基于中医传承辅助平台分析含黄连-干姜药对方剂的组方规律
|
摘要
目的:为含黄连-干姜药对(简称"黄连-干姜")方剂的后续产品开发提供理论依据。方法:收集整理《中医方剂大辞典》中包含黄连-干姜的方剂,录入中医传承辅助平台软件(V2.5)建立数据库,统计主治疾病频次、配伍药材频次;采用关联规则Apriori算法对含黄连-干姜方剂药材核心组合进行统计分析(设置支持度分别为15%、20%、25%,置信度为0.90);选择频次排前2位的主治疾病和配伍药材频次最高的温里药和清热药进行组方规律分析。结果:共筛选出492首含黄连-干姜方剂,涉及主治疾病9种(频次≥15),包括痢疾、泄泻、积聚、痞满等;常用配伍药材21味(频次≥55),包括当归、厚朴、附子、黄芩等;常用药材组合有19个,其中核心药材组合包括黄连-干姜-人参、黄连-干姜-厚朴、黄连-干姜-当归;常与黄连-干姜配伍治疗痢疾的核心药材有5种,治疗泄泻的核心药材有9种;在黄连-干姜配伍温里药附子的方剂中核心药材有8种,在配伍清热药黄芩的方剂中核心药材有7种。结论:含黄连-干姜药对方剂主治疾病以消化道疾病为主;该药对可配伍不同药材用于不同疾病的治疗;本研究可为其后续产品的开发提供理论依据。
OBJECTIVE:To provide a theoretical basis for the development of the following products of Coptis chinensisZingiber ojjicinale couplet medicine("Coptis chinensis-Zingiber ojjicinale"for short)prescription. METHODS:The prescriptions containing Coptis chinensis-Zingiber ojjicinale were collected from the Dictionary of TCM Prescription and input into TCM inheritance support platform software(V2.5)to establish the database. The frequency of major diseases and compatibility medicinal materials were analyzed statistically. The core combination of medicinal materials in the prescriptions containing Coptis chinensis-Zingiber ojjicinale were analyzed statistically with association rule Apriori algorithm(support degrees were 15%,20%,25%,confidence was 0.90). Top 2 main diseases in the list of frequency,compatibility medicinal materials for dispelling internal cold and medicine for clearing heat with highest compatibility frequency were selected and analyzed in respect of prescription rules.RESULTS:A total of 492 prescriptions containing Coptis chinensis-Zingiber ojjicinale were screened,9 kinds of major diseases(frequency≥15),such as dysentery,diarrhea,accumulation,fullness. There were 21 commonly used compatibility medicinal materials(frequency≥55),including Angelica sinensis-Panax ginseng,Magnolia officinalis,Aconitum carmichaelii,Scutellaria baicalensis, etc. There were 19 commonly used medicinal materials combinations, including Coptis chinensis-Zingiber ojjicinale-Panax ginseng,Coptis chinensis-Zingiber ojjicinale-Magnolia officinalis,Coptis chinensis-Zingiber ojjicinale-Angelica sinensis. There are 5 kinds of core medicinal materials commonly used in treating dysentery with Coptis chinensis-Zingiber ojjicinale,and 9 kinds of core medicinal materials for treating dysentery. There are 8 kinds of core medicinal materials in Coptis chinensis-Zingiber ojjicinale compatible with medicine for dispelling internal cold Aconitum carmichaelii prescription.and 7 core medicinal materials in compatible with medicine for clearing heat Scutellaria baicalensis prescription. CONCLUSIONS:The major diseases treated with prescriptions containing Coptis chinensis-Zingiber ojjicinale are mainly digestive tract diseases. It can treat different diseases being compatible with different medicinal materials, this study aslo can provide theoretical basis for the development of subsequent products.
OBJECTIVE:To provide a theoretical basis for the development of the following products of Coptis chinensisZingiber ojjicinale couplet medicine("Coptis chinensis-Zingiber ojjicinale"for short)prescription. METHODS:The prescriptions containing Coptis chinensis-Zingiber ojjicinale were collected from the Dictionary of TCM Prescription and input into TCM inheritance support platform software(V2.5)to establish the database. The frequency of major diseases and compatibility medicinal materials were analyzed statistically. The core combination of medicinal materials in the prescriptions containing Coptis chinensis-Zingiber ojjicinale were analyzed statistically with association rule Apriori algorithm(support degrees were 15%,20%,25%,confidence was 0.90). Top 2 main diseases in the list of frequency,compatibility medicinal materials for dispelling internal cold and medicine for clearing heat with highest compatibility frequency were selected and analyzed in respect of prescription rules.RESULTS:A total of 492 prescriptions containing Coptis chinensis-Zingiber ojjicinale were screened,9 kinds of major diseases(frequency≥15),such as dysentery,diarrhea,accumulation,fullness. There were 21 commonly used compatibility medicinal materials(frequency≥55),including Angelica sinensis-Panax ginseng,Magnolia officinalis,Aconitum carmichaelii,Scutellaria baicalensis, etc. There were 19 commonly used medicinal materials combinations, including Coptis chinensis-Zingiber ojjicinale-Panax ginseng,Coptis chinensis-Zingiber ojjicinale-Magnolia officinalis,Coptis chinensis-Zingiber ojjicinale-Angelica sinensis. There are 5 kinds of core medicinal materials commonly used in treating dysentery with Coptis chinensis-Zingiber ojjicinale,and 9 kinds of core medicinal materials for treating dysentery. There are 8 kinds of core medicinal materials in Coptis chinensis-Zingiber ojjicinale compatible with medicine for dispelling internal cold Aconitum carmichaelii prescription.and 7 core medicinal materials in compatible with medicine for clearing heat Scutellaria baicalensis prescription. CONCLUSIONS:The major diseases treated with prescriptions containing Coptis chinensis-Zingiber ojjicinale are mainly digestive tract diseases. It can treat different diseases being compatible with different medicinal materials, this study aslo can provide theoretical basis for the development of subsequent products.
引文
[1]苗明三,王智民.对药的化学、药理与临床[M].北京:军事医学科学出版社,2002:78.
[2]周幸来.消化系统疾病临证药对[M].北京:金盾出版社,2014:46.
[3]史琪荣,于少云,孙晓迪,等.黄连干姜药对对功能性消化不良大鼠胃排空和血清胃泌素的影响[J].中国药学杂志,2011,46(13):988-992.
[4]李阳,郝艺照,傅熠俊,等.黄连-干姜药对预防DSS诱导的小鼠结肠炎作用及其机制[J].中国实验方剂学杂志,2017,23(15):154-159.
[5]卢朋,李健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012,18(9):1-4.
[6]丁晓洁,董正平,孙喜灵.从《中药成方制剂》含乌梅方剂的配伍规律探讨乌梅的临床应用[J].辽宁中医杂志,2017,44(12):2529-2532.
[7]牟胜群,王海瑞,刘伟,等.含鸡血藤中成药用药规则分析[J].河南中医,2017,37(6):1102-1106.
[8]贾蔷,申丹,石作荣,等.含川芎中成药用药规律分析[J].中国中医基础医学杂志,2014,20(2):235-239.
[9]王嘉俊,李双蕾,李梦瑶.中药药对的现代认识与研究[J].中医杂志,2016,57(8):701-704.
[10]唐于平,束晓云,李伟霞,等.药对的形成与发展[J].中国中药杂志,2013,38(24):4185-4190.
[11]孟祥乐,余奇,郭澄.中药药对的临床应用与配伍机制研究概述[J].中国药房,2009,20(30):2394-2396.
[12]徐萍,顾治平.黄连的药理作用研究进展[J].临床医药文献电子杂志,2017,4(27):5333、5336.
[13]王维琪.黄连有效成分的药理研究与进展[J].中医临床研究,2016,8(26):147-148.
[14]孙凤娇,李振麟,钱士辉,等.干姜化学成分和药理作用研究进展[J].中国野生植物资源,2015,34(3):34-37.
[15]王文心.干姜的化学、药理及临床应用特点分析[J].中医临床研究,2016,8(6):146-148.
[16]张文君,宁浩辰,周游,等.黄连与干姜配伍对黄连中5种生物碱的大鼠体内药动学影响[J].中医药学报,2015,43(4):15-19.
[2]周幸来.消化系统疾病临证药对[M].北京:金盾出版社,2014:46.
[3]史琪荣,于少云,孙晓迪,等.黄连干姜药对对功能性消化不良大鼠胃排空和血清胃泌素的影响[J].中国药学杂志,2011,46(13):988-992.
[4]李阳,郝艺照,傅熠俊,等.黄连-干姜药对预防DSS诱导的小鼠结肠炎作用及其机制[J].中国实验方剂学杂志,2017,23(15):154-159.
[5]卢朋,李健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012,18(9):1-4.
[6]丁晓洁,董正平,孙喜灵.从《中药成方制剂》含乌梅方剂的配伍规律探讨乌梅的临床应用[J].辽宁中医杂志,2017,44(12):2529-2532.
[7]牟胜群,王海瑞,刘伟,等.含鸡血藤中成药用药规则分析[J].河南中医,2017,37(6):1102-1106.
[8]贾蔷,申丹,石作荣,等.含川芎中成药用药规律分析[J].中国中医基础医学杂志,2014,20(2):235-239.
[9]王嘉俊,李双蕾,李梦瑶.中药药对的现代认识与研究[J].中医杂志,2016,57(8):701-704.
[10]唐于平,束晓云,李伟霞,等.药对的形成与发展[J].中国中药杂志,2013,38(24):4185-4190.
[11]孟祥乐,余奇,郭澄.中药药对的临床应用与配伍机制研究概述[J].中国药房,2009,20(30):2394-2396.
[12]徐萍,顾治平.黄连的药理作用研究进展[J].临床医药文献电子杂志,2017,4(27):5333、5336.
[13]王维琪.黄连有效成分的药理研究与进展[J].中医临床研究,2016,8(26):147-148.
[14]孙凤娇,李振麟,钱士辉,等.干姜化学成分和药理作用研究进展[J].中国野生植物资源,2015,34(3):34-37.
[15]王文心.干姜的化学、药理及临床应用特点分析[J].中医临床研究,2016,8(6):146-148.
[16]张文君,宁浩辰,周游,等.黄连与干姜配伍对黄连中5种生物碱的大鼠体内药动学影响[J].中医药学报,2015,43(4):15-19.