摘要
目的:探讨二甲双胍辅助治疗青春期PCOS的可行性。方法:选择某院接诊的75例青春期PCOS患者,将其以奇偶数法随机分为D组(n=38)和MD组(n=37),D组以达英-35(Diane-35)治疗,MD组以二甲双胍(Metformin)+达英-35治疗,对比两组临床用药效果、用药前后性激素、FG(Ferriman-Gallway)体毛评分及代谢指标情况。结果:MD组用药总有效率(94.59%)高于D组(73.68%)(P<0.05);用药后两组LH(黄体生成素)、T(睾酮)、PRL(催乳素)和FG评分均低于用药前,E_2(雌二醇)水平高于用药前,且用药后MD组E_2水平高于D组,其他激素指标低于D组(P<0.05);用药后MD组TC、TG、空腹血糖、空腹胰岛素和胰岛素抵抗指数均低于用药前,且低于D组用药后(P<0.05);而D组用药前后各指标均无显著差异(P>0.05)。结论:二甲双胍辅助治疗青春期PCOS能达到较好用药效果,能显著调节体内性激素水平和月经状况,改善糖及脂类代谢。
Objective:To investigate the feasibility of metformin in adjuvant treatment of adolescent PCOS. Methods: 75 adolescent PCOS patients admitted to a hospital were randomly divided into D group(n=38) and MD group(n=37). Group D was treated with Diane-35. MD group was treated with Metformin + Diane-35. The clinical effects, sex hormones, FG hair score and metabolic indicators were compared. Results: The total effective rate of MD group(94.59%) was higher than D group(73.68%)(P<0.05). After treatment, the LH(luteinizing hormone), T(testosterone), PRL(prolactin) and FG scores were lower than before administration, E_2(estradiol) level was higher than before administration, and in group MD after administration, the E_2 level was higher and other hormone indicators were lower than group D(P<0.05); After treatment, the TC, TG, fasting blood glucose, fasting insulin and insulin resistance index of MD group were lower than before treatment, and lower than group D(P<0.05), but there was no significant difference between the indexes before and after treatment in group D(P>0.05). Conclusion: Metformin in the adjuvant treatment of adolescent PCOS can achieve better drug effect, significantly regulate the level of sex hormones and menstrual conditions, improving the metabolism of sugar and lipids.
引文
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