Rho/Rho激酶信号通路与缺氧性肺动脉高压
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摘要
本文简要综述了近年来Rho/Rho激酶信号通路的研究进展,对缺氧性肺动脉高压(hypoxia induced pulmonary hypertension,HPH)的发病机制,对发病过程中肺血管收缩(HPV)和肺血管重建(HPSR)进行分析和总结,重点讨论了Rho/Rho激酶信号通路与HPH的关系并进行简要概述。
This paper reviewed the research pathway of Rho/Rho kinase signal in recent years,Analysis and summary the pathogenesis of hypoxia pulmonary hypertension,HPV and HPSR in pathogenesis of HPH,Deeply discussed the relationship between Rho/Rho kinase signal pathway and hypoxic pulmonary hypertension.
This paper reviewed the research pathway of Rho/Rho kinase signal in recent years,Analysis and summary the pathogenesis of hypoxia pulmonary hypertension,HPV and HPSR in pathogenesis of HPH,Deeply discussed the relationship between Rho/Rho kinase signal pathway and hypoxic pulmonary hypertension.
引文
[1]Kimura K,Ito M,Amano M,et al.Regulation of myosinphosphat ase by Rho and Rho-associat ed-kinase[J].Science,1996,273(5272):245-248.
[2]Sakurada S,Okamoto H,Takuwa N,et al.Rho activation in excit at ory agonist-st imulated vascular smooth muscle[J].Am JPhysiol Cell Physiol,2001,281(2):571-578.30-40.
[3]Is hizaki T,Natio M,Fuji sawa K,et al.p160ROCK,a Rhoassociated coiled-coil forming protein kinase,works downst reamof Rhoan dinduces focal adhesions[J].FEBS Lett,1997,404(2-3):118-124
[4]Yamakaw a T,Tanak a S,Numaguchi K,et al.Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascu larsmooth muscle cells[J].Hypert ension,2000,35(1pt2):313-318.
[5]谢楠.牛磺酸对心血管系统保护作用及发生机制研究综述[J].黑龙江医药,2014,27(3):536~538.
[6]Ohuchi N,Koike K,Sano M,et al.Proliferative effects of angiotensin II andendothelin-1 on guinea pig gingival fibroblast cells in culture[J].Comp Biochem Physiol CToxicol Pharmacol,2002,132(4):451-460.
[7]Grisk 2,Schluter T,Reimer N,et al.The Rho kinase inhibitor SAR407899 potently inhibits endothelin-l-induced constriction of renal resistance arteries[J].J Hypertens,2012,30(5):980-989.
[8]Wang HM,Wang Y,Liu M,et al.Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of Rho A-Rho kinase and Akt signalling pathways in rats[J].Can J Physiol Pharmacol,2012,90(11):1506-1515
[9]陈雪彦,刘焕龙,潘振华,苗庆峰等.Rho/Rho激酶通路在5-羟色胺诱导的大鼠肺动脉平滑肌细胞增殖中的作用[J].细胞生物学杂志,2009,38(6):853-858.
[10]Takemoto M,Sun J,Hiroki J,et al.Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase[J].Circulation,2002,106(1):57-62.
[11]Somlyo AP,S om lyo AV.Ca2+s ensitivity of smooth muscle and nonmuscle myosin II:modulated by G proteins,kinases,and myosin phosphatase[J].Phys iol Rev,2003,83(4):1325-1358.
[12]Fagan KA,Oka M,Bau er NR,et al.At tenuation of acute hypoxic pulmonary vasocons triction and hypoxic pulmon ary hypert ension in mice by inhibition of Rho-kinase[J].Am J Physi ol Lung Cell Mol Physiol,2004,287(4):L656-664.
[13]孙兴珍,王大为,李军等.Rock-1基因在缺氧性肺动脉高压大鼠肺组织中的表达及法舒地尔的预防作用[J].南京医科大学学报(自然科学版),2006,26(2):96-100.
[2]Sakurada S,Okamoto H,Takuwa N,et al.Rho activation in excit at ory agonist-st imulated vascular smooth muscle[J].Am JPhysiol Cell Physiol,2001,281(2):571-578.30-40.
[3]Is hizaki T,Natio M,Fuji sawa K,et al.p160ROCK,a Rhoassociated coiled-coil forming protein kinase,works downst reamof Rhoan dinduces focal adhesions[J].FEBS Lett,1997,404(2-3):118-124
[4]Yamakaw a T,Tanak a S,Numaguchi K,et al.Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascu larsmooth muscle cells[J].Hypert ension,2000,35(1pt2):313-318.
[5]谢楠.牛磺酸对心血管系统保护作用及发生机制研究综述[J].黑龙江医药,2014,27(3):536~538.
[6]Ohuchi N,Koike K,Sano M,et al.Proliferative effects of angiotensin II andendothelin-1 on guinea pig gingival fibroblast cells in culture[J].Comp Biochem Physiol CToxicol Pharmacol,2002,132(4):451-460.
[7]Grisk 2,Schluter T,Reimer N,et al.The Rho kinase inhibitor SAR407899 potently inhibits endothelin-l-induced constriction of renal resistance arteries[J].J Hypertens,2012,30(5):980-989.
[8]Wang HM,Wang Y,Liu M,et al.Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of Rho A-Rho kinase and Akt signalling pathways in rats[J].Can J Physiol Pharmacol,2012,90(11):1506-1515
[9]陈雪彦,刘焕龙,潘振华,苗庆峰等.Rho/Rho激酶通路在5-羟色胺诱导的大鼠肺动脉平滑肌细胞增殖中的作用[J].细胞生物学杂志,2009,38(6):853-858.
[10]Takemoto M,Sun J,Hiroki J,et al.Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase[J].Circulation,2002,106(1):57-62.
[11]Somlyo AP,S om lyo AV.Ca2+s ensitivity of smooth muscle and nonmuscle myosin II:modulated by G proteins,kinases,and myosin phosphatase[J].Phys iol Rev,2003,83(4):1325-1358.
[12]Fagan KA,Oka M,Bau er NR,et al.At tenuation of acute hypoxic pulmonary vasocons triction and hypoxic pulmon ary hypert ension in mice by inhibition of Rho-kinase[J].Am J Physi ol Lung Cell Mol Physiol,2004,287(4):L656-664.
[13]孙兴珍,王大为,李军等.Rock-1基因在缺氧性肺动脉高压大鼠肺组织中的表达及法舒地尔的预防作用[J].南京医科大学学报(自然科学版),2006,26(2):96-100.