胰岛素抵抗在肝癌作用中的研究进展
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摘要
肝癌的发病率逐年升高,具有较高的死亡率,术后复发率高,严重影响肝癌远期疗效,进一步深入探讨肝癌的发病机制对诊疗具有重要意义。相关研究发现胰岛素抵抗与一些癌症的发生、发展有一定的关系,大量研究也证实胰岛素抵抗参与了多种肝脏疾病的发生发展过程,尤其是与肝癌的发病密切相关,胰岛素抵抗在肝癌发病过程中可能的具体机制也都得到了进一步的研究,改善胰岛素抵抗有可能成为治疗肝癌患者新的切入点。
The incidence of liver cancer increases year by year,which has high mortality.However the rate of recurrence postoperative of liver cancer is high too.which seriously influences the long-term curative effect of liver cancer.Further exploring the pathogenesis of liver cancer is of great significance for diagnosis and treatment.Researches have found that the insulin resistanc has a certain relationship with the occurrence and development of some cancer.A large number of researches also confirmed that the insulin resistance participates in the development process of a variety of liver diseases,especially closely associated with the liver cancer. The specific mechanism of the insulin resistance in the developing process of liver cancer has also got further research.Improving insulin resistance may be a new treatment for liver cancer patients.
The incidence of liver cancer increases year by year,which has high mortality.However the rate of recurrence postoperative of liver cancer is high too.which seriously influences the long-term curative effect of liver cancer.Further exploring the pathogenesis of liver cancer is of great significance for diagnosis and treatment.Researches have found that the insulin resistanc has a certain relationship with the occurrence and development of some cancer.A large number of researches also confirmed that the insulin resistance participates in the development process of a variety of liver diseases,especially closely associated with the liver cancer. The specific mechanism of the insulin resistance in the developing process of liver cancer has also got further research.Improving insulin resistance may be a new treatment for liver cancer patients.
引文
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[2]Byrne C D,Targher G.Ectopic fat,insulin resistance,and nonalcoholic fatty liver disease:implications for cardiovascular disease[J].Arteriosclerosis Thrombosis&Vascular Biology,2013,72(4):412-419.
[3]Arslan N,Sayin O,Tokgoz Y.Evaluation of serum xenin and ghrelin levels and their relationship with nonalcoholic fatty liver disease and insulin resistance in obese adolescents[J].Journal of Endocrinological Investigation,2014,37(11):1091-1097.
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[8]李冰昱,王福生,刘慧霞.慢性乙型肝炎患者胰岛素抵抗与临床病理特点相关性研究[J].中国医师杂志,2009,11(5):603-605.
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[12]叶宏平,魏育华,李延灿.糖尿病前期患者C反应蛋白和胰岛素抵抗与非酒精性脂肪肝相关性分析[J].黑龙江医药,2016,29(4):788-790.
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[14]申甜,徐碧林,盛霞,等.非酒精性脂肪肝大鼠肝组织FGF21m RNA表达与脂质沉积、胰岛素抵抗的关系[J].山东医药,2016,56(8):10-13.
[15]Yatsuya H,Nihashi T,Li Y,et al.Independent association of liver fat accumulation with insulin resistance[J].Obesity Research&Clinical Practice,2014,8(4):e350.
[16]周博,郭秦乐,李会霞,等.成纤维细胞生长因子21通过抑制肥胖小鼠肝脏氧化应激改善胰岛素抵抗[J].西安交通大学学报:医学版,2017,38(2):161-165.
[17]刘蓉,秦嶽.胰岛素受体酪氨酸激酶底物p53蛋白在上皮性卵巢癌中的表达及其对患者预后的影响[J].肿瘤防治研究,2017,44(4):272-275.
[18]许丹丹,王茹瑶,刘蕊,等.循环IGF-1水平与结直肠癌临床病理因素的相关性[J].检验医学,2017,32(1):1-4.
[19]Valério E G,Müller A L,Martins-Costa S H,et al.Are insulin resistance index,IGF-1 and metabolic syndrome components correlates with severe preeclampsia?[J].Hypertension in Pregnancy,2011,30(3):302-310.
[20]Faderl S,Ferrajoli A,Wierda W,et al.IGF-1 gene polymorphism in obese patients with insulin resistance[J].Molecular Biology Reports,2010,37(1):529-533.
[21]Garofalo C,Manara M C,Nicoletti G,et al.Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling[J].Oncogene,2011,30(24):2730-2740.
[22]Lasram M M,Dhouib I B,Bouzid K,et al.Association of inflammatory response and oxidative injury in the pathogenesis of liver steatosis and insulin resistance following subchronic exposure to malathion in rats[J].Environmental Toxicology&Pharmacology,2014,38(2):542-553.
[23]Zhou X,You S.Rosiglitazone inhibits hepatic insulin resistance induced by chronic pancreatitis and IKK-?2/NF-?oB expression in liver[J].Pancreas,2014,43(8):1291-1298.
[24]Young-Ah M,Ochoa C R,Mitsche M A,et al.Deletion of ELOVL6blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance[J].Journal of Lipid Research,2014,55(12):2597-2605.
[25]Posadasromero C,Jorgegalarza E,Posadassánchez R,et al.Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance,metabolic syndrome,and subclinical coronary atherosclerosis.[J].European Journal of Endocrinology,2014,171(3):319-325.
[26]Zheng F,Zhang S,Lu W,et al.Regulation of insulin resistance and adiponectin signaling in adipose tissue by liver X receptor activation highlights a cross-talk with PPARgamma[J].Plos One,2014,9(6):e101269.
[27]康文娟,王春兰,张美兰,等.脂联素与胰岛素抵抗的关系探讨[J].中国药物与临床,2007,7(6):408-409.
[28]张岩,陈晓亭,宋惠珠,等.肥胖所导致的胰岛素抵抗分子机制的研究进展[J].检验医学,2014,29(7):774-778.
[29]肖洪涛,郑建彬,翟木绪.雌激素对去卵巢大鼠肝细胞胰岛素受体底物-1和2表达的影响[J].中国妇幼保健,2017,23(2):377-380.
[2]Byrne C D,Targher G.Ectopic fat,insulin resistance,and nonalcoholic fatty liver disease:implications for cardiovascular disease[J].Arteriosclerosis Thrombosis&Vascular Biology,2013,72(4):412-419.
[3]Arslan N,Sayin O,Tokgoz Y.Evaluation of serum xenin and ghrelin levels and their relationship with nonalcoholic fatty liver disease and insulin resistance in obese adolescents[J].Journal of Endocrinological Investigation,2014,37(11):1091-1097.
[4]Bazotte R B,Silva L G,Schiavon F P.Insulin resistance in the liver:Deficiency or excess of insulin?[J].Cell Cycle,2014,13(16):2494-2500.
[5]付刚,夏豪.胰岛素抵抗与相关生化指标及冠心病危险因素的相关性[J].西南国防医药,2016,26(10):1164-1167.
[6]Helaly G F,Hussein N G,Refai W,et al.Relation of serum insulin-like growth factor-1(IGF-1)levels with hepatitis C virus infection and insulin resistance[J].Translational Research,2011,158(3):155-162.
[7]Zampino R,Coppola N,Cirillo G,et al.Insulin resistance and steatosis in HBV-HCV co-infected patients:Role of PNPLA3 polymorphisms and impact on liver fibrosis progression[J].World Journal of Hepatology,2014,6(9):677.
[8]李冰昱,王福生,刘慧霞.慢性乙型肝炎患者胰岛素抵抗与临床病理特点相关性研究[J].中国医师杂志,2009,11(5):603-605.
[9]Taguchi K,Yamanaka-Okumura H,Mizuno A,et al.Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis[J].J Med Invest,2014,61(1.2):180-189.
[10]Kahl S,Stra?burger K,Nowotny B,et al.Comparison of Liver Fat Indices for the Diagnosis of Hepatic Steatosis and Insulin Resistance[J].Plos One,2014,9(4):e94059.
[11]Saki F,Karamizadeh Z.Metabolic Syndrome,Insulin Resistance and Fatty Liver in Obese Iranian Children[J].Iranian Red Crescent Medical Journal,2014,16(5):e6656.
[12]叶宏平,魏育华,李延灿.糖尿病前期患者C反应蛋白和胰岛素抵抗与非酒精性脂肪肝相关性分析[J].黑龙江医药,2016,29(4):788-790.
[13]Lee S,Rivera-Vega M,Alsayed H M,et al.Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease[J].Pediatric Diabetes,2015,16(3):211-218.
[14]申甜,徐碧林,盛霞,等.非酒精性脂肪肝大鼠肝组织FGF21m RNA表达与脂质沉积、胰岛素抵抗的关系[J].山东医药,2016,56(8):10-13.
[15]Yatsuya H,Nihashi T,Li Y,et al.Independent association of liver fat accumulation with insulin resistance[J].Obesity Research&Clinical Practice,2014,8(4):e350.
[16]周博,郭秦乐,李会霞,等.成纤维细胞生长因子21通过抑制肥胖小鼠肝脏氧化应激改善胰岛素抵抗[J].西安交通大学学报:医学版,2017,38(2):161-165.
[17]刘蓉,秦嶽.胰岛素受体酪氨酸激酶底物p53蛋白在上皮性卵巢癌中的表达及其对患者预后的影响[J].肿瘤防治研究,2017,44(4):272-275.
[18]许丹丹,王茹瑶,刘蕊,等.循环IGF-1水平与结直肠癌临床病理因素的相关性[J].检验医学,2017,32(1):1-4.
[19]Valério E G,Müller A L,Martins-Costa S H,et al.Are insulin resistance index,IGF-1 and metabolic syndrome components correlates with severe preeclampsia?[J].Hypertension in Pregnancy,2011,30(3):302-310.
[20]Faderl S,Ferrajoli A,Wierda W,et al.IGF-1 gene polymorphism in obese patients with insulin resistance[J].Molecular Biology Reports,2010,37(1):529-533.
[21]Garofalo C,Manara M C,Nicoletti G,et al.Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling[J].Oncogene,2011,30(24):2730-2740.
[22]Lasram M M,Dhouib I B,Bouzid K,et al.Association of inflammatory response and oxidative injury in the pathogenesis of liver steatosis and insulin resistance following subchronic exposure to malathion in rats[J].Environmental Toxicology&Pharmacology,2014,38(2):542-553.
[23]Zhou X,You S.Rosiglitazone inhibits hepatic insulin resistance induced by chronic pancreatitis and IKK-?2/NF-?oB expression in liver[J].Pancreas,2014,43(8):1291-1298.
[24]Young-Ah M,Ochoa C R,Mitsche M A,et al.Deletion of ELOVL6blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance[J].Journal of Lipid Research,2014,55(12):2597-2605.
[25]Posadasromero C,Jorgegalarza E,Posadassánchez R,et al.Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance,metabolic syndrome,and subclinical coronary atherosclerosis.[J].European Journal of Endocrinology,2014,171(3):319-325.
[26]Zheng F,Zhang S,Lu W,et al.Regulation of insulin resistance and adiponectin signaling in adipose tissue by liver X receptor activation highlights a cross-talk with PPARgamma[J].Plos One,2014,9(6):e101269.
[27]康文娟,王春兰,张美兰,等.脂联素与胰岛素抵抗的关系探讨[J].中国药物与临床,2007,7(6):408-409.
[28]张岩,陈晓亭,宋惠珠,等.肥胖所导致的胰岛素抵抗分子机制的研究进展[J].检验医学,2014,29(7):774-778.
[29]肖洪涛,郑建彬,翟木绪.雌激素对去卵巢大鼠肝细胞胰岛素受体底物-1和2表达的影响[J].中国妇幼保健,2017,23(2):377-380.