乳腺癌组织中RBM38基因表达的临床意义
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摘要
探讨RNA结合蛋白38(RBM38)基因表达的改变在乳腺癌发生、发展中的临床意义。收集上海中医药大学附属曙光医院2015年2月—2018年8月普外科治疗的乳腺癌患者78例,另取因良性病变手术切除的乳腺标本40例作为对照。RT-PCR检测RBM38基因的相对表达。乳腺癌组织中RBM38基因的表达量为0.27±0.08,显著低于对照组的0.48±0.16(P<0.01)。乳腺癌组织中RBM38基因的表达量在Ⅲ、Ⅳ期患者为0.21±0.05,显著低于Ⅰ、Ⅱ期患者的0.32±0.12(P<0.01),中、低分化患者为0.25±0.06,显著低于高分化患者的0.39±0.14(P<0.01),淋巴结有转移患者为0.19±0.04,显著低于无转移患者的0.31±0.11(P<0.01)。乳腺癌组织中RBM38低表达,低表达的RBM38可能参与了乳腺癌的发生、分化和转移过程。
引文
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[5] Zhou XJ, Wu J, Shi L, et al. PTEN expression is upregulated by aRNA-binding protein RBM38 via enhancing its mRNA stability inbreast cancer[J]. J Exp Clin Cancer Res, 2017, 36(1):149-158.
[6] Jiang Y, Xu E, Zhang J, et al. The Rbm38-p63 feedback loop iscritical for tumor suppression and longevity[J]. Oncogene, 2018, 37(21):2863-2872.
[7]尚自强,王洪江,杜同心,等.肺腺癌组织中RNA结合蛋白38的表达及意义[J].山东医药,2017,57(6):45-47.
[8]季春梅,黄雯,杨年钊,等.RNPC1基因对胃癌细胞MGC-823增殖、迁移及侵袭的影响[J].江苏医药,2016,42(5):507-510.
[9] Li XX, Shi L, Zhou XJ, et al. The role of c-Myc-RBM38 loop inthe growth suppression in breast cancer[J]. J Exp Clin Cancer Res,2017, 36(1):49-58.
[10]吴靓,周旭婕,李小霞,等. RNPC1通过抑制Snail表达影响乳腺癌转移[J].南京医科大学学报(自然科学版),2017,37(8):938-942.
[11] Wu J, Zhou XJ, Sun X, et al. RBM38 is involved in TGF-β-in-duced epithelial-to-mesenchymal transition by stabilising zonulaoccludens-1 m RNA in breast cancer[J]. Br J Cancer, 2017, 117(5):675-684.
[2]陈伟,许馨,孙绍光.RNA结合蛋白与RNA相互作用鉴定技术[J].中国生物化学与分子生物学报,2017,33(2):103-107.
[3]程功名,朱本磊,夏建国,等. RBM38在结直肠癌中的表达及其意义[J].江苏医药,2016,42(7):774-777,740.
[4] Ye J, Liang R, Bai T, et al. RBM38 plays a tumor-suppressor rolevia stabilizing the p53-mdm2 loop function in hepatocellular carci-noma[J]. J Exp Clin Cancer Res, 2018, 37(1):212-221.
[5] Zhou XJ, Wu J, Shi L, et al. PTEN expression is upregulated by aRNA-binding protein RBM38 via enhancing its mRNA stability inbreast cancer[J]. J Exp Clin Cancer Res, 2017, 36(1):149-158.
[6] Jiang Y, Xu E, Zhang J, et al. The Rbm38-p63 feedback loop iscritical for tumor suppression and longevity[J]. Oncogene, 2018, 37(21):2863-2872.
[7]尚自强,王洪江,杜同心,等.肺腺癌组织中RNA结合蛋白38的表达及意义[J].山东医药,2017,57(6):45-47.
[8]季春梅,黄雯,杨年钊,等.RNPC1基因对胃癌细胞MGC-823增殖、迁移及侵袭的影响[J].江苏医药,2016,42(5):507-510.
[9] Li XX, Shi L, Zhou XJ, et al. The role of c-Myc-RBM38 loop inthe growth suppression in breast cancer[J]. J Exp Clin Cancer Res,2017, 36(1):49-58.
[10]吴靓,周旭婕,李小霞,等. RNPC1通过抑制Snail表达影响乳腺癌转移[J].南京医科大学学报(自然科学版),2017,37(8):938-942.
[11] Wu J, Zhou XJ, Sun X, et al. RBM38 is involved in TGF-β-in-duced epithelial-to-mesenchymal transition by stabilising zonulaoccludens-1 m RNA in breast cancer[J]. Br J Cancer, 2017, 117(5):675-684.