乙醇发酵原位分离产物耦合方法研究进展
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摘要
乙醇发酵过程存在明显的产物抑制现象,严重制约了乙醇产率的提高。乙醇发酵与产物分离的耦合可有效解决这一难题,目前乙醇发酵耦合产物分离的方法主要有乙醇气提发酵、乙醇真空发酵、乙醇吸附发酵、乙醇萃取发酵、乙醇膜分离发酵等。作者主要概述了各种乙醇发酵耦合产物分离方法的研究进展,并对今后乙醇发酵耦合产物分离研究开发提出了展望。
The inhibition of product exists during ethanol production by fermentation,which severely restricts the increase of ethanol yield.This problem can be solved though coupling of ethanol fermentation and product separation.The methods of ethanol fermentation coupled with in situ product separation are mainly ethanol fermentation of gas stripping,ethanol fermentation of vacuum,ethanol fermentation of adsorption,ethanol fermentation of extractive,ethanol fermentation of membrane separation,etc.This article has outlined the research progress of the method of ethanol fermentation coupled with in situ product separation.The prospect of research for the method of ethanol fermentation coupled with in situ product separation is forecast.
The inhibition of product exists during ethanol production by fermentation,which severely restricts the increase of ethanol yield.This problem can be solved though coupling of ethanol fermentation and product separation.The methods of ethanol fermentation coupled with in situ product separation are mainly ethanol fermentation of gas stripping,ethanol fermentation of vacuum,ethanol fermentation of adsorption,ethanol fermentation of extractive,ethanol fermentation of membrane separation,etc.This article has outlined the research progress of the method of ethanol fermentation coupled with in situ product separation.The prospect of research for the method of ethanol fermentation coupled with in situ product separation is forecast.
引文
[1]岳军,胡世洋,惠继星,等.木薯渣资源利用现状及发展趋势[J].化工科技,2012,20(6):60-62.
[2]幸婷,程可可,张建安,等.利用木质纤维原料制取燃料乙醇预处理方法的研究进展[J].现代化工,2007,27(增刊2):92-95.
[3]吴伟光,仇焕广,黄季焜,等.全球生物乙醇发展现状、可能影响与我国的对策分析[J].科技与经济,2009(3):23-29.
[4]张丽君,程可可,张建安,等.乙醇发酵在线分离产物耦合的研究现状[J].现代化工,2006,26(增刊2):48-50.
[5]Walsh P K,LIU C P,Findley M E,et al.Ethanol separation from water in a two-stage adsorption process[J].Biotech Bioeng Symp,1983(13):629-637.
[6]董永胜,王立言,王瑞明,等.CO2气载乙醇固态发酵分离耦合过程的初步研究[J].生物加工过程,2005,3(1):54-57.
[7]张君,刘宏娟,刘德华,等.不同类型载气对乙醇气提发酵的影响[J].过程工程学报,2005,5(3):349-352.
[8]Lin J J,Dale M C,Okos M R.Ethanol production by zymomonas mobilis in an immobilized cell reactor separator[J].Process Biochemistry,1990,25(2):61-66.
[9]Hwai-shen Liu,HsuHsien-Wen.Analysis of gas stripping during ethanol fermentation,in a continuous stirred tank reactor[J].Chemical Engineering Science,1990,45(5):1289-1299.
[10]JoseM Dominguez,NingjunCao,Cheng S Gong,et al.Ethanol production from xylose with the yeast pichiastipitis and simulteous product recovery by gas stripping using agas lift loop fermentor with attached side-arm(GLSA)[J].Biotehnologyand Bioenginering,2000,67(3):336-343.
[11]Frank Taylor,Michael J Kurantz,Neil Goldberg,et a1.Drygrind process for fuel ethanol by continuous fermentation and stripping[J].Biotechnology Progress,2000,16(4):541-547.
[12]FrankTaylor,Michael J Kurantz,Nell Goldberg,et a1.Kinetics of continuous fermentation and stripping of ethanol[J].Biotechnology Letters,1998,20(1):67-72.
[13]金付强,王建梅,胡素琴,等.萃取耦合发酵生产生物丁醇的研究进展[J].现代化工,2010,30(Z2):52-54.
[14]M Minier,G Goma.Ethanol production by extractive fermentation[J].Biotehnology and Bioengineering,1982,24(7):1565-1579.
[15]Masatoshi Matsumura,Herbert MarkL.Elimination of ethanol inhibition by perstraction[J].Biotechnology and Bioengineering,1986,28(4):534-541.
[16]Masatoshi Matsumura,Herbert Markl.Application of solvent extraction to ethanol fermentation[J].Applied Microbiology and Biotechnology,1984,20(6):371-377.
[17]尚龙安,凌海燕,范代娣,等.固定化酵母乙醇萃取发酵研究[J].化学工程,1997(6):111-113.
[18]惠继星,崔维怡,惠彦臣,等.真空间歇精馏法精制双环戊二烯的研究[J].化工科技,2012,20(3):36-39.
[19]Cysewski,G R,Wilke C R.Rapid ethanol fermentation using vacuum and cell reycle[J].Biotehnology and Bioengineering,1977,19(8):1125-l143.
[20]A Ramalingham,R K Finn.The vacu ferm process:a new approach to fermentation alcohol[J].Biotechnology Bioengineering,1977,19(4):583-589.
[21]Kohji Ishida,Kazuyuki Shimizu.Novel repeated batch operation for flash fermentation system:experimental data and mathematical modeling[J].Chemical Technology and Biotechnology,1996,66(4):340-346.
[22]Aline C Costa,Daniel l P Atala,Francisco Maugeri,et a1.Factorialdesign and simulation for the optimization and determination of control structures for all extractive alcohol in fermentation[J].Process Biochemistry,2001,37(2):125-137.
[23]Flavio L Honoratoda Silva,Maria IRodrigues,Francisco Mangeri.Dynamic modeling simulation and optimization of an extractive continuous alcoholic fermentation process[J].Journal of Chemical Technology and Biotechnology,1999(74):176-182.
[24]I S Chung,Y Y Lee.Effect of in situ ethanol removal on fermentation of d-xylose by pachysolen tannophilus[J].Enzyme and Microbiol Technology,1985,7(5):217-219.
[25]范立梅.用大网格树脂从发酵液中吸附分离乙醇[J].浙江农业大学学报,1999,25(1):59-61.
[26]Wang X L,Toshinori Tsurut,Togoh M,et al.Evaluation of pore structure and electrical properties of nanofiltration membrance[J].Journal of Chemlcal Engineering of Japan,1995,28(2):186-192.
[27]张广信,郑邦婞,于京鑫,等.膜分离技术用于气体脱湿的研究现状[J].化工科技,2010,18(5):73-76.
[28]刘荣娥.膜分离技术[M].北京:化学工业出版社,2001:3-18.
[29]Yutaka Mori,Toshiharu Inaba.Ethanol production from starch in a pervaporation membrane bioreactor using clostridium thermohydrosulfuricum[J].Biotechnology and Bioengineering,1990,36(8):849-853.
[30]Toru Ikegami,Hiroshi Yanagishita,Dai Kitamoto,et a1.Concentration of fermented ethanol by pervaporation using siliealite membranes coated with silicone rubber[J].Desalination,2002,149(1-3):49-54.
[31]邱恒,闵浩.改性PVDF膜在MBR中膜污染的研究[J].化工科技,2009,17(5):34-39.
[32]Mikihiro Nomura,Tang Bin,Sin-ichi Nakao.Selective ethanol extraction from fermentation broth using a silicalite membrane[J].Separation and Purification Technology,2002,27(1):59-66.
[33]杨晶,伍云涛,汤晓玉,等.乙醇连续发酵-渗透汽化耦合系统发酵动力学研究[J].四川化工,2006,9(5):13-16.
[34]张卫,虞星炬,张衍坤.乙醇发酵-完全细胞截留渗透汽化膜分离耦合过程[J].膜科学与技术,1997,17(3):42-47.
[35]P Christen,M Minier,H Renon.Ethanol extraction by supported liquid membrane during fermentation[J].Biotechnology and Bioengineering,1990,36(2):l16-123.
[36]李贝贝,张元秀,王树立,等.膜蒸馏和膜吸收技术现状及发展[J].化工科技,2007,15(5):61-65.
[37]Y Shabtai,et al.Continuous ethanol production by immobilized yeast reactor coupled with membrane pervaporation unit[J].Biotechnology and Bioengineering,1991,38(8):869-876.
[38]Marek Gryta,Antoni Waldemar Morawski,MariaTomaszewska.Ethanol production in membrane distillation bioreactor[J].Catalysis Today,2000,56(1-3):159-165.
[39]杨斌,李宝璋,高孔荣.乙醇连续发酵与膜超滤耦合过程的研究[J].华南理工大学学报,1995,23(10):8-15.
[40]Hugo S Garcia,et al.Use of candida rugose lipase immobilized in a spiral wound membrane reactor for the hydrolysis of milkfat[J].Enzyme and Microbial Technology,1992,14(7):535-545.
[41]Karel Melzoch,Mojmir Rychtera,Nikolay S Markvichov,et al.Application of a membrane recycle bioreactor for continuous ethanol production[J].Applied Microbiology and Biotechnology,1991,34(4):469-472.
[42]尚德玲.外置式气相循环蒸汽渗透技术用于乙醇发酵原位分离的研究[D].北京:北京化工大学,2010:1-65.
[2]幸婷,程可可,张建安,等.利用木质纤维原料制取燃料乙醇预处理方法的研究进展[J].现代化工,2007,27(增刊2):92-95.
[3]吴伟光,仇焕广,黄季焜,等.全球生物乙醇发展现状、可能影响与我国的对策分析[J].科技与经济,2009(3):23-29.
[4]张丽君,程可可,张建安,等.乙醇发酵在线分离产物耦合的研究现状[J].现代化工,2006,26(增刊2):48-50.
[5]Walsh P K,LIU C P,Findley M E,et al.Ethanol separation from water in a two-stage adsorption process[J].Biotech Bioeng Symp,1983(13):629-637.
[6]董永胜,王立言,王瑞明,等.CO2气载乙醇固态发酵分离耦合过程的初步研究[J].生物加工过程,2005,3(1):54-57.
[7]张君,刘宏娟,刘德华,等.不同类型载气对乙醇气提发酵的影响[J].过程工程学报,2005,5(3):349-352.
[8]Lin J J,Dale M C,Okos M R.Ethanol production by zymomonas mobilis in an immobilized cell reactor separator[J].Process Biochemistry,1990,25(2):61-66.
[9]Hwai-shen Liu,HsuHsien-Wen.Analysis of gas stripping during ethanol fermentation,in a continuous stirred tank reactor[J].Chemical Engineering Science,1990,45(5):1289-1299.
[10]JoseM Dominguez,NingjunCao,Cheng S Gong,et al.Ethanol production from xylose with the yeast pichiastipitis and simulteous product recovery by gas stripping using agas lift loop fermentor with attached side-arm(GLSA)[J].Biotehnologyand Bioenginering,2000,67(3):336-343.
[11]Frank Taylor,Michael J Kurantz,Neil Goldberg,et a1.Drygrind process for fuel ethanol by continuous fermentation and stripping[J].Biotechnology Progress,2000,16(4):541-547.
[12]FrankTaylor,Michael J Kurantz,Nell Goldberg,et a1.Kinetics of continuous fermentation and stripping of ethanol[J].Biotechnology Letters,1998,20(1):67-72.
[13]金付强,王建梅,胡素琴,等.萃取耦合发酵生产生物丁醇的研究进展[J].现代化工,2010,30(Z2):52-54.
[14]M Minier,G Goma.Ethanol production by extractive fermentation[J].Biotehnology and Bioengineering,1982,24(7):1565-1579.
[15]Masatoshi Matsumura,Herbert MarkL.Elimination of ethanol inhibition by perstraction[J].Biotechnology and Bioengineering,1986,28(4):534-541.
[16]Masatoshi Matsumura,Herbert Markl.Application of solvent extraction to ethanol fermentation[J].Applied Microbiology and Biotechnology,1984,20(6):371-377.
[17]尚龙安,凌海燕,范代娣,等.固定化酵母乙醇萃取发酵研究[J].化学工程,1997(6):111-113.
[18]惠继星,崔维怡,惠彦臣,等.真空间歇精馏法精制双环戊二烯的研究[J].化工科技,2012,20(3):36-39.
[19]Cysewski,G R,Wilke C R.Rapid ethanol fermentation using vacuum and cell reycle[J].Biotehnology and Bioengineering,1977,19(8):1125-l143.
[20]A Ramalingham,R K Finn.The vacu ferm process:a new approach to fermentation alcohol[J].Biotechnology Bioengineering,1977,19(4):583-589.
[21]Kohji Ishida,Kazuyuki Shimizu.Novel repeated batch operation for flash fermentation system:experimental data and mathematical modeling[J].Chemical Technology and Biotechnology,1996,66(4):340-346.
[22]Aline C Costa,Daniel l P Atala,Francisco Maugeri,et a1.Factorialdesign and simulation for the optimization and determination of control structures for all extractive alcohol in fermentation[J].Process Biochemistry,2001,37(2):125-137.
[23]Flavio L Honoratoda Silva,Maria IRodrigues,Francisco Mangeri.Dynamic modeling simulation and optimization of an extractive continuous alcoholic fermentation process[J].Journal of Chemical Technology and Biotechnology,1999(74):176-182.
[24]I S Chung,Y Y Lee.Effect of in situ ethanol removal on fermentation of d-xylose by pachysolen tannophilus[J].Enzyme and Microbiol Technology,1985,7(5):217-219.
[25]范立梅.用大网格树脂从发酵液中吸附分离乙醇[J].浙江农业大学学报,1999,25(1):59-61.
[26]Wang X L,Toshinori Tsurut,Togoh M,et al.Evaluation of pore structure and electrical properties of nanofiltration membrance[J].Journal of Chemlcal Engineering of Japan,1995,28(2):186-192.
[27]张广信,郑邦婞,于京鑫,等.膜分离技术用于气体脱湿的研究现状[J].化工科技,2010,18(5):73-76.
[28]刘荣娥.膜分离技术[M].北京:化学工业出版社,2001:3-18.
[29]Yutaka Mori,Toshiharu Inaba.Ethanol production from starch in a pervaporation membrane bioreactor using clostridium thermohydrosulfuricum[J].Biotechnology and Bioengineering,1990,36(8):849-853.
[30]Toru Ikegami,Hiroshi Yanagishita,Dai Kitamoto,et a1.Concentration of fermented ethanol by pervaporation using siliealite membranes coated with silicone rubber[J].Desalination,2002,149(1-3):49-54.
[31]邱恒,闵浩.改性PVDF膜在MBR中膜污染的研究[J].化工科技,2009,17(5):34-39.
[32]Mikihiro Nomura,Tang Bin,Sin-ichi Nakao.Selective ethanol extraction from fermentation broth using a silicalite membrane[J].Separation and Purification Technology,2002,27(1):59-66.
[33]杨晶,伍云涛,汤晓玉,等.乙醇连续发酵-渗透汽化耦合系统发酵动力学研究[J].四川化工,2006,9(5):13-16.
[34]张卫,虞星炬,张衍坤.乙醇发酵-完全细胞截留渗透汽化膜分离耦合过程[J].膜科学与技术,1997,17(3):42-47.
[35]P Christen,M Minier,H Renon.Ethanol extraction by supported liquid membrane during fermentation[J].Biotechnology and Bioengineering,1990,36(2):l16-123.
[36]李贝贝,张元秀,王树立,等.膜蒸馏和膜吸收技术现状及发展[J].化工科技,2007,15(5):61-65.
[37]Y Shabtai,et al.Continuous ethanol production by immobilized yeast reactor coupled with membrane pervaporation unit[J].Biotechnology and Bioengineering,1991,38(8):869-876.
[38]Marek Gryta,Antoni Waldemar Morawski,MariaTomaszewska.Ethanol production in membrane distillation bioreactor[J].Catalysis Today,2000,56(1-3):159-165.
[39]杨斌,李宝璋,高孔荣.乙醇连续发酵与膜超滤耦合过程的研究[J].华南理工大学学报,1995,23(10):8-15.
[40]Hugo S Garcia,et al.Use of candida rugose lipase immobilized in a spiral wound membrane reactor for the hydrolysis of milkfat[J].Enzyme and Microbial Technology,1992,14(7):535-545.
[41]Karel Melzoch,Mojmir Rychtera,Nikolay S Markvichov,et al.Application of a membrane recycle bioreactor for continuous ethanol production[J].Applied Microbiology and Biotechnology,1991,34(4):469-472.
[42]尚德玲.外置式气相循环蒸汽渗透技术用于乙醇发酵原位分离的研究[D].北京:北京化工大学,2010:1-65.