高度远视性弱视患者弱视治疗对视网膜神经纤维层厚度的影响
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摘要
目的探讨高度远视性弱视治疗前后视网膜神经纤维层厚度的变化。方法对68例(136眼)高度远视性弱视患者行常规弱视治疗,采用相干光断层扫描(OCT)成像仪于治疗前与治疗后3、6、12、24个月对视盘周围视网膜神经纤维层和黄斑中心凹视网膜进行扫描,比较治疗前后视盘周围视网膜神经纤维层厚度和黄斑中心凹视网膜厚度的变化。结果 68例(136眼)高度远视性弱视患者视盘周围视网膜神经纤维层厚度治疗后3、6、12、24个月均较治疗前减少,其中治疗后3、6、12个月与治疗前相比差异均无统计学意义(P>0.01),治疗后24个月与治疗前相比差异有统计学意义(P<0.01);黄斑中心凹视网膜厚度治疗后3、6、12、24个月均较治疗前减少,其中治疗后3个月与治疗前相比差异无统计学意义(P>0.01),治疗后6、12、24个月与治疗前相比差异有统计学意义(P<0.01)。结论高度远视性弱视患者通过弱视治疗后,视盘周围视网膜神经纤维层和黄斑中心凹视网膜厚度均变薄。
Objective To investigate the change in retinal nerve fiber layer(RNFL) thickness after treatment of hyperopic amblyopia.Methods A total of 68 patients with hyperopic amblyopia(136 eyes) received routine treatment.The RNFL thickness around the optic disc and retinal thickness in the central fovea were measured using the optical coherence tomography before and 3,6,12 and 24 months after treatment.Results The thickness of RNFL around the optic disc measured at 24 months after treatment was significantly less than that measured before treatment(P<0.01),but no obvious change was found at 3,6 and 12 months after treatment(P>0.01).Retinal thickness in the central fovea determined at 6,12 and 24 months after treatment was remarkably less than that determined before treatment(P<0.01),but the change was not significant at 3 month after treatment(P>0.01).Conclusion Amblyopia treatment can reduce the thickness of RNFL around optic disc and retina in central fovea in patients with hyperopic amblyopia.
Objective To investigate the change in retinal nerve fiber layer(RNFL) thickness after treatment of hyperopic amblyopia.Methods A total of 68 patients with hyperopic amblyopia(136 eyes) received routine treatment.The RNFL thickness around the optic disc and retinal thickness in the central fovea were measured using the optical coherence tomography before and 3,6,12 and 24 months after treatment.Results The thickness of RNFL around the optic disc measured at 24 months after treatment was significantly less than that measured before treatment(P<0.01),but no obvious change was found at 3,6 and 12 months after treatment(P>0.01).Retinal thickness in the central fovea determined at 6,12 and 24 months after treatment was remarkably less than that determined before treatment(P<0.01),but the change was not significant at 3 month after treatment(P>0.01).Conclusion Amblyopia treatment can reduce the thickness of RNFL around optic disc and retina in central fovea in patients with hyperopic amblyopia.
引文
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[3] 张丛,李倩,刘武,等.频域OCT测量正常学龄期儿童黄斑区视网膜厚度[J].眼科新进展,2015,35(2):180-182.
[4] MATHERON E,ZANDI A,WANG D,et al.A I-Diopter vertical prism induces a decrease of head rotation:a pilot investigation[J].Front Neurol,2016,7(1):135-140.
[5] 张红,罗英子,宋柯,等.视网膜色素变性患眼黄斑中心凹下脉络膜厚度与视功能的相关性分析[J].中华眼底病杂志,2015,31(5):435-438.
[6] 魏文斌.重视眼底相干光断层成像技术的临床应用与图像解读[J].中华眼科杂志,2012,48(2):97-99.
[7] 黄江,张沁,徐国旭,等.帕金森病患者视网膜黄斑区形态及视盘周围神经纤维层厚度的频域光相干断层扫描观察[J].中华眼底病杂志,2017,33(1):27-30.
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