肠道菌群与高血压相关性的研究进展
|
摘要
高血压的病理机制目前尚不清楚,但近年来不断有研究证实肠道菌群失衡与高血压发病机制相关。故针对高血压发病时肠道菌群变化,肠道菌群在高血压发病机制的作用以及以肠道菌群为干预靶点治疗的措施进行阐述。
The pathological mechanism of hypertension is still unclear,but in recent years there have been studies that have confirmed that intestinal flora imbalance is associated with the pathogenesis of hypertension.Therefore,the changes of intestinal flora during the onset of hypertension,the role of intestinal flora in the pathogenesis of hypertension and the treatment of intestinal flora as intervention targets are described in this paper.
The pathological mechanism of hypertension is still unclear,but in recent years there have been studies that have confirmed that intestinal flora imbalance is associated with the pathogenesis of hypertension.Therefore,the changes of intestinal flora during the onset of hypertension,the role of intestinal flora in the pathogenesis of hypertension and the treatment of intestinal flora as intervention targets are described in this paper.
引文
[1]FARACO G,IADECOLA C.Hypertension:a harbinger of stroke and dementia[J].Hypertension,2013,62(5):810-817.
[2]HE FJ,LI J,MACGREGOR GA.Effect of longer-term modest salt reduction on blood pressure[J].The Cochrane Database of Systematic Reviews,2013,(4):Cd004937.
[3]KATO N,TAKEUCHI F,TABARA Y,et al.Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians[J].Nature Genetics,2011,43(6):531-538.
[4]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[5]FUCHS FD,CHAMBLESS LE,WHELTON PK,et al.Alcohol consumption and the incidence of hypertension:The atherosclerosis risk in communities study[J].Hypertension,2001,37(5):1242-1250.
[6]QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[7]许杰,王伊龙,王拥军.肠道菌群与高血压[J].中国卒中杂志,2017,12(2):175-178.
[8]ECKBURG PB,BIK EM,BERNSTEIN CN,et al.Diversity of the human intestinal microbial flora[J].Science(New York,N.Y.),2005,308(5728):1635-1638.
[9]FORSLUND K,HILDEBRAND F,NIELSEN T,et al.Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J].Nature,2015,528(7581):262-266.
[10]GARCIA-RIOS A,TORRES-PENA JD,PEREZ-JIMENEZ F,et al.Gut microbiota:a new marker of cardiovascular disease[J].Curr Pharm Des,2017,23(22):3233-3238.
[11]THORBURN AN,MACIA L,MACKAY CR.Diet,metabolites,and"western-lifestyle"inflammatory diseases[J].Immunity,2014,40(6):833-842.
[12]QIN N,YANG F,LI A,et al.Alterations of the human gut microbiome in liver cirrhosis[J].Nature,2014,513(7516):59-64.
[13]SCHER JU,SCZESNAK A,LONGMAN RS,et al.Expansion of intestinal prevotella copri correlates with enhanced susceptibility to arthritis[J].eLife,2013,2:e01202.
[14]RIDAURA VK,FAITH JJ,REY FE,et al.Gut microbiota from twins discordant for obesity modulate metabolism in mice[J].Science(New York,N.Y.),2013,341(6150):1241214.
[15]KOETH RA,WANG Z,LEVISON BS,et al.Intestinal microbiota metabolism of L-carnitine,a nutrient in red meat,promotes atherosclerosis[J].Nature Medicine,2013,19(5):576-585.
[16]FOSTER JA,MCVEY N KA.Gut-brain axis:how the microbiome influences anxiety and depression[J].Trends in Neurosciences,2013,36(5):305-312.
[17]VENKATESAN P.Gut microbiota and the risk of childhood asthma[J].The Lancet,Respiratory Medicine,2015,3(11):843.
[18]KALLIOMAKI M,ISOLAURI E.Role of intestinal flora in the development of allergy[J].Curr Opin Allergy Clin Immunol,2003,3(1):15-20.
[19]刘金宝.新疆哈萨克族正常血压人群和高血压人群肠道菌群中拟杆菌属和梭菌属结构特征分析[D].乌鲁木齐:新疆医科大学,2010.
[20]江维·哈吾,吐尔洪·吐送,马秀敏,等.维医异常黑胆质体液质高血压人群和正常黑胆质体液质健康人群肠道菌群多样性分析[J].中国病原生物学杂志,2012,7(2):132-136.
[21]YANG T,SANTISTEBAN MM,RODRIGUEZ V,et al.Gut dysbiosis is linked to hypertension[J].Hypertension(Dallas,Tex.:1979),2015,65(6):1331-1340.
[22]LI J,ZHAO F,WANG Y,et al.Gut microbiota dysbiosis contributes to the development of hypertension[J].Microbiome,2017,5(1):14.
[23]YAN Q,GU Y,LI X,et al.Alterations of the gut microbiome in hypertension[J].Frontiers in Cellular and Infection Microbiology,2017,7(3):381.
[24]KIM S,GOEL R,KUMAR A,et al.Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure[J].Clinical science(London,England:1979),2018,132(6):701-718.
[25]SANTISTEBAN MM,QI Y,ZUBCEVIC J,et al.Hypertensionlinked pathophysiological alterations in the gut[J].Circulation Research,2017,120(2):312-323.
[26]DURGAN DJ,GANESH BP,COPE JL,et al.Role of the gut microbiome in obstructive sleep apnea-induced hypertension[J].Hypertension(Dallas,Tex.:1979),2016,67(2):469-474.
[27]MELL B,JALA VR,MATHEW AV,et al.Evidence for a link between gut microbiota and hypertension in the Dahl rat[J].Physiological Genomics,2015,47(6):187-197.
[28]WILCK N,MATUS MG,KEARNEY SM,et al.Salt-responsive gut commensal modulates TH17 axis and disease[J].Nature,2017,551(7682):585-589.
[29]MARQUES FZ,NELSON E,CHU PY,et al.High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice[J].Circulation,2017,135(10):964-977.
[30]ADNAN S,NELSON JW,AJAMI NJ,et al.Alterations in the gut microbiota can elicit hypertension in rats[J].Physiological Genomics,2017,49(2):96-104.
[31]WILCK N,MATUS MG,KEARNEY SM,et al.Salt-responsive gut commensal modulates TH17 axis and disease[J].Nature,2017,551(7682):585-589.
[32]PLUZNICK JL,PROTZKO RJ,GEVORGYAN H,et al.Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation[J].Proc Natl Acad Sci USA,2013,110(11):4410-4415.
[33]BROWN AJ,GOLDSWORTHY SM,BARNES AA,et al.The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids[J].The Journal of Biological Chemistry,2003,278(13):11312-11319.
[34]MIYAMOTO J,KASUBUCHI M,NAKAJIMA A,et al.The role of short-chain fatty acid on blood pressure regulation[J].Current Opinion in Nephrology and Hypertension,2016,25(5):379-383.
[35]ROMANO KA,VIVAS EI,AMADOR-NOGUEZ D,et al.Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide[J].m Bio,2015,6(2):e02481.
[36]SERRANO M,MORENO-NAVARRETE JM,PUIG J,et al.Serum lipopolysaccharide-binding protein as a marker of atherosclerosis[J].Atherosclerosis,2013,230(2):223-227.
[37]RICHARDS EM,PEPINE CJ,RAIZADA MK,et al.The gut,its microbiome,and hypertension[J].Current Hypertension Reports,2017,19(4):36.
[38]TOMASOVA L,DOBROWOLSKI L,JURKOWSKA H,et al.Intracolonic hydrogen sulfide lowers blood pressure in rats[J].Nitric Oxide:Biology and Chemistry,2016,60:50-58.
[39]AFSAR B,VAZIRI ND,ASLAN G,et al.Gut hormones and gut microbiota:implications for kidney function and hyperten sion[J].Journal of the American Society of Hypertension:JASH,2016,10(12):954-961.
[40]YANG T,RICHARDS EM,PEPINE CJ.The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease[J].2018,14(7):442-456.
[41]MACPHERSON AJ,HARRIS NL.Interactions between commensal intestinal bacteria and the immune system.Nature reviews[J].Immunology,2004,4(6):478-485.
[42]ERNY D,HRABE DE ANGELIS AL,JAITIN D,et al.Host microbiota constantly control maturation and function of microglia in the CNS[J].Nat Neurosci,2015,18(7):965-977.
[43]SANTISTEBAN MM,KIM S,PEPINE CJ,et al.Brain-gutbone marrow axis:Implications for hypertension and related therapeutics[J].Circulation Research,2016,118(8):1327-1336.
[44]RAMEZANI A,RAJ DS.The gut microbiome,kidney disease,and targeted interventions[J].Journal of the American Society of Nephrology:JASN,2014,25(4):657-670.
[45]IRAPORDA C,ERREA A,ROMANIN DE,et al.Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells[J].Immunobiology,2015,220(10):1161-1169.
[46]STREPPEL MT,ARENDS LR,VAN'T VEER P,et al.Dietary fiber and blood pressure:a meta-analysis of randomized placebo-controlled trials[J].Archives of internal medicine,2005,165(2):150-156.
[47]WHELTON SP,HYRE AD,PEDERSEN B,et al.Effect of dietary fiber intake on blood pressure:a meta-analysis of randomized,controlled clinical trials[J].Journal of Hypertension,2005,23(3):475-481.
[48]UPADRASTA A,MADEMPUDI RS.Probiotics and blood pressure:current insights[J].Integrated Blood Pressure Control,2016,9(1):33-42.
[49]SEPPO L,JAUHIAINEN T,POUSSA T,et al.A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects[J].The American Journal of Clinical Nutrition,2003,77(2):326-330.
[50]AHREN IL,XU J,ONNING G,et al.Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM15313 and effects on the gut microbiota in healthy rats[J].Clinical Nutrition(Edinburgh,Scotland),2015,34(4):719-726.
[51]GOMEZ-GUZMAN M,TORAL M,ROMERO M,et al.Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats[J].Molecular Nutrition&Food Research,2015,59(11):2326-2336.
[52]HENNESSY AA,ROSS RP,DEVERY R,et al.The health promoting properties of the conjugated isomers of alpha-linolenic acid[J].Lipids,2011,46(2):105-119.
[53]HAYAKAWA K,KIMURA M,KASAHA K,et al.Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats[J].The British Journal of Nutrition,2004,92(3):411-417.
[54]RASHID SK,IDRIS-KHODJA N,AUGER C,et al.Probiotics(VSL#3)prevent endothelial dysfunction in rats with portal hypertension:role of the angiotensin system[J].PloS One,2014,9(5):e97458.
[55]ENRIGHT EF,GAHAN CG,JOYCE SA,et al.The impact of the gut microbiota on drug metabolism and clinical outcome[J].The Yale Journal of Biology and Medicine,2016,89(3):375-382.
[56]YOO HH,KIM IS,YOO DH,et al.Effects of orally administered antibiotics on the bioavailability of amlodipine:gut microbiota-mediated drug interaction[J].Journal of Hypertension,2016,34(1):156-162.
[57]UPALA S,ANAWIN S.Bariatric surgery and risk of postoperative endometrial cancer:a systematic review and meta-analysis[J].Surgery for Obesity and Related Diseases,2015,11(4):949-955.
[58]SJOSTROM L,LINDROOS AK,PELTONEN M,et al.Lifestyle,diabetes,and cardiovascular risk factors 10 years after bariatric surgery[J].The New England Journal of Medicine,2004,351(26):2683-2693.
[2]HE FJ,LI J,MACGREGOR GA.Effect of longer-term modest salt reduction on blood pressure[J].The Cochrane Database of Systematic Reviews,2013,(4):Cd004937.
[3]KATO N,TAKEUCHI F,TABARA Y,et al.Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians[J].Nature Genetics,2011,43(6):531-538.
[4]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[5]FUCHS FD,CHAMBLESS LE,WHELTON PK,et al.Alcohol consumption and the incidence of hypertension:The atherosclerosis risk in communities study[J].Hypertension,2001,37(5):1242-1250.
[6]QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[7]许杰,王伊龙,王拥军.肠道菌群与高血压[J].中国卒中杂志,2017,12(2):175-178.
[8]ECKBURG PB,BIK EM,BERNSTEIN CN,et al.Diversity of the human intestinal microbial flora[J].Science(New York,N.Y.),2005,308(5728):1635-1638.
[9]FORSLUND K,HILDEBRAND F,NIELSEN T,et al.Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J].Nature,2015,528(7581):262-266.
[10]GARCIA-RIOS A,TORRES-PENA JD,PEREZ-JIMENEZ F,et al.Gut microbiota:a new marker of cardiovascular disease[J].Curr Pharm Des,2017,23(22):3233-3238.
[11]THORBURN AN,MACIA L,MACKAY CR.Diet,metabolites,and"western-lifestyle"inflammatory diseases[J].Immunity,2014,40(6):833-842.
[12]QIN N,YANG F,LI A,et al.Alterations of the human gut microbiome in liver cirrhosis[J].Nature,2014,513(7516):59-64.
[13]SCHER JU,SCZESNAK A,LONGMAN RS,et al.Expansion of intestinal prevotella copri correlates with enhanced susceptibility to arthritis[J].eLife,2013,2:e01202.
[14]RIDAURA VK,FAITH JJ,REY FE,et al.Gut microbiota from twins discordant for obesity modulate metabolism in mice[J].Science(New York,N.Y.),2013,341(6150):1241214.
[15]KOETH RA,WANG Z,LEVISON BS,et al.Intestinal microbiota metabolism of L-carnitine,a nutrient in red meat,promotes atherosclerosis[J].Nature Medicine,2013,19(5):576-585.
[16]FOSTER JA,MCVEY N KA.Gut-brain axis:how the microbiome influences anxiety and depression[J].Trends in Neurosciences,2013,36(5):305-312.
[17]VENKATESAN P.Gut microbiota and the risk of childhood asthma[J].The Lancet,Respiratory Medicine,2015,3(11):843.
[18]KALLIOMAKI M,ISOLAURI E.Role of intestinal flora in the development of allergy[J].Curr Opin Allergy Clin Immunol,2003,3(1):15-20.
[19]刘金宝.新疆哈萨克族正常血压人群和高血压人群肠道菌群中拟杆菌属和梭菌属结构特征分析[D].乌鲁木齐:新疆医科大学,2010.
[20]江维·哈吾,吐尔洪·吐送,马秀敏,等.维医异常黑胆质体液质高血压人群和正常黑胆质体液质健康人群肠道菌群多样性分析[J].中国病原生物学杂志,2012,7(2):132-136.
[21]YANG T,SANTISTEBAN MM,RODRIGUEZ V,et al.Gut dysbiosis is linked to hypertension[J].Hypertension(Dallas,Tex.:1979),2015,65(6):1331-1340.
[22]LI J,ZHAO F,WANG Y,et al.Gut microbiota dysbiosis contributes to the development of hypertension[J].Microbiome,2017,5(1):14.
[23]YAN Q,GU Y,LI X,et al.Alterations of the gut microbiome in hypertension[J].Frontiers in Cellular and Infection Microbiology,2017,7(3):381.
[24]KIM S,GOEL R,KUMAR A,et al.Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure[J].Clinical science(London,England:1979),2018,132(6):701-718.
[25]SANTISTEBAN MM,QI Y,ZUBCEVIC J,et al.Hypertensionlinked pathophysiological alterations in the gut[J].Circulation Research,2017,120(2):312-323.
[26]DURGAN DJ,GANESH BP,COPE JL,et al.Role of the gut microbiome in obstructive sleep apnea-induced hypertension[J].Hypertension(Dallas,Tex.:1979),2016,67(2):469-474.
[27]MELL B,JALA VR,MATHEW AV,et al.Evidence for a link between gut microbiota and hypertension in the Dahl rat[J].Physiological Genomics,2015,47(6):187-197.
[28]WILCK N,MATUS MG,KEARNEY SM,et al.Salt-responsive gut commensal modulates TH17 axis and disease[J].Nature,2017,551(7682):585-589.
[29]MARQUES FZ,NELSON E,CHU PY,et al.High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice[J].Circulation,2017,135(10):964-977.
[30]ADNAN S,NELSON JW,AJAMI NJ,et al.Alterations in the gut microbiota can elicit hypertension in rats[J].Physiological Genomics,2017,49(2):96-104.
[31]WILCK N,MATUS MG,KEARNEY SM,et al.Salt-responsive gut commensal modulates TH17 axis and disease[J].Nature,2017,551(7682):585-589.
[32]PLUZNICK JL,PROTZKO RJ,GEVORGYAN H,et al.Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation[J].Proc Natl Acad Sci USA,2013,110(11):4410-4415.
[33]BROWN AJ,GOLDSWORTHY SM,BARNES AA,et al.The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids[J].The Journal of Biological Chemistry,2003,278(13):11312-11319.
[34]MIYAMOTO J,KASUBUCHI M,NAKAJIMA A,et al.The role of short-chain fatty acid on blood pressure regulation[J].Current Opinion in Nephrology and Hypertension,2016,25(5):379-383.
[35]ROMANO KA,VIVAS EI,AMADOR-NOGUEZ D,et al.Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide[J].m Bio,2015,6(2):e02481.
[36]SERRANO M,MORENO-NAVARRETE JM,PUIG J,et al.Serum lipopolysaccharide-binding protein as a marker of atherosclerosis[J].Atherosclerosis,2013,230(2):223-227.
[37]RICHARDS EM,PEPINE CJ,RAIZADA MK,et al.The gut,its microbiome,and hypertension[J].Current Hypertension Reports,2017,19(4):36.
[38]TOMASOVA L,DOBROWOLSKI L,JURKOWSKA H,et al.Intracolonic hydrogen sulfide lowers blood pressure in rats[J].Nitric Oxide:Biology and Chemistry,2016,60:50-58.
[39]AFSAR B,VAZIRI ND,ASLAN G,et al.Gut hormones and gut microbiota:implications for kidney function and hyperten sion[J].Journal of the American Society of Hypertension:JASH,2016,10(12):954-961.
[40]YANG T,RICHARDS EM,PEPINE CJ.The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease[J].2018,14(7):442-456.
[41]MACPHERSON AJ,HARRIS NL.Interactions between commensal intestinal bacteria and the immune system.Nature reviews[J].Immunology,2004,4(6):478-485.
[42]ERNY D,HRABE DE ANGELIS AL,JAITIN D,et al.Host microbiota constantly control maturation and function of microglia in the CNS[J].Nat Neurosci,2015,18(7):965-977.
[43]SANTISTEBAN MM,KIM S,PEPINE CJ,et al.Brain-gutbone marrow axis:Implications for hypertension and related therapeutics[J].Circulation Research,2016,118(8):1327-1336.
[44]RAMEZANI A,RAJ DS.The gut microbiome,kidney disease,and targeted interventions[J].Journal of the American Society of Nephrology:JASN,2014,25(4):657-670.
[45]IRAPORDA C,ERREA A,ROMANIN DE,et al.Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells[J].Immunobiology,2015,220(10):1161-1169.
[46]STREPPEL MT,ARENDS LR,VAN'T VEER P,et al.Dietary fiber and blood pressure:a meta-analysis of randomized placebo-controlled trials[J].Archives of internal medicine,2005,165(2):150-156.
[47]WHELTON SP,HYRE AD,PEDERSEN B,et al.Effect of dietary fiber intake on blood pressure:a meta-analysis of randomized,controlled clinical trials[J].Journal of Hypertension,2005,23(3):475-481.
[48]UPADRASTA A,MADEMPUDI RS.Probiotics and blood pressure:current insights[J].Integrated Blood Pressure Control,2016,9(1):33-42.
[49]SEPPO L,JAUHIAINEN T,POUSSA T,et al.A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects[J].The American Journal of Clinical Nutrition,2003,77(2):326-330.
[50]AHREN IL,XU J,ONNING G,et al.Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM15313 and effects on the gut microbiota in healthy rats[J].Clinical Nutrition(Edinburgh,Scotland),2015,34(4):719-726.
[51]GOMEZ-GUZMAN M,TORAL M,ROMERO M,et al.Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats[J].Molecular Nutrition&Food Research,2015,59(11):2326-2336.
[52]HENNESSY AA,ROSS RP,DEVERY R,et al.The health promoting properties of the conjugated isomers of alpha-linolenic acid[J].Lipids,2011,46(2):105-119.
[53]HAYAKAWA K,KIMURA M,KASAHA K,et al.Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats[J].The British Journal of Nutrition,2004,92(3):411-417.
[54]RASHID SK,IDRIS-KHODJA N,AUGER C,et al.Probiotics(VSL#3)prevent endothelial dysfunction in rats with portal hypertension:role of the angiotensin system[J].PloS One,2014,9(5):e97458.
[55]ENRIGHT EF,GAHAN CG,JOYCE SA,et al.The impact of the gut microbiota on drug metabolism and clinical outcome[J].The Yale Journal of Biology and Medicine,2016,89(3):375-382.
[56]YOO HH,KIM IS,YOO DH,et al.Effects of orally administered antibiotics on the bioavailability of amlodipine:gut microbiota-mediated drug interaction[J].Journal of Hypertension,2016,34(1):156-162.
[57]UPALA S,ANAWIN S.Bariatric surgery and risk of postoperative endometrial cancer:a systematic review and meta-analysis[J].Surgery for Obesity and Related Diseases,2015,11(4):949-955.
[58]SJOSTROM L,LINDROOS AK,PELTONEN M,et al.Lifestyle,diabetes,and cardiovascular risk factors 10 years after bariatric surgery[J].The New England Journal of Medicine,2004,351(26):2683-2693.