TRIM家族在非小细胞肺癌中的研究进展
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摘要
肺癌是全世界范围内死亡率最高的恶性肿瘤,而非小细胞肺癌是其主要类型,在研究非小细胞肺癌的过程中,越来越多的研究发现TRIM蛋白家族成员与癌症的发生与发展密切相关,本文将重点对TRIM蛋白家族在非小细胞肺癌中的研究进展进行综述。
Lung cancer is the most common malignant tumor in the world.Non-small cell lung cancer(NSCLC)is the main type.In the process of studying non-small cell lung cancer,more and more studies have found that TRIM protein family members is closely related with the occurrence and development of cancer.This article will focus on the research progress of the TRIM protein family in non-small cell lung cancer.
Lung cancer is the most common malignant tumor in the world.Non-small cell lung cancer(NSCLC)is the main type.In the process of studying non-small cell lung cancer,more and more studies have found that TRIM protein family members is closely related with the occurrence and development of cancer.This article will focus on the research progress of the TRIM protein family in non-small cell lung cancer.
引文
[1]Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
[2]Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[3]Hirsch FR,Bunn PA Jr.Progress in research on screening and genetics in lung cancer[J].Lancet Respir Med,2014,2(1):19-21.
[4]Esposito D,Koliopoulos MG,Rittinger K.Structural determinants of TRIM protein function[J].Biochem Soc Trans,2017,45(1):183-191.
[5]Watanabe M,Hatakeyama S.TRIM proteins and diseases[J].J Biochem,2017,161(2):135-144.
[6]Cambiaghi V,Giuliani V,Lombardi S,et al.TRIM proteins in cancer[J].Adv Exp Med Biol,2012,770:77-91.
[7]Koliopoulos MG,Esposito D,Christodoulou E,et al.Functional role of TRIM E3ligase oligomerization and regulation of catalytic activity[J].EMBO J,2016,35(11):1 204-1 218.
[8]Wang XL,Shi WP,Shi HC,et al.TRIM11overexpression promotes proliferation,migration and invasion of lung cancer cells[J].J Exp Clin Cancer Res,2016,35(1):100.
[9]Di K,Linskey ME,Bota DA.TRIM11is overexpressed in high-grade gliomas and promotes proliferation,invasion,migration and glial tumor growth[J].Oncogene,2013,32(42):5 038-5 047.
[10]Huo XW,Li SN,Shi TT,et al.Tripartite motif 16inhibits epithelial-mesenchymal transition and metastasis by down-regulating sonic hedgehog pathway in nonsmall cell lung cancer cells[J].Biochemical and Biophysical Research Communications,2015,460(4):1 021-1 028.
[11]Raif A,Marshall GM,Bell JL,et al.The estrogen-responsive B box protein(EBBP)restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation[J].Cancer Lett,2009,277(1):82-90.
[12]Bell JL,Malyukova A,Kavallaris M,et al.TRIM16inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization[J].Cell Cycle,2013,12(6):889-898.
[13]Chen L,Chen DT,Kurtyka C,et al.Tripartite motif containing 28(Trim28)can regulate cell proliferation by bridging HDAC1/E2F interactions[J].J Biol Chem,2012,287(48):40 106-40 118.
[14]Chen L,Munoz-Antonia T,Cress WD.Trim28contributes to EMT via regulation of E-cadherin and Ncadherin in lung cancer cell lines[J].PLoS One,2014,9(7):10.
[15]Wang L,Heidt DG,Lee CJ,et al.Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization[J].Cancer Cell,2009,15(3):207-219.
[16]Tang ZP,Cui QZ,Dong QZ,et al.Ataxia-telangiectasia group D complementing gene(ATDC)upregulates matrix metalloproteinase 9(MMP-9)to promote lung cancer cell invasion by activating ERK and JNK pathways[J].Tumour Biol,2013,34(5):2 835-2 842.
[17]Tang ZP,Dong QZ,Cui QZ,et al.Ataxia-telangiectasia group D complementing gene(ATDC)promotes lung cancer cell proliferation by activating NF-kappa B pathway[J].PLoS One,2013,8(6):e63676.
[18]Song XM,Fu CH,Yang XD,et al.Tripartite motifcontaining 29as a novel biomarker in non-small cell lung cancer[J].Oncology Letters,2015,10(4):2 283-2 288.
[19]Zhou ZY,Yang GY,Zhou J,et al.Significance of TRIM29and beta-catenin expression in non-small-cell lung cancer[J].Journal of the Chinese Medical Association,2012,75(6):269-274.
[20]Liu C,Huang X,Hou S,et al.Silencing of tripartite motif(TRIM)29inhibits proliferation and invasion and increases chemosensitivity to cisplatin in human lung squamous cancer NCI-H520cells[J].Thorac Cancer,2015,6(1):31-37.
[21]Xing Y,Meng QW,Chen XS,et al.TRIM44promotes proliferation and metastasis in non-small cell lung cancer via mTOR signaling pathway[J].Oncotarget,2016,7(21):30 479-30 491.
[22]Pineda CT,Potts PR.Oncogenic MAGEA-TRIM28ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancer[J].Autophagy,2015,11(5):844-846.
[23]Luo QQ,Lin H,Ye XY,et al.TRIM44facilitates the migration and invasion of human lung cancer cells via the NF-kappa B signaling pathway[J].International Journal of Clinical Oncology,2015,20(3):508-517.
[24]Li Y,Ma CY,Zhou T,et al.TRIM65negatively regulates p53through ubiquitination[J].Biochemical and Biophysical Research Communications,2016,473(1):278-282.
[25]Li S,Wang L,Fu B,et al.TRIM65regulates microRNA activity by ubiquitination of TNRC6[J].Proc Natl Acad Sci U S A,2014,111(19):6 970-6 975.
[26]Li S,Wang L,Fu B,et al.TTRIM65:a cofactor for regulation of the microRNA pathway[J].RNA Biol,2014,11(9):1 113-1 121.
[27]Qin Y,Cui H,Zhang H.Overexpression of TRIM25in lung cancer regulates tumor cell progression[J].Technology in Cancer Research&Treatment,2016,15(5):707-715.
[28]Zoumpoulidou G,Broceno C,Li H,et al.Role of the tripartite motif protein 27in cancer development[J].Journal of the National Cancer Institute,2012,104(12):941-952.
[29]Zhan WH,Han TY,Zhang CF,et al.TRIM59promotes the proliferation and migration of non-small cell lung cancer cells by upregulating cell cycle related proteins[J].PLoS One,2015,10(11):13.
[30]Liu JL,Wu WX,Xie YH,et al.Overexpression of TRIM66functions as an oncogene in lung cancer progression[J].International Journal of Clinical and Experimental Pathology,2016,9(5):4 966-4 977.
[2]Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[3]Hirsch FR,Bunn PA Jr.Progress in research on screening and genetics in lung cancer[J].Lancet Respir Med,2014,2(1):19-21.
[4]Esposito D,Koliopoulos MG,Rittinger K.Structural determinants of TRIM protein function[J].Biochem Soc Trans,2017,45(1):183-191.
[5]Watanabe M,Hatakeyama S.TRIM proteins and diseases[J].J Biochem,2017,161(2):135-144.
[6]Cambiaghi V,Giuliani V,Lombardi S,et al.TRIM proteins in cancer[J].Adv Exp Med Biol,2012,770:77-91.
[7]Koliopoulos MG,Esposito D,Christodoulou E,et al.Functional role of TRIM E3ligase oligomerization and regulation of catalytic activity[J].EMBO J,2016,35(11):1 204-1 218.
[8]Wang XL,Shi WP,Shi HC,et al.TRIM11overexpression promotes proliferation,migration and invasion of lung cancer cells[J].J Exp Clin Cancer Res,2016,35(1):100.
[9]Di K,Linskey ME,Bota DA.TRIM11is overexpressed in high-grade gliomas and promotes proliferation,invasion,migration and glial tumor growth[J].Oncogene,2013,32(42):5 038-5 047.
[10]Huo XW,Li SN,Shi TT,et al.Tripartite motif 16inhibits epithelial-mesenchymal transition and metastasis by down-regulating sonic hedgehog pathway in nonsmall cell lung cancer cells[J].Biochemical and Biophysical Research Communications,2015,460(4):1 021-1 028.
[11]Raif A,Marshall GM,Bell JL,et al.The estrogen-responsive B box protein(EBBP)restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation[J].Cancer Lett,2009,277(1):82-90.
[12]Bell JL,Malyukova A,Kavallaris M,et al.TRIM16inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization[J].Cell Cycle,2013,12(6):889-898.
[13]Chen L,Chen DT,Kurtyka C,et al.Tripartite motif containing 28(Trim28)can regulate cell proliferation by bridging HDAC1/E2F interactions[J].J Biol Chem,2012,287(48):40 106-40 118.
[14]Chen L,Munoz-Antonia T,Cress WD.Trim28contributes to EMT via regulation of E-cadherin and Ncadherin in lung cancer cell lines[J].PLoS One,2014,9(7):10.
[15]Wang L,Heidt DG,Lee CJ,et al.Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization[J].Cancer Cell,2009,15(3):207-219.
[16]Tang ZP,Cui QZ,Dong QZ,et al.Ataxia-telangiectasia group D complementing gene(ATDC)upregulates matrix metalloproteinase 9(MMP-9)to promote lung cancer cell invasion by activating ERK and JNK pathways[J].Tumour Biol,2013,34(5):2 835-2 842.
[17]Tang ZP,Dong QZ,Cui QZ,et al.Ataxia-telangiectasia group D complementing gene(ATDC)promotes lung cancer cell proliferation by activating NF-kappa B pathway[J].PLoS One,2013,8(6):e63676.
[18]Song XM,Fu CH,Yang XD,et al.Tripartite motifcontaining 29as a novel biomarker in non-small cell lung cancer[J].Oncology Letters,2015,10(4):2 283-2 288.
[19]Zhou ZY,Yang GY,Zhou J,et al.Significance of TRIM29and beta-catenin expression in non-small-cell lung cancer[J].Journal of the Chinese Medical Association,2012,75(6):269-274.
[20]Liu C,Huang X,Hou S,et al.Silencing of tripartite motif(TRIM)29inhibits proliferation and invasion and increases chemosensitivity to cisplatin in human lung squamous cancer NCI-H520cells[J].Thorac Cancer,2015,6(1):31-37.
[21]Xing Y,Meng QW,Chen XS,et al.TRIM44promotes proliferation and metastasis in non-small cell lung cancer via mTOR signaling pathway[J].Oncotarget,2016,7(21):30 479-30 491.
[22]Pineda CT,Potts PR.Oncogenic MAGEA-TRIM28ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancer[J].Autophagy,2015,11(5):844-846.
[23]Luo QQ,Lin H,Ye XY,et al.TRIM44facilitates the migration and invasion of human lung cancer cells via the NF-kappa B signaling pathway[J].International Journal of Clinical Oncology,2015,20(3):508-517.
[24]Li Y,Ma CY,Zhou T,et al.TRIM65negatively regulates p53through ubiquitination[J].Biochemical and Biophysical Research Communications,2016,473(1):278-282.
[25]Li S,Wang L,Fu B,et al.TRIM65regulates microRNA activity by ubiquitination of TNRC6[J].Proc Natl Acad Sci U S A,2014,111(19):6 970-6 975.
[26]Li S,Wang L,Fu B,et al.TTRIM65:a cofactor for regulation of the microRNA pathway[J].RNA Biol,2014,11(9):1 113-1 121.
[27]Qin Y,Cui H,Zhang H.Overexpression of TRIM25in lung cancer regulates tumor cell progression[J].Technology in Cancer Research&Treatment,2016,15(5):707-715.
[28]Zoumpoulidou G,Broceno C,Li H,et al.Role of the tripartite motif protein 27in cancer development[J].Journal of the National Cancer Institute,2012,104(12):941-952.
[29]Zhan WH,Han TY,Zhang CF,et al.TRIM59promotes the proliferation and migration of non-small cell lung cancer cells by upregulating cell cycle related proteins[J].PLoS One,2015,10(11):13.
[30]Liu JL,Wu WX,Xie YH,et al.Overexpression of TRIM66functions as an oncogene in lung cancer progression[J].International Journal of Clinical and Experimental Pathology,2016,9(5):4 966-4 977.