滑膜软骨瘤:如何提高诊断准确率和治疗中肿瘤细胞的清除率
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摘要
背景:近年来,滑膜软骨瘤病的诊断和治疗方法发展迅速。体格检查、CT和MRI被视为诊断滑膜软骨病的重要方法,CT和MRI更是在临床上广泛应用,关节镜手术是治疗的常规方法。文章重点介绍了近5年来滑膜软骨瘤病的诊断和治疗研究进展,并为今后的研究提供方案和建议。目的:总结滑膜软骨瘤病的诊断和治疗方案的最新进展。方法:由第一作者用计算机检索PubMed和Embase数据库,检索时间2012年至2018年,检索词分别为"Chondromatosis,Synovial""Diagnosis""Therapy""Imaging Diagnosis",语言设定为英文。根据体格检查、MRI和关节镜手术的进展,总结并分析滑膜软骨瘤病的诊断和治疗研究进展。结果与结论:共检索到569篇文章,按纳入和排除标准对文献进行筛选,共纳入34篇文章。结果表明,MRI是诊断关节疾病的常用方法,但由于受假阳性率的影响,应结合体格检查来提高滑膜软骨瘤病诊断的准确率。在治疗方面,如何提高肿瘤的清除率还有待进一步的研究来证实。
BACKGROUND: The diagnosis and treatment methods of synovial chondromatosis develop rapidly. Physical examination, CT and MRI are considered as the important methods to diagnos e the synovial chondraomatosis,but MRI and CT are more extensively applied in clinical practice. Arthroscopic surgery is a conventional treatment method. The article focuses on the diagnosis and treatment research progress of synovial chondromatosis in recent 5 years and proposes a protocol and suggestions for future research.OBJECTIVE: To summarize the latest progress of diagnosis and treatment of synovial chondromatosis.METHODS: PubMed and Embase databases from 2012 to 2018 were searched. The keywords were"chondromatosis, synovial, diagnosis, therapy, imaging diagnosis" in English. The research progress in the diagnosis and treatment of synovial chondromatosis were summarized in aspects of physical examination,MRI and arthroscopic surgery.RESULTS AND CONCLUSION: Totally 569 papers were retrieved and 34 articles eligible for inclusion and exclusion criteria were included.MRI is a common method to diagnose the joint diseases, but due to its false positive rate, we should combine with physical examination to enhance diagnosis rate of synovial chondromatosis. As for the therapy, how to improve clearance rate of tumor still needs further investigation.
BACKGROUND: The diagnosis and treatment methods of synovial chondromatosis develop rapidly. Physical examination, CT and MRI are considered as the important methods to diagnos e the synovial chondraomatosis,but MRI and CT are more extensively applied in clinical practice. Arthroscopic surgery is a conventional treatment method. The article focuses on the diagnosis and treatment research progress of synovial chondromatosis in recent 5 years and proposes a protocol and suggestions for future research.OBJECTIVE: To summarize the latest progress of diagnosis and treatment of synovial chondromatosis.METHODS: PubMed and Embase databases from 2012 to 2018 were searched. The keywords were"chondromatosis, synovial, diagnosis, therapy, imaging diagnosis" in English. The research progress in the diagnosis and treatment of synovial chondromatosis were summarized in aspects of physical examination,MRI and arthroscopic surgery.RESULTS AND CONCLUSION: Totally 569 papers were retrieved and 34 articles eligible for inclusion and exclusion criteria were included.MRI is a common method to diagnose the joint diseases, but due to its false positive rate, we should combine with physical examination to enhance diagnosis rate of synovial chondromatosis. As for the therapy, how to improve clearance rate of tumor still needs further investigation.
引文
[1]Trevino M,Laks S,Kafchinski L,et al.Intermetatarsal bursa primary synovial chondromatosis:case report and review of the literature.Skeletal Radiol.2017;46(12):1769-1773.
[2]Habusta SF,Tuck JA.Synovial Chondromatosis.StatPearls.Treasure Island(FL):StatPearls Publishing.StatPearls Publishing LLC.2018.
[3]Derek Stensby J,Fox MG,Kwon MS,et al.Primary synovial chondromatosis of the subtalar joint:case report and review of the literature.Skeletal Radiol.2018;47(3):391-396.
[4]Chen TJ,Tsai YF,Chou YH,et al.Shoulder joint synovial chondromatosis presenting as multiple axillary masses:a case report.J Clin Ultrasound.2018;46(5):361-363.
[5]Selvi F,Messina J,Faquin WC,et al.Relapsing polychondritis concomitant with synovial chondromatosis of the temporomandibular joint.J Oral Maxillofac Surg.2016;74(11):2207-2215.
[6]Ionna F,Amantea M,Mastrangelo F,et al.Innovative surgical management of the synovial chondromatosis of temporomandibular joints:highly conservative surgical technique.JCraniofac Surg.2016;27(5):1197-201.
[7]Jaganathan S,Goyal A,Gadodia A,et al.Spectrum of synovial pathologies:a pictorial assay.Curr Probl Diagn Radiol.2012;41(1):30-42.
[8]Leite PCC,Tolentino ES,Yamashita AL,et al.Surgical treatment of synovial chondromatosis in the inferior compartment of the temporomandibular joint with articular disc involvement.J Craniofacial Surg.2018;29(2):e199-e203.
[9]Liu X,Huang Z,Zhu W,et al.Clinical and imaging findings of temporomandibular joint synovial chondromatosis:an analysis of 10 cases and literature review.J Oral Maxillofac Surg.2016;74(11):2159-2168.
[10]Levine BD,Motamedi K,Seeger LL.Synovial tumors and proliferative diseases.Rheum Dis Clin North Am.2016;42(4):753-768.
[11]Cho HJ,Suh JD.An unusual presentation of synovial chondromatosis of the knee in a 10-year-old girl.Acta Orthop Traumatol Turc.2018;52(2):162-165.
[12]Dash KK,Gavai PV,Wade R,et al.It's not what it looks like:challenges in diagnosis of synovial lesions of the knee joint.JExp Orthop.2016;3(1):5.
[13]Kim HK,Ha SH,Lee GJ,et al.Uncalcified synovial chondromatosis in the pisotriquetral joint.Clin Orthop Surg.2015;7(3):414-417.
[14]Ferro FP,Philippon MJ.Arthroscopy provides symptom relief and good functional outcomes in patients with hip synovial chondromatosis.J Hip Preserv Surg.2015;2(3):265-271.
[15]Dai X,Feng YY,Bu LX,et al.Synovial chondromatosis in the temporomandibular joint:report of 2 cases.Shanghai Kou Qiang Yi Xue.2016;25(5):633-637.
[16]Ivask O,Leibur E,Voog-Oras U.Synovial chondromatosis in the temporomandibular joint:case report with review of the literature.Stomatologija.2015;17(3):97-101.
[17]Biazzo A,Confalonieri N.Synovial chondrosarcoma.Ann transl Med.2016;4(15):280.
[18]Wake M,Hamada Y,Kumagai K,et al.Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibular joints affected by synovial chondromatosis.Br J Oral Maxillofac Surg.2013;51(2):164-169.
[19]Ji JH,Shafi M,Jeong DS.Secondary synovial chondromatosis of the shoulder.Knee Surg Sports Traumatol Arthrosc.2015;23(9):2624-2627.
[20]Sozzi D,Bocchialini G,Novelli G,et al.A rare case of synovial chondromatosis of the inferior TMJ compartment.Diagnosis and treatment aspect.Ann Stomatol(Roma).2016;6(3-4):91-95.
[21]Milgram JW,Dunn EJ.Para-articular chondromas and osteochondromas:a report of three cases.Clin Orthop Relat Res.1980;(148):147-151.
[22]Lui TH.Tenosynovial(extra-articular)chondromatosis of the extensor digitorum longus tendon and synovial chondromatosis of the ankle:treated by extensor digitorum longus tendoscopy and ankle arthroscopy.Foot Ankle Spec.2015;8(5):422-425.
[23]Cirolia JT.Left knee synovial osteochondromatosis.J Orthop Sports Phys Ther.2017;47(4):294.
[24]Sozzi D,Bocchialini G,Novelli G,et al.A rare case of synovial chondromatosis of the inferior TMJ compartment.Diagnosis and treatment aspect.Ann Stomatol(Roma).2015;6(3-4):91-95.
[25]Lui TH.Arthroscopic treatment of pigmented villonodular synovitis of the proximal tibiofibular joint.Knee Surg Sports Traumatol Arthrosc.2015;23(8):2278-2282.
[26]Frank JM,Saltzman BM,Hemu M,et al.Synovial chondromatosis of the elbow with asymptomatic ulnar nerve compression.J Hand Surg.2016;41(11):e429-e431.
[27]Startzman A,Collins D,Carreira D.A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip.Phys Sportsmed.2016;44(4):425-431.
[28]Fernandez Sanroman J,Costas Lopez A,Anton Badiola I,et al.Indications of arthroscopy in the treatment of synovial chondromatosis of the temporomandibular joint:report of 5new cases.J Oral Maxillofac Surg.2008;66(8):1694-1699.
[29]Li J,Li Z,Su X,et al.Effectiveness of arthroscopy for synovial chondromatosis of hip joint.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi.2017;31(8):897-901.
[30]Houdek MT,Wyles CC,Rose PS,et al.High rate of local recurrence and complications following total knee arthroplasty in the setting of synovial chondromatosis.J Arthrop.2017;32(7):2147-2150.
[31]Durr HR,Klein A.Diagnosis and therapy of benign intraarticular tumors.Orthopade.2017;46(6):498-504.
[32]Tissot C,Merlini L,Mercier M,et al.Reasons for and functional results of repeated hip arthroscopy:a continuous prospective study of 17 revisions out of 295 primary hip arthroscopies at mean 28 months'follow-up.Orthop Traumatol Surg Res.2017;103(5):645-649.
[33]de Sa D,Horner NS,MacDonald A,et al.Arthroscopic surgery for synovial chondromatosis of the hip:a systematic review of rates and predisposing factors for recurrence.Arthroscopy.2014;30(11):1499-1504.
[34]Bai G,Yang C,Qiu Y,et al.Open surgery assisted with arthroscopy to treat synovial chondromatosis of the temporomandibular joint.Int J Oral Maxillofac Surg.2017;46(2):208-213.
[2]Habusta SF,Tuck JA.Synovial Chondromatosis.StatPearls.Treasure Island(FL):StatPearls Publishing.StatPearls Publishing LLC.2018.
[3]Derek Stensby J,Fox MG,Kwon MS,et al.Primary synovial chondromatosis of the subtalar joint:case report and review of the literature.Skeletal Radiol.2018;47(3):391-396.
[4]Chen TJ,Tsai YF,Chou YH,et al.Shoulder joint synovial chondromatosis presenting as multiple axillary masses:a case report.J Clin Ultrasound.2018;46(5):361-363.
[5]Selvi F,Messina J,Faquin WC,et al.Relapsing polychondritis concomitant with synovial chondromatosis of the temporomandibular joint.J Oral Maxillofac Surg.2016;74(11):2207-2215.
[6]Ionna F,Amantea M,Mastrangelo F,et al.Innovative surgical management of the synovial chondromatosis of temporomandibular joints:highly conservative surgical technique.JCraniofac Surg.2016;27(5):1197-201.
[7]Jaganathan S,Goyal A,Gadodia A,et al.Spectrum of synovial pathologies:a pictorial assay.Curr Probl Diagn Radiol.2012;41(1):30-42.
[8]Leite PCC,Tolentino ES,Yamashita AL,et al.Surgical treatment of synovial chondromatosis in the inferior compartment of the temporomandibular joint with articular disc involvement.J Craniofacial Surg.2018;29(2):e199-e203.
[9]Liu X,Huang Z,Zhu W,et al.Clinical and imaging findings of temporomandibular joint synovial chondromatosis:an analysis of 10 cases and literature review.J Oral Maxillofac Surg.2016;74(11):2159-2168.
[10]Levine BD,Motamedi K,Seeger LL.Synovial tumors and proliferative diseases.Rheum Dis Clin North Am.2016;42(4):753-768.
[11]Cho HJ,Suh JD.An unusual presentation of synovial chondromatosis of the knee in a 10-year-old girl.Acta Orthop Traumatol Turc.2018;52(2):162-165.
[12]Dash KK,Gavai PV,Wade R,et al.It's not what it looks like:challenges in diagnosis of synovial lesions of the knee joint.JExp Orthop.2016;3(1):5.
[13]Kim HK,Ha SH,Lee GJ,et al.Uncalcified synovial chondromatosis in the pisotriquetral joint.Clin Orthop Surg.2015;7(3):414-417.
[14]Ferro FP,Philippon MJ.Arthroscopy provides symptom relief and good functional outcomes in patients with hip synovial chondromatosis.J Hip Preserv Surg.2015;2(3):265-271.
[15]Dai X,Feng YY,Bu LX,et al.Synovial chondromatosis in the temporomandibular joint:report of 2 cases.Shanghai Kou Qiang Yi Xue.2016;25(5):633-637.
[16]Ivask O,Leibur E,Voog-Oras U.Synovial chondromatosis in the temporomandibular joint:case report with review of the literature.Stomatologija.2015;17(3):97-101.
[17]Biazzo A,Confalonieri N.Synovial chondrosarcoma.Ann transl Med.2016;4(15):280.
[18]Wake M,Hamada Y,Kumagai K,et al.Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibular joints affected by synovial chondromatosis.Br J Oral Maxillofac Surg.2013;51(2):164-169.
[19]Ji JH,Shafi M,Jeong DS.Secondary synovial chondromatosis of the shoulder.Knee Surg Sports Traumatol Arthrosc.2015;23(9):2624-2627.
[20]Sozzi D,Bocchialini G,Novelli G,et al.A rare case of synovial chondromatosis of the inferior TMJ compartment.Diagnosis and treatment aspect.Ann Stomatol(Roma).2016;6(3-4):91-95.
[21]Milgram JW,Dunn EJ.Para-articular chondromas and osteochondromas:a report of three cases.Clin Orthop Relat Res.1980;(148):147-151.
[22]Lui TH.Tenosynovial(extra-articular)chondromatosis of the extensor digitorum longus tendon and synovial chondromatosis of the ankle:treated by extensor digitorum longus tendoscopy and ankle arthroscopy.Foot Ankle Spec.2015;8(5):422-425.
[23]Cirolia JT.Left knee synovial osteochondromatosis.J Orthop Sports Phys Ther.2017;47(4):294.
[24]Sozzi D,Bocchialini G,Novelli G,et al.A rare case of synovial chondromatosis of the inferior TMJ compartment.Diagnosis and treatment aspect.Ann Stomatol(Roma).2015;6(3-4):91-95.
[25]Lui TH.Arthroscopic treatment of pigmented villonodular synovitis of the proximal tibiofibular joint.Knee Surg Sports Traumatol Arthrosc.2015;23(8):2278-2282.
[26]Frank JM,Saltzman BM,Hemu M,et al.Synovial chondromatosis of the elbow with asymptomatic ulnar nerve compression.J Hand Surg.2016;41(11):e429-e431.
[27]Startzman A,Collins D,Carreira D.A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip.Phys Sportsmed.2016;44(4):425-431.
[28]Fernandez Sanroman J,Costas Lopez A,Anton Badiola I,et al.Indications of arthroscopy in the treatment of synovial chondromatosis of the temporomandibular joint:report of 5new cases.J Oral Maxillofac Surg.2008;66(8):1694-1699.
[29]Li J,Li Z,Su X,et al.Effectiveness of arthroscopy for synovial chondromatosis of hip joint.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi.2017;31(8):897-901.
[30]Houdek MT,Wyles CC,Rose PS,et al.High rate of local recurrence and complications following total knee arthroplasty in the setting of synovial chondromatosis.J Arthrop.2017;32(7):2147-2150.
[31]Durr HR,Klein A.Diagnosis and therapy of benign intraarticular tumors.Orthopade.2017;46(6):498-504.
[32]Tissot C,Merlini L,Mercier M,et al.Reasons for and functional results of repeated hip arthroscopy:a continuous prospective study of 17 revisions out of 295 primary hip arthroscopies at mean 28 months'follow-up.Orthop Traumatol Surg Res.2017;103(5):645-649.
[33]de Sa D,Horner NS,MacDonald A,et al.Arthroscopic surgery for synovial chondromatosis of the hip:a systematic review of rates and predisposing factors for recurrence.Arthroscopy.2014;30(11):1499-1504.
[34]Bai G,Yang C,Qiu Y,et al.Open surgery assisted with arthroscopy to treat synovial chondromatosis of the temporomandibular joint.Int J Oral Maxillofac Surg.2017;46(2):208-213.