急性ST段抬高型心肌梗死术前强化他汀治疗的临床疗效观察
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摘要
<正>急性心肌梗死(aircraft myocardial infarction,AMI)是冠状动脉闭塞,血流中断,引起相应的心肌缺血发生缺血性坏死。经皮冠状动脉造影术(percutaneous coronary angiography)是治疗AMI最有效的手段,但心肌再灌注可导致血清炎性因子升高。他汀可通过降低血管炎症反应,改善内皮功能~([1]),从而降低术后不良事件发生率~([2-4])。本研究进一步探
引文
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[2] ZhaoXY, Li L, ZhangJY, et al. Atorvastatin prevents left ventricular remodeling in spontaneously hypertensive rats[J]. Int Heart J, 2010, 51(6):426-431.
[3] Ward S, Lloyd Jones M, Pandor A, et al. A systematic review and economic evaluation of statins for the prevention of coronary events[J]. Health Technol Assess, 2007, 11(14):1-160,iii-iv.
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[5]杨树森,甘润韬,孙延明,等.阿托伐他汀对ST段抬高型急性心肌梗死患者急诊PCI术后无复流现象的影响[J].临床心血管病杂志, 2011,27(1):35-38
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[8]张迎花,华琦,王云飞,等.急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入治疗术后ST段回落不良的相关因素分析[J].中国心血管杂志, 2016,21(5):363-367.
[9]赵秋实,王大杰,孙剑萍,等. ST段抬高指数回落对急性ST段抬高型心肌梗死患者左心室功能的预测价值[J].实用心电学杂志, 2015,24(6):440-442, 445.
[10]Dai J, Lyu SZ, Chen YD, et al. Stenting versus non-stenting treatment of intermediate stenosis culprit lesion in acute STsegment elevation myocardial infarction:a multicenter randomized clinical trial[J]. J GeriatrCardiol, 2017, 14(2):108-117.
[11]WeaverJC, RamsayDD, Rees D, et al. Dynamic changes in ST segment resolution after myocardial infarction and the association with microvascular injury on cardiac magnetic resonance imaging[J]. Heart LungCirc, 2011, 20(2):111-118
[12]KumarS, Sivagangabalan G, HsiehC, et al. Predictive value of ST resolution analysis performed immediately versus at ninety minutes after primary percutaneous coronary intervention[J]. Am J Cardiol, 2010, 105(4):467-474.
[13]Kim JS, Kim J, Choi D, et al. Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction:the STATIN STEMI trial[J]. JACC Cardiovasc Interv, 2010, 3(3):332-339.
[14]Nissen SE, Tuzcu EM, Schoenhagen P, et al. Statin therapy,LDLcholesterol, C-reactive protein, and coronary artery disease[J]. N Engl J Med, 2005, 352(1):29-38.
[15]Baptista SB, Faustino M, Simoes J, et al. Endothelial dysfunction evaluated by peripheral arterial tonometry is related with peak TnIvalues in patients with ST elevation myocardial infarction treated with primary angioplasty[J]. Microvasc Res,2016,105:34-39.
[16]Jugdutt BI, Palaniyappan A, Uwiera RR, et al. Role of healingspecific-matricellular proteins and matrix metalloproteinases in age-related enhanced early remodeling after reperfused STEMI in dogs[J]. Mol Cell Biochem, 2009, 322(1/2):25-36.
[17]WeaverJC, RamsayDD, Rees D, et al. Dynamic changes in ST segment resolution after myocardial infarction and the association with microvascular injury on cardiac magnetic resonance imaging[J]. Heart LungCirc, 2011, 20(2):111-118.
[18]Nakata S, Tsutsui M, Shimokawa H, et al. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway[J]. ArteriosclerThrombVasc Biol,2007, 27(1):92-98.
[19]闫洪娟,谢悦陶,刘光,等.瑞舒伐他汀对自发性高血压大鼠心肌组织SOD、MDA、NO、ET的影响[J].大连医科大学学报, 2015, 37(3):232-236.
[20]闫洪娟,谢悦陶,刘光,等.自发性高血压大鼠血液中SOD、MDA、NO、ET的变化及瑞舒伐他汀干预的影响[J].现代中西医结合杂志, 2015, 24(16):1727-1730.
[2] ZhaoXY, Li L, ZhangJY, et al. Atorvastatin prevents left ventricular remodeling in spontaneously hypertensive rats[J]. Int Heart J, 2010, 51(6):426-431.
[3] Ward S, Lloyd Jones M, Pandor A, et al. A systematic review and economic evaluation of statins for the prevention of coronary events[J]. Health Technol Assess, 2007, 11(14):1-160,iii-iv.
[4] TopolEJ. Intensive statin therapy——a sea change in cardiovascular prevention[J]. N Engl J Med, 2004, 350(15):1562-1564.
[5]杨树森,甘润韬,孙延明,等.阿托伐他汀对ST段抬高型急性心肌梗死患者急诊PCI术后无复流现象的影响[J].临床心血管病杂志, 2011,27(1):35-38
[6] Wilcox LJ, Barrett PH, Huff M W. Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMGCoA reductase inhibitors, atorvastatin and simvastatin[J].Journal of Lipid Research, 1999, 40(6):1078-89.
[7] Walter DH, Dimmeler S, Zeiher AM. Effects of statins on endothelium and endothelial progenitor cell recruitment[J].SeminVasc Med, 2004, 4(4):385-393.
[8]张迎花,华琦,王云飞,等.急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入治疗术后ST段回落不良的相关因素分析[J].中国心血管杂志, 2016,21(5):363-367.
[9]赵秋实,王大杰,孙剑萍,等. ST段抬高指数回落对急性ST段抬高型心肌梗死患者左心室功能的预测价值[J].实用心电学杂志, 2015,24(6):440-442, 445.
[10]Dai J, Lyu SZ, Chen YD, et al. Stenting versus non-stenting treatment of intermediate stenosis culprit lesion in acute STsegment elevation myocardial infarction:a multicenter randomized clinical trial[J]. J GeriatrCardiol, 2017, 14(2):108-117.
[11]WeaverJC, RamsayDD, Rees D, et al. Dynamic changes in ST segment resolution after myocardial infarction and the association with microvascular injury on cardiac magnetic resonance imaging[J]. Heart LungCirc, 2011, 20(2):111-118
[12]KumarS, Sivagangabalan G, HsiehC, et al. Predictive value of ST resolution analysis performed immediately versus at ninety minutes after primary percutaneous coronary intervention[J]. Am J Cardiol, 2010, 105(4):467-474.
[13]Kim JS, Kim J, Choi D, et al. Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction:the STATIN STEMI trial[J]. JACC Cardiovasc Interv, 2010, 3(3):332-339.
[14]Nissen SE, Tuzcu EM, Schoenhagen P, et al. Statin therapy,LDLcholesterol, C-reactive protein, and coronary artery disease[J]. N Engl J Med, 2005, 352(1):29-38.
[15]Baptista SB, Faustino M, Simoes J, et al. Endothelial dysfunction evaluated by peripheral arterial tonometry is related with peak TnIvalues in patients with ST elevation myocardial infarction treated with primary angioplasty[J]. Microvasc Res,2016,105:34-39.
[16]Jugdutt BI, Palaniyappan A, Uwiera RR, et al. Role of healingspecific-matricellular proteins and matrix metalloproteinases in age-related enhanced early remodeling after reperfused STEMI in dogs[J]. Mol Cell Biochem, 2009, 322(1/2):25-36.
[17]WeaverJC, RamsayDD, Rees D, et al. Dynamic changes in ST segment resolution after myocardial infarction and the association with microvascular injury on cardiac magnetic resonance imaging[J]. Heart LungCirc, 2011, 20(2):111-118.
[18]Nakata S, Tsutsui M, Shimokawa H, et al. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway[J]. ArteriosclerThrombVasc Biol,2007, 27(1):92-98.
[19]闫洪娟,谢悦陶,刘光,等.瑞舒伐他汀对自发性高血压大鼠心肌组织SOD、MDA、NO、ET的影响[J].大连医科大学学报, 2015, 37(3):232-236.
[20]闫洪娟,谢悦陶,刘光,等.自发性高血压大鼠血液中SOD、MDA、NO、ET的变化及瑞舒伐他汀干预的影响[J].现代中西医结合杂志, 2015, 24(16):1727-1730.