钛表面二氧化钛纳米管/微米坑复合结构的制备及亲水性
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摘要
为改善钛的生物相容性,促进成骨细胞在其表面的附着与分化,设计了一种新型工艺。通过微弧氧化后酸洗的技术在钛表面制备微米级凹坑(10～20μm)。通过阳极氧化技术在上述微米级凹坑上制备定向生长的二氧化钛纳米管(70～80 nm)。采用微弧氧化、酸洗和阳极氧化复合工艺,制备出二氧化钛纳米管/微米坑复合结构。研究了使用不同电解液制备的微弧氧化涂层所获得复合结构的形貌,分析了复合结构形貌对亲水性的影响。结果表明,采用Na_2B_4O_7电解液制备的微弧氧化涂层所获得的复合结构具有显著的微纳米分级结构特征,并展现出优异的亲水性。
A novel process was proposed to improve the biocompatibility of titanium and promote the adhesion and differentiation of osteoblasts on its surface. Firstly, the micro-arc oxidation(MAO), followed by the acid-washing, was adopted to prepare micron-scale pits(10-20 μm) on the surface of titanium, then the sample was anodized to prepare TiO_2 nanotube arrays(70-80 nm) on the micron-scale pits described above. The composite structures using MAO treated samples prepared in different electrolytes were studied. The influence of the composite structure on the surface hydrophilicity was investigated. The results suggest that the sample surface, during the preparation of which Na_2B_4O_7 was adopted as the MAO electrolyte, had a micro/nano hierarchical structure and showed excellent hydrophilicity.
A novel process was proposed to improve the biocompatibility of titanium and promote the adhesion and differentiation of osteoblasts on its surface. Firstly, the micro-arc oxidation(MAO), followed by the acid-washing, was adopted to prepare micron-scale pits(10-20 μm) on the surface of titanium, then the sample was anodized to prepare TiO_2 nanotube arrays(70-80 nm) on the micron-scale pits described above. The composite structures using MAO treated samples prepared in different electrolytes were studied. The influence of the composite structure on the surface hydrophilicity was investigated. The results suggest that the sample surface, during the preparation of which Na_2B_4O_7 was adopted as the MAO electrolyte, had a micro/nano hierarchical structure and showed excellent hydrophilicity.
引文
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[4] Park J,Bauer S,Von D M K,et al.Nanosize and vitality:TiO2 nanotube diameter directs cell fate [J].Nano Letters,2007,7 (6):1686-1691.
[5] Brammer K S,Oh S,Cobb C J,et al.Improved bone-forming functionality on diameter-controlled TiO2 nanotube surface [J].Acta Biomaterialia,2009,5(8):3215-3223.
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[8] Hoyer P.Formation of a titanium dioxide nanotube array [J].Langmuir,1996,12 (6):1411-1413.
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[10] Gong D,Grimes C A,Varghese O K,et al.Titanium oxide nanotube arrays prepared by anodic oxidation [J].Journal of Materials Research,2001,16(12):3331-3334.
[11] Xiang L,Li C,Yang P,et al.Fabrication of micro-patterned titanium dioxide nanotubes thin film and its biocompatibility [J].The Journal of Engineering,2014,2014(12):665-671.
[12] Dikici T,Demirci S,Erol M.Enhanced photocatalytic activity of micro/nano textured TiO2 surfaces prepared by sandblasting/acid-etching/anodizing process [J].Journal of Alloys and Compounds,2017,694:246-252.
[13] Han C M,Kim H E,Koh Y H.Creation of hierarchical micro/nano-porous TiO2,surface layer onto Ti implants for improved biocompatibility [J].Surface & Coatings Technology,2014,251 (8):226-231.
[14] Li Y,Wang W,Liu H,et al.Formation and in vitro/in vivo performance of “cortex-like” micro/nano-structured TiO2 coatings on titanium by micro-arc oxidation [J].Materials Science and Engineering:C,2018,87:90-103.
[15] Ercan B,Taylor E,Alpaslan E,et al.Diameter of titanium nanotubes influences anti-bacterial efficacy [J].Nanotechnology,2011,22 (29):295102.
[16] Li H,Cui Q,Feng B,et al.Antibacterial activity of TiO2 nanotubes:influence of crystal phase,morphology and Ag deposition [J].Applied Surface Science,2013,284:179-183.