摘要
转录因子KLF家族(Krüppel-like factors)成员的C-末端区域中均存在3个保守的Cys2/His2锌指结构,它们能够参与调控真核生物的多种生理过程并发挥重要作用,包括促进脂肪组织和肌肉形成、影响神经系统发育、参与肿瘤发生过程、调控细胞和组织及系统水平的代谢和修复损伤的代谢组织等,是当前生物领域的研究热点。因此,综述了KLF家族成员的共同结构特征,以及KLF3、KLF5、KLF6、KLF7、KLF8、KLF14、KLF15的主要生理功能及其调控机制的研究进展,为未来进一步探讨KLF家族转录因子的作用和相关疾病的分子机制提供参考。
Members of the Krüppel-like factors(KLFs),which are characterized by the presence of three conserved Cys2/His2 zinc-fingers in the C-terminal region,and control varieties of biological processes.Recent studies have shown that KLFs can promote the formation of adipose tissue and muscle,affect the development of the nervous system,participate in the regulation of cancer,and play an important role in the metabolic regulation and repair of metabolic tissue at the level of cells,tissues and systems. At present,it has become a hotspot in biological research.This paper summarizes the common structural characteristics of KLFs,and introduces the research progress of KLF3,KLF5,KLF6,KLF7,KLF8,KLF14,KLF15's main physiological functions and regulatory mechanisms to provide reference and direction for future scientific research.
引文
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