循环肿瘤细胞在胃癌中的研究进展
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摘要
胃癌在现有的临床治疗手段外需要寻求良好的生物标志物来辅助早期诊断、尽早评估疗效以及早期判定预后。循环肿瘤细胞(CTC)是一种罕见的从肿瘤中释放到外周血液中的细胞,在多项研究中被证实与肿瘤的转移有关。文章主要就CTC生物学功能和前景以及CTC对胃癌的诊断、监测疗效、判定预后的意义进行综述。
Apart from current clinical treatment methodologies,effective biomarkers are required to help with early diagnosis,early prediction of therapeutic response and early prognosis of gastric cancer. Circulating tumor cell(CTC)is a kind of tumor cells originating from tumors to peripheral blood,which has been confirmed to associate with metastasis. This article reviews the biological function and prospect of CTC and its significance in the diagnosis,monitoring efficacy and prognosis of gastric cancer.
Apart from current clinical treatment methodologies,effective biomarkers are required to help with early diagnosis,early prediction of therapeutic response and early prognosis of gastric cancer. Circulating tumor cell(CTC)is a kind of tumor cells originating from tumors to peripheral blood,which has been confirmed to associate with metastasis. This article reviews the biological function and prospect of CTC and its significance in the diagnosis,monitoring efficacy and prognosis of gastric cancer.
引文
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[36] Kubisch I,de Albuquerque A,Schuppan D,et al. Prognostic Role of a Multimarker Analysis of Circulating Tumor Cells in Advanced Gastric and Gastroesophageal Adenocarcinomas[J]. Oncology,2015,89(5):294-303.
[37] Zhang ZY,Dai ZL,Yin XW,et al. Meta-analysis shows that circulating tumor cells including circulating microRNAs are useful to predict the survival of patients with gastric cancer[J].BMC Cancer,2014,14:773.
[38] Ito H,Sato J,Tsujino Y,et al. Long-term prognostic impact of circulating tumour cells in gastric cancer patients[J]. World J Gastroenterol,2016,22(46):10232-10241.
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[40] Zheng X,Fan L,Zhou P,et al. Detection of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer[J].Transl Oncol,2017,10(3):431-441.
[2] Yang L. Incidence and mortality of gastric cancer in China[J].World J Gastroenterol,2006,12(1):17-20.
[3] Shimada H,Noie T,Ohashi M,et al. Clinical significance of serum tumor markers for gastric cancer:a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association[J]. Gastric Cancer,2014,17(1):26-33.
[4] Levy I,Gralnek IM. Complications of diagnostic colonoscopy,upper endoscopy,and enteroscopy[J]. Best Pract Res Clin Gastroenterol,2016,30(5):705-718.
[5] Crisan A,Badulescu F,Badulescu A,et al. Clinical,Histological and Prognosis Correlations in Diagnosis and Treatment of Gastric Cancer[J]. Curr Health Sci J,2016,42(3):238-256.
[6] Robertson EG,Baxter G. Tumour seeding following percutaneous needle biopsy:the real story[J]. Clin Radiol,2011,66(11):1007-1014.
[7] Meng S,Tripathy D,Frenkel EP,et al. Circulating tumor cells in patients with breast cancer dormancy[J]. Clin Cancer Res,2004,10(24):8152-8162.
[8] Anderson KJ,de Guillebon A,Hughes AD,et al. Effect of circulating tumor cell aggregate configuration on hemodynamic transport and wall contact[J]. Math Biosci,2017,294:181-194.
[9] Pantel K,Speicher MR. The biology of circulating tumor cells[J]. Oncogene,2016,35(10):1216-1224.
[10] Zhang C,Guan Y,Sun Y,et al. Tumor heterogeneity and circulating tumor cells[J]. Cancer Lett,2016,374(2):216-223.
[11] Steinert G,Sch?lch S,Koch M,et al. Biology and significance of circulating and disseminated tumour cells in colorectal cancer[J]. Langenbecks Arch Surg,2012,397(4):535-542.
[12] Aceto N,Bardia A,Miyamoto DT,et al. Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis[J]. Cell,2014,158(5):1110-1122.
[13]王学浩,徐静. CTC/CTM在肝癌肝移植中的应用前景[J].医学研究生学报,2018,31(1):1-4.
[14] Rhim AD,Mirek ET,Aiello NM,et al. EMT and dissemination precede pancreatic tumor formation[J]. Cell,2012,148(1-2):349-361.
[15]黄迎娣,崔蕾,黄利鸣,等.上皮间质转化与肿瘤耐药[J].东南国防医药,2014,16(6):624-628.
[16] Yu M,Bardia A,Wittner BS,et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition[J]. Science,2013,339(6119):580-584.
[17] Li TT,Liu H,Li FP,et al. Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer:Relevance to therapy response[J]. World J Gastroenterol,2015,21(47):13259-13267.
[18] Alix-Panabières C,Pantel K. Challenges in circulating tumour cell research[J]. Nat Rev Cancer,2014,14(9):623-631.
[19] Nagrath S,Sequist LV,Maheswaran S,et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology[J]. Nature,2007,450(7173):1235-1239.
[20] Siddiqui JA,Singh A,Chagtoo M,et al. Phytochemicals for breast cancer therapy:current status and future implications[J].Curr Cancer Drug Targets,2015,15(2):116-135.
[21]于海涛,刘秀娜. CEA联合CA199、CA724、CA242在胃癌检测的诊断价值[J].医学检验与临床,2013,4:15-16.
[22]杨莹,王峻峰,李鹏.循环肿瘤细胞检测在胰腺癌早期诊断中的作用[J].世界华人消化杂志,2016,18:2838-2843.
[23] Uenosono Y,Arigami T,Kozono T,et al. Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer[J]. Cancer,2013,119(22):3984-3991.
[24]郭迎雪,李贵新,李方超,等.胃癌中循环肿瘤细胞与临床特征的关系[J].潍坊医学院学报,2016,1:73-75.
[25] Kang HM,Kim GH,Jeon HK,et al. Circulating tumor cells detected by lab-on-a-disc:Role in early diagnosis of gastric cancer[J]. PLoS One,2017,12(6):e0180251.
[26] Kim TH,Lim M,Park J,et al. FAST:Size-Selective,ClogFree Isolation of Rare Cancer Cells from Whole Blood at a Liquid-Liquid Interface[J]. Anal Chem,2017,89(2):1155-1162.
[27] Yie SM,Lou B,Ye SR,et al. Detection of survivin-expressing circulating cancer cells(CCCs)in peripheral blood of patients with gastric and colorectal cancer reveals high risks of relapse[J]. Ann Surg Oncol,2008,15(11):3073-3082.
[28] Okabe H,Tsunoda S,Hosogi H,et al. Circulating Tumor Cells as an Independent Predictor of Survival in Advanced Gastric Cancer[J]. Ann Surg Oncol,2015,22(12):3954-3961.
[29]胃癌中循环肿瘤细胞及其核型特征与临床分期的相关性[J].诊断病理学杂志,2018,25(11):754-760.
[30] Watanabe T,Okumura T,Hirano K,et al. Circulating tumor cells expressing cancer stem cell marker CD44 as a diagnostic biomarker in patients with gastric cancer[J]. Oncol Lett,2017,13(1):281-288.
[31] Li Y,Gong J,Zhang Q,et al. Dynamic monitoring of circulating tumour cells to evaluate therapeutic efficacy in advanced gastric cancer[J]. Br J Cancer,2016,114(2):138-145.
[32] Lee SJ,Lee J,Kim ST,et al. Circulating tumor cells are predictive of poor response to chemotherapy in metastatic gastric cancer[J]. Int J Biol Markers,2015,30(4):e382-e386.
[33] Shimazu K,Fukuda K,Yoshida T,et al. High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis[J]. World J Gastroenterol,2016,22(26):6083-6088.
[34] Iwatsuki M,Toyoshima K,Watanabe M,et al. Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer[J]. Br J Cancer,2013,109(11):2829-2832.
[35]王启鸣.精准医学背景下肺癌化疗的新角度和新思考[J].医学研究生学报,2017,30(11):1151-1154.
[36] Kubisch I,de Albuquerque A,Schuppan D,et al. Prognostic Role of a Multimarker Analysis of Circulating Tumor Cells in Advanced Gastric and Gastroesophageal Adenocarcinomas[J]. Oncology,2015,89(5):294-303.
[37] Zhang ZY,Dai ZL,Yin XW,et al. Meta-analysis shows that circulating tumor cells including circulating microRNAs are useful to predict the survival of patients with gastric cancer[J].BMC Cancer,2014,14:773.
[38] Ito H,Sato J,Tsujino Y,et al. Long-term prognostic impact of circulating tumour cells in gastric cancer patients[J]. World J Gastroenterol,2016,22(46):10232-10241.
[39] Pernot S,Badoual C,Terme M,et al. Dynamic evaluation of circulating tumour cells in patients with advanced gastric and oesogastric junction adenocarcinoma:Prognostic value and early assessment of therapeutic effects[J]. Eur J Cancer,2017,79:15-22.
[40] Zheng X,Fan L,Zhou P,et al. Detection of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer[J].Transl Oncol,2017,10(3):431-441.