Does dyslipidemia worsen the hearing level in diabetics?
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摘要
Objective: To identify the effect of dyslipidemia on auditory function detected by Pure Tone Audiometry. To check if dyslipidemia worsens the hearing level in diabetics.Design: This was a comparative study where 120 subjects between the age group of 20 and 50 years underwent pure tone audiometry, lipid profile and blood sugars. Group 1 consisted of 30 subjects with type 2 diabetes and dyslipidemia; Group 2 had 30 subjects with isolated diabetes;Group 3 had 30 with isolated dyslipidemia and Group 4 included 30 normal subjects as control.Results: Significant hearing loss was seen only in the group with isolated diabetes(63%). The most common type of hearing loss was high frequency sensorineural hearing loss. When comparison was made between the combinations of different lipid profiles, no association was found to the level of hearing.Conclusions: Diabetics are more prone to high frequency hearing loss. Altered lipid profile has no role in causing hearing loss.
Objective: To identify the effect of dyslipidemia on auditory function detected by Pure Tone Audiometry. To check if dyslipidemia worsens the hearing level in diabetics.Design: This was a comparative study where 120 subjects between the age group of 20 and 50 years underwent pure tone audiometry, lipid profile and blood sugars. Group 1 consisted of 30 subjects with type 2 diabetes and dyslipidemia; Group 2 had 30 subjects with isolated diabetes;Group 3 had 30 with isolated dyslipidemia and Group 4 included 30 normal subjects as control.Results: Significant hearing loss was seen only in the group with isolated diabetes(63%). The most common type of hearing loss was high frequency sensorineural hearing loss. When comparison was made between the combinations of different lipid profiles, no association was found to the level of hearing.Conclusions: Diabetics are more prone to high frequency hearing loss. Altered lipid profile has no role in causing hearing loss.
Objective: To identify the effect of dyslipidemia on auditory function detected by Pure Tone Audiometry. To check if dyslipidemia worsens the hearing level in diabetics.Design: This was a comparative study where 120 subjects between the age group of 20 and 50 years underwent pure tone audiometry, lipid profile and blood sugars. Group 1 consisted of 30 subjects with type 2 diabetes and dyslipidemia; Group 2 had 30 subjects with isolated diabetes;Group 3 had 30 with isolated dyslipidemia and Group 4 included 30 normal subjects as control.Results: Significant hearing loss was seen only in the group with isolated diabetes(63%). The most common type of hearing loss was high frequency sensorineural hearing loss. When comparison was made between the combinations of different lipid profiles, no association was found to the level of hearing.Conclusions: Diabetics are more prone to high frequency hearing loss. Altered lipid profile has no role in causing hearing loss.
引文
Aladag,I.,Eyibilen,A.,Güven,M.,At?s?,?.,Erkokmaz,.,2009.Role of oxidative stress in hearing impairment in patients with type two diabetes mellitus.J.Laryngol.Otol.123,957.http://dx.doi.org/10.1017/s0022215109004502.
Badimon,L.,Vilahur,G.,2012.LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque:inflammatory resolution versus thrombotic chaos.Ann.N.Y.Acad.Sci.1254,18e32.http://dx.doi.org/10.1111/j.1749-6632.2012.06480.x.
Bainbridge,K.E.,Hoffman,H.J.,Cowie,C.C.,2008.Diabetes and hearing impairment in the United States:audiometric evidence from the national health and nutrition examination survey,1999 to 2004.Ann.Intern.Med.149,1.http://dx.doi.org/10.7326/0003-4819-149-1-200807010-00231.
Belal,A.,1979.The effects of vascular occlusion on the human inner ear.J.Laryngol.Otol.93,955e968.http://dx.doi.org/10.1017/s0022215100-087958.
Berardino,F.D.,Alpini,D.,Ambrosetti,U.,Amadeo,C.,Cesarani,A.,2007.Sensorineural hearing-loss in the Smithe Lemli-opitz syndrome.Int.J.Pediatr.Otorhinolaryngol.Extra 2,169e172.http://dx.doi.org/10.1016/j.pedex.2007.05.002.
Carvalho,A.C.A.,Colman,R.W.,Lees,R.S.,1974.Platelet function in hyperlipoproteinemia.N.Engl.J.Med.290,434e438.http://dx.doi.org/10.1056/nejm197402212900805.
Clark,J.G.,1981.Uses and abuses of hearing loss classification.Asha 23,493e500.
Cullen,J.R.,Cinnamond,M.J.,1993.Hearing loss in diabetics.J.Laryngol.Otol.107,179e182.http://dx.doi.org/10.1017/s0022215100122571.
Evans,M.B.,Tonini,R.,Shope,C.D.,Oghalai,J.S.,Jerger,J.F.,Insull,W.,Brownell,W.E.,2006.Dyslipidemia and auditory function.Otol.Neurotol.27,609e614.http://dx.doi.org/10.1097/01.mao.0000226286.19295.34.
Fukushima,H.,Cureoglu,S.,Schachern,P.A.,Paparella,M.M.,Harada,T.,Oktay,M.F.,2006.Effects of type 2 diabetes mellitus on cochlear structure in humans.Arch.Otolaryngol.Head Neck Surg.132,934.http://dx.doi.org/10.1001/archotol.132.9.934.
Gratton,M.A.,Wright,C.G.,1992.Alterations of inner ear morphology in experimental hypercholesterolemia.Hear.Res.61,97e105.http://dx.doi.org/10.1016/0378-5955(92)90040-t.
King,K.A.,Gordon-Salant,S.,Yanjanin,N.,Zalewski,C.,Houser,A.,Porter,F.D.,Brewer,C.C.,2014.Auditory phenotype of Niemanne Pick disease,type C1.Ear Hear.35,110e117.http://dx.doi.org/10.1097/aud.0b013e3182a362b8.
National Cholesterol Education Programme,2001 May 16.Executive summary of the third report of the national cholesterol education program(NCEP)expert panel on detection,evaluation,and treatment of high blood cholesterol in adults(Adult Treatment Panel III).JAMA 285(19),2486e2497.
Nguyen,T.V.,Brownell,W.E.,1998.Contribution of membrane cholesterol to outer hair cell lateral wall stiffness.Otolaryngol.Head Neck Surg.119,14e20.
Nomiya,R.,Nomiya,S.,Kariya,S.,Okano,M.,Morita,N.,Cureoglu,S.,Schachern,P.A.,Nishizaki,K.,Paparella,M.M.,2008.Generalized arteriosclerosis and changes of the cochlea in young adults.Otol.Neurotol.29,1193e1197.http://dx.doi.org/10.1097/mao.0b013e31818a0906.
Rader,D.,Pure,E.,2005.Lipoproteins,macrophage function,and atherosclerosis:beyond the foam cell?Cell Metab.1(4),223e230.http://dx.doi.org/10.1016/j.cmet.2005.03.005.
Satar,B.,Ozkaptan,Y.,Surucu,H.S.,Ozturk,H.,2001.Ultrastructural effects of hypercholesterolemia on the cochlea.Otol.Neurotol.22,786e789.http://dx.doi.org/10.1097/00129492-200111000-00012.
Seidman,M.D.,Ahmad,N.,Bai,U.,2002.Molecular mechanisms of agerelated hearing loss.Ageing Res.Rev.1,331e343.http://dx.doi.org/10.1016/s1568-1637(02)00004-1.
Suzuki,K.,Kaneko,M.,Murai,K.,2000.Influence of serum lipids on auditory function.Laryngoscope 110,1736e1738.http://dx.doi.org/10.1097/00005537-200010000-00033.
Swaminathan,A.,Sambandam,R.,Bhaskaran,M.,2011.Evaluation of the auditory effects of hyperlipidaemia and diabetes mellitus by using audiometry.J.Clin.Diagn.Res.5(8),1528e1532.
WHO,2006.Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia.Report of a WHO/IDF Consultation.
Wright,A.,1997.Scott Brown's Otorhinolaryngology(Basic Sciences),sixth ed.Butterworth-Heineman,Oxford.pp.1/1/43.
Yamamoto,K.,Kubo,T.,Matsunaga,T.,1991.Autoregulation of inner ear blood flow in normal and hydropic Guinea pigs.Acta Otolaryngol 111,312e318.http://dx.doi.org/10.3109/00016489109137393.
Badimon,L.,Vilahur,G.,2012.LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque:inflammatory resolution versus thrombotic chaos.Ann.N.Y.Acad.Sci.1254,18e32.http://dx.doi.org/10.1111/j.1749-6632.2012.06480.x.
Bainbridge,K.E.,Hoffman,H.J.,Cowie,C.C.,2008.Diabetes and hearing impairment in the United States:audiometric evidence from the national health and nutrition examination survey,1999 to 2004.Ann.Intern.Med.149,1.http://dx.doi.org/10.7326/0003-4819-149-1-200807010-00231.
Belal,A.,1979.The effects of vascular occlusion on the human inner ear.J.Laryngol.Otol.93,955e968.http://dx.doi.org/10.1017/s0022215100-087958.
Berardino,F.D.,Alpini,D.,Ambrosetti,U.,Amadeo,C.,Cesarani,A.,2007.Sensorineural hearing-loss in the Smithe Lemli-opitz syndrome.Int.J.Pediatr.Otorhinolaryngol.Extra 2,169e172.http://dx.doi.org/10.1016/j.pedex.2007.05.002.
Carvalho,A.C.A.,Colman,R.W.,Lees,R.S.,1974.Platelet function in hyperlipoproteinemia.N.Engl.J.Med.290,434e438.http://dx.doi.org/10.1056/nejm197402212900805.
Clark,J.G.,1981.Uses and abuses of hearing loss classification.Asha 23,493e500.
Cullen,J.R.,Cinnamond,M.J.,1993.Hearing loss in diabetics.J.Laryngol.Otol.107,179e182.http://dx.doi.org/10.1017/s0022215100122571.
Evans,M.B.,Tonini,R.,Shope,C.D.,Oghalai,J.S.,Jerger,J.F.,Insull,W.,Brownell,W.E.,2006.Dyslipidemia and auditory function.Otol.Neurotol.27,609e614.http://dx.doi.org/10.1097/01.mao.0000226286.19295.34.
Fukushima,H.,Cureoglu,S.,Schachern,P.A.,Paparella,M.M.,Harada,T.,Oktay,M.F.,2006.Effects of type 2 diabetes mellitus on cochlear structure in humans.Arch.Otolaryngol.Head Neck Surg.132,934.http://dx.doi.org/10.1001/archotol.132.9.934.
Gratton,M.A.,Wright,C.G.,1992.Alterations of inner ear morphology in experimental hypercholesterolemia.Hear.Res.61,97e105.http://dx.doi.org/10.1016/0378-5955(92)90040-t.
King,K.A.,Gordon-Salant,S.,Yanjanin,N.,Zalewski,C.,Houser,A.,Porter,F.D.,Brewer,C.C.,2014.Auditory phenotype of Niemanne Pick disease,type C1.Ear Hear.35,110e117.http://dx.doi.org/10.1097/aud.0b013e3182a362b8.
National Cholesterol Education Programme,2001 May 16.Executive summary of the third report of the national cholesterol education program(NCEP)expert panel on detection,evaluation,and treatment of high blood cholesterol in adults(Adult Treatment Panel III).JAMA 285(19),2486e2497.
Nguyen,T.V.,Brownell,W.E.,1998.Contribution of membrane cholesterol to outer hair cell lateral wall stiffness.Otolaryngol.Head Neck Surg.119,14e20.
Nomiya,R.,Nomiya,S.,Kariya,S.,Okano,M.,Morita,N.,Cureoglu,S.,Schachern,P.A.,Nishizaki,K.,Paparella,M.M.,2008.Generalized arteriosclerosis and changes of the cochlea in young adults.Otol.Neurotol.29,1193e1197.http://dx.doi.org/10.1097/mao.0b013e31818a0906.
Rader,D.,Pure,E.,2005.Lipoproteins,macrophage function,and atherosclerosis:beyond the foam cell?Cell Metab.1(4),223e230.http://dx.doi.org/10.1016/j.cmet.2005.03.005.
Satar,B.,Ozkaptan,Y.,Surucu,H.S.,Ozturk,H.,2001.Ultrastructural effects of hypercholesterolemia on the cochlea.Otol.Neurotol.22,786e789.http://dx.doi.org/10.1097/00129492-200111000-00012.
Seidman,M.D.,Ahmad,N.,Bai,U.,2002.Molecular mechanisms of agerelated hearing loss.Ageing Res.Rev.1,331e343.http://dx.doi.org/10.1016/s1568-1637(02)00004-1.
Suzuki,K.,Kaneko,M.,Murai,K.,2000.Influence of serum lipids on auditory function.Laryngoscope 110,1736e1738.http://dx.doi.org/10.1097/00005537-200010000-00033.
Swaminathan,A.,Sambandam,R.,Bhaskaran,M.,2011.Evaluation of the auditory effects of hyperlipidaemia and diabetes mellitus by using audiometry.J.Clin.Diagn.Res.5(8),1528e1532.
WHO,2006.Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia.Report of a WHO/IDF Consultation.
Wright,A.,1997.Scott Brown's Otorhinolaryngology(Basic Sciences),sixth ed.Butterworth-Heineman,Oxford.pp.1/1/43.
Yamamoto,K.,Kubo,T.,Matsunaga,T.,1991.Autoregulation of inner ear blood flow in normal and hydropic Guinea pigs.Acta Otolaryngol 111,312e318.http://dx.doi.org/10.3109/00016489109137393.