湿热瘀阻型子宫内膜异位症痛经的中医治疗研究
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摘要
目的探讨中药红藤方治疗湿热瘀阻型子宫内膜异位症引起的痛经的临床疗效。方法选取该院2014年2月-2017年3月门诊收治的80例湿热瘀阻型子宫内膜异位症术后患者为研究样本,根据患者就诊时间顺序,将所有患者分为对照组和研究组。对照组应用吲哚美辛治疗,研究组采用红藤方治疗。比较两组患者用药后临床疗效、中医证候评分、血清CA125变化情况。结果研究组远期临床疗效有效率为87. 50%,对照组为45. 00%。两组治疗比较差异有统计学意义(P<0. 05);两组在中医证候评分上,服药后均低于服药前,研究组低于对照组,差异有统计学意义(均P<0. 05);两组服药后血清CA125均降低,研究组低于对照组,差异有统计学意义(均P<0. 05)。结论红藤方治疗子宫内膜异位症能够较好缓解患者疼痛症状及相关中医证候,改善患者各项体征指标平衡,是临床治疗子宫内膜异位症较好的医学方案。
Objective To investigate the clinical efficacy of traditional Chinese Medicine Hongteng Prescription in the treatment of wet-heat and blood stasis retention in endometriosis. Methods In the 3 rd People's Hospital of Chongming in Shanghai from February 2014 to March 2017 a total of 80 cases of endometriosis patients as the research sample,All patients were divided into control group and study group according to the time sequence of patients' visit,the control group was treated by indometacin therapy,the study group using traditional Chinese medicine therapy,compared two groups of patients with treatment of The clinical curative effect,symptoms curative effect of TCM,and the change of serum CA125. Results The effective rate of clinical curative effect of long-term study group 87. 55%,control group 45. 00%,two groups were statistically significant difference( P< 0. 05); the two groups on symptoms curative effect of TCM,after the treatment were lower than those before treatment,the study group was lower than the control group,there was significant difference( P<0. 05); the two groups after the treatment the serum CA125 were lower in study group compared with the control group,there were significant difference. Conclusion Traditional Chinese Medicine Hongteng Prescription in the treatment of endometriosis can relieve the pain and improve the TCM syndrome,help to improve the balance of the signs of patients,is a better medical treatment of endometriosis clinical program.
Objective To investigate the clinical efficacy of traditional Chinese Medicine Hongteng Prescription in the treatment of wet-heat and blood stasis retention in endometriosis. Methods In the 3 rd People's Hospital of Chongming in Shanghai from February 2014 to March 2017 a total of 80 cases of endometriosis patients as the research sample,All patients were divided into control group and study group according to the time sequence of patients' visit,the control group was treated by indometacin therapy,the study group using traditional Chinese medicine therapy,compared two groups of patients with treatment of The clinical curative effect,symptoms curative effect of TCM,and the change of serum CA125. Results The effective rate of clinical curative effect of long-term study group 87. 55%,control group 45. 00%,two groups were statistically significant difference( P< 0. 05); the two groups on symptoms curative effect of TCM,after the treatment were lower than those before treatment,the study group was lower than the control group,there was significant difference( P<0. 05); the two groups after the treatment the serum CA125 were lower in study group compared with the control group,there were significant difference. Conclusion Traditional Chinese Medicine Hongteng Prescription in the treatment of endometriosis can relieve the pain and improve the TCM syndrome,help to improve the balance of the signs of patients,is a better medical treatment of endometriosis clinical program.
引文
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[10]李雅男,王丹波,陈英汉,等.不同类型子宫内膜异位症临床特点及意义分析[J].实用妇产科杂志,2015,31(1):34-36.
[11]张春雁,张晓云,李连波,等.针药结合预防子宫内膜异位症手术后复发的临床疗效评价[J].中国针灸,2016,36(3):237-242.
[12]马晓燕,郭英.卵巢子宫内膜异位症术后联合GnRH-a类药物副反应的中西医治疗[J].新疆中医药,2016,34(1):112-115.
[13]张小莎,黄作香,李萍.GnRHa联合反向添加戊酸雌二醇对重度子宫内膜异位症腹腔镜术后患者的疼痛感及远期复发率影响[J].中国生化药物杂志,2016,36(1):134-136.
[14]曹阳,赵莉,陈华,等.戴德英运用红藤方治疗子宫内膜异位症经验[J].上海中医药杂志,2013,47(4):4-6.
[15]李晓欣,张萍,张纯溪.促性腺激素释放激素激动剂联合腹腔镜手术治疗大子宫腺肌病疗效的研究[J].中国计划生育和妇产科,2016,8(7):63-67.
[16]宋知理,束兰娣,戴德英.清热活血法治疗子宫内膜异位症临床观察[J].湖北中医杂志,2000,22(11):12-13.
[2]Fauconnier A,Chapron C,Dubuisson JB,et al.Relation between pain symptoms and the anatomic location of deep infiltrating endometriosis[J].Fertil Steril,2002,78(4):719-726.
[3]Vercellini P,Crosignani PG,Abbiati A,et al.The effect of surgery for symptomatic endometriosis:the other side of the story[J].Hum Reprod Update,2009,15(2):177-188.
[4]陆月梅,卢红,刘娅,等.子宫内膜异位症患者病灶组织和血清VEGF-A、CA125表达变化及其意义[J].山东医药,2017,57(3):81-83.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:131-132.
[6]罗元恺.实用中医妇科学[M].上海:上海科学技术出版社,1996:278.
[7]中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症的诊治指南[J].中华妇产科杂志,2015,50(3):167.
[8]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:59.
[9]王秋香.内异康复片治疗湿热瘀阻型子宫内膜异位症盆腔疼痛的临床研究[D].成都:成都中医药大学,2016.
[10]李雅男,王丹波,陈英汉,等.不同类型子宫内膜异位症临床特点及意义分析[J].实用妇产科杂志,2015,31(1):34-36.
[11]张春雁,张晓云,李连波,等.针药结合预防子宫内膜异位症手术后复发的临床疗效评价[J].中国针灸,2016,36(3):237-242.
[12]马晓燕,郭英.卵巢子宫内膜异位症术后联合GnRH-a类药物副反应的中西医治疗[J].新疆中医药,2016,34(1):112-115.
[13]张小莎,黄作香,李萍.GnRHa联合反向添加戊酸雌二醇对重度子宫内膜异位症腹腔镜术后患者的疼痛感及远期复发率影响[J].中国生化药物杂志,2016,36(1):134-136.
[14]曹阳,赵莉,陈华,等.戴德英运用红藤方治疗子宫内膜异位症经验[J].上海中医药杂志,2013,47(4):4-6.
[15]李晓欣,张萍,张纯溪.促性腺激素释放激素激动剂联合腹腔镜手术治疗大子宫腺肌病疗效的研究[J].中国计划生育和妇产科,2016,8(7):63-67.
[16]宋知理,束兰娣,戴德英.清热活血法治疗子宫内膜异位症临床观察[J].湖北中医杂志,2000,22(11):12-13.