经皮骨水泥成形术治疗骨转移瘤研究进展
|
摘要
经皮骨水泥成形术用于临床治疗骨转移瘤,其主要目的在于止痛和缓解症状,除常规并发症以外,还存在局部抗肿瘤作用不足、甚至可能促进肿瘤进展等问题,与物理消融、动脉栓塞、其他骨内金属植入物、放疗等手段联合应用有助于提高疗效。本文主要对骨水泥成形术治疗骨转移瘤现状、存在的问题及其与其他治疗手段联合应用进展进行综述。
Percutaneous cementoplasty has been widely used to treat bone metastases in clinic, with the main purpose of relieve pain and other symptoms. However, in addition to routine complications, there were still some other problems, such as local insufficient antitumor effect and even promoting tumor progress. Combining with physical ablation, arterial embolism, metal implantation, radiotherapy or other means may be helpful to improve the curative effect of percutaneous cementoplasty. The present situation, existing problems and combined application of bone cement in treatment of bone metastases were reviewed in this article.
Percutaneous cementoplasty has been widely used to treat bone metastases in clinic, with the main purpose of relieve pain and other symptoms. However, in addition to routine complications, there were still some other problems, such as local insufficient antitumor effect and even promoting tumor progress. Combining with physical ablation, arterial embolism, metal implantation, radiotherapy or other means may be helpful to improve the curative effect of percutaneous cementoplasty. The present situation, existing problems and combined application of bone cement in treatment of bone metastases were reviewed in this article.
引文
[1]Mohme M,Riethdorf S,Dreimann M,et al.Circulating tumour cell release after cement augmentation of vertebral metastases.Sci Rep,2017,7(1):7196.
[2]Kam NM,Maingard J,Kok HK,et al.Combined vertebral augmentation and radiofrequency ablation in the management of spinal metastases:An update.Curr Treat Options Oncol,2017,18(12):74.
[3]Galibert P,Deramond H,Rosat P,et al.Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty.Neurochirurgie,1987,33(2):166-168.
[4]Kaemmerlen P,Thiesse P,Bouvard H,et al.Percutaneous vertebroplasty in the treatment of metastases Technic and results.J Radiol,1989,70(10):557-562.
[5]Tai CL,Lai PL,Lin WD,et al.Modification of mechanical properties,polymerization temperature,and handling time of polymethylmethacrylate cement for enhancing applicability in vertebroplasty.Biomed Res Int,2016,2016:7901562.
[6]Tian QH,Sun XQ,Lu YY,et al.Percutaneous vertebroplasty for palliative treatment of painful osteoblastic spinal metastases:A singlecenter experience.J Vasc Interv Radiol,2016,27(9):1420-1424.
[7]Leeson MC.Thermal aspects of the use of polymethylmethacrylate in large metaphyseal defects in bone.Aclinical review and laboratory study.Clin Orthop Relat Res,1993,295:239-245.
[8]Dahl OE,Garvik LJ,Lyberg T.Toxic effects of methylmethacrylate monomer on leukocytes and endothelial cells in vitro.Acta Orthop Scand,1994,65(2):147-153.
[9]Yang HL,Sun ZY,Wu GZ,et al.Do vertebroplasty and kyphoplasty have an antitumoral effect?Med Hypotheses,2011,76(1):145-146.
[10]Roedel B,Claren9on F,Touraine S,et al.Has the percutaneous vertebroplasty a role to prevent progression or local recurrence in spinal metastases of breast cancer?J Neuroradiol,2015,42(4):222-228.
[11]Lai PL,Tai CL,Chen LH,et al.Cement leakage causes potential thermal injury in vertebroplasty.BMC Musculoskelet Disord,2011,5(12):116.
[12]Gangi A,Buy X.Percutaneous bone tumor management.Semin Intervent Radiol,2010,27(2):124-136.
[13]Cruz JP,Sahgal A,Whyne C,et al.Tumor extravasation following a cement augmentation procedure for vertebral compression fracture in metastatic spinal disease.J Neurosurg Spine,2014,21(3):372-377.
[14]Axelsen M,Thomassen LD,Bünger C,et al.Estimating risk of pulmonary neoplastic embolism during vertebroplasty.Spine(Phila Pa 1976),2012,37(7):551-556.
[15]Lea W.Decision making:Osteoplasty,ablation,or combined therapy for spinal metastases.Semin Intervent Radiol,2017,34(2):121-131.
[16]Tsoumakidou G,Too CW,Koch G,et al.CIRSE guidelines on percutaneous vertebral augmentation.Cardiovasc Intervent Radiol,2017,40(3):331-342.
[17]Anchala PR,Irving WD,Hillen TJ,et al.Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device:A multicenter retrospective study.Pain Physician,2014,17(4):317-327.
[18]Laredo JD,Chiras J,Kemel S,et al.Vertebroplasty and interventional radiology procedures for bone metastases.Joint Bone Spine,2018,85(2):191-199.
[19]Trumm CG,Jakobs TF,Stahl R,et al.CT fluoroscopy-guided vertebral augmentation with a radiofrequency-induced,highviscosity bone cement(StabiliT?):Technical results and polymethylmethacrylate leakages in 25patients.Skeletal Radiol,2013,42(1):113-120.
[20]Reyes M,Georgy M,Brook L,et al.Multicenter clinical and imaging evaluation of targeted radiofrequency ablation(t-RFA)and cement augmentation of neoplastic vertebral lesions.JNeurointerv Surg,2018,10(2):176-182.
[21]Bauones S,Garnon J,Chari B,et al.Protection of the proximal articular cartilage during percutaneous thermal ablation of acetabular metastasis using temperature monitoring.Cardiovasc Intervent Radiol,2018,41(1):163-169.
[22]Cazzato RL,Garnon J,Caudrelier J,et al.Percutaneous radiofrequency ablation of painful spinal metastasis:Asystematic literature assessment of analgesia and safety.Int JHyperthermia,2018,34(8):1272-1281.
[23]Schaefer O,Lohrmann C,Markmiller M,et al.Combined treatment of a spinal metastasis with radiofrequency heat ablation and vertebroplasty.Am J Roentgenol,2003,180(4):1075-1077.
[24]Georgy BA,Wong W.Plasma-mediated radiofrequency ablation assisted percutaneous cement injection for treating advanced malignant vertebral compression fractures.AJNR Am JNeuroradiol,2007,28(4):700-705.
[25]Reyad RM,Ghobrial HZ,Hakim SM,et al.Thick cement usage in percutaneous vertebroplasty for malignant vertebral fractures at high risk for cement leakage.Diagn Interv Imaging,2017,98(10):721-728.
[26]Chen Y,Yan Z,Wang J,et al.Transarterial chemoembolization for pain relief in patients with hypervascular painful metastatic spinal tumors refractory to percutaneous vertebroplasty.J Cancer Res Clin Oncol,2013,139(8):1343-1348.
[27]Wang FA,He SC,Xiao EH,et al.Sequential transarterial embolization followed by percutaneous vertebroplasty is safe and effective in pain management in vertebral metastases.Pain Physician,2016,19(4):E559-E567.
[28]Muto M,Guarnieri G,Giurazza F,et al.What's new in vertebral cementoplasty?Br J Radiol,2016,89(1059):20150337.
[29]Spratt DE,Beeler WH,de Moraes FY,et al.An integrated multidisciplinary algorithm for the management of spinal metastases:An International Spine Oncology Consortium report.Lancet Oncol,2017,18(12):e720-e730.
[30]Itshayek E,Fraifeld S,Vargas AA,et al.Efficacy and safety of vertebral stenting for painful vertebral compression fractures in patients with metastatic disease.Neurol Res,2014,36(12):1086-1093.
[31]Laredo JD,Mosseri J.Percutaneous nailing and cementoplasty for palliative management of supra-acetabular iliac wing metastases:A case report.JBJS Case Connect,2017,7(3):e46.
[32]Deschamps F,Farouil G,Hakime A,et al.Percutaneous stabilization of impending pathological fracture of the proximal femur.Cardiovasc Intervent Radiol,2012,35(6):1428-1432.
[33]Premat K,Claren9on F,Bonaccorsi R,et al.Reinforced cementoplasty using dedicated spindles in the management of unstable malignant lesions of the cervicotrochanteric region.Eur Radiol,2017,27(9):3973-3982.
[34]Pusceddu C,Fancellu A,Ballicu N,et al.CT-guided percutaneous screw fixation plus cementoplasty in the treatment of painful bone metastases with fractures or a high risk of pathological fracture.Skeletal Radiol,2017,46(4):539-545.
[35]Chew C,Craig L,Edwards R,et al.Safety and efficacy of percutaneous vertebroplasty in malignancy:A systematic review.Clin Radiol,2011,66(1):63-72.
[36]Jawad MS,Fahim DK,Gerszten PC,et al.Vertebral compression fractures after stereotactic body radiation therapy:A large,multi-institutional,multinational evaluation.JNeurosurg Spine,2016,24(6):928-936.
[37]Sahgal A,Whyne CM,Ma L,et al.Vertebral compression fracture after stereotactic body radiotherapy for spinal metastases.Lancet Oncol,2013,14(8):e310-e320.
[38]Wang W,Liu Z,Zhu J,et al.Brachytherapy with iodine 125seeds for bone metastases.J Cancer Res Ther,2017,13(5):742-747.
[39]Onen MR,Simsek M,Naderi S.Robotic assisted sacroplasty:A case report.Turk Neurosurg,2014,24(4):574-578.
[40]Barzilay Y,Schroeder JE,Hiller N,et al.Robot-assisted vertebral body augmentation:A radiation reduction tool.Spine(Phila Pa 1976),2014,39(2):153-157.
[41]Kim JA,Yun HS,Choi YA,et al.Magnesium phosphate ceramics incorporating a novel indene compound promote osteoblast differentiation in vitro and bone regeneration in vivo.Biomaterials,2018,157:51-61.
[42]Nabiyouni M,Brückner T,Zhou H,et al.Magnesium-based bioceramics in orthopedic applications.Acta biomaterialia,2018,15(66):23-43.
[43]Lode A,Heiss C,Knapp G,et al.Strontium-modified premixed calcium phosphate cements for the therapy of osteoporotic bone defects.Acta Biomater,2018,65:475-485.
[2]Kam NM,Maingard J,Kok HK,et al.Combined vertebral augmentation and radiofrequency ablation in the management of spinal metastases:An update.Curr Treat Options Oncol,2017,18(12):74.
[3]Galibert P,Deramond H,Rosat P,et al.Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty.Neurochirurgie,1987,33(2):166-168.
[4]Kaemmerlen P,Thiesse P,Bouvard H,et al.Percutaneous vertebroplasty in the treatment of metastases Technic and results.J Radiol,1989,70(10):557-562.
[5]Tai CL,Lai PL,Lin WD,et al.Modification of mechanical properties,polymerization temperature,and handling time of polymethylmethacrylate cement for enhancing applicability in vertebroplasty.Biomed Res Int,2016,2016:7901562.
[6]Tian QH,Sun XQ,Lu YY,et al.Percutaneous vertebroplasty for palliative treatment of painful osteoblastic spinal metastases:A singlecenter experience.J Vasc Interv Radiol,2016,27(9):1420-1424.
[7]Leeson MC.Thermal aspects of the use of polymethylmethacrylate in large metaphyseal defects in bone.Aclinical review and laboratory study.Clin Orthop Relat Res,1993,295:239-245.
[8]Dahl OE,Garvik LJ,Lyberg T.Toxic effects of methylmethacrylate monomer on leukocytes and endothelial cells in vitro.Acta Orthop Scand,1994,65(2):147-153.
[9]Yang HL,Sun ZY,Wu GZ,et al.Do vertebroplasty and kyphoplasty have an antitumoral effect?Med Hypotheses,2011,76(1):145-146.
[10]Roedel B,Claren9on F,Touraine S,et al.Has the percutaneous vertebroplasty a role to prevent progression or local recurrence in spinal metastases of breast cancer?J Neuroradiol,2015,42(4):222-228.
[11]Lai PL,Tai CL,Chen LH,et al.Cement leakage causes potential thermal injury in vertebroplasty.BMC Musculoskelet Disord,2011,5(12):116.
[12]Gangi A,Buy X.Percutaneous bone tumor management.Semin Intervent Radiol,2010,27(2):124-136.
[13]Cruz JP,Sahgal A,Whyne C,et al.Tumor extravasation following a cement augmentation procedure for vertebral compression fracture in metastatic spinal disease.J Neurosurg Spine,2014,21(3):372-377.
[14]Axelsen M,Thomassen LD,Bünger C,et al.Estimating risk of pulmonary neoplastic embolism during vertebroplasty.Spine(Phila Pa 1976),2012,37(7):551-556.
[15]Lea W.Decision making:Osteoplasty,ablation,or combined therapy for spinal metastases.Semin Intervent Radiol,2017,34(2):121-131.
[16]Tsoumakidou G,Too CW,Koch G,et al.CIRSE guidelines on percutaneous vertebral augmentation.Cardiovasc Intervent Radiol,2017,40(3):331-342.
[17]Anchala PR,Irving WD,Hillen TJ,et al.Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device:A multicenter retrospective study.Pain Physician,2014,17(4):317-327.
[18]Laredo JD,Chiras J,Kemel S,et al.Vertebroplasty and interventional radiology procedures for bone metastases.Joint Bone Spine,2018,85(2):191-199.
[19]Trumm CG,Jakobs TF,Stahl R,et al.CT fluoroscopy-guided vertebral augmentation with a radiofrequency-induced,highviscosity bone cement(StabiliT?):Technical results and polymethylmethacrylate leakages in 25patients.Skeletal Radiol,2013,42(1):113-120.
[20]Reyes M,Georgy M,Brook L,et al.Multicenter clinical and imaging evaluation of targeted radiofrequency ablation(t-RFA)and cement augmentation of neoplastic vertebral lesions.JNeurointerv Surg,2018,10(2):176-182.
[21]Bauones S,Garnon J,Chari B,et al.Protection of the proximal articular cartilage during percutaneous thermal ablation of acetabular metastasis using temperature monitoring.Cardiovasc Intervent Radiol,2018,41(1):163-169.
[22]Cazzato RL,Garnon J,Caudrelier J,et al.Percutaneous radiofrequency ablation of painful spinal metastasis:Asystematic literature assessment of analgesia and safety.Int JHyperthermia,2018,34(8):1272-1281.
[23]Schaefer O,Lohrmann C,Markmiller M,et al.Combined treatment of a spinal metastasis with radiofrequency heat ablation and vertebroplasty.Am J Roentgenol,2003,180(4):1075-1077.
[24]Georgy BA,Wong W.Plasma-mediated radiofrequency ablation assisted percutaneous cement injection for treating advanced malignant vertebral compression fractures.AJNR Am JNeuroradiol,2007,28(4):700-705.
[25]Reyad RM,Ghobrial HZ,Hakim SM,et al.Thick cement usage in percutaneous vertebroplasty for malignant vertebral fractures at high risk for cement leakage.Diagn Interv Imaging,2017,98(10):721-728.
[26]Chen Y,Yan Z,Wang J,et al.Transarterial chemoembolization for pain relief in patients with hypervascular painful metastatic spinal tumors refractory to percutaneous vertebroplasty.J Cancer Res Clin Oncol,2013,139(8):1343-1348.
[27]Wang FA,He SC,Xiao EH,et al.Sequential transarterial embolization followed by percutaneous vertebroplasty is safe and effective in pain management in vertebral metastases.Pain Physician,2016,19(4):E559-E567.
[28]Muto M,Guarnieri G,Giurazza F,et al.What's new in vertebral cementoplasty?Br J Radiol,2016,89(1059):20150337.
[29]Spratt DE,Beeler WH,de Moraes FY,et al.An integrated multidisciplinary algorithm for the management of spinal metastases:An International Spine Oncology Consortium report.Lancet Oncol,2017,18(12):e720-e730.
[30]Itshayek E,Fraifeld S,Vargas AA,et al.Efficacy and safety of vertebral stenting for painful vertebral compression fractures in patients with metastatic disease.Neurol Res,2014,36(12):1086-1093.
[31]Laredo JD,Mosseri J.Percutaneous nailing and cementoplasty for palliative management of supra-acetabular iliac wing metastases:A case report.JBJS Case Connect,2017,7(3):e46.
[32]Deschamps F,Farouil G,Hakime A,et al.Percutaneous stabilization of impending pathological fracture of the proximal femur.Cardiovasc Intervent Radiol,2012,35(6):1428-1432.
[33]Premat K,Claren9on F,Bonaccorsi R,et al.Reinforced cementoplasty using dedicated spindles in the management of unstable malignant lesions of the cervicotrochanteric region.Eur Radiol,2017,27(9):3973-3982.
[34]Pusceddu C,Fancellu A,Ballicu N,et al.CT-guided percutaneous screw fixation plus cementoplasty in the treatment of painful bone metastases with fractures or a high risk of pathological fracture.Skeletal Radiol,2017,46(4):539-545.
[35]Chew C,Craig L,Edwards R,et al.Safety and efficacy of percutaneous vertebroplasty in malignancy:A systematic review.Clin Radiol,2011,66(1):63-72.
[36]Jawad MS,Fahim DK,Gerszten PC,et al.Vertebral compression fractures after stereotactic body radiation therapy:A large,multi-institutional,multinational evaluation.JNeurosurg Spine,2016,24(6):928-936.
[37]Sahgal A,Whyne CM,Ma L,et al.Vertebral compression fracture after stereotactic body radiotherapy for spinal metastases.Lancet Oncol,2013,14(8):e310-e320.
[38]Wang W,Liu Z,Zhu J,et al.Brachytherapy with iodine 125seeds for bone metastases.J Cancer Res Ther,2017,13(5):742-747.
[39]Onen MR,Simsek M,Naderi S.Robotic assisted sacroplasty:A case report.Turk Neurosurg,2014,24(4):574-578.
[40]Barzilay Y,Schroeder JE,Hiller N,et al.Robot-assisted vertebral body augmentation:A radiation reduction tool.Spine(Phila Pa 1976),2014,39(2):153-157.
[41]Kim JA,Yun HS,Choi YA,et al.Magnesium phosphate ceramics incorporating a novel indene compound promote osteoblast differentiation in vitro and bone regeneration in vivo.Biomaterials,2018,157:51-61.
[42]Nabiyouni M,Brückner T,Zhou H,et al.Magnesium-based bioceramics in orthopedic applications.Acta biomaterialia,2018,15(66):23-43.
[43]Lode A,Heiss C,Knapp G,et al.Strontium-modified premixed calcium phosphate cements for the therapy of osteoporotic bone defects.Acta Biomater,2018,65:475-485.