Feasibility study of computed vs measured high b-value(1400 s/mm2) diffusion-weighted MR images of the prostate
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摘要
AIM: To evaluate the impact of computed b = 1400 s/mm2(C-b1400) vs measured b = 1400 s/mm2(M-b1400) diffusion-weighted images(DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence(sFOV). METHODS: Thirty patients(PSA: 9.5 ± 8.7 ng/mL; 68 ± 12 years) referred for magnetic resonance imaging(MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR system.For DWI, a single-shot EPI diffusion sequence(b = 0, 100, 400, 800 s/mm2) was utilized. C-b1400 was cal-culated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. Lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated accord-ing to a 5-point Likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity(SI) were calculated to estimate the signal-to-noise-ratio(SNR). RESULTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. Overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400(2.3 ± 0.8 vs 3.1 ± 1.0, P < 0.001; 5.6 ± 1.8 vs 2.8 ± 0.9, P < 0.001). Comparison of lesion size showed no significant differences between C- and M-b1400(P = 0.22). CONCLUSION: Combination of a high b-value extrap-olation and sFOV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI(mMRI) especially under economical aspects in a pri-vate practice setting.
AIM: To evaluate the impact of computed b = 1400 s/mm2(C-b1400) vs measured b = 1400 s/mm2(M-b1400) diffusion-weighted images(DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence(sFOV). METHODS: Thirty patients(PSA: 9.5 ± 8.7 ng/mL; 68 ± 12 years) referred for magnetic resonance imaging(MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR system.For DWI, a single-shot EPI diffusion sequence(b = 0, 100, 400, 800 s/mm2) was utilized. C-b1400 was cal-culated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. Lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated accord-ing to a 5-point Likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity(SI) were calculated to estimate the signal-to-noise-ratio(SNR). RESULTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. Overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400(2.3 ± 0.8 vs 3.1 ± 1.0, P < 0.001; 5.6 ± 1.8 vs 2.8 ± 0.9, P < 0.001). Comparison of lesion size showed no significant differences between C- and M-b1400(P = 0.22). CONCLUSION: Combination of a high b-value extrap-olation and sFOV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI(mMRI) especially under economical aspects in a pri-vate practice setting.
AIM: To evaluate the impact of computed b = 1400 s/mm2(C-b1400) vs measured b = 1400 s/mm2(M-b1400) diffusion-weighted images(DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence(sFOV). METHODS: Thirty patients(PSA: 9.5 ± 8.7 ng/mL; 68 ± 12 years) referred for magnetic resonance imaging(MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR system.For DWI, a single-shot EPI diffusion sequence(b = 0, 100, 400, 800 s/mm2) was utilized. C-b1400 was cal-culated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. Lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated accord-ing to a 5-point Likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity(SI) were calculated to estimate the signal-to-noise-ratio(SNR). RESULTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. Overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400(2.3 ± 0.8 vs 3.1 ± 1.0, P < 0.001; 5.6 ± 1.8 vs 2.8 ± 0.9, P < 0.001). Comparison of lesion size showed no significant differences between C- and M-b1400(P = 0.22). CONCLUSION: Combination of a high b-value extrap-olation and sFOV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI(mMRI) especially under economical aspects in a pri-vate practice setting.
引文
1 Brawley OW.Prostate cancer epidemiology in the United States.World J Urol 2012;30:195-200[PMID:22476558 DOI:10.1007/s00345-012-0824-2]
2 Klimberg I,Locke DR,Madore RA,Smith WW.Early prostate cancer:is there a need for new treatment optionsUrol Oncol 2003;21:105-116[PMID:12856638 DOI:10.1016/S1078-1439(02)00211-9]
3 Weidner AM,Michaely HJ,Lemke A,Breitinger L,Wenz F,Marx A,Schoenberg SO,Dinter DJ.Value of multiparamet-ric prostate MRI of the peripheral zone.Z Med Phys 2011;21:198-205[PMID:21247742 DOI:10.1016/j.zemedi.2010.12.004]
4 Turkbey B,Pinto PA,Mani H,Bernardo M,Pang Y,McKinney YL,Khurana K,Ravizzini GC,Albert PS,Merino MJChoyke PL.Prostate cancer:value of multiparametric MRimaging at 3 T for detection--histopathologic correlationRadiology 2010;255:89-99[PMID:20308447 DOI:10.1148/radiol.09090475]
5 Caldas ME,Miranda LC,Bittencourt LK.Magnetic reso-nance imaging in staging of locoregional prostate cancer:comparison of results with analysis post-surgical histopa-thology.Rev Col Bras Cir 2010;37:447-449[PMID:21340261]
6 Hoeks CM,Barentsz JO,Hambrock T,Yakar D,Somford DM,Heijmink SW,Scheenen TW,Vos PC,Huisman H,van Oort IM,Witjes JA,Heerschap A,Fütterer JJ.Prostate cancer:multiparametric MR imaging for detection,localization,and staging.Radiology 2011;261:46-66[PMID:21931141 DOI:10.1148/radiol.11091822]
7 Scheenen TW,Fütterer J,Weiland E,van Hecke P,Lemort M,Zechmann C,Schlemmer HP,Broome D,Villeirs G,Lu J,Barentsz J,Roell S,Heerschap A.Discriminating cancer from noncancer tissue in the prostate by 3-dimensional proton magnetic resonance spectroscopic imaging:a prospective multicenter validation study.Invest Radiol 2011;46:25-33[PMID:21188832 DOI:10.1097/RLI.0b013e3181f54081]
8 Scherr MK,Seitz M,Müller-Lisse UG,Ingrisch M,Reiser MF,Müller-Lisse UL.MR-perfusion(MRP)and diffusion-weighted imaging(DWI)in prostate cancer:quantitative and model-based gadobenate dimeglumine MRP parameters in detection of prostate cancer.Eur J Radiol 2010;76:359-366[PMID:20471189 DOI:10.1016/j.ejrad.2010.04.023]
9 Schlemmer HP.[Multiparametric MRI of the prostate:meth-od for early detection of prostate cancer].Rofo 2010;182:1067-1075[PMID:20972932 DOI:10.1055/s-0029-1245786]
10 Fütterer JJ,Heijmink SW,Scheenen TW,Veltman J,Huis-man HJ,Vos P,Hulsbergen-Van de Kaa CA,Witjes JA,Krab-be PF,Heerschap A,Barentsz JO.Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging.Radiology 2006;241:449-458[PMID:16966484 DOI:10.1148/radiol.2412051866]
11 Bittencourt LK,Barentsz JO,de Miranda LC,Gasparetto EL.Prostate MRI:diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason Grades than TRUS-guid-ed biopsies in peripheral zone tumours.Eur Radiol 2012;22:468-475[PMID:21913058 DOI:10.1007/s00330-011-2269-1]
12 Oto A,Yang C,Kayhan A,Tretiakova M,Antic T,Schmid-Tannwald C,Eggener S,Karczmar GS,Stadler WM.Dif-fusion-weighted and dynamic contrast-enhanced MRI of prostate cancer:correlation of quantitative MR parameters with Gleason score and tumor angiogenesis.AJR Am J Roent-genol 2011;197:1382-1390[PMID:22109293 DOI:10.2214/AJR.11.6861]
13 Somford DM,Hambrock T,Hulsbergen-van de Kaa CA,Fütterer JJ,van Oort IM,van Basten JP,Karthaus HF,Witjes JA,Barentsz JO.Initial experience with identifying high-grade prostate cancer using diffusion-weighted MR imaging(DWI)in patients with a Gleason score≤3+3=6 upon sche-matic TRUS-guided biopsy:a radical prostatectomy corre-lated series.Invest Radiol 2012;47:153-158[PMID:22293513]
14 Park SY,Kim CK,Park BK,Park W,Park HC,Han DH,Kim B.Early changes in apparent diffusion coefficient from diffu-sion-weighted MR imaging during radiotherapy for prostate cancer.Int J Radiat Oncol Biol Phys 2012;83:749-755[PMID:22154286]
15 Ohgiya Y,Suyama J,Seino N,Hashizume T,Kawahara M,Sai S,Saiki M,Munechika J,Hirose M,Gokan T.Di-agnostic accuracy of ultra-high-b-value 3.0-T diffusion-weighted MR imaging for detection of prostate cancer.Clin Imaging 2012;36:526-531[PMID:22920357 DOI:10.1016/j.clinimag.2011.11.016]
16 Kitajima K,Kaji Y,Kuroda K,Sugimura K.High b-value diffusion-weighted imaging in normal and malignant pe-ripheral zone tissue of the prostate:effect of signal-to-noise ratio.Magn Reson Med Sci 2008;7:93-99[PMID:18603841DOI:10.2463/mrms.7.93]
17 Dietrich O,Biffar A,Baur-Melnyk A,Reiser MF.Techni-cal aspects of MR diffusion imaging of the body.Eur J Radiol 2010;76:314-322[PMID:20299172 DOI:10.1016/j.ejrad.2010.02.018]
18 Blackledge MD,Leach MO,Collins DJ,Koh DM.Computed diffusion-weighted MR imaging may improve tumor de-tection.Radiology 2011;261:573-581[PMID:21852566 DOI:10.1148/radiol.11101919]
19 Barentsz JO,Richenberg J,Clements R,Choyke P,Verma S,Villeirs G,Rouviere O,Logager V,Fütterer JJ.ESUR prostate MR guidelines 2012.Eur Radiol 2012;22:746-757[PMID:22322308]
20 Reischauer C,Wilm BJ,Froehlich JM,Gutzeit A,Prikler L,Gablinger R,Boesiger P,Wentz KU.High-resolution diffu-sion tensor imaging of prostate cancer using a reduced FOV technique.Eur J Radiol 2011;80:e34-e41[PMID:20638208 DOI:10.1016/j.ejrad.2010.06.038]
21 Finsterbusch J.Improving the performance of diffusion-weighted inner field-of-view echo-planar imaging based on 2D-selective radiofrequency excitations by tilting the excita-tion plane.J Magn Reson Imaging 2012;35:984-992[PMID:22170770]
22 Metens T,Miranda D,Absil J,Matos C.What is the optimal b value in diffusion-weighted MR imaging to depict prostate cancer at 3TEur Radiol 2012;22:703-709[PMID:21971824 DOI:10.1007/s00330-011-2298-9]
23 Rosenkrantz AB,Sigmund EE,Johnson G,Babb JS,Mussi TC,Melamed J,Taneja SS,Lee VS,Jensen JH.Prostate can-cer:feasibility and preliminary experience of a diffusional kurtosis model for detection and assessment of aggressive-ness of peripheral zone cancer.Radiology 2012;264:126-135[PMID:22550312 DOI:10.1148/radiol.12112290]
24 Mazzoni LN,Lucarini S,Chiti S,Busoni S,Gori C,Menchi I.Diffusion-weighted signal models in healthy and cancer-ous peripheral prostate tissues:comparison of outcomes obtained at different b-values.J Magn Reson Imaging 2014;39:512-518[PMID:23723087]
25 Quentin M,Blondin D,Klasen J,Lanzman RS,Miese FR,Ar-sov C,Albers P,Antoch G,Wittsack HJ.Comparison of dif-ferent mathematical models of diffusion-weighted prostate MR imaging.Magn Reson Imaging 2012;30:1468-1474[PMID:22819178]
2 Klimberg I,Locke DR,Madore RA,Smith WW.Early prostate cancer:is there a need for new treatment optionsUrol Oncol 2003;21:105-116[PMID:12856638 DOI:10.1016/S1078-1439(02)00211-9]
3 Weidner AM,Michaely HJ,Lemke A,Breitinger L,Wenz F,Marx A,Schoenberg SO,Dinter DJ.Value of multiparamet-ric prostate MRI of the peripheral zone.Z Med Phys 2011;21:198-205[PMID:21247742 DOI:10.1016/j.zemedi.2010.12.004]
4 Turkbey B,Pinto PA,Mani H,Bernardo M,Pang Y,McKinney YL,Khurana K,Ravizzini GC,Albert PS,Merino MJChoyke PL.Prostate cancer:value of multiparametric MRimaging at 3 T for detection--histopathologic correlationRadiology 2010;255:89-99[PMID:20308447 DOI:10.1148/radiol.09090475]
5 Caldas ME,Miranda LC,Bittencourt LK.Magnetic reso-nance imaging in staging of locoregional prostate cancer:comparison of results with analysis post-surgical histopa-thology.Rev Col Bras Cir 2010;37:447-449[PMID:21340261]
6 Hoeks CM,Barentsz JO,Hambrock T,Yakar D,Somford DM,Heijmink SW,Scheenen TW,Vos PC,Huisman H,van Oort IM,Witjes JA,Heerschap A,Fütterer JJ.Prostate cancer:multiparametric MR imaging for detection,localization,and staging.Radiology 2011;261:46-66[PMID:21931141 DOI:10.1148/radiol.11091822]
7 Scheenen TW,Fütterer J,Weiland E,van Hecke P,Lemort M,Zechmann C,Schlemmer HP,Broome D,Villeirs G,Lu J,Barentsz J,Roell S,Heerschap A.Discriminating cancer from noncancer tissue in the prostate by 3-dimensional proton magnetic resonance spectroscopic imaging:a prospective multicenter validation study.Invest Radiol 2011;46:25-33[PMID:21188832 DOI:10.1097/RLI.0b013e3181f54081]
8 Scherr MK,Seitz M,Müller-Lisse UG,Ingrisch M,Reiser MF,Müller-Lisse UL.MR-perfusion(MRP)and diffusion-weighted imaging(DWI)in prostate cancer:quantitative and model-based gadobenate dimeglumine MRP parameters in detection of prostate cancer.Eur J Radiol 2010;76:359-366[PMID:20471189 DOI:10.1016/j.ejrad.2010.04.023]
9 Schlemmer HP.[Multiparametric MRI of the prostate:meth-od for early detection of prostate cancer].Rofo 2010;182:1067-1075[PMID:20972932 DOI:10.1055/s-0029-1245786]
10 Fütterer JJ,Heijmink SW,Scheenen TW,Veltman J,Huis-man HJ,Vos P,Hulsbergen-Van de Kaa CA,Witjes JA,Krab-be PF,Heerschap A,Barentsz JO.Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging.Radiology 2006;241:449-458[PMID:16966484 DOI:10.1148/radiol.2412051866]
11 Bittencourt LK,Barentsz JO,de Miranda LC,Gasparetto EL.Prostate MRI:diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason Grades than TRUS-guid-ed biopsies in peripheral zone tumours.Eur Radiol 2012;22:468-475[PMID:21913058 DOI:10.1007/s00330-011-2269-1]
12 Oto A,Yang C,Kayhan A,Tretiakova M,Antic T,Schmid-Tannwald C,Eggener S,Karczmar GS,Stadler WM.Dif-fusion-weighted and dynamic contrast-enhanced MRI of prostate cancer:correlation of quantitative MR parameters with Gleason score and tumor angiogenesis.AJR Am J Roent-genol 2011;197:1382-1390[PMID:22109293 DOI:10.2214/AJR.11.6861]
13 Somford DM,Hambrock T,Hulsbergen-van de Kaa CA,Fütterer JJ,van Oort IM,van Basten JP,Karthaus HF,Witjes JA,Barentsz JO.Initial experience with identifying high-grade prostate cancer using diffusion-weighted MR imaging(DWI)in patients with a Gleason score≤3+3=6 upon sche-matic TRUS-guided biopsy:a radical prostatectomy corre-lated series.Invest Radiol 2012;47:153-158[PMID:22293513]
14 Park SY,Kim CK,Park BK,Park W,Park HC,Han DH,Kim B.Early changes in apparent diffusion coefficient from diffu-sion-weighted MR imaging during radiotherapy for prostate cancer.Int J Radiat Oncol Biol Phys 2012;83:749-755[PMID:22154286]
15 Ohgiya Y,Suyama J,Seino N,Hashizume T,Kawahara M,Sai S,Saiki M,Munechika J,Hirose M,Gokan T.Di-agnostic accuracy of ultra-high-b-value 3.0-T diffusion-weighted MR imaging for detection of prostate cancer.Clin Imaging 2012;36:526-531[PMID:22920357 DOI:10.1016/j.clinimag.2011.11.016]
16 Kitajima K,Kaji Y,Kuroda K,Sugimura K.High b-value diffusion-weighted imaging in normal and malignant pe-ripheral zone tissue of the prostate:effect of signal-to-noise ratio.Magn Reson Med Sci 2008;7:93-99[PMID:18603841DOI:10.2463/mrms.7.93]
17 Dietrich O,Biffar A,Baur-Melnyk A,Reiser MF.Techni-cal aspects of MR diffusion imaging of the body.Eur J Radiol 2010;76:314-322[PMID:20299172 DOI:10.1016/j.ejrad.2010.02.018]
18 Blackledge MD,Leach MO,Collins DJ,Koh DM.Computed diffusion-weighted MR imaging may improve tumor de-tection.Radiology 2011;261:573-581[PMID:21852566 DOI:10.1148/radiol.11101919]
19 Barentsz JO,Richenberg J,Clements R,Choyke P,Verma S,Villeirs G,Rouviere O,Logager V,Fütterer JJ.ESUR prostate MR guidelines 2012.Eur Radiol 2012;22:746-757[PMID:22322308]
20 Reischauer C,Wilm BJ,Froehlich JM,Gutzeit A,Prikler L,Gablinger R,Boesiger P,Wentz KU.High-resolution diffu-sion tensor imaging of prostate cancer using a reduced FOV technique.Eur J Radiol 2011;80:e34-e41[PMID:20638208 DOI:10.1016/j.ejrad.2010.06.038]
21 Finsterbusch J.Improving the performance of diffusion-weighted inner field-of-view echo-planar imaging based on 2D-selective radiofrequency excitations by tilting the excita-tion plane.J Magn Reson Imaging 2012;35:984-992[PMID:22170770]
22 Metens T,Miranda D,Absil J,Matos C.What is the optimal b value in diffusion-weighted MR imaging to depict prostate cancer at 3TEur Radiol 2012;22:703-709[PMID:21971824 DOI:10.1007/s00330-011-2298-9]
23 Rosenkrantz AB,Sigmund EE,Johnson G,Babb JS,Mussi TC,Melamed J,Taneja SS,Lee VS,Jensen JH.Prostate can-cer:feasibility and preliminary experience of a diffusional kurtosis model for detection and assessment of aggressive-ness of peripheral zone cancer.Radiology 2012;264:126-135[PMID:22550312 DOI:10.1148/radiol.12112290]
24 Mazzoni LN,Lucarini S,Chiti S,Busoni S,Gori C,Menchi I.Diffusion-weighted signal models in healthy and cancer-ous peripheral prostate tissues:comparison of outcomes obtained at different b-values.J Magn Reson Imaging 2014;39:512-518[PMID:23723087]
25 Quentin M,Blondin D,Klasen J,Lanzman RS,Miese FR,Ar-sov C,Albers P,Antoch G,Wittsack HJ.Comparison of dif-ferent mathematical models of diffusion-weighted prostate MR imaging.Magn Reson Imaging 2012;30:1468-1474[PMID:22819178]