艾灸通过调控信号转导通路干预治疗相关疾病的研究进展
|
摘要
查阅近年来国内外相关文献,从艾灸对Toll样受体(TLRs)/核因子κB(NF-κB)信号转导通路的作用、艾灸对RAS-丝裂原活化蛋白激酶(MAPK)信号通路的作用、艾灸对程序性细胞死亡蛋白(PD)-1/PDL1通路的作用、艾灸对RAS/RAF/细胞外调节蛋白激酶(ERK)信号通路的作用、艾灸对雷帕霉素机能视蛋白(m TOR)信号通路的干预、艾灸对应激活化蛋白激酶(JNK)信号通路的干预、艾灸对Rho/Rho激酶(ROCK)信号通路的干预等7个方面概述艾灸通过调控信号转导通路干预治疗的相关疾病,为艾灸治疗相关疾病的进一步研究提供参考。
By consulting the relevant literature in China and abroad,this paper summarizes the intervention treatment of moxibustion on related diseases by regulating signaling transduction pathways in seven aspects as follows: the function of moxibustion on TLRs/NF-κB signaling transduction pathways,on Ras-MAPK signaling pathways,and on the programmed death proteins( PD)-1/PD-L1 pathway; the interference of moxibustion on rapamycin and m TOR signaling pathway,on stress-activated protein kinase( JNK) signaling pathway,and on Rho/ROCK signaling pathway,aiming at providing a reference for an in-depth study of moxibustion in treating related diseases.
By consulting the relevant literature in China and abroad,this paper summarizes the intervention treatment of moxibustion on related diseases by regulating signaling transduction pathways in seven aspects as follows: the function of moxibustion on TLRs/NF-κB signaling transduction pathways,on Ras-MAPK signaling pathways,and on the programmed death proteins( PD)-1/PD-L1 pathway; the interference of moxibustion on rapamycin and m TOR signaling pathway,on stress-activated protein kinase( JNK) signaling pathway,and on Rho/ROCK signaling pathway,aiming at providing a reference for an in-depth study of moxibustion in treating related diseases.
引文
[1]彭芬,易受乡.古代医家对灸法的若干见解[J].针灸临床杂志,2010,26(4):1-3.
[2]吴焕淦,马晓芃,刘慧荣,等.灸法研究的战略思考[J].世界科学技术-中医药现代化,2016,18(3):355-360.
[3]陈薇薇.艾灸减轻产妇分娩疼痛40例临床观察[J].甘肃中医药大学学报,2017,34(2):95-97.
[4]袁娟,胡玲,宋小鸽,等.艾灸对类风湿性关节炎大鼠关节滑膜组织Toll样受体4-骨髓样分化因子88-核转录因子-κB信号通路的影响[J].针刺研究,2015,40(3):199-204.
[5]WANG Z C,LU H,ZHOU Q,et al.MiR-451 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion in rheumatoid arthritis through mediating p38 MAPK signaling pathway[J]. Int J Clin Exp Pathol,2015,8(11):14562-14567.
[6]YAO J,HU L,SONG X,et al. Influence of moxibustion at“Shenshu”(BL23)and“Zusanli”(ST36)on Ras-MAPK signal pathway in synovial tissue of rats with experimental rheumatoid arthritis[J].World Journal of Acupuncture-Moxibustion,2013,23(2):29-33.
[7]Keir M E,Butte M J,Freeman G J,et al. PD-1 and its ligands in tolerance and immunity[J]. Ann Rev Immunol,2008,26(1):677-704.
[8]Patsoukis N,Brown J,Petkova V,et al. Selective effects of PD-1 on Akt and R as pathways regulate molecular components of thecell cycle and inhibit T cell proliferation[J].Sci Signaling,2012,230:1755-1762.
[9]Hodi F S,Day S J,Mcdermott D F,et al.Improved survival with ipilimumab in patients with metastatic melanoma[J].N Eng J Med,2010,363(8):711-723.
[10]吴菲.艾灸调控实验性RA模型T细胞功能的PD-1/PDL1机制研究[D].成都:成都中医药大学,2016.
[11]LIU L,CAO Y,CHEN C,et al. Sorafenib blocks the raf/mek/erk pathway,inhibits tumor angiogenesis,and induces tumor cellapoptosis in hepatocellular carcinoma model PLC/PRF/5[J]. Cancer Res,2006,66(24):11851-11858.
[12]Asati V,Mahapatra D K,Bharti S K.PI3K/Akt/m TOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents:structural and pharmacological perspectives[J].Eur J Med Chem,2016,109:314-341.
[13]刘静,吕娜,李永辉,等.Ras/Raf/MEK/ERK信号通路与白血病[J].中国实验血液学杂志,2017,25(3):947-951.
[14]于杰.基于RAS/RAF/ERK信号通路探讨艾灸促进压疮组织血管新生的分子调控机制研究[D].哈尔滨:黑龙江中医药大学,2017.
[15]欧阳厚淦,赵志东,卢文静,等.热敏灸信号在骨质疏松症大鼠筋膜结缔组织传导途径的研究[J].中国骨质疏松杂志,2013,19(9):919-921.
[16]贺洁宇,刘峰.m TOR信号通路与衰老及衰老相关重大疾病[J].生物化学与生物物理进展,2014,8(3):257-265.
[17]WANG X,CHU Y,WANG W,et al.m TORC signaling in hematopoiesis[J].Int J Hematol,2016,103(5):510-518.
[18]黄畅.基于m TOR信号通路探讨艾灸及艾烟对APP/PS1双转基因小鼠认知障碍的影响及机制研究[D].北京:北京中医药大学,2017.
[19]JI R R,Goreau R W,Mal Cangio M,et al.MAP kinase and pain[J].Brmn Res Rev,2009,60(1):135-148.
[20]高世超,殷海波,刘宏潇,等.MAPK信号通路在骨关节炎发病机制中的研究进展[J].中国骨伤,2014,27(5):441-444.
[21]武永利,马晓秀,刘娣,等.针砂马准灸对兔膝骨关节炎软骨组织中JNK信号通路表达的影响[J].辽宁中医杂志,2017,44(6):1133-1135.
[22]Wittinghofer I A,Vetter I R.Structure-function relationships of the G domain,a canonical switch motif[J]. Annual Review of Biochemistry,2011,80(1):943-971.
[23]Satoh K,Fukumoto Y,Shimokawa H.Rho-kinase:important new therapeutic target in cardiovascular disease[J]. Am J Physiol Heart Circ Physiol,2011,301(2):287-296.
[24]张宏如,管媛媛,陶嘉磊,等.基于Rho/ROCK信号通路的麦粒灸对自发性高血压大鼠主动脉血管内皮功能保护作用机制探讨[J].南京中医药大学学报,2016,32(6):557-560.
[25]赵怡坤,朱田田,赵中亭,等.不同灸法治疗类风湿关节炎临床研究进展[J].甘肃中医药大学学报,2017,34(2):101-104.
[2]吴焕淦,马晓芃,刘慧荣,等.灸法研究的战略思考[J].世界科学技术-中医药现代化,2016,18(3):355-360.
[3]陈薇薇.艾灸减轻产妇分娩疼痛40例临床观察[J].甘肃中医药大学学报,2017,34(2):95-97.
[4]袁娟,胡玲,宋小鸽,等.艾灸对类风湿性关节炎大鼠关节滑膜组织Toll样受体4-骨髓样分化因子88-核转录因子-κB信号通路的影响[J].针刺研究,2015,40(3):199-204.
[5]WANG Z C,LU H,ZHOU Q,et al.MiR-451 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion in rheumatoid arthritis through mediating p38 MAPK signaling pathway[J]. Int J Clin Exp Pathol,2015,8(11):14562-14567.
[6]YAO J,HU L,SONG X,et al. Influence of moxibustion at“Shenshu”(BL23)and“Zusanli”(ST36)on Ras-MAPK signal pathway in synovial tissue of rats with experimental rheumatoid arthritis[J].World Journal of Acupuncture-Moxibustion,2013,23(2):29-33.
[7]Keir M E,Butte M J,Freeman G J,et al. PD-1 and its ligands in tolerance and immunity[J]. Ann Rev Immunol,2008,26(1):677-704.
[8]Patsoukis N,Brown J,Petkova V,et al. Selective effects of PD-1 on Akt and R as pathways regulate molecular components of thecell cycle and inhibit T cell proliferation[J].Sci Signaling,2012,230:1755-1762.
[9]Hodi F S,Day S J,Mcdermott D F,et al.Improved survival with ipilimumab in patients with metastatic melanoma[J].N Eng J Med,2010,363(8):711-723.
[10]吴菲.艾灸调控实验性RA模型T细胞功能的PD-1/PDL1机制研究[D].成都:成都中医药大学,2016.
[11]LIU L,CAO Y,CHEN C,et al. Sorafenib blocks the raf/mek/erk pathway,inhibits tumor angiogenesis,and induces tumor cellapoptosis in hepatocellular carcinoma model PLC/PRF/5[J]. Cancer Res,2006,66(24):11851-11858.
[12]Asati V,Mahapatra D K,Bharti S K.PI3K/Akt/m TOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents:structural and pharmacological perspectives[J].Eur J Med Chem,2016,109:314-341.
[13]刘静,吕娜,李永辉,等.Ras/Raf/MEK/ERK信号通路与白血病[J].中国实验血液学杂志,2017,25(3):947-951.
[14]于杰.基于RAS/RAF/ERK信号通路探讨艾灸促进压疮组织血管新生的分子调控机制研究[D].哈尔滨:黑龙江中医药大学,2017.
[15]欧阳厚淦,赵志东,卢文静,等.热敏灸信号在骨质疏松症大鼠筋膜结缔组织传导途径的研究[J].中国骨质疏松杂志,2013,19(9):919-921.
[16]贺洁宇,刘峰.m TOR信号通路与衰老及衰老相关重大疾病[J].生物化学与生物物理进展,2014,8(3):257-265.
[17]WANG X,CHU Y,WANG W,et al.m TORC signaling in hematopoiesis[J].Int J Hematol,2016,103(5):510-518.
[18]黄畅.基于m TOR信号通路探讨艾灸及艾烟对APP/PS1双转基因小鼠认知障碍的影响及机制研究[D].北京:北京中医药大学,2017.
[19]JI R R,Goreau R W,Mal Cangio M,et al.MAP kinase and pain[J].Brmn Res Rev,2009,60(1):135-148.
[20]高世超,殷海波,刘宏潇,等.MAPK信号通路在骨关节炎发病机制中的研究进展[J].中国骨伤,2014,27(5):441-444.
[21]武永利,马晓秀,刘娣,等.针砂马准灸对兔膝骨关节炎软骨组织中JNK信号通路表达的影响[J].辽宁中医杂志,2017,44(6):1133-1135.
[22]Wittinghofer I A,Vetter I R.Structure-function relationships of the G domain,a canonical switch motif[J]. Annual Review of Biochemistry,2011,80(1):943-971.
[23]Satoh K,Fukumoto Y,Shimokawa H.Rho-kinase:important new therapeutic target in cardiovascular disease[J]. Am J Physiol Heart Circ Physiol,2011,301(2):287-296.
[24]张宏如,管媛媛,陶嘉磊,等.基于Rho/ROCK信号通路的麦粒灸对自发性高血压大鼠主动脉血管内皮功能保护作用机制探讨[J].南京中医药大学学报,2016,32(6):557-560.
[25]赵怡坤,朱田田,赵中亭,等.不同灸法治疗类风湿关节炎临床研究进展[J].甘肃中医药大学学报,2017,34(2):101-104.