原发性卵巢恶性黑色素瘤合并成熟性畸胎瘤一例并文献复习
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摘要
原发性卵巢恶性黑色素瘤临床罕见,恶性程度高、预后差。本文回顾性分析了1例原发性卵巢恶性黑色素瘤合并成熟性畸胎瘤病例,患者表现为腹胀,盆腔核磁示盆腔内可见巨大囊实性肿块,盆腹腔大量积液。给予手术处理,病理证实为原发性卵巢恶性黑色素瘤伴成熟性畸胎瘤,随访4个月,患者因多器官功能衰竭死亡。同时复习了该病相关文献资料,以提高对本病的认识。
Primary malignant melanoma of ovary is rare clinically, with high malignancy and poor prognosis. This article retrospectively analyzed a case of primary ovarian malignant melanoma with mature teratoma. The patient showed abdominal distension, and the pelvic magnetic resonance imaging showed a large cystic solid mass in the pelvic cavity, and a large amount of fluid in the pelvic and abdominal cavity. Surgical treatment was given. Histopathological result was confirmed as primary ovarian malignant melanoma with mature teratoma. The patient died of multiple orgon failure after 4 months of followed-up. This paper reviewed the relevant literature to improve the understanding of the disease.
Primary malignant melanoma of ovary is rare clinically, with high malignancy and poor prognosis. This article retrospectively analyzed a case of primary ovarian malignant melanoma with mature teratoma. The patient showed abdominal distension, and the pelvic magnetic resonance imaging showed a large cystic solid mass in the pelvic cavity, and a large amount of fluid in the pelvic and abdominal cavity. Surgical treatment was given. Histopathological result was confirmed as primary ovarian malignant melanoma with mature teratoma. The patient died of multiple orgon failure after 4 months of followed-up. This paper reviewed the relevant literature to improve the understanding of the disease.
引文
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[2]孙亮,王巍,徐炼.卵巢成熟性囊性畸胎瘤恶变为恶性黑色素瘤并复发1例[J].诊断病理学杂志,2018,25(7):543-544,封3.Sun L,Wang W,Xu L.One case of ovarian mature cystic teratoma progresses to malignant melanoma with recurrence[J].J Diag Pathol,2018,25(7):543-544,Seal 3.doi:10.3969/j.issn.1007-8096.2018.07.019.
[3]Yano M,Asami Y,Nishikawa T,et al.Immune checkpoint inhibitors of CTLA4 and PD-1 for malignant melanoma arising in ovarian cystic teratoma:A case report[J].Medicine(Baltimore),2018,97(43):e12937.doi:10.1097/MD.0000000000012937.
[4]赵焕芬,李冰洁,郑国娜,等.原发于卵巢囊性成熟型畸胎瘤的恶性黑色素瘤1例报道并文献复习[J].现代妇产科进展,2018,27(7):558-559.Zhao HF,Li BJ,Zheng GN,et al.Malignant melanoma originating from ovarian cystic mature teratoma:a case report and literature review[J].Prog Obstet Gynecol,2018,27(7):558-559.doi:10.13283/j.cnki.xdfckjz.2018.07.022.
[5]Lee SH,Lee KB,Shin JW,et al.Ovarian malignant melanoma without evidence of teratoma[J].J Obstet Gynaecol Res,2010,36(4):898-901.doi:10.1111/j.1447-0756.2010.01233.x.
[6]Brudie LA,Khan F,Radi MJ,et al.Malignant melanoma arising in a mature teratoma:A case report with review of the recent literature[J].Gynecol Oncol Rep,2016,16:47-50.doi:10.1016/j.gore.2016.04.005.
[7]Cronje HS,Woodruff JD.Primary ovarian malignant melanoma arising in cystic teratoma[J].Gynecol Oncol,1981,12(3):379-383.
[8]Shen X,Fan Y,Cao S.Primary malignant melanoma arising in an ovarian cystic teratoma[J].Melanoma Research,2017,27(6):601-606.doi:10.1097/CMR.0000000000000402.
[9]Ueng SH,Pinto MM,Alvarado-Cabrero I,et al.Ovarian malignant melanoma:a clinicopathologic study of 5 cases[J].Int J Surg Pathol,2010,18(3):184-192.doi:10.1177/1066896908320834.
[10]Feldman DR.State-of-the-art management of germ cell tumors[J].Am Soc Clin Oncol Educ Book,2018(38):319-323.doi:10.1200/EDBK_201139.
[11]Kudva R,Ayachit GS,Ayachit A.Malignant melanoma arising in an ovarian mature cystic teratoma-a rare entity[J].J Clin Diagn Res,2015,9(4):D14-D16.doi:10.7860/JCDR/2015/12457.5817.
[12]Genc M,Sivrikoz O,Genc B,et al.Synchronous primary endometrial carcinoma and metastatic malignant melanoma in an ovarian cystic teratoma[J].Turk Patoloji Derg,2015,31(3):215-218.doi:10.5146/tjpath.2013.01215.2019-01-172019-03-04
[2]孙亮,王巍,徐炼.卵巢成熟性囊性畸胎瘤恶变为恶性黑色素瘤并复发1例[J].诊断病理学杂志,2018,25(7):543-544,封3.Sun L,Wang W,Xu L.One case of ovarian mature cystic teratoma progresses to malignant melanoma with recurrence[J].J Diag Pathol,2018,25(7):543-544,Seal 3.doi:10.3969/j.issn.1007-8096.2018.07.019.
[3]Yano M,Asami Y,Nishikawa T,et al.Immune checkpoint inhibitors of CTLA4 and PD-1 for malignant melanoma arising in ovarian cystic teratoma:A case report[J].Medicine(Baltimore),2018,97(43):e12937.doi:10.1097/MD.0000000000012937.
[4]赵焕芬,李冰洁,郑国娜,等.原发于卵巢囊性成熟型畸胎瘤的恶性黑色素瘤1例报道并文献复习[J].现代妇产科进展,2018,27(7):558-559.Zhao HF,Li BJ,Zheng GN,et al.Malignant melanoma originating from ovarian cystic mature teratoma:a case report and literature review[J].Prog Obstet Gynecol,2018,27(7):558-559.doi:10.13283/j.cnki.xdfckjz.2018.07.022.
[5]Lee SH,Lee KB,Shin JW,et al.Ovarian malignant melanoma without evidence of teratoma[J].J Obstet Gynaecol Res,2010,36(4):898-901.doi:10.1111/j.1447-0756.2010.01233.x.
[6]Brudie LA,Khan F,Radi MJ,et al.Malignant melanoma arising in a mature teratoma:A case report with review of the recent literature[J].Gynecol Oncol Rep,2016,16:47-50.doi:10.1016/j.gore.2016.04.005.
[7]Cronje HS,Woodruff JD.Primary ovarian malignant melanoma arising in cystic teratoma[J].Gynecol Oncol,1981,12(3):379-383.
[8]Shen X,Fan Y,Cao S.Primary malignant melanoma arising in an ovarian cystic teratoma[J].Melanoma Research,2017,27(6):601-606.doi:10.1097/CMR.0000000000000402.
[9]Ueng SH,Pinto MM,Alvarado-Cabrero I,et al.Ovarian malignant melanoma:a clinicopathologic study of 5 cases[J].Int J Surg Pathol,2010,18(3):184-192.doi:10.1177/1066896908320834.
[10]Feldman DR.State-of-the-art management of germ cell tumors[J].Am Soc Clin Oncol Educ Book,2018(38):319-323.doi:10.1200/EDBK_201139.
[11]Kudva R,Ayachit GS,Ayachit A.Malignant melanoma arising in an ovarian mature cystic teratoma-a rare entity[J].J Clin Diagn Res,2015,9(4):D14-D16.doi:10.7860/JCDR/2015/12457.5817.
[12]Genc M,Sivrikoz O,Genc B,et al.Synchronous primary endometrial carcinoma and metastatic malignant melanoma in an ovarian cystic teratoma[J].Turk Patoloji Derg,2015,31(3):215-218.doi:10.5146/tjpath.2013.01215.2019-01-172019-03-04