小花清风藤茎叶的化学成分研究
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摘要
目的:研究小花清风藤茎叶的化学成分。方法:小花清风藤以70%乙醇提取,利用多种色谱技术进行分离,所得化合物经波谱数据和相关文献鉴定。结果:从小花清风藤中分离得到10个化合物,分别鉴定为:柴胡皂苷A(1)、柴胡皂苷B2(2)、6″-O-acetyl-saikosaponin B2(3)、柴胡皂苷B1(4)、柴胡皂苷D(5)、6″-O-acetyl-saikosaponin B1(6)、1α,3β-dihydroxyl-olean-12-en-28-oic acid(7)、2α-羟基齐墩果酸(8)、木兰花碱(9)、枸杞酰胺C(10)。结论:其中,化合物1～6、8～10为首次从该属植物中分离得到。
Objective:To investigate the chemical constituents from the stems and leaves of Sabia parviflora.Methods:The 70% ethanol extract of Sabia parviflora was isolated and various column chromatographic techniques were used to separate,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Results:Ten compounds were isolated from the stems and leaves of Sabia parviflora and identified as saikosaponin A(1),saikosaponin B2(2),6″-O-acetyl-saikosaponin B2(3),saikosaponin B1(4),saikosaponin D(5),6″-O-acetyl-saikosaponin B1(6),1α,3β-dihydroxyl-olean-12-en-28-oic acid(7),2α-hydroxyoleanolic acid(8),magnoflorine(9)and lyciumamide C(10).Conclusion:Compounds 1～6,8～10 are isolated from this genus for the first time.
Objective:To investigate the chemical constituents from the stems and leaves of Sabia parviflora.Methods:The 70% ethanol extract of Sabia parviflora was isolated and various column chromatographic techniques were used to separate,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Results:Ten compounds were isolated from the stems and leaves of Sabia parviflora and identified as saikosaponin A(1),saikosaponin B2(2),6″-O-acetyl-saikosaponin B2(3),saikosaponin B1(4),saikosaponin D(5),6″-O-acetyl-saikosaponin B1(6),1α,3β-dihydroxyl-olean-12-en-28-oic acid(7),2α-hydroxyoleanolic acid(8),magnoflorine(9)and lyciumamide C(10).Conclusion:Compounds 1～6,8～10 are isolated from this genus for the first time.
引文
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[12] 陈喜奎,张如意,张志亮,等.黑柴胡中皂苷成分的研究[J].北京大学学报(医学版),1992,24(3):222-224.
[13] Yu JQ,Deng AJ,Wu LQ,et al.Osteoclast-inhibiting saikosaponin derivatives from Bupleurum chinense[J].Fitoterapia,2013,85(1):101-8.
[14] Chen J,Chen B,TIAN J,et al.Two new pentacyclic triterpenes from Sabia parviflora[J].Chinese Chemical Letters,2002,13(4):345-348.
[15] Huang Y,Aisa HA,Isaev MI.Isoprenoids of Euphorbia sororia.Ⅰ.triterpenoids[J].Chemistry of Natural Compounds,2009,45(6):921-924.
[16] 吕子明,张庆建,陈若芸,等.陵水暗罗枝、叶中的化学成分[J].中国中药杂志,2011,36(8):1024-1027.
[17] 高凯.宁夏枸杞子的活性成分研究和应用开发[D].西安:第四军医大学,2014.
[2] 刘玉壶,罗献瑞.中国植物志[M].第47(1)卷.北京:科学出版社,1985:93.
[3] 李朝斗.贵州产清风藤科入药植物[J].中药通报,1987,12(8):5-6.
[4] 刘易蓉,邱晓春,陈慧.小花清风藤保肝作用实验研究[J].中国药房,2008,19(30):2341-2342.
[5] 邓云飞.中国清风藤属Sabia Colebr.(清风藤科)的订正[J].热带亚热带植物学报,2001,9(1):45-48.
[6] 曲新艳,张会敏,张晓娟,等.小花清风藤水提物体内抗流感病毒的研究[J].生物技术通讯,2015,26(6):802-804.
[7] 杨莹,张永萍,梁光义.小花清风藤胶囊的保肝作用研究及其急毒实验[J].中国现代应用药学,2013,30(11):1166-1170.
[8] 温迪,孙庆文,潘国吉,等.清风藤属药用植物研究进展[J].贵州科学,2016,34(3):25-31.
[9] 刘易蓉,梁光义,张永萍.清风藤属药用植物的研究概况[J].贵阳中医学院学报,2006,28(1):50-52.
[10] 方伟,杨印军,郭宝林,等.藏柴胡中三萜皂苷类成分的研究[J].中国中药杂志,2016,41(7):1251-1256.
[11] Liu QX,Liang H,Zhao YY,et al.Saikosaponin v-1 from roots of Bupleurum chinense DC.[J].Journal of Asian Natural Products Research,2001,3(2):139-144.
[12] 陈喜奎,张如意,张志亮,等.黑柴胡中皂苷成分的研究[J].北京大学学报(医学版),1992,24(3):222-224.
[13] Yu JQ,Deng AJ,Wu LQ,et al.Osteoclast-inhibiting saikosaponin derivatives from Bupleurum chinense[J].Fitoterapia,2013,85(1):101-8.
[14] Chen J,Chen B,TIAN J,et al.Two new pentacyclic triterpenes from Sabia parviflora[J].Chinese Chemical Letters,2002,13(4):345-348.
[15] Huang Y,Aisa HA,Isaev MI.Isoprenoids of Euphorbia sororia.Ⅰ.triterpenoids[J].Chemistry of Natural Compounds,2009,45(6):921-924.
[16] 吕子明,张庆建,陈若芸,等.陵水暗罗枝、叶中的化学成分[J].中国中药杂志,2011,36(8):1024-1027.
[17] 高凯.宁夏枸杞子的活性成分研究和应用开发[D].西安:第四军医大学,2014.