有核梭状杆菌与结直肠癌发病关系研究进展
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摘要
结直肠癌(CRC)是人体最常见恶性肿瘤之一,早期诊断和早期治疗是提高肿瘤患者生存率的重点和难点。有核梭状杆菌(FN)是寄生于人体口腔的主要厌氧致病菌,与多种牙周疾病和其他疾病发生高度相关。近年来,对FN和CRC发生之间的关系和FN导致CRC的机制研究是国内外肿瘤学研究热点之一,同时也取得了一定的进展。笔者就FN导致CRC发生的相关性研究的最新进展进行综述。
Colorectal cancer(CRC)is one of the most common human malignant tumor, and the earlier diagnosis and treatment of CRC is critical and also difficult to increase survival rate of CRC patients. Fusobacterium nucleatum(FN)is the major anaerobic pathogens parasitizing human oral cavity, and it may causes various kinds of periodontal diseases and other diseases. In recent years, the research on the relationship between FN and CRC occurrence and the mechanism of FN leading to CRC is one of the hotspots in oncology research at home and abroad, in which certain progresses have already been made. Here, we review the latest correlated research progress between FN resulting and CRC.
Colorectal cancer(CRC)is one of the most common human malignant tumor, and the earlier diagnosis and treatment of CRC is critical and also difficult to increase survival rate of CRC patients. Fusobacterium nucleatum(FN)is the major anaerobic pathogens parasitizing human oral cavity, and it may causes various kinds of periodontal diseases and other diseases. In recent years, the research on the relationship between FN and CRC occurrence and the mechanism of FN leading to CRC is one of the hotspots in oncology research at home and abroad, in which certain progresses have already been made. Here, we review the latest correlated research progress between FN resulting and CRC.
引文
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[12] TAHARA T,YAMAMOTO E,SUZUKI H,et al.fusobacterium in colonic flora and molecular features of colorectal carcinoma[J].Cancer Res,2014,74,1311-1318.
[13] HUANG S,YANG Z,ZOU D,et al.Rapid detection of nusG and fadA in Fusobacterium nucleatum by loop-mediated isothermal amplification.[J] J Med Microbiol,2016,65:760-769.
[14] COPPENHAGEN-GLAZER S,SOL A,ABED J,et al.Fap2 of Fusobacterium nucleatum is a galactose-inhibitable adhesin involved in coaggregation,cell adhesion,and preterm birth[J].Infect Immun,2015,83:1104-1113.
[15] ABED J,EMGARD J E,ZAMIR G,et al.Fap2 mediates fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed gal-GalNAc[J].Cell Host Microbe,2016,20:215-225.
[16] CHEN Y,PENG Y,YU J,et al.Invasive fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade[J].Oncotarget,2017,8:31802-31814.
[17] MIMA K,CAO Y,CHAN A T,et al.Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location[J].Clin Transl Gastroenterol,2016,7:e200.
[18] YE X,WANG R,BHATTAHARYA R,et al.Fusobacterium nucleatum subspecies snimalis influences proinflammatory cytokine expression and monocyte activation in human colorectal tumors[J].Cancer Prev Res(Phila),2017,10:398-409.
[19] O’KEEFE S J,LI J V,LAHTI L,et al.Fat,fibre and cancer risk in african americans and rural africans[J].Nature Communication,2015,28:6342-6364.
[20] MEHTA R S,NISHIHARA R,CAO Y,et al.Association of dietary patterns with risk of colorectal cancer subtypes classified by fusobacterium nucleatum in Tumor Tissue[J].JAMA oncology,2017,3:921-927.
[21] AMBALAM P,RAMAN M,PURAMA R K,et al.Probiotics and colorectal cancerprevention[J].Best Pract Res Clin Gastroenterol,2016,30:119-131.
[22] MEHTA R S,NISHIHARA R,CAO Y,et al.Association of dietary pattern with risk of colorectal cancer subtypes classified by fosobacterium nucleatum in tumor tissue[J].JAMA Oncol,2017,3:921-927.
[2] 杜灵彬李辉章王悠清,等.2013年中国结直肠癌发病和死亡分析[J].中华肿瘤杂志,2017(9):701-706.
[3] 中华医学会消化内镜学分会,中国抗癌协会肿瘤内镜学专业委员会.中国早期结直肠癌筛查及内镜诊治指南(2014年)[J].胃肠病学,2015,32(6):345-365.
[4] SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2018[J].CA Cancer J Clin,2016,66(1):7-30.
[5] YAMAMURA K,BAB Y,MIYAKE K,et al.Fusobacterium nucleatum in gastroenterological cancer:Evaluation of measurement methods using quantitative polymerase chain reaction and a literature review[J].Onco Lett,2017,14(6):6373-6378.
[6] 张静,鲁晓岚,赵刚,等.肠毒素肠毒素脆弱拟杆菌具核梭杆菌和幽门螺旋杆菌在肠道内富集度与结直肠癌的关系[J].中华肿瘤杂志,2018,40(2):99-104.
[7] YU T,GUO F,YU Y,et al.Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy[J].Cell,2017,170(3):548-563.
[8] HANY W.Fusobacterium nucleatum:a commensal-turnedpathogen[J].CurrOpinMicrobiol,2015,23:141-147.
[9] FLYNN K J,BAXTER N T,SCHLOSS P D.Metabolic and community synergy of oral bacteria in colorectal cancer[J].mSphere,2016 1(3):e00102.
[10] ABED J,EMGARD J E,ZAMIR G,et al.Fap2 mediates fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed gal-GalNAc[J].Cell Host Microbe,2016,20(2):215.
[11] LI Y Y,GE Q X,CAO J,et al.Association of fusobacterium nucleatum infection with colorectal cancer in chinese patients[J].World J Gasteroenterol,2016,22:3227-3233.
[12] TAHARA T,YAMAMOTO E,SUZUKI H,et al.fusobacterium in colonic flora and molecular features of colorectal carcinoma[J].Cancer Res,2014,74,1311-1318.
[13] HUANG S,YANG Z,ZOU D,et al.Rapid detection of nusG and fadA in Fusobacterium nucleatum by loop-mediated isothermal amplification.[J] J Med Microbiol,2016,65:760-769.
[14] COPPENHAGEN-GLAZER S,SOL A,ABED J,et al.Fap2 of Fusobacterium nucleatum is a galactose-inhibitable adhesin involved in coaggregation,cell adhesion,and preterm birth[J].Infect Immun,2015,83:1104-1113.
[15] ABED J,EMGARD J E,ZAMIR G,et al.Fap2 mediates fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed gal-GalNAc[J].Cell Host Microbe,2016,20:215-225.
[16] CHEN Y,PENG Y,YU J,et al.Invasive fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade[J].Oncotarget,2017,8:31802-31814.
[17] MIMA K,CAO Y,CHAN A T,et al.Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location[J].Clin Transl Gastroenterol,2016,7:e200.
[18] YE X,WANG R,BHATTAHARYA R,et al.Fusobacterium nucleatum subspecies snimalis influences proinflammatory cytokine expression and monocyte activation in human colorectal tumors[J].Cancer Prev Res(Phila),2017,10:398-409.
[19] O’KEEFE S J,LI J V,LAHTI L,et al.Fat,fibre and cancer risk in african americans and rural africans[J].Nature Communication,2015,28:6342-6364.
[20] MEHTA R S,NISHIHARA R,CAO Y,et al.Association of dietary patterns with risk of colorectal cancer subtypes classified by fusobacterium nucleatum in Tumor Tissue[J].JAMA oncology,2017,3:921-927.
[21] AMBALAM P,RAMAN M,PURAMA R K,et al.Probiotics and colorectal cancerprevention[J].Best Pract Res Clin Gastroenterol,2016,30:119-131.
[22] MEHTA R S,NISHIHARA R,CAO Y,et al.Association of dietary pattern with risk of colorectal cancer subtypes classified by fosobacterium nucleatum in tumor tissue[J].JAMA Oncol,2017,3:921-927.