痤疮相关易感基因多态性的研究进展
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摘要
痤疮是一种由多基因遗传决定、多种环境因素共同作用引起的毛囊皮脂腺慢性炎症性疾病,其发病机制十分复杂。目前影响痤疮发病的具体基因仍不清楚。随着人类基因多态性的发展,现已证实基因多态性与痤疮的相关性。该文将从各种细胞因子、核转录因子等几个方面阐述痤疮的易感基因多态性的研究现状。
Acne is a chronic inflammatory disease of sebaceous glands and hair follicles, which is caused by polygenic inheritance factors and multiple environmental factors. Its pathogenesis is very complicated. At present, the specific genes that affect the incidence of acne are still unclear. With the development of human genetic polymorphism research, the correlation between gene polymorphism and acne has been confirmed. This article reviews the research status of susceptibility gene polymorphism of acne from several aspects, including various cytokines, insulin-like growth factor-1 and nuclear transcription factors.
Acne is a chronic inflammatory disease of sebaceous glands and hair follicles, which is caused by polygenic inheritance factors and multiple environmental factors. Its pathogenesis is very complicated. At present, the specific genes that affect the incidence of acne are still unclear. With the development of human genetic polymorphism research, the correlation between gene polymorphism and acne has been confirmed. This article reviews the research status of susceptibility gene polymorphism of acne from several aspects, including various cytokines, insulin-like growth factor-1 and nuclear transcription factors.
引文
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[2]Tasli L,Turgut S,Kacar N,et al.Insulin-like growth factor-Igene polymorphism in acne vulgaris[J].J Eur Acad Dermatol Venereol,2013,27(2):254-257.
[3]Al-Shobaili HA,Salem TA,Alzolibani AA,et al.Tumor necrosis factor-α-308G/A and interleukin 10-1082A/G gene polymorphisms in patients with acne vulgaris[J].J Dermatol Sci,2012,68(1):52-55.
[4]Yang JK,Wu WJ,Qi J,et al.TNF-308G/A polymorphism and risk of acne vulgaris:a meta-analysis[J].PLoS One,2014,9(2):e87806.
[5]SzabóK,Tax G,Teodorescu-Brinzeu D,et al.TNFαgene polymorphisms in the pathogenesis of acne vulgaris[J].Arch Dermatol Res,2011,303(1):19-27.
[6]Aisha NM,Haroon J,Hussain S,et al.Association between tumour necrosis-αgene polymorphisms and acne vulgaris in a Pakistani population[J].Clin Exp Dermatol,2016,41(3):297-301.
[7]Tian LM,Xie HF,Yang T,et al.Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group[J].Dermatology,2010,221(3):276-284.
[8]Sobjanek M,Zablotna M,Glen J,et al.Polymorphism in interleukin1A but not in interleukin 8 gene predisposes to acne vulgaris in Polish population[J].J Eur Acad Dermatol Venereol,2013,27(2):259-260.
[9]Hussain S,Iqbal T,Sadiq I,et al.Polymorphism in the IL-8 gene promoter and the risk of acne vulgaris in a Pakistani population[J].Iran J Allergy Asthma Immunol,2015,14(4):443-449.
[10]Al Robaee AA,AlZolibani A,Al Shobaili H,et al.Association of interleukin 4(-590 T/C)and interleukin 4 receptor(Q551R A/G)gene polymorphisms with acne vulgaris[J].Ann Saudi Med,2012,32(4):349-354.
[11]Younis S,Javed Q.The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis of acne vulgaris[J].Arch Dermatol Res,2015,307(4):365-370.
[12]Yang G,Fan W,Luo B,et al.Circulating resistin levels and risk of colorectal cancer:a Meta-analysis[J].Biomed Res Int,2016,2016(4):1-11.
[13]Younis S,Blumenberg M,Javed Q.Resistin gene polymorphisms are associated with acne and serum lipid levels,providing a potential nexus between lipid metabolism and inflammation[J].Arch Dermatol Res,2016,308(4):229-237.
[14]Hussain S,Faraz A,Iqbal T.The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial acne vulgaris in a Pakistani population[J].Iran J Basic Med Sci,2015,18(5):526-528.
[15]Agamia NF,Abdallah DM,Sorour O,et al.Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1,and serum insulin‐like growth factor-1 in patients with acne vulgaris and their relationship with diet[J].Br J Dermatol,2016,174(6):1299-1307.
[16]Tasli L,Turgut S,Kacar N,et al.Insulin-like growth factor-I gene polymorphism in acne vulgaris[J].J Eur Acad Dermatol Venereol,2013,27(2):254-257.
[17]Rahaman SMA,De D,Handa S,et al.Association of insulinlike growth factor(IGF)-1 gene polymorphisms with plasma levels of IGF-1 and acne severity[J].J Am Acad Dermatol,2016,75(4):768-773.
[18]Melnik BC.The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action[J].G Ital Dermatol Venereol,2010,145(5):559-571.
[19]Kim HJ,Kobayashi M,Sasaki T.Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance[J].Endocrinology,2011,153(2):659-671.
[20]Cohen J,Blethen S,Kuntze J,et al.Managing the child with severe primary insulin-like growth factor-1 deficiency(IGFD):IGFDdiagnosis and management[J].Drugs in RD,2014,14(1):25-29.
[21]Knuever J,Willenborg S,Ding X,et al.Myeloid cell-restricted insulin/IGF-1 receptor deficiency protects against skin inflammation[J].J Immunol,2015,195(11):5296-5308.
[22]Melnik BC.Western diet-induced imbalances of FoxO1 and mTORC1 signaling promote the sebofollicular inflammasomopathy acne vulgaris[J].Exp Dermatol,2016,25(2):103-104.
[23]Fang Z,Zhang T,Dizeyi N,et al.Androgen receptor enhances p27degradation in prostate cancer cells through rapid and selective TORC2 activation[J].J Biol Chem,2012,287(3):2090-2098.
[24]Olokpa E,Moss PE,Stewart LV.Crosstalk between the androgen receptor and PPAR gamma signaling pathways in the prostate[J].Ppar Research,2017,2017(2):9456020.
[25]Amr K,Abdel-Hameed M,Sayed K,et al.The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris[J].Clin Exp Dermatol,2014,39(6):741-745.
[2]Tasli L,Turgut S,Kacar N,et al.Insulin-like growth factor-Igene polymorphism in acne vulgaris[J].J Eur Acad Dermatol Venereol,2013,27(2):254-257.
[3]Al-Shobaili HA,Salem TA,Alzolibani AA,et al.Tumor necrosis factor-α-308G/A and interleukin 10-1082A/G gene polymorphisms in patients with acne vulgaris[J].J Dermatol Sci,2012,68(1):52-55.
[4]Yang JK,Wu WJ,Qi J,et al.TNF-308G/A polymorphism and risk of acne vulgaris:a meta-analysis[J].PLoS One,2014,9(2):e87806.
[5]SzabóK,Tax G,Teodorescu-Brinzeu D,et al.TNFαgene polymorphisms in the pathogenesis of acne vulgaris[J].Arch Dermatol Res,2011,303(1):19-27.
[6]Aisha NM,Haroon J,Hussain S,et al.Association between tumour necrosis-αgene polymorphisms and acne vulgaris in a Pakistani population[J].Clin Exp Dermatol,2016,41(3):297-301.
[7]Tian LM,Xie HF,Yang T,et al.Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group[J].Dermatology,2010,221(3):276-284.
[8]Sobjanek M,Zablotna M,Glen J,et al.Polymorphism in interleukin1A but not in interleukin 8 gene predisposes to acne vulgaris in Polish population[J].J Eur Acad Dermatol Venereol,2013,27(2):259-260.
[9]Hussain S,Iqbal T,Sadiq I,et al.Polymorphism in the IL-8 gene promoter and the risk of acne vulgaris in a Pakistani population[J].Iran J Allergy Asthma Immunol,2015,14(4):443-449.
[10]Al Robaee AA,AlZolibani A,Al Shobaili H,et al.Association of interleukin 4(-590 T/C)and interleukin 4 receptor(Q551R A/G)gene polymorphisms with acne vulgaris[J].Ann Saudi Med,2012,32(4):349-354.
[11]Younis S,Javed Q.The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis of acne vulgaris[J].Arch Dermatol Res,2015,307(4):365-370.
[12]Yang G,Fan W,Luo B,et al.Circulating resistin levels and risk of colorectal cancer:a Meta-analysis[J].Biomed Res Int,2016,2016(4):1-11.
[13]Younis S,Blumenberg M,Javed Q.Resistin gene polymorphisms are associated with acne and serum lipid levels,providing a potential nexus between lipid metabolism and inflammation[J].Arch Dermatol Res,2016,308(4):229-237.
[14]Hussain S,Faraz A,Iqbal T.The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial acne vulgaris in a Pakistani population[J].Iran J Basic Med Sci,2015,18(5):526-528.
[15]Agamia NF,Abdallah DM,Sorour O,et al.Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1,and serum insulin‐like growth factor-1 in patients with acne vulgaris and their relationship with diet[J].Br J Dermatol,2016,174(6):1299-1307.
[16]Tasli L,Turgut S,Kacar N,et al.Insulin-like growth factor-I gene polymorphism in acne vulgaris[J].J Eur Acad Dermatol Venereol,2013,27(2):254-257.
[17]Rahaman SMA,De D,Handa S,et al.Association of insulinlike growth factor(IGF)-1 gene polymorphisms with plasma levels of IGF-1 and acne severity[J].J Am Acad Dermatol,2016,75(4):768-773.
[18]Melnik BC.The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action[J].G Ital Dermatol Venereol,2010,145(5):559-571.
[19]Kim HJ,Kobayashi M,Sasaki T.Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance[J].Endocrinology,2011,153(2):659-671.
[20]Cohen J,Blethen S,Kuntze J,et al.Managing the child with severe primary insulin-like growth factor-1 deficiency(IGFD):IGFDdiagnosis and management[J].Drugs in RD,2014,14(1):25-29.
[21]Knuever J,Willenborg S,Ding X,et al.Myeloid cell-restricted insulin/IGF-1 receptor deficiency protects against skin inflammation[J].J Immunol,2015,195(11):5296-5308.
[22]Melnik BC.Western diet-induced imbalances of FoxO1 and mTORC1 signaling promote the sebofollicular inflammasomopathy acne vulgaris[J].Exp Dermatol,2016,25(2):103-104.
[23]Fang Z,Zhang T,Dizeyi N,et al.Androgen receptor enhances p27degradation in prostate cancer cells through rapid and selective TORC2 activation[J].J Biol Chem,2012,287(3):2090-2098.
[24]Olokpa E,Moss PE,Stewart LV.Crosstalk between the androgen receptor and PPAR gamma signaling pathways in the prostate[J].Ppar Research,2017,2017(2):9456020.
[25]Amr K,Abdel-Hameed M,Sayed K,et al.The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris[J].Clin Exp Dermatol,2014,39(6):741-745.