基于功能纳米材料的液相生物芯片检测技术
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摘要
近年来基于编码微球的液相生物芯片技术在对单一样本进行高通量和多指标检测中发挥巨大的作用。由于其快速的动力学结合速率、高通量、高灵敏和多元检测的优势,因此基于编码微球的液相芯片对基因分析、蛋白表达、疾病的早期诊断、预后等也是一种强有力的检测工具。受益于纳米技术和纳米材料的快速发展,特别是功能纳米颗粒/聚合物复合微球的应用,液相生物芯片在提高其多元分析能力、分析灵敏度和自动化检测等多方面取得了巨大进展。本文将分别从液相生物芯片概述、功能纳米颗粒编码微球、功能纳米颗粒编码微球的制备、基于编码微球的液相生物芯片的设计及性能调控等方面来介绍近年来基于功能纳米材料的液相生物芯片技术的研究进展。最后,我们对液相生物芯片技术存在的挑战和可能的解决方案进行总结,并对其技术发展方向及应用前景进行展望。希望通过本文的系统介绍可助力液相生物芯片检测技术及其相关研究领域的发展。
Suspension array or liquid biochips technique based on spectrometrically encoded microspheres plays a prominent role in simultaneously high-throughput multiplexed detection of multiple analytes within a small,single sample volume. It is a quite powerful tool for genes analysis,proteins profiling,disease early diagnosis,treatment monitoring and so on,due to its faster binding kinetics,high-throughput multiplexed detection,high detection sensitivity,and good reproducibility. Commercial suspension array platforms based on organic dye-encoded microspheres showvarious limitations such as limited encoding capacity,sensitivity,photostability,requirement of instruments with multiple excitation,tedious color compensation processes,etc. Substantial development has been achieved in improving the multiplexed detecting capability,detection sensitivity,and automatic platform of suspension arrays due to the rapid growth of nanotechnology and nanomaterials. In this review,we systematically introduce the recent progress on functional nanomaterials based suspension array technology,including functional nanoparticles-encoded microspheres and their fabrication technologies,design and regulation of suspension arrays. At last,we make a summary of the current challenges and their possible solutions in suspension array technology. We hope that our reviewon the recent progress,current challenges,possible solutions and the future prospects of suspension array based on encoded microspheres,will help drive the development of suspension array technology and its related fields.
Suspension array or liquid biochips technique based on spectrometrically encoded microspheres plays a prominent role in simultaneously high-throughput multiplexed detection of multiple analytes within a small,single sample volume. It is a quite powerful tool for genes analysis,proteins profiling,disease early diagnosis,treatment monitoring and so on,due to its faster binding kinetics,high-throughput multiplexed detection,high detection sensitivity,and good reproducibility. Commercial suspension array platforms based on organic dye-encoded microspheres showvarious limitations such as limited encoding capacity,sensitivity,photostability,requirement of instruments with multiple excitation,tedious color compensation processes,etc. Substantial development has been achieved in improving the multiplexed detecting capability,detection sensitivity,and automatic platform of suspension arrays due to the rapid growth of nanotechnology and nanomaterials. In this review,we systematically introduce the recent progress on functional nanomaterials based suspension array technology,including functional nanoparticles-encoded microspheres and their fabrication technologies,design and regulation of suspension arrays. At last,we make a summary of the current challenges and their possible solutions in suspension array technology. We hope that our reviewon the recent progress,current challenges,possible solutions and the future prospects of suspension array based on encoded microspheres,will help drive the development of suspension array technology and its related fields.
引文
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