心肌缺血再灌注损伤中阿片受体的研究进展
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摘要
心肌缺血再灌注损伤(MIRI)是心肌梗塞后冠脉再通治疗和心脏外科手术常见的并发症,其威胁着患者预后和健康。如何有效减少MIRI一直是科研工作者和临床医生努力的目标。阿片类药物除具有镇痛作用外,其药物处理激动阿片受体还可发挥减少心肌收缩功能障碍、降低心律失常以及心室重构发生等保护作用。本文就心肌缺血再灌注损伤中阿片受体的研究进展进行综述。
引文
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[21]SZEPESI J,ACSAI K,SEBOK Z,et al.Comparison of the efficiency of Na+/Ca2+exchanger or Na+/H+exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias[J].J Physiol Pharmacol,2015,66(2):215-226.
[22]CHAO D,WANG Q,BALBONI G,et al.Attenuating ischemic disruption of K+homeostasis in the cortex of hypoxic-ischemic neonatal rats:DOR activation vs.acupuncture treatment.[J].Mol Neurobiol,2016,53(10):7213-7227.
[23]GROSS G J,HSU A,NITHIPATIKOM K,et al.Eribis peptide 94 reduces infarct size in rat hearts via activation of centrally located mu opioid receptors[J].J Cardiovasc Pharmacol,2012,59(2):194-197.
[24]MELO Z,ISHIDA C,GOLDARAZ M D L P,et al.Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection[J].Non-coding RNA,2018,4(3):1-21.
[25]DAVE R S,KHALILI K.Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression:impact on inflammation and oxidative stress in the central nervous system[J].J Cell Biochem,2010,110(4):834-845.
[26]ZHAO Z,HAO W,MENG Q,et al.Long non-coding RNAMALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia-reperfusion injury[J].Cell Biol Int,2017,41(1):62-70.
[2]MASLOV L N,KHALIULIN I,OELTGEN P R,et al.Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists[J].Med Res Rev,2016,36(5):871-923.
[3]JOHN P,HEADRICK L E S H.Opioid receptors and cardioprotection-‘opioidergic conditioning’of the heart[J].Br J Pharmacol,2015,2(17):2026-2050.
[4]SINOVA R,KUDOVA J,NESPOROVA K,et al.Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells[J].J Cell Physiol,2018.2(11):1-11.
[5]KUNECKI M,PLAZAK W,ROLEDER T,et al.‘Opioidergic postconditioning’of heart muscle during ischemia/reperfusion injury[J].Cardiol J,2017,24(4):419-426.
[6]FRAESSDORF J,HOLLMANN M W,HANSCHMANN I,et al.Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning.[J].PLoS one,2015,10(7):e134283.
[7]YOU L,LI L,XU Q,et al.Postconditioning reduces infarct size and cardiac myocyte apoptosis via the opioid receptor and JAK-STAT signaling pathway[J].Mol Biol Rep,2011,38(1):437-443.
[8]SURENDRA H,DIAZ R J,HARVEY K,et al.Interaction of delta and kappa opioid receptors with adenosine A1 receptors mediates cardioprotection by remote ischemic preconditioning.[J].J Mol Cell Cardiol,2013,60(7):142-150.
[9]BORGES J P,VERDOORN K S,DALIRY A,et al.Delta opioid receptors:the link between exercise and cardioprotection[J].PLoS One,2014,9(11):e113541.
[10]XIA Z,LI H,IRWIN M G.Myocardial ischaemia reperfusion injury:the challenge of translating ischaemic and anaesthetic protection from animal models to humans[J].Br J Anaesth,2016,117(Suppl 2):i44-i62.
[11]MIURA T,YANO T,NAITOH K,et al.Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43[J].Am J Physiol Heart Circ Physiol,2007,293(3):H1425-H1431.
[12]ZHANG S,ZHOU Y,ZHAO L,et al.kappa-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation[J].Eur J Pharmacol,2018,833:100-108.
[13]NGUYEN V T,WU Y,GUILLORY A N,et al.Delta-opioid augments cardiac contraction through beta-adrenergic and CGRP-receptor co-signaling[J].Peptides,2012,33(1):77-82.
[14]FRIDOLFSSON H N,ROTH D M,INSEL P A,et al.Regulation of intracellular signaling and function by caveolin[J].FASEB J,2014,28(9):3823-3831.
[15]FRIDOLFSSON H N,KAWARAGUCHI Y,ALI S S,et al.Mitochondria-localized caveolin in adaptation to cellular stress and injury[J].FASEB J,2012,26(11):4637-4649.
[16]PARTON R G,DEL POZO M A.Caveolae as plasma membrane sensors,protectors and organizers[J].Nat Rev Mol Cell Biol,2013,14(2):98-112.
[17]HEAD B P,PATEL H H,ROTH D M,et al.G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes[J].J Biol Chem,2005,280(35):31036-31044.
[18]QIU Y,WANG Y,LAW P,et al.Cholesterol regulates microopioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts.[J].Mole Pharmacol,2011,80(1):210-218.
[19]PEART J N,GROSS G J.Morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype[J].Circulation,2004,109(10):1219-1222.
[20]EGAWA J,PEARN M L,LEMKUIL B P,et al.Membrane lipid rafts and neurobiology:age-related changes in membrane lipids and loss of neuronal function[J].J Physiol,2016,594(16):4565-4579.
[21]SZEPESI J,ACSAI K,SEBOK Z,et al.Comparison of the efficiency of Na+/Ca2+exchanger or Na+/H+exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias[J].J Physiol Pharmacol,2015,66(2):215-226.
[22]CHAO D,WANG Q,BALBONI G,et al.Attenuating ischemic disruption of K+homeostasis in the cortex of hypoxic-ischemic neonatal rats:DOR activation vs.acupuncture treatment.[J].Mol Neurobiol,2016,53(10):7213-7227.
[23]GROSS G J,HSU A,NITHIPATIKOM K,et al.Eribis peptide 94 reduces infarct size in rat hearts via activation of centrally located mu opioid receptors[J].J Cardiovasc Pharmacol,2012,59(2):194-197.
[24]MELO Z,ISHIDA C,GOLDARAZ M D L P,et al.Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection[J].Non-coding RNA,2018,4(3):1-21.
[25]DAVE R S,KHALILI K.Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression:impact on inflammation and oxidative stress in the central nervous system[J].J Cell Biochem,2010,110(4):834-845.
[26]ZHAO Z,HAO W,MENG Q,et al.Long non-coding RNAMALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia-reperfusion injury[J].Cell Biol Int,2017,41(1):62-70.