阿莫西林与四环素治疗肠上皮化生合并幽门螺杆菌感染的疗效比较
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摘要
目的比较阿莫西林与四环素治疗肠上皮化生合并幽门螺杆菌感染的疗效。方法 72例肠上皮化生合并幽门螺杆菌感染患者,按照治疗方案不同分为阿莫西林组与四环素组,每组36例。阿莫西林组患者应用铋剂+埃索美拉唑+呋喃唑酮+阿莫西林治疗,四环素组患者应用铋剂+埃索美拉唑+呋喃唑酮+四环素治疗,对比两组患者幽门螺杆菌根除率及不良反应发生率。结果阿莫西林组患者幽门螺杆菌根除率为88.9%,与四环素组的86.1%比较差异无统计学意义(P>0.05);阿莫西林组患者不良反应发生率为19.4%,与四环素组的22.2%比较差异无统计学意义(P>0.05)。结论阿莫西林与四环素治疗肠上皮化生合并幽门螺杆菌感染的疗效相当,幽门螺杆菌根除率高,不良反应发生率低,值得临床推行。
Objective To compare the efficacy of amoxicillin and tetracycline in the treatment of intestinal metaplasia with Helicobacter pylori infection. Methods A total of 72 patients with intestinal metaplasia with Helicobacter pylori infection were divided by different treatment regimens into amoxicillin group and tetracycline group, with 36 cases in each group. Amoxicillin group was treated with tincture + esomeprazole + furazolidone + amoxicillin, and tetracycline group was treated with tincture + esomeprazole + furazolidone + tetracycline. The Helicobacter pylori eradication rate and incidence of adverse reactions in the two groups was compared. Results Amoxicillin group had no statistically significant difference in Helicobacter pylori eradication rate as 88.9%, comparing with 86.1% in tetracycline group(P>0.05). Amoxicillin group had no statistically significant difference in incidence of adverse reactions as 19.4%, comparing with 22.2% in tetracycline group(P>0.05). Conclusion Amoxicillin and tetracycline have similar efficacy in the treatment of intestinal metaplasia with Helicobacter pylori infection. The eradication rate of Helicobacter pylori is high and the incidence of adverse reactions is low. It is worthy of clinical implementation.
Objective To compare the efficacy of amoxicillin and tetracycline in the treatment of intestinal metaplasia with Helicobacter pylori infection. Methods A total of 72 patients with intestinal metaplasia with Helicobacter pylori infection were divided by different treatment regimens into amoxicillin group and tetracycline group, with 36 cases in each group. Amoxicillin group was treated with tincture + esomeprazole + furazolidone + amoxicillin, and tetracycline group was treated with tincture + esomeprazole + furazolidone + tetracycline. The Helicobacter pylori eradication rate and incidence of adverse reactions in the two groups was compared. Results Amoxicillin group had no statistically significant difference in Helicobacter pylori eradication rate as 88.9%, comparing with 86.1% in tetracycline group(P>0.05). Amoxicillin group had no statistically significant difference in incidence of adverse reactions as 19.4%, comparing with 22.2% in tetracycline group(P>0.05). Conclusion Amoxicillin and tetracycline have similar efficacy in the treatment of intestinal metaplasia with Helicobacter pylori infection. The eradication rate of Helicobacter pylori is high and the incidence of adverse reactions is low. It is worthy of clinical implementation.
引文
[1]尹立新,胡颖新,付婷霞.含铋剂/阿莫西林/四环素四联方案对比序贯疗法根除幽门螺杆菌有效性和安全性比较.中国病原生物学杂志, 2017, 42(8):783-785.
[2]陈菲,潘晨,王瑞睿,等. 3种四联方案根除幽门螺杆菌的效果及安全性观察.贵州医科大学学报, 2017, 42(5):588-591.
[3]廖晓敏,卫金歧,黎琮毅.艾普拉唑四联疗法初次治疗及补救治疗幽门螺杆菌感染慢性胃炎的效果.广东医学, 2016, 37(s1):189-193.
[4]张迪,柯丽,聂爱英,等.黄连素四联方案补救治疗幽门螺杆菌感染的有效性和安全性.现代生物医学进展, 2017, 17(3):464-469.
[5]李兴丰.含铋剂四联方案根除幽门螺杆菌疗效观察.中国基层医药, 2016, 23(7):998-1001.
[6]赵向阳.阿莫西林联合不同抗生素在抗幽门螺杆菌治疗中的疗效观察.南京医科大学学报(自然科学版), 2013(2):255-256.
[7]马田.合并幽门螺杆菌感染的非萎缩性胃炎、萎缩伴肠上皮化生和胃癌患者的胃内菌群.山东大学, 2017.
[8]刘忠鑫,李恒,王海清.不同抗生素组合的四联疗法根除幽门螺杆菌疗效比较.现代医药卫生, 2016(24):3851-3852.
[2]陈菲,潘晨,王瑞睿,等. 3种四联方案根除幽门螺杆菌的效果及安全性观察.贵州医科大学学报, 2017, 42(5):588-591.
[3]廖晓敏,卫金歧,黎琮毅.艾普拉唑四联疗法初次治疗及补救治疗幽门螺杆菌感染慢性胃炎的效果.广东医学, 2016, 37(s1):189-193.
[4]张迪,柯丽,聂爱英,等.黄连素四联方案补救治疗幽门螺杆菌感染的有效性和安全性.现代生物医学进展, 2017, 17(3):464-469.
[5]李兴丰.含铋剂四联方案根除幽门螺杆菌疗效观察.中国基层医药, 2016, 23(7):998-1001.
[6]赵向阳.阿莫西林联合不同抗生素在抗幽门螺杆菌治疗中的疗效观察.南京医科大学学报(自然科学版), 2013(2):255-256.
[7]马田.合并幽门螺杆菌感染的非萎缩性胃炎、萎缩伴肠上皮化生和胃癌患者的胃内菌群.山东大学, 2017.
[8]刘忠鑫,李恒,王海清.不同抗生素组合的四联疗法根除幽门螺杆菌疗效比较.现代医药卫生, 2016(24):3851-3852.