喹硫平联合氟哌啶醇对精神分裂症患者激越行为的影响
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摘要
目的探讨喹硫平联合氟哌啶醇治疗对精神分裂症患者激越行为的影响。方法采用回顾性研究方法,2015年1月—2016年9月选择在新乡医学院第二附属医院诊治的精神分裂症患者115例,根据治疗方法的不同分为观察组60例与对照组55例,对照组给予喹硫平治疗,观察组给予喹硫平联合氟哌啶醇治疗,比较两组的治疗效果、不良反应、血脂改变及激越行为评分情况。结果观察组的总有效率96.7%(58/60)高于对照组87.3%(48/55),差异有统计学意义(P<0.05)。观察组的不良反应发生率为21.7%(13/60),对照组为21.8%(12/55),且两组的不良反应都为轻中度。治疗后两组血清低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)含量对比无差异。治疗后观察组与对照组的激越行为评分分别为(8.14±6.33)分和(13.01±6.10)分,显著低于治疗前的(22.22±5.33)分和(22.09±4.82)分(P<0.05),同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。结论喹硫平联合氟哌啶醇治疗精神分裂症患者能有效控制激越行为,提高治疗效果,且不会增加不良反应的发生,也不会影响患者的血脂水平,有很好的应用价值。
Objective To investigate the effects of quetiapine combined with haloperidol on the aggressive behavior of schizophrenic patients. Methods Used a retrospective study, From January 2015 to September 2016, 115 patients with aggressive behavior of schizophrenic patients in our hospital for treatment were selected. All the patients were divided into the observation group of 70 patients and control group of 45 patients accorded to the different methods of drugs, the control group was treated with quetiapinet, the observation group was quetiapine combined with haloperidol. Compare the therapeutic effect of two groups. Results The total effective rate of observation group was 96.7%(58/60) compared to 87.3%(48/55) of the control group(P < 0.05). The adverse reaction rate of the observation group was 21.7%(13/60), and the control group was 21.8%(12/55), and the adverse reactions in both groups were mild to moderate. After treatment, the content of serum HDL-C, TC and TG in the observation group werelower than that of the control group(P < 0.05), and there were no difference in the comparison of the content of HDL-C in the two groups. After treatment, the agitation score of the observation group and the control group were(8.14 ± 6.33) points and(13.01 ± 6.10) points, which was significantly lower than those before treatment of(22.22 ± 5.33) points and(22.09 ± 4.82) points(P < 0.05). The observation group was lower than the control group(P < 0.05). Conclusion The quetiapine combined with haloperidol in the treatment of schizophrenia can effectively control the agitation behavior, improve the treatment effect, and will not increase the occurrence of adverse reactions, and will not affect the level of blood lipids of patients. It has a very good application value.
Objective To investigate the effects of quetiapine combined with haloperidol on the aggressive behavior of schizophrenic patients. Methods Used a retrospective study, From January 2015 to September 2016, 115 patients with aggressive behavior of schizophrenic patients in our hospital for treatment were selected. All the patients were divided into the observation group of 70 patients and control group of 45 patients accorded to the different methods of drugs, the control group was treated with quetiapinet, the observation group was quetiapine combined with haloperidol. Compare the therapeutic effect of two groups. Results The total effective rate of observation group was 96.7%(58/60) compared to 87.3%(48/55) of the control group(P < 0.05). The adverse reaction rate of the observation group was 21.7%(13/60), and the control group was 21.8%(12/55), and the adverse reactions in both groups were mild to moderate. After treatment, the content of serum HDL-C, TC and TG in the observation group werelower than that of the control group(P < 0.05), and there were no difference in the comparison of the content of HDL-C in the two groups. After treatment, the agitation score of the observation group and the control group were(8.14 ± 6.33) points and(13.01 ± 6.10) points, which was significantly lower than those before treatment of(22.22 ± 5.33) points and(22.09 ± 4.82) points(P < 0.05). The observation group was lower than the control group(P < 0.05). Conclusion The quetiapine combined with haloperidol in the treatment of schizophrenia can effectively control the agitation behavior, improve the treatment effect, and will not increase the occurrence of adverse reactions, and will not affect the level of blood lipids of patients. It has a very good application value.
引文
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[13]陈贲,施海姗,钟笑梅,等.麻痹性痴呆患者认知功能障碍与精神行为症状的随访研究[J].中华精神科杂志,2017,50(3):226-230.
[14]Mc Guire J L,Depasquale E A,Funk A J,et al.Abnormalities of signal transduction networks in chronic schizophrenia[J].NPJ Schizophr,2017,12(3):30.
[15]王洁,许敏,张燕,等.额颞叶痴呆与阿尔茨海默病患者认知功能和神经精神行为的差异性研究[J].医学临床研究,2017,34(1):103-105.
[16]Chikama K,Yamada H,Tsukamoto T,et al.Chronic atypical antipsychotics,but not haloperidol,increase neurogenesis in the hippocampus of adult mouse[J].Brain Res,2017,1(1676):77-82.
[17]Wang H,Farhan M,Xu J,et al.The involvement of DARPP-32 in the pathophysiology of schizophrenia[J].Oncotarget,2017,8(32):53791-53803.
[18]苏中华,徐芳芳,张怀晨,等.院前具有攻击行为的急性精神分裂症患者的住院治疗特点[J].神经疾病与精神卫生,2017,17(4):243-247.
[19]Okpataku C I,Tawani D.Psychotropic prescriptions for the treatment of schizophrenia in an outpatient clinic[J].Trends Psychiatry Psychother,2017,39(3):165-172.
[20]Telgote S A,Pendharkar S S,Kelkar A D,et al.Very early-onset schizophrenia with secondary onset tic disorder[J].Indian J Psychol Med,2017,39(4):519-522.
[21]沐楠,饶冬萍,张若曦,等.痴呆伴发精神行为症状的临床研究[J].实用医学杂志,2017,33(10):1612-1615.
[22]Ning H,Cao D,Wang H,et al.Effects of haloperidol,olanzapine,ziprasidone,and PHA-543613 on spatial learning and memory in the Morris water maze test in na?ve and MK-801-treated mice[J].Brain Behav,2017,7(8):e00764.
[2]Taraskina A E,Nasyrova R F,Zabotina A M,et al.Potential diagnostic markers of olanzapine efficiency for acute psychosis:a focus on peripheral biogenic amines[J].BMC Psychiatry,2017,17(1):394.
[3]Zaman H,Sampson S J,Beck A L,et al.Benzodiazepines for psychosis-induced aggression or agitation[J].Cochrane Database Syst Rev,2017,8(12):CD003079.
[4]Lum J S,Pan B,Deng C,et al.Effects of short-and long-term aripiprazole treatment on Group I m Glu Rs in the nucleus accumbens:Comparison with haloperidol[J].Psychiatry Res,2017,21(260):152-157.
[5]陈立勇,刘秀丽.丙戊酸钠缓释片对阿尔茨海默病患者精神行为症状的疗效及安全性[J].齐齐哈尔医学院学报,2017,38(3):255-257.
[6]Yazici E,S Cilli A,Yazici A B,et al.Antipsychotic use pattern in schizophrenia outpatients:Correlates of polypharmacy[J].Clin Pract Epidemiol Ment Health,2017,11(13):92-103.
[7]Hawkins P C T,Wood T C,Vernon A C,et al.An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers[J].Hum Brain Mapp,2018,39(1):319-331.
[8]Yan T,Greene M,Chang E,et al.All-cause hospitalization and associated costs in patients with schizophrenia or bipolar disorder initiating long-acting injectable antipsychotics[J].Curr Med Res Opin,2017,11(3):1-7.
[9]Nikoli?T,Petronijevi?M,Sopta J,et al.Haloperidol affects bones while clozapine alters metabolic parameters-sex specific effects in rats perinatally treated with phencyclidine[J].BMC Pharmacol Toxicol,2017,18(1):65.
[10]安善佐,孙长军,季爱民,等.无抽搐电休克治疗精神分裂症激越行为对照研究[J].临床心身疾病杂志,2017,23(3):58-60.
[11]Stürup A E,Jensen H D,Dolmer S,et al.TAILORtapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms:study protocol for a randomized clinical trial[J].Trials,2017,18(1):445.
[12]Dzyubenko E,Juckel G,Faissner A.The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro[J].Sci Rep,2017,7(1):11609.
[13]陈贲,施海姗,钟笑梅,等.麻痹性痴呆患者认知功能障碍与精神行为症状的随访研究[J].中华精神科杂志,2017,50(3):226-230.
[14]Mc Guire J L,Depasquale E A,Funk A J,et al.Abnormalities of signal transduction networks in chronic schizophrenia[J].NPJ Schizophr,2017,12(3):30.
[15]王洁,许敏,张燕,等.额颞叶痴呆与阿尔茨海默病患者认知功能和神经精神行为的差异性研究[J].医学临床研究,2017,34(1):103-105.
[16]Chikama K,Yamada H,Tsukamoto T,et al.Chronic atypical antipsychotics,but not haloperidol,increase neurogenesis in the hippocampus of adult mouse[J].Brain Res,2017,1(1676):77-82.
[17]Wang H,Farhan M,Xu J,et al.The involvement of DARPP-32 in the pathophysiology of schizophrenia[J].Oncotarget,2017,8(32):53791-53803.
[18]苏中华,徐芳芳,张怀晨,等.院前具有攻击行为的急性精神分裂症患者的住院治疗特点[J].神经疾病与精神卫生,2017,17(4):243-247.
[19]Okpataku C I,Tawani D.Psychotropic prescriptions for the treatment of schizophrenia in an outpatient clinic[J].Trends Psychiatry Psychother,2017,39(3):165-172.
[20]Telgote S A,Pendharkar S S,Kelkar A D,et al.Very early-onset schizophrenia with secondary onset tic disorder[J].Indian J Psychol Med,2017,39(4):519-522.
[21]沐楠,饶冬萍,张若曦,等.痴呆伴发精神行为症状的临床研究[J].实用医学杂志,2017,33(10):1612-1615.
[22]Ning H,Cao D,Wang H,et al.Effects of haloperidol,olanzapine,ziprasidone,and PHA-543613 on spatial learning and memory in the Morris water maze test in na?ve and MK-801-treated mice[J].Brain Behav,2017,7(8):e00764.