摘要
目的:探讨汉族与维吾尔族与慢性肾脏病(CKD)相关危险因素的异同。方法:收集2010年5月~2014年5月新疆医科大学第一附属医院体检中心体检者、肾病科、高血压科、内分泌科CKD患者总共17 520例,其中汉族CKD患者853例,汉族健康体检者899例,维吾尔族CKD患者297例,维吾尔族健康体检者291例。维吾尔族和汉组两民族患者的性别、年龄、肥胖、血脂异常、总胆固醇、三酰甘油、糖代谢紊乱、血尿酸、血压、蛋白尿等相关危险因素,分别进行单因素及多因素Logistic回归分析。结果:健康体检者汉族与维吾尔族相比,糖代谢紊乱比率较高(P<0.05),体重偏大、血压偏高、总胆固醇水平较高、血尿酸偏高(均P<0.05),CKD患者汉族与维吾尔族相比,糖代谢紊乱比率较高(P<0.05),血尿酸偏高、三酰甘油偏高、总胆固醇偏高(均P<0.05),年龄较小、血压偏低(均P<0.05)。经Logistic回归分析结果显示:糖代谢紊乱(OR=1.693,P<0.000)、高血压(OR=2.110,P<0.000)、尿酸(OR=1.349,P<0.05)与汉族CKD独立相关;高血压(OR=46.954,P<0.000)、血脂异常(OR=1.911,P=0.045)以及蛋白尿(OR=83.052,P<0.000)与维吾尔族CKD独立相关。结论:高血压是维汉CKD共同的独立危险因素。
Objective: To investigate the risk factors of chronic kidney disease( CKD) in the Han nationality and the Uygur nationality.Methods: From May 2014 to May 2010,there were 17520 cases of CKD patients in the First Affiliated Hospital of Xinjiang Medical University,Department of nephropathy,hypertension,Department of Endocrinology,including 853 patients with CKD,899 cases of healthy people,297 cases of Uygur CKD,291 cases of healthy physical examination.Sex,age,obesity,dyslipidemia,total cholesterol,total cholesterol,triglyceride,glucose metabolism disorder,blood uric acid,blood pressure,proteinuria and other related risk factors were analyzed by single factor and multi factor Logistic regression analysis.Results: Healthy physical examination compared with the Uygur nationality,the metabolic disorders,the body weight,blood pressure,high blood pressure,high blood uric acid of the Han nationality were higher( P < 0.05).Compared with the Uygur nationality in CKD patients,the metabolic disorders,the age,the body weight,blood pressure,high blood pressure,high blood uric acid of the Han nationality were higher( P < 0.05),Logistic regression analysis showed that the metabolic disorders( OR = 1.693,P < 0.000),the blood pressure( OR = 2.110,P <0.000),the uric acid( OR = 1.349,P < 0.05) were independently associated with CKD in Han nationality.The blood pressure( OR =46.954,P < 0.000),disorder of blood lipid( P = 0.045,OR = 1.911) and proteinuria( P < 0.000,OR = 83.052) in Uygur nationality.Conclusion: Hypertension is an independent risk factor for CKD in Uygur and Han nationality.
引文
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