丁苯酞对老年蛛网膜下腔出血性脑血管痉挛患者的血清IL-6、CRP和NSE水平及预后的影响分析
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摘要
目的 :探究丁苯酞对老年蛛网膜下腔出血性脑血管痉挛患者的血清IL-6、CRP、NSE水平及其预后的影响。方法 :将我院收治的89例蛛网膜下腔出血性脑血管痉挛患者进行研究,按照治疗方式的不同将其分为观察组(51例)和对照组(38例)。对照组在常规治疗的基础上给予尼莫地平注射液进行治疗,观察组则在对照组的基础上给予丁苯酞进行治疗。对比两组患者的血清IL-6、CRP和NSE水平变化及预后。结果 :治疗后,观察组患者的大脑动脉血流速度、血清IL-6、CRP以及NSE水平的下降幅度均明显大于对照组,差异有统计学意义。住院期间,观察组患者的并发症发生率为19.61%,明显低于对照组(44.74%)。观察组的预后恢复优良率为88.24%,明显高于对照组(63.16%)。结论 :在治疗老年蛛网膜下腔出血性脑血管痉挛上,丁苯酞能够显著降低其血清IL-6、CRP以及NSE水平,使脑部血流状况得到显著改善,对于改善其预后结局能够发挥积极作用。
Objective To research the effect of butylphthalide on serum IL-6, CRP and NSE and prognosis in elderly patients with subarachnoid hemorrhage cerebral vasospasm. Method 89 cases of patients with subarachnoid hemorrhage cerebral vasospasm in our hospital were studied. According to the different treatment methods, they were divided into the observation group(51 cases) and the control group(38 cases). The control group was given nimodipine injection on the basis of conventional treatment, while the observation group was given butylphthalide on the basis of the control group. Compared the changes of serum IL-6, CRP, NSE and the prognosis. Result After the treatment, the cerebral artery blood flow velocity, serum IL-6, CRP and NSE levels in the observation group were significantly lower than in the control group, and the differences were statistically significant. During hospitalization, the incidence of complications in the observation group was 19.61%, which was significantly lower than that in the control group(44.74%). The recovery rate of the prognosis of the observation group was 88.24%, which was significantly higher than that of the control group(63.16%). Conclusion In the treatment of elderly patients with subarachnoid hemorrhage cerebral vasospasm, butylphthalide can significantly reduce the serum levels of IL-6, CRP and NSE, so that the blood flow of the brain has been significantly improved, and it can play an active role in improving the prognosis.
Objective To research the effect of butylphthalide on serum IL-6, CRP and NSE and prognosis in elderly patients with subarachnoid hemorrhage cerebral vasospasm. Method 89 cases of patients with subarachnoid hemorrhage cerebral vasospasm in our hospital were studied. According to the different treatment methods, they were divided into the observation group(51 cases) and the control group(38 cases). The control group was given nimodipine injection on the basis of conventional treatment, while the observation group was given butylphthalide on the basis of the control group. Compared the changes of serum IL-6, CRP, NSE and the prognosis. Result After the treatment, the cerebral artery blood flow velocity, serum IL-6, CRP and NSE levels in the observation group were significantly lower than in the control group, and the differences were statistically significant. During hospitalization, the incidence of complications in the observation group was 19.61%, which was significantly lower than that in the control group(44.74%). The recovery rate of the prognosis of the observation group was 88.24%, which was significantly higher than that of the control group(63.16%). Conclusion In the treatment of elderly patients with subarachnoid hemorrhage cerebral vasospasm, butylphthalide can significantly reduce the serum levels of IL-6, CRP and NSE, so that the blood flow of the brain has been significantly improved, and it can play an active role in improving the prognosis.
引文
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[10]邢娟.法舒地尔联合尼莫地平治疗动脉瘤性蛛网膜下腔出血后脑血管痉挛的疗效[J].江苏医药, 2014, 40(01):100-101.
[11]邢军,李玲,郭颖,等.中西医结合治疗老年人心脑血管病用药研究[J].世界中医药, 2017, 12(03):529-532.
[12]刘艳,朱明秋,林丽晴,等.尼莫地平防治蛛网膜下腔出血后脑血管痉挛的疗效分析[J].神经损伤与功能重建, 2014, 09(03):249-250.
[13]程冉冉,李焰,周燕,等.丁苯酞联合依达拉奉对急性脑梗死患者血清SOD、MDA的影响[J].中国老年学杂志, 2014, 34(11):2974-2975.
[14]王国军,马涛.氟伐他汀与丁苯酞软胶囊联合治疗急性脑梗死的疗效及对血清C反应蛋白的动态影响[J].中国生化药物杂志,2014, 34(07):150-152.
[15] Alturki AY, Alamri AS, Badawy MM, et al. Basilar artery vasospasm after pretuncal non-aneurysmal subarachnoid hemorrhage responding to milrinone[J]. Neurosciences(Riyadh), 2017, 22(02):134-137.
[16]濮捷,崔敏,吴非,等.阿替普酶联合丁苯酞注射液对超早期缺血性卒中患者神经功能缺损的影响分析[J].湖南师范大学学报(医学版), 2016, 13(01):103-105.
[2]苏海涛,刘建风,郑立志,等.丁苯酞软胶囊对蛛网膜下腔出血后血流动力学和血管痉挛的影响[J].中国临床研究, 2015, 28(05):621-623.
[3]Xu T, Wang W, Zhai L, et al. Serum Gamma-glutamyl Transferase Levels Predict Functional Outcomes after Aneurysmal Subarachnoid Hemorrhage[J]. Biomed Environ Sci, 2017, 30(03):170-176.
[4]陈林.尼莫地平与硫酸镁治疗蛛网膜下腔出血后脑血管痉挛随机对照研究[J].中国实用神经疾病杂志, 2014, 17(16):22-23.
[5]李琦,吕静,杨妹琴,等.丁苯酞联合血栓通治疗缺血性脑卒中患者神经功能的效果[J].中国生化药物杂志, 2014, 34(06):107-109.
[6]周望溪,伍苏芳.丁苯酞软胶囊对帕金森伴抑郁患者的协同治疗作用观察[J].湖南师范大学学报(医学版), 2014, 11(02):71-73.
[7]陆俊.脑血管意外合并抑郁症患者对神经功能康复的影响[J].中国健康心理学杂志, 2017, 25(09):1321-1324.
[8]Petridis AK, Kamp MA, Cornelius JF, et al. Aneurysmal Subarachnoid Hemorrhage[J]. Dtsch Arztebl Int, 2017, 114(13):226-236.
[9]孙久君,何朝晖,唐玖宁,等.血红蛋白浓度与动脉瘤性蛛网膜下腔出血术后症状性脑血管痉挛的相关研究[J].中国神经精神疾病杂志, 2014, 40(05):275-278.
[10]邢娟.法舒地尔联合尼莫地平治疗动脉瘤性蛛网膜下腔出血后脑血管痉挛的疗效[J].江苏医药, 2014, 40(01):100-101.
[11]邢军,李玲,郭颖,等.中西医结合治疗老年人心脑血管病用药研究[J].世界中医药, 2017, 12(03):529-532.
[12]刘艳,朱明秋,林丽晴,等.尼莫地平防治蛛网膜下腔出血后脑血管痉挛的疗效分析[J].神经损伤与功能重建, 2014, 09(03):249-250.
[13]程冉冉,李焰,周燕,等.丁苯酞联合依达拉奉对急性脑梗死患者血清SOD、MDA的影响[J].中国老年学杂志, 2014, 34(11):2974-2975.
[14]王国军,马涛.氟伐他汀与丁苯酞软胶囊联合治疗急性脑梗死的疗效及对血清C反应蛋白的动态影响[J].中国生化药物杂志,2014, 34(07):150-152.
[15] Alturki AY, Alamri AS, Badawy MM, et al. Basilar artery vasospasm after pretuncal non-aneurysmal subarachnoid hemorrhage responding to milrinone[J]. Neurosciences(Riyadh), 2017, 22(02):134-137.
[16]濮捷,崔敏,吴非,等.阿替普酶联合丁苯酞注射液对超早期缺血性卒中患者神经功能缺损的影响分析[J].湖南师范大学学报(医学版), 2016, 13(01):103-105.