Effect of Shexiang Tongxin Dropping Pills(麝香通心滴丸) on the Immediate Blood Flow of Patients with Coronary Slow Flow
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  • 英文篇名:Effect of Shexiang Tongxin Dropping Pills(麝香通心滴丸) on the Immediate Blood Flow of Patients with Coronary Slow Flow
  • 作者:WANG ; Sheng-huang ; CHU ; Lin ; XU ; Zhao ; ZHOU ; Hong-lin ; CHEN ; Jiang-fei ; NING ; Huang-fu
  • 英文作者:WANG Sheng-huang;CHU Lin;XU Zhao;ZHOU Hong-lin;CHEN Jiang-fei;NING Huang-fu;Department of Cardiovascular Medicine, Ningbo Hosptial of Zhejiang University, Ningbo First Hospital;
  • 英文关键词:coronary artery;;slow blood ?ow;;Shexiang Tongxin dropping pills;;Chinese medicine;;ischemic chest pain
  • 中文刊名:ZXYY
  • 英文刊名:中国结合医学杂志(英文版)
  • 机构:Department of Cardiovascular Medicine, Ningbo Hospital of Zhejiang University, Ningbo First Hospital;
  • 出版日期:2019-05-13
  • 出版单位:Chinese Journal of Integrative Medicine
  • 年:2019
  • 期:v.25
  • 基金:Supported by the Zhejiang Institute of Integrative Medicine Clinical Special Fund for Pharmacy Research(No.2014LYK009)
  • 语种:英文;
  • 页:ZXYY201905007
  • 页数:6
  • CN:05
  • ISSN:11-4928/R
  • 分类号:42-47
摘要
Objective: To observe the immediate effect and safety of Shexiang Tongxin dropping pills(麝香通心滴丸, STDP) on patients with coronary slow flow(CSF), and furthermore, to explore new evidence for the use of Chinese medicine in treating ischemic chest pain. Methods: Coronary angiography(CAG) with corrected thrombolysis in myocardial infarction(TIMI) frame count(CTFC) was applied(collected at 30 frames/s). The treatment group included 22 CSF patients, while the control group included 22 individuals with normal coronary?ow. CSF patients were given 4 STDP through sublingual administration, and CAG was performed 5 min after the medication. The immediate blood ?ow frame count, blood pressure, and heart rate of patients before and after the use of STDP were compared. The liver and kidney functions of patients were examined before and after treatments. Results: There was a signi?cant difference in CTFC between groups(P<0.05). The average CTFC values of the vessels with slow blood ?ow in CSF patients were, respectively, 49.98±10.01 and 40.42±11.33 before and after the treatment with STDP, a 19.13% improvement. The CTFC values(frame/s) measured before and after treatment at the left anterior descending coronary artery, left circumflex artery, and right coronary artery were, respectively, 48.00±13.32 and 41.80±15.38, 59.00±4.69 and 50.00±9.04, and 51.90±8.40 and40.09±10.46, giving 12.92%, 15.25%, and 22.76% improvements, respectively. The CTFC values of vessels with slow ?ow before treatment were signi?cantly decreased after treatment(P<0.05). There were no apparent changes in the heart rate, blood pressure, or liver or kidney function of CSF patients after treatment with STDP(all P>0.05). Conclusions: The immediate effect of STDP in treating CSF patients was apparent. This medication could signi?cantly improve coronary ?ow without affecting blood pressure or heart rate. Our ?ndings support the potential of Chinese medicine to treat ischemic chest pain.
        Objective: To observe the immediate effect and safety of Shexiang Tongxin dropping pills(麝香通心滴丸, STDP) on patients with coronary slow flow(CSF), and furthermore, to explore new evidence for the use of Chinese medicine in treating ischemic chest pain. Methods: Coronary angiography(CAG) with corrected thrombolysis in myocardial infarction(TIMI) frame count(CTFC) was applied(collected at 30 frames/s). The treatment group included 22 CSF patients, while the control group included 22 individuals with normal coronary?ow. CSF patients were given 4 STDP through sublingual administration, and CAG was performed 5 min after the medication. The immediate blood ?ow frame count, blood pressure, and heart rate of patients before and after the use of STDP were compared. The liver and kidney functions of patients were examined before and after treatments. Results: There was a signi?cant difference in CTFC between groups(P<0.05). The average CTFC values of the vessels with slow blood ?ow in CSF patients were, respectively, 49.98±10.01 and 40.42±11.33 before and after the treatment with STDP, a 19.13% improvement. The CTFC values(frame/s) measured before and after treatment at the left anterior descending coronary artery, left circumflex artery, and right coronary artery were, respectively, 48.00±13.32 and 41.80±15.38, 59.00±4.69 and 50.00±9.04, and 51.90±8.40 and40.09±10.46, giving 12.92%, 15.25%, and 22.76% improvements, respectively. The CTFC values of vessels with slow ?ow before treatment were signi?cantly decreased after treatment(P<0.05). There were no apparent changes in the heart rate, blood pressure, or liver or kidney function of CSF patients after treatment with STDP(all P>0.05). Conclusions: The immediate effect of STDP in treating CSF patients was apparent. This medication could signi?cantly improve coronary ?ow without affecting blood pressure or heart rate. Our ?ndings support the potential of Chinese medicine to treat ischemic chest pain.
引文
1.Tambe AA,Demany MA,Zimmerman HA,Mascarenhas E.Angina pectoris and slow flow velocity of dye in coronary arteries-a new angiographic finding.Am Heart J1972;84:66-71.
    2.Hawkins BM,Stavrakis S,Rousan TA,Abu-Fadel M,Schechter E.Coronary slow flow-prevalence and clinical correlations.Circ J 2012;76:936-942.
    3.Kurtoglu N,Akcay A,Dindar I.Usefulness of oral dipyridamole therapy for angiographic slow coronary artery flow.Am J Cardiol 2001;87:777-779.
    4.Wang SH,Zhu N,Zhou HL,Chen LB,Cui HB.Evaluation of myocardial perfusion in patients with coronary slow flow by myocardial contrast echocardiography.Chin J Cardiol(Chin)2013;41:293-296.
    5.Chu L,Wang SH,Zhou HL,Zhu N,Chen XM.Potential of Shexiang Tongxin Dropping Pills on the coronary slow flow phenomenon.Zhejiang J Integr Tradit Chin West Med(Chin)2011;21:399-400.
    6.Xu Z,Wang SH.Progress of drug treatment in the coronary slow flow phenomenon.Chin Circ J(Chin)2015:81-83.
    7.Zhu N,Wang SH,Liu YH,Zhou HL.Levels of nitric oxide and endothelin-1 in patients with coronary slow flow.Chin JGeriatric Heart Brain Vessel Dis(Chin)2012;14:828-830.
    8.Wang PL,Zhang L,Wang SL,Yang QN,Gao ZY,Du JP,et al.Long-term follow-up of Chinese herbal medicines combined with conventional treatment in patients with acute coronary syndrome after percutaneous coronary intervention:A multicenter randomized controlled trial.Chin J Integr Med 2017;23:740-746.
    9.Shi HZ,Li YZ,Tang ZZ,Zhong CF,Fan QC,Gao JY,et al.Impact of 60 days of 6°head down bed rest on cardiopulmonary function,and the effects of Taikong Yangxin Prescription(太空养心方)as a countermeasure.Chin JIntegr Med 2014;20:654-660.
    10.Beltrame JF,Limaye SB,Horowitz JD.The coronary slow flow phenomenon-a new coronary microvascular disorder.Cardiology 2002;97:197-202.
    11.Gibson CM,Cannon CP,Daley WL,Dodge JT Jr.,Alexander B Jr.,et al.TIMI frame count:a quantitative method of assessing coronary artery flow.Circulation1996;93:879-888.
    12.Chan PS,Jones PG,Arnold SA,Spertus JA.Development and validation of a short version of the Seattle angina questionnaire.Circ Cardiovasc Qual Outcomes 2014;7:640-647.
    13.Mangieri E,Macchiarelli G,Ciavolella M,Barilla F,Avella A,Martinotti A,et al.Slow coronary flow:clinical and histopathological features in patients with otherwise normal epicardial coronary arteries.Cathet Cardiovasc Diagn1996;37:375-381.
    14.Fineschi M,Gori T.Coronary slow-flow phenomenon or syndrome Y:a microvascular angina awaiting recognition.JAm Coll Cardiol 2010;56:239-240.
    15.Celebi H,Catakoglu A B,Kurtog lu H,Sener M,Hanavdelogullari R,Demiroglu C,et al.The relation between coronary flow rate,plasma endothelin-1 concentrations,and clinical characteristics in patients with normal coronary arteries.Cardiovasc Revasc Med 2008;9:144-148.
    16.Yucel H,Ozaydin M,Dogan A,Erdogan D,Turker Y,Ceyhan BM.Plasma concentrations of asymmetric dimethylarginine,nitric oxide and homocysteine in patients with slow coronary flow.Scand J Clin Lab Invest 2012;72:495-500.
    17.Sadamatsu K,Tashiro H,Yoshida K,Shikada T,Iwamoto K,Morishige K,et al.Acute effects of isosorbide dinitrate and nicorandil on the coronary slow flow phenomenon.Am J Cardiovasc Drugs 2010;10:203-208.
    18.Ozdogru I,Zencir C,Dogan A,Orscelik O,Inanc MT,Celik A,et al.Acute effects of intracoronary nitroglycerin and diltiazem in coronary slow flow phenomenon.J Investig Med 2013;61:45-49.
    19.Chang SF,Ma JY,Qian JY,Shu XH,Ge JB.Effects of intracoronary administration of nitroglycerin and verapamil for treatment of coronary slow flow phenomenon.Chin JCardiol(Chin)2010;38:27-30.
    20.Chen D,Lin S,Xu W,Huang M,Chu J,Xiao F,et al.Qualitative and quantitative analysis of the major constituents in Shexiang Tongxin Dropping Pill by HPLC-Q-TOF-MS/MSand UPLC-Qq Q-MS/MS.Molecules 2015;20:18597-18619.
    21.Xiong M,Jia C,Cui J,Wang P,Du X,Yang Q,et al.Shexiang Tongxin dropping pil attenuates at herosclerotic lesions in Apo Edeficient mouse model.J Ethnopharmacol 2015;159:84-92.
    22.Jin JG,Shen HJ,Shan YL,Chen L,Zhao XY,Wang LR.Effect of two administration routes of Shenmai Injection on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion.Chin J Integr Med 2017;23:18-24.
    23.Wang LF,Xu ZY,Wang ZQ,Zhang M,Yan GY,Hou AJ,et al.Clinical observation of Shuanghuang Shengbai Granule on prevention and treatment of myelosuppression caused by chemotherapy in cancer patients.Chin J Integr Med2017;23:105-109.
    24.Liu XD,Wang YQ,Cai L,Ye LH,Wang F,Feng YY.Effect of Wenhua Juanbi Recipe(sic)on expression of receptor activator of nuclear factor kappa B ligand,osteoprotegerin,and tumor necrosis factor receptor superfamily member 14in rats with collagen-induced arthritis.Chin J Integr Med2017;23:208-214.
    25.Wang Y,Niu ZC,He B,Xie XG,Liu J,Wang WM.Potential of Shexiang Tongxin Dropping Pills.Chin J Integr Med Cardio/Cerebrovas Dis(Chin)2011;9:1083-1086.
    26.Zhang HQ,Xu DL,Yan L,Yuan LY,Jia JGo,Sun AJ,et al.The protective function of Shexiang on endothelial injury induced by angiotensinⅡosmotic pump in the rat.Chin JClin Med(Chin)2009;16:669-672.

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