乔松素临床应用和作用机制的研究进展
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摘要
乔松素是一种天然的黄酮类化合物,在蜂胶、姜科植物、牛至属植物等植物中有较高的含量。在临床前期研究中,乔松素表现出良好的抗炎、抗肿瘤、抗氧化、降低血脂和神经保护作用等。近年来国内外对乔松素神经保护方面的研究发现,其可以通过减少活性氧产生、保护血脑屏障完整性、调节线粒体功能和调控细胞凋亡等发挥作用。该文对乔松素的药物代谢动力学和潜在的治疗应用及其作用机制等方面进行综述,为乔松素的后续研究提供参考。
Pinocembrin is a natural flavonoid compound extracted from propolis,ginger plants,wild marjoram,and other plants which have a higher content. In the preclinical studies,it has shown anti-inflammatory,anti-tumor,antioxidant,decrease blood lipids,neuroprotective effects and other pharmacological effects. In recent domestic and foreign studies focused on pinocembrin neuroprotective effects as well as the ability to attenuate reactive oxygen species,protect the blood-brain barrier,modulate mitochondrial function,and regulate apoptosis. Pinocembrin is a potential drug to treat ischemic stroke and other clinical conditions. In this review,we summarize its pharmacokinetics,mechanisms of action and potential therapeutic applications,in order to provide a reference for pinocembrin mechanisms research and therapeutic applications.
Pinocembrin is a natural flavonoid compound extracted from propolis,ginger plants,wild marjoram,and other plants which have a higher content. In the preclinical studies,it has shown anti-inflammatory,anti-tumor,antioxidant,decrease blood lipids,neuroprotective effects and other pharmacological effects. In recent domestic and foreign studies focused on pinocembrin neuroprotective effects as well as the ability to attenuate reactive oxygen species,protect the blood-brain barrier,modulate mitochondrial function,and regulate apoptosis. Pinocembrin is a potential drug to treat ischemic stroke and other clinical conditions. In this review,we summarize its pharmacokinetics,mechanisms of action and potential therapeutic applications,in order to provide a reference for pinocembrin mechanisms research and therapeutic applications.
引文
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[23]Liu R,Gao M,Yang Z H,et al.Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemiareperfusion both in vivo and in vitro[J].Brain Res,2008,1216:104-115.
[24]Gao Mei,Zhu Shen-yin,Tan Chu-bing,et al.Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats[J].J Asian Nat Prod Res,2010,12(5):407-418.
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[26]Wang Shou-bao,P a n g Xiao-bin,Gao Mei,e t a l.Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids[J].Chin J Nat Med,2013,11(3):207-213.
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[32]Priyanka Sura,Radhakrishna Sura,Ahmed E Enayetallah,et al.Distribution and expression of soluble epoxide hydrolase in human brain[J].J Histochem Cytochem,2008,56(6):551-559.
[33]Sari A Jouihan,Kristen L Zuloaga,Zhang Wen-ri,et al.Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus[J].JCereb Blood Flow Metab,2013,33(10):1650-1656.
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[35]Zhang Wen-ri,Takashi Otsuka,Nobuo Sugo,et al.Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia[J].Stroke,2008,39(7):2073-2078.
[36]Jafar Sadik Shaik,Muzamil Ahmad,Li Wen-jin,et al.Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke[J].Am JPhysiol Heart Circ Physiol,2013,305(11):H1605-H1613.
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[38]Wu Cai-xia,Liu Rui,Gao Mei,et al.Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis[J].Neurosci Lett,2013,546:57-62.
[39]Meng Fan-rui,Liu Rui,Gao Mei,et al.Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats[J].Brain Res,2011,1391:93-101.
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