贻贝提取物护理软膏治疗面部敏感性皮肤疗效观察
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摘要
目的:评价贻贝提取物护理软膏治疗面部敏感性皮肤的临床疗效及耐受性。方法:对38例面部敏感性皮肤就医者进行观察,每日外用贻贝提取物护理软膏2次,连续外用1周。采用包含5项主观症状(刺痛、烧灼感、紧绷感、瘙痒、潮红)及5项客观体征(红肿、脱屑、水肿/肿胀、渗液、结痂)的敏感指数评估标尺,对皮肤严重程度及临床疗效进行评估。应用VISIA图像分析系统记录面部皮肤治疗前及治疗后红斑项的绝对分值。治疗结束后评估就医者对贻贝提取物护理软膏的耐受性。结果:使用1周后,10项评价敏感皮肤严重程度的指标与治疗前比较均明显改善,差异有统计学意义(P<0.001);98%的就医者对产品耐受性良好。结论:贻贝提取物护理软膏治疗面部敏感性皮肤安全、有效,耐受性良好。
Objective To evaluatethe clinical efficacy and tolerance of mussel adhesive protein extractive ointment in patients with facial sensitive skin. Methods Total 38 cases of facial sensitive skin, were enrolled and observed. For all the patients,mussel adhesive protein extractive ointment was applied twice daily for 1 weeks, and a new scale, which including 5 subjective skin conditions and 5 visible skin conditions was adopted for sensitive skin assessment. The images were collected and analyzed by VISIA. The tolerance of patients to mussel adhesive protein extractive ointment was evaluated after treatment. Results One weeks after the treatment, all the 10 sensitive scale items was significantly improved(P<0.001). The erythema of the facial skin was significantly improved(P<0.01) as shown by VISIA image analysis. The tolerance was judged to be very good for the large majority of the patients. Conclusion Great efficacy and tolerance can be obtained in the treatment of facial sensitive skin by using this mussel adhesive protein extractive ointment.
Objective To evaluatethe clinical efficacy and tolerance of mussel adhesive protein extractive ointment in patients with facial sensitive skin. Methods Total 38 cases of facial sensitive skin, were enrolled and observed. For all the patients,mussel adhesive protein extractive ointment was applied twice daily for 1 weeks, and a new scale, which including 5 subjective skin conditions and 5 visible skin conditions was adopted for sensitive skin assessment. The images were collected and analyzed by VISIA. The tolerance of patients to mussel adhesive protein extractive ointment was evaluated after treatment. Results One weeks after the treatment, all the 10 sensitive scale items was significantly improved(P<0.001). The erythema of the facial skin was significantly improved(P<0.01) as shown by VISIA image analysis. The tolerance was judged to be very good for the large majority of the patients. Conclusion Great efficacy and tolerance can be obtained in the treatment of facial sensitive skin by using this mussel adhesive protein extractive ointment.
引文
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[11]黄海峰,毕鸣晔,胡君,等.贻贝粘蛋白的生物特性及在皮肤色素痣CO2激光术后创面的临床应用[J].中华损伤与修复杂志(电子版),2016,11(1):49-52.
[12]费烨,王韵,沈征宇,等.贻贝粘蛋白在微等离子体治疗痤疮凹陷性瘢痕后的应用[J].临床皮肤科杂志,2015,44(1):40-42.
[2]何黎,郑捷,马慧群,等.中国敏感性皮肤诊治专家共识[J].中国皮肤性病学杂志,2017,31(1):10-13.
[3]高敏,张长虹,周俊,等.贻贝粘蛋白综述[J].安徽农业科学,2011,39(32):19860-19862.
[4]李梅.“贻贝粘蛋白”推动生物科技美容进步[J].黄金时代,2017,37(1):66-67.
[5]李芸,孙秋宁,杨蓉娅,等.舒缓特护面霜辅助治疗862例面部敏感性皮肤就医者疗效观察[J].实用皮肤病学杂志,2015,8(2):85-88.
[6]廖勇,杨蓉娅(主译).敏感性皮肤综合征[M].2版.北京:北京大学医学出版社,2019:3.
[7]栾梅,戴茹,范林明,等.敏感性皮肤问卷的编制及其与鲍曼敏感性皮肤问卷的信度和效度比较[J].中国皮肤性病学杂志,2018,32(1):80-83.
[8]Sookhai S,Wang JH,Winter D,et al.Dopamine attenuates the chemoattractant effect of interleukin-8:a novel role in the systemic inflammatory response syndrome[J].Shock,2000,14(3):295-299.
[9]Yan Y,Jiang W,Liu L,et al.Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome[J].Cell,2015,160(1-2):62-73.
[10]谢晓繁,陈宇飞.贻贝粘蛋白治疗烧伤后瘙痒的临床效果[J].中国医药,2016,11(2):267-270.
[11]黄海峰,毕鸣晔,胡君,等.贻贝粘蛋白的生物特性及在皮肤色素痣CO2激光术后创面的临床应用[J].中华损伤与修复杂志(电子版),2016,11(1):49-52.
[12]费烨,王韵,沈征宇,等.贻贝粘蛋白在微等离子体治疗痤疮凹陷性瘢痕后的应用[J].临床皮肤科杂志,2015,44(1):40-42.