Ki-67、P53 and ER、axillary lymph node metastasis in Her-2 negative breast cancer were dicussed.Results In Her-2 negative breast cancer tissue,Ki-67 proliferation index was obviously higher in ER negative group than in ER positive group(P<0.05) and it was also obviously higher in group with axillary lymph node metastasis than in groupwithout lymph node metastasis(P<0.05).The expression of P53 was obviously higher in ER negative group than in ER positive group(P<0.05)and it was not obviously higher in group with axillary lymph node metastasis than in group without lymph node metastasis(P>0.05).Conclusion In Her-2 negative breast cancer,the expression of Ki-67 has positive correlation with ER negative expression,may indicate possibility of axillary lymph node metastasis.The expression of P53 has positive correlation with ER negative expression,but it has no significant correlation with axillary lymph node metastasis.The positive correlation between P53 and ER negative expression may indicate poor prognosis in Her-2 negative breast.
引文
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[10]刘晓斌,袁智勇,李瑞英,等.ER、PR单阳性表达乳腺癌患者临床病理特征和预后分析[J].中国肿瘤临床,2010,37(7):381-384.
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[12]董华英,吴诚义,陈元文.ER阳性乳腺癌和ER阴性乳腺癌的癌干/祖细胞生物学行为比较[J].激光杂志,2011,23(3):55-57.
[13]余辉,杨云振,崔振.宁夏回汉856例女性乳腺癌受体ER、PR及Her-2与肿瘤特性相关性研究[J],宁夏医学杂志,2010,32(3):254-257.
[2]Dowsett M,Smith IE,Ebbs SR.Prognostic value of Ki67ex-pression after short-term presurgical endocrine therapy for pri-mary breast cancer[J].J Natl Cancer Inst,2007,99(2):167-170.
[3]Tan PH,Bay BH,Yip G.Immunohistochemical detection of Ki67in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death[J].Mod Pathol,2005,18(3):374-381.
[4]Railo M,lundin J,Nordling S,et al.Ki-67,p53,ER recep-tors,ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer[J].Tumour Biol,2007,28(1):45-51.
[5]王洪,祁保国.乳腺癌C-erbB-2的表达与淋巴结转移的关系及其临床意义[J].地方病通报,2008,23(1):88-89.
[6]Malamou-Mitsi V,Gogas H,Dafni U.Evaluation of the prog-nostic and predictive value of p53and Bcl-2in breast cancerpatients participating in a randomized study with dose-dense sequential adjuvant chemotherapy[J].Ann Oncol,2006,17(10):1504-1511.
[7]杜长征,李惠平,马立文,等.中国乳腺癌患者p53表达临床生物学意义的Meta分析[J].中国癌症杂志,2005,15(6):514-517.
[8]Li Zheng,Jia Qiang,Ren Hua,et al.Downregulation of wild-type p53protein by HER-2/neu mediated PI3K pathway acti-vation in human breast cancer cells:its effect on cell prolifera-tion and implication for therapy[J].Cell Research,2004,14(6):497-506.
[9]周力恒,殷文瑾,陆劲松.雌激素受体阳性孕激素受体表达不同的乳腺癌患者肿瘤特征比较[J].中华医学杂志,2007,87(39):2764-2767.
[10]刘晓斌,袁智勇,李瑞英,等.ER、PR单阳性表达乳腺癌患者临床病理特征和预后分析[J].中国肿瘤临床,2010,37(7):381-384.
[11]Assersohn L,Salter J,Powles TJ.Studies of the potential utility of Ki67as a predictive molecular marker of clinical response in primary breast cancer[J].Breast cancer research and treat-ment,2003,82(2):113-123.
[12]董华英,吴诚义,陈元文.ER阳性乳腺癌和ER阴性乳腺癌的癌干/祖细胞生物学行为比较[J].激光杂志,2011,23(3):55-57.
[13]余辉,杨云振,崔振.宁夏回汉856例女性乳腺癌受体ER、PR及Her-2与肿瘤特性相关性研究[J],宁夏医学杂志,2010,32(3):254-257.