反刍动物POU1 F1基因多态性与经济性状关联研究进展
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摘要
垂体特异性转录因子(pituitary specific transcription factor,POU1F1)在动物垂体前叶特异性表达,是参与机体细胞生长与发育调节的一类重要的转录因子,对垂体细胞基因转录起重要调节作用,从而显著影响家畜的生长、发育及繁殖等方面。本文从反刍动物POU1F1基因的结构特征与生物学特性、近年来对牛、山羊、绵羊等反刍动物POU1F1基因多态性的挖掘及其与经济性状关联的最新进展等几个方面进行总结,以期为反刍动物POU1F1基因研究提供研究思路和研究方向。
Pituitary specific transcription factor(POU1 F1) is an important transcriptional factor that specifically expressed in the anterior pituitary of animals. It has crucial biological functions and plays a significant role in the regulation of growth, development and reproduction of livestock. In this paper, the structural characteristics and functions of POU1F1 gene ofruminant, the recent studies of polymorphisms and their relationships with economic traits in ruminant are discussed, which provides ideas and research directions for ruminant breeding.
Pituitary specific transcription factor(POU1 F1) is an important transcriptional factor that specifically expressed in the anterior pituitary of animals. It has crucial biological functions and plays a significant role in the regulation of growth, development and reproduction of livestock. In this paper, the structural characteristics and functions of POU1F1 gene ofruminant, the recent studies of polymorphisms and their relationships with economic traits in ruminant are discussed, which provides ideas and research directions for ruminant breeding.
引文
[1] Steinfelder H J,Radovick S,Wondisford F E.Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1[J].Proceedings of the National Academy of Sciences of the United States of America,1992,89(13):5942-5945.
[2] Scully K M,Rosenfeld M G.Pituitary development:Regulatory codes in mammalian organogenesis[J].Science,2002,295(5563):2231-2235.
[3] Li S,Crenshaw E B,Rawson E J,et al.Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene PIT-1[J].Nature,1990,347(6293):528-533.
[4] Bas F,Abal Z Y,Toksoy G,et al.Precocious or early puberty in patients with combined pituitary hormone deficiency due to POU1F1 gene mutation:Case report and review of possible mechanisms[J].Hormones (Athens),2018,17(4):581-588.
[5] 宋娜娜,柴志欣,胡丹,等.西藏牦牛POU1F1基因的多态性及其与生长性状的相关性分析[J].西南农业学报,2016,29(12):2994-3000.
[6] 赵宪林,曹少杰,王若勇,等.POU1F1基因多态性与藏羊生长性状的关联性分析[J].西北农林科技大学学报(自然科学版),2017,45(9):25-31.
[7] Feng T,Chu M X,Cao G L,et al.Polymorphisms of caprine POU1F1 gene and their association with litter size in Jining Grey goats[J].Molecular Biology Reports,2012,39(4):4029-4038.
[8] Woollard J,Tuggle C K,Ponce de León F A.Rapid communication:Localization of POU1F1 to bovine,ovine,and caprine 1q21-22[J].Journal of Animal Science,2000,78(1):242-243.
[9] 高岩.垂体特异性转录因子研究进展[J].国际内分泌代谢杂志,1995,15(3):116-120.
[10] Heidari M,Azari M A,Hasani S,et al.Effect of polymorphic variants of GH,Pit-1,and beta-LG genes on milk production of Holstein cows[J].Genetika,2012,48(4):417-421.
[11] Seong J,Oh J D,Cheong I C,et al.Association between polymorphisms of Myf5 and POU1F1 genes with growth and carcass traits in Hanwoo (Korean cattle)[J].Genes & Genomics,2011,33(4):425-430.
[12] Lan X Y,Pan C Y,Chen H,et al.DdeI polymorphism in coding region of goat POU1F1 gene and its association with production traits[J].Asian Australasian Journal of Animal Sciences,2007,20(9):1342-1348.
[13] Lan X Y,Shu J H,Chen H,et al.A PstI polymorphism at 3′UTR of goat POU1F1gene and its effect on cashmere production[J].Molecular Biology Reports,2009,36(6):1371-1374.
[14] Ozmen O,Kul S,Unal E O.Polymorphism of sheep POU1F1 gene exon 6 and 3′UTR region and their association with milk production traits[J].Iranian Journal of Veterinary Research,2014,15(4):331.
[15] Zhu H J,Zhang Y H,Bai Y Y,et al.Relationship between SNPs of POU1F1 gene and litter size and growth traits in Shaanbei White Cashmere goats[J].Animals,2019,9(3):114.
[16] Woollard J,Schmitz C B,Freeman A E,et al.HinfI polymorphism at the bovine PIT1 locus[J].Journal of Animal Science,1994,72(12):3267.
[17] Pytlewski J,Antkowiak I,Czerniawska-Piatkowska E.Relationship of PIT-1 gene polymorphism with breeding parameters and body weights of cows and calves[J].Pakistan Journal of Zoology,2018,20(1):183-187.
[18] Thuy N T D,Thu N T,Cuong N H,et al.Polymorphism of PIT-1 and prolactin genes and their effects on milk yield in Holstein Frisian dairy cows breed in Vietnam[J].Russian Journal of Genetics,2018,54(3):346-352.
[19] Pan C,Lan X,Chen H,et al.A TaqI PCR-RFLP detecting a novel SNP in exon 2 of the bovine POU1F1 gene[J].Biochemical Genetics,2008,46(7/8):424-432.
[20] Mukesh M,Sodhi M,Sobti R C,et al.Analysis of bovine pituitary specific transcription factor-HinfI gene polymorphism in Indian zebuine cattle[J].Livestock Science,2008,113(1):81-86.
[21] Huang W,Maltecca C,Khatib H.A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle[J].Animal Genetics,2008,39(5):554-557.
[22] Han S H,Cho I C,Ko M S,et al.Effects of POU1F1 and GH1 genotypes on carcass traits in Hanwoo cattle[J].Genes & Genomics,2010,32(2):105-109.
[23] Grossi D do A,Buzanskas M E,Grupioni N V,et al.Effect of IGF1,GH,and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle[J].Molecular Biology Reports,2015,42(1):245-251.
[24] Ahmadi M M,Mirzaei A,Sharifiyazdi H,et al.Pituitary-specific transcription factor 1(Pit-1) polymorphism and its association on milk production and some reproductive performance in Holstein dairy cows[J].Revue De Medecine Veterinaire,2015,166(5/6):127-131.
[25] Stasio L D,Sartore S,Albera A.Lack of association of GH1 and POU1F1 gene variants with meat production traits in Piemontese cattle[J].Animal Genetics,2015,33(1):61-64.
[26] 吴慧光,赵静雯,孙国权,等.牛POU1F1-exon2多态性与部分线性和乳用性状相关研究[J].内蒙古民族大学学报(自然科学版),2010,25(5):530-534.
[27] 赵静雯,吴慧光,孙国权,等.牛POU1F1-exon6多态性与生长性状的相关性研究[J].黑龙江畜牧兽医,2010(12):4-6.
[28] 贾祥捷,王长法,杨桂文,等.中国荷斯坦牛POU1F1基因与PRL基因的多态性及其聚合效应对产奶性状的影响[J].遗传,2011,33(12):1359-1365.
[29] 陈然,王传波,李春明,等.新疆褐牛POU1F1基因PCR-RFLP分析[J].新疆畜牧业,2016(6):17-20.
[30] Xue K,Chen H,Wang S,e tal.Effect of genetic variations of the POU1F1 gene on growth traits of Nanyang cattle[J].Acta Genetica Sinica,2006,33(10):901-907.
[31] 滑留帅,陈宏,杨晓冰,等.固原本地黄牛及其利杂群体Pit-1基因多态性与育肥性状的关系[J].西北农林科技大学学报(自然科学版),2007,35(12):1-5.
[32] Lan X Y,Pan C Y,Chen H,et al.An AluI PCR-RFLP detecting a silent allele at the goat POU1F1 locus and its association with production traits[J].Small Ruminant Research,2007,73(1):8-12.
[33] Lan X Y,Li M J,Chen H,et al.Analysis of caprine pituitary specific transcription factor-1 gene polymorphism in indigenous Chinese goats[J].Molecular Biology Reports,2009,36(4):705-709.
[34] Lan X Y,Pan C Y,Li J Y,et al.Twelve novel SNPs of the goat POU1F1 gene and their associations with cashmere traits[J].Small Ruminant Research,2009,85(2/3):116-121.
[35] 罗卫星,蔡惠芬,王兴群,等.山羊垂体转录因子POU1F1基因多态性及其与屠宰性状相关性研究[J].中国畜牧杂志,2011,47(9):5-9.
[36] 王兴群,毛以智,罗卫星,等.贵州黑山羊POU1F1基因第4内含子的多态性分析[J].贵州农业科学,2014,42(7):124-126.
[37] Bastos E,Santos I,Parmentier I,et al.Ovisaries POU1F1 gene:Cloning,characterization and polymorphism analysis[J].Genetica (Dordrecht),2006,126(3):303-314.
[38] Mura M C,Daga C,Paludo M,et al.Analysis of polymorphism within POU1F1 gene in relation to milk production traits in dairy Sarda sheep breed[J].Molecular Biology Reports,2012,39(6):6975-6979.
[39] Jalil-Sarghale A,Shahrbabak M M,Sharbabak H M,et al.Association of pituitary specific transcription factor-1 (POU1F1) gene polymorphism with growth and biometric traits and blood metabolites in Iranian Zel and Lori-Bakhtiari sheep[J].Molecular Biology Reports,2014,41(9):5787-5792.
[40] 宋成义,赵芹,高波,等.猪POU1F1基因启动子区多态分析及其与生长性状的关联[J].中国农业科学,2011,44(24):5067-5072.
[41] Yan L J,Fang X T,Liu Y,et al.Effects of single and combined genotypes of MC4R and POU1F1 genes on two production traits in Langshan chicken[J].Molecular Biology Reports,2013,40(7):4645-4650.
[42] 于农淇,高源,蓝贤勇,等.伊犁马PRL、POU1F1基因多态性及其与产奶量的关联分析[J].家畜生态学报,2017,38(4):15-18,24.
[2] Scully K M,Rosenfeld M G.Pituitary development:Regulatory codes in mammalian organogenesis[J].Science,2002,295(5563):2231-2235.
[3] Li S,Crenshaw E B,Rawson E J,et al.Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene PIT-1[J].Nature,1990,347(6293):528-533.
[4] Bas F,Abal Z Y,Toksoy G,et al.Precocious or early puberty in patients with combined pituitary hormone deficiency due to POU1F1 gene mutation:Case report and review of possible mechanisms[J].Hormones (Athens),2018,17(4):581-588.
[5] 宋娜娜,柴志欣,胡丹,等.西藏牦牛POU1F1基因的多态性及其与生长性状的相关性分析[J].西南农业学报,2016,29(12):2994-3000.
[6] 赵宪林,曹少杰,王若勇,等.POU1F1基因多态性与藏羊生长性状的关联性分析[J].西北农林科技大学学报(自然科学版),2017,45(9):25-31.
[7] Feng T,Chu M X,Cao G L,et al.Polymorphisms of caprine POU1F1 gene and their association with litter size in Jining Grey goats[J].Molecular Biology Reports,2012,39(4):4029-4038.
[8] Woollard J,Tuggle C K,Ponce de León F A.Rapid communication:Localization of POU1F1 to bovine,ovine,and caprine 1q21-22[J].Journal of Animal Science,2000,78(1):242-243.
[9] 高岩.垂体特异性转录因子研究进展[J].国际内分泌代谢杂志,1995,15(3):116-120.
[10] Heidari M,Azari M A,Hasani S,et al.Effect of polymorphic variants of GH,Pit-1,and beta-LG genes on milk production of Holstein cows[J].Genetika,2012,48(4):417-421.
[11] Seong J,Oh J D,Cheong I C,et al.Association between polymorphisms of Myf5 and POU1F1 genes with growth and carcass traits in Hanwoo (Korean cattle)[J].Genes & Genomics,2011,33(4):425-430.
[12] Lan X Y,Pan C Y,Chen H,et al.DdeI polymorphism in coding region of goat POU1F1 gene and its association with production traits[J].Asian Australasian Journal of Animal Sciences,2007,20(9):1342-1348.
[13] Lan X Y,Shu J H,Chen H,et al.A PstI polymorphism at 3′UTR of goat POU1F1gene and its effect on cashmere production[J].Molecular Biology Reports,2009,36(6):1371-1374.
[14] Ozmen O,Kul S,Unal E O.Polymorphism of sheep POU1F1 gene exon 6 and 3′UTR region and their association with milk production traits[J].Iranian Journal of Veterinary Research,2014,15(4):331.
[15] Zhu H J,Zhang Y H,Bai Y Y,et al.Relationship between SNPs of POU1F1 gene and litter size and growth traits in Shaanbei White Cashmere goats[J].Animals,2019,9(3):114.
[16] Woollard J,Schmitz C B,Freeman A E,et al.HinfI polymorphism at the bovine PIT1 locus[J].Journal of Animal Science,1994,72(12):3267.
[17] Pytlewski J,Antkowiak I,Czerniawska-Piatkowska E.Relationship of PIT-1 gene polymorphism with breeding parameters and body weights of cows and calves[J].Pakistan Journal of Zoology,2018,20(1):183-187.
[18] Thuy N T D,Thu N T,Cuong N H,et al.Polymorphism of PIT-1 and prolactin genes and their effects on milk yield in Holstein Frisian dairy cows breed in Vietnam[J].Russian Journal of Genetics,2018,54(3):346-352.
[19] Pan C,Lan X,Chen H,et al.A TaqI PCR-RFLP detecting a novel SNP in exon 2 of the bovine POU1F1 gene[J].Biochemical Genetics,2008,46(7/8):424-432.
[20] Mukesh M,Sodhi M,Sobti R C,et al.Analysis of bovine pituitary specific transcription factor-HinfI gene polymorphism in Indian zebuine cattle[J].Livestock Science,2008,113(1):81-86.
[21] Huang W,Maltecca C,Khatib H.A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle[J].Animal Genetics,2008,39(5):554-557.
[22] Han S H,Cho I C,Ko M S,et al.Effects of POU1F1 and GH1 genotypes on carcass traits in Hanwoo cattle[J].Genes & Genomics,2010,32(2):105-109.
[23] Grossi D do A,Buzanskas M E,Grupioni N V,et al.Effect of IGF1,GH,and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle[J].Molecular Biology Reports,2015,42(1):245-251.
[24] Ahmadi M M,Mirzaei A,Sharifiyazdi H,et al.Pituitary-specific transcription factor 1(Pit-1) polymorphism and its association on milk production and some reproductive performance in Holstein dairy cows[J].Revue De Medecine Veterinaire,2015,166(5/6):127-131.
[25] Stasio L D,Sartore S,Albera A.Lack of association of GH1 and POU1F1 gene variants with meat production traits in Piemontese cattle[J].Animal Genetics,2015,33(1):61-64.
[26] 吴慧光,赵静雯,孙国权,等.牛POU1F1-exon2多态性与部分线性和乳用性状相关研究[J].内蒙古民族大学学报(自然科学版),2010,25(5):530-534.
[27] 赵静雯,吴慧光,孙国权,等.牛POU1F1-exon6多态性与生长性状的相关性研究[J].黑龙江畜牧兽医,2010(12):4-6.
[28] 贾祥捷,王长法,杨桂文,等.中国荷斯坦牛POU1F1基因与PRL基因的多态性及其聚合效应对产奶性状的影响[J].遗传,2011,33(12):1359-1365.
[29] 陈然,王传波,李春明,等.新疆褐牛POU1F1基因PCR-RFLP分析[J].新疆畜牧业,2016(6):17-20.
[30] Xue K,Chen H,Wang S,e tal.Effect of genetic variations of the POU1F1 gene on growth traits of Nanyang cattle[J].Acta Genetica Sinica,2006,33(10):901-907.
[31] 滑留帅,陈宏,杨晓冰,等.固原本地黄牛及其利杂群体Pit-1基因多态性与育肥性状的关系[J].西北农林科技大学学报(自然科学版),2007,35(12):1-5.
[32] Lan X Y,Pan C Y,Chen H,et al.An AluI PCR-RFLP detecting a silent allele at the goat POU1F1 locus and its association with production traits[J].Small Ruminant Research,2007,73(1):8-12.
[33] Lan X Y,Li M J,Chen H,et al.Analysis of caprine pituitary specific transcription factor-1 gene polymorphism in indigenous Chinese goats[J].Molecular Biology Reports,2009,36(4):705-709.
[34] Lan X Y,Pan C Y,Li J Y,et al.Twelve novel SNPs of the goat POU1F1 gene and their associations with cashmere traits[J].Small Ruminant Research,2009,85(2/3):116-121.
[35] 罗卫星,蔡惠芬,王兴群,等.山羊垂体转录因子POU1F1基因多态性及其与屠宰性状相关性研究[J].中国畜牧杂志,2011,47(9):5-9.
[36] 王兴群,毛以智,罗卫星,等.贵州黑山羊POU1F1基因第4内含子的多态性分析[J].贵州农业科学,2014,42(7):124-126.
[37] Bastos E,Santos I,Parmentier I,et al.Ovisaries POU1F1 gene:Cloning,characterization and polymorphism analysis[J].Genetica (Dordrecht),2006,126(3):303-314.
[38] Mura M C,Daga C,Paludo M,et al.Analysis of polymorphism within POU1F1 gene in relation to milk production traits in dairy Sarda sheep breed[J].Molecular Biology Reports,2012,39(6):6975-6979.
[39] Jalil-Sarghale A,Shahrbabak M M,Sharbabak H M,et al.Association of pituitary specific transcription factor-1 (POU1F1) gene polymorphism with growth and biometric traits and blood metabolites in Iranian Zel and Lori-Bakhtiari sheep[J].Molecular Biology Reports,2014,41(9):5787-5792.
[40] 宋成义,赵芹,高波,等.猪POU1F1基因启动子区多态分析及其与生长性状的关联[J].中国农业科学,2011,44(24):5067-5072.
[41] Yan L J,Fang X T,Liu Y,et al.Effects of single and combined genotypes of MC4R and POU1F1 genes on two production traits in Langshan chicken[J].Molecular Biology Reports,2013,40(7):4645-4650.
[42] 于农淇,高源,蓝贤勇,等.伊犁马PRL、POU1F1基因多态性及其与产奶量的关联分析[J].家畜生态学报,2017,38(4):15-18,24.